IF 1.9 4区医学

Lipids Pub Date : 2021-11-05 DOI: 10.1002/lipd.12327

Carina P. Van Nieuwenhove, Andrea del Huerto Moyano, Guido A. Van Nieuwenhove, Verónica Molina, Patricia Luna Pizarro

{"title":"Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues","authors":"Carina P. Van Nieuwenhove, Andrea del Huerto Moyano, Guido A. Van Nieuwenhove, Verónica Molina, Patricia Luna Pizarro","doi":"10.1002/lipd.12327","DOIUrl":"10.1002/lipd.12327","url":null,"abstract":"Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO), is considered a potent anticarcinogenic agent. Several studies have focused on its biological effects, but the metabolism once consumed is not clear yet. The aim of this work was to evaluate the effects of two different daily doses of JO on serum parameters and fatty acid (FA) profile of mice tissues after 4 weeks of feeding. No significant changes on body weight gain, food intake, or tissue weight were determined after 0.7 or 2 ml/kg of JO supplementation compared to control animals. Significantly lower blood low-density lipoproteins-cholesterol (20 mg/dl) and glucose (~147–148 mg/dl) levels were detected in both oil-treated groups compared to control (31.2 and 165 mg/dl, respectively). Moreover, jacaric acid was partially converted into cis9, trans11 conjugated linoleic acid (CLA) and thus further incorporated into tissues. Liver evidenced the highest total conjugated fatty acid content (1.1%–2.2%), followed by epididymal (0.7%–1.9%) and mesenteric (1.4%–1.8%) fat. Lower saturated and higher unsaturated fatty acid content was detected in both oil-treated groups compared to control. Our results support the safety of JO and its potential application with a functional or nutraceutical propose, by increasing human CLNA consumption and further availability of CLA.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"57 1","pages":"33-44"},"PeriodicalIF":1.9,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aocs.onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39848244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease 在胆固醇酯储存病的小鼠模型中，尽管脑质量较小，但脑胆固醇稳态的分子标记并未改变

IF 1.9 4区医学

Lipids Pub Date : 2021-10-07 DOI: 10.1002/lipd.12325

Amal A. Aqul, Charina M. Ramirez, Adam M. Lopez, Dennis K. Burns, Joyce J. Repa, Stephen D. Turley

{"title":"Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease","authors":"Amal A. Aqul, Charina M. Ramirez, Adam M. Lopez, Dennis K. Burns, Joyce J. Repa, Stephen D. Turley","doi":"10.1002/lipd.12325","DOIUrl":"10.1002/lipd.12325","url":null,"abstract":"Lysosomal acid lipase (LAL), encoded by the gene LIPA, facilitates the intracellular processing of lipids by hydrolyzing cholesteryl esters and triacylglycerols present in newly internalized lipoproteins. Loss-of-function mutations in LIPA result in cholesteryl ester storage disease (CESD) or Wolman disease when mutations cause complete loss of LAL activity. Although the phenotype of a mouse CESD model has been extensively characterized, there has not been a focus on the brain at different stages of disease progression. In the current studies, whole-brain mass and the concentrations of cholesterol in both the esterified (EC) and unesterified (UC) fractions were measured in Lal−/− and matching Lal+/+ mice (FVB-N strain) at ages ranging from 14 up to 280 days after birth. Compared to Lal+/+controls at 50, 68–76, 140–142, and 230–280 days of age, Lal−/− mice had brain weights that averaged approximately 6%, 7%, 18%, and 20% less, respectively. Brain EC levels were higher in the Lal−/− mice at every age, being elevated 27-fold at 230–280 days. Brain UC concentrations did not show a genotypic difference at any age. The elevated brain EC levels in the Lal−/− mice did not reflect EC in residual blood. An mRNA expression analysis for an array of genes involved in the synthesis, catabolism, storage, and transport of cholesterol in the brains of 141-day old mice did not detect any genotypic differences although the relative mRNA levels for several markers of inflammation were moderately elevated in the Lal−/− mice. The possible sites of EC accretion in the central nervous system are discussed.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"57 1","pages":"3-16"},"PeriodicalIF":1.9,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766890/pdf/nihms-1743044.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10805503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Trans-10 18:1 in ruminant meats: A review 反刍动物肉中的Trans-10 18:1:综述

IF 1.9 4区医学

Lipids Pub Date : 2021-10-04 DOI: 10.1002/lipd.12324

Susana P. Alves, Payam Vahmani, Cletos Mapiye, Tim A. McAllister, Rui J. B. Bessa, Michael E. R. Dugan

{"title":"Trans-10 18:1 in ruminant meats: A review","authors":"Susana P. Alves, Payam Vahmani, Cletos Mapiye, Tim A. McAllister, Rui J. B. Bessa, Michael E. R. Dugan","doi":"10.1002/lipd.12324","DOIUrl":"10.1002/lipd.12324","url":null,"abstract":"Trans (t) fatty acids (TFA) from partially hydrogenated vegetable oils (i.e., industrial trans) have been phased out of foods in many countries due to their promotion of cardiovascular disease. This leaves ruminant-derived foods as the main source of TFA. Unlike industrial TFA where catalytic hydrogenation yields a broad distribution of isomers, ruminant TFA are enzymatically derived and can result in enrichment of specific isomers. Comparisons between industrial and ruminant TFA have often exonerated ruminant TFA due to their lack or at times positive effects on health. At extremes, however, ruminant-sourced foods can have either high levels of t10- or t11-18:1, and when considering enriched sources, t10-18:1 has properties similar to industrial TFA, whereas t11-18:1 can be converted to an isomer of conjugated linoleic acid (cis(c)9,t11-conjugated linoleic acid), both of which have potential positive health effects. Increased t10-18:1 in meat-producing ruminants has not been associated with negative effects on live animal production or meat quality. As such, reducing t10-18:1 has not been of immediate concern to ruminant meat producers, as there have been no economic consequences for its enrichment; nevertheless at high levels, it can compromise the nutritional quality of beef and lamb. In anticipation that regulations regarding TFA may focus more on t10-18:1 in beef and lamb, the present review will cover its production, analysis, biological effects, strategies for manipulation, and regulatory policy.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 6","pages":"539-562"},"PeriodicalIF":1.9,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39485671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1 2-花生四烯醇甘油可通过大麻素受体CB1诱导小鼠肠内分泌STC-1细胞分泌胆囊收缩素

IF 1.9 4区医学

Lipids Pub Date : 2021-09-17 DOI: 10.1002/lipd.12323

Keita Ochiai, Rina Hirooka, Masayoshi Sakaino, Shigeo Takeuchi, Tohru Hira

{"title":"2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1","authors":"Keita Ochiai, Rina Hirooka, Masayoshi Sakaino, Shigeo Takeuchi, Tohru Hira","doi":"10.1002/lipd.12323","DOIUrl":"10.1002/lipd.12323","url":null,"abstract":"Cholecystokinin (CCK) is a peptide hormone secreted from enteroendocrine cells and regulates the exocrine pancreas, gastric motility, and appetite. Dietary triacylglycerols are hydrolyzed to fatty acids (FA) and 2-monoacylglycerols (2-MAG) in the small intestine. Although it is well known that FA stimulate CCK secretion, whether 2-MAG have the CCK-releasing activity remains unclear. We examined the CCK-releasing activity of four commercially available 2-MAG in a murine CCK-producing cell line, STC-1, and the molecular mechanism underlying 2-MAG-induced CCK secretion. CCK released from the cells was measured using ELISA. Among four 2-MAG (2-palmitoyl, 2-oleoyl, 2-linoleoyl, and 2-arachidonoyl monoacylglycerols) examined, 2-arachidonoyl glycerol (2-AG) potently stimulated CCK secretion in a dose-dependent manner. Structurally related compounds, such as 2-arachidonoyl glycerol ether and 1-arachidonoyl glycerol, did not stimulate CCK secretion. Both arachidonic acid and 2-AG stimulated CCK secretion at 100 μM, but only 2-AG did at 50 μM. 2-AG-induced CCK secretion but not arachidonic acid-induced CCK secretion was attenuated by treatment with a cannabinoid receptor 1 (CB1) antagonist. These results indicate that a specific 2-MAG, 2-AG, directly stimulates CCK secretion via CB1.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 6","pages":"603-611"},"PeriodicalIF":1.9,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39425083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Issue Information 问题信息

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 DOI: 10.1002/lipd.12259

引用次数: 0

FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents. 青少年FADS1基因多态性与血脂脂肪酸组成的关系

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 Epub Date: 2021-06-30 DOI: 10.1002/lipd.12317

Tereza Metelcová, Markéta Vaňková, Hana Zamrazilová, Milena Hovhannisyan, Barbora Staňková, Eva Tvrzická, Martin Hill, Vojtěch Hainer, Josef Včelák, Marie Kunešová

{"title":"FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents.","authors":"Tereza Metelcová, Markéta Vaňková, Hana Zamrazilová, Milena Hovhannisyan, Barbora Staňková, Eva Tvrzická, Martin Hill, Vojtěch Hainer, Josef Včelák, Marie Kunešová","doi":"10.1002/lipd.12317","DOIUrl":"https://doi.org/10.1002/lipd.12317","url":null,"abstract":"Polyunsaturated fatty acids (PUFA) influence many physiological functions. Associations have been found between single nucleotide polymorphisms (SNP) in the FADS1 (Fatty acid desaturase 1) gene and the relative abundance of PUFA in serum lipids. This study examines the relationship between two SNPs in the FADS1 gene (rs174546, rs174537) and the fatty acid (FA) composition of serum lipids in adolescents (13-18 years). We used DNA samples (670 children; 336 girls and 334 boys) from the Childhood Obesity Prevalence and Treatment (COPAT) project. Genomic DNA was extracted from peripheral blood leukocytes in whole blood samples. For genotype analysis, TaqMan SNP Genotyping assays (Applied Biosystems) were used. Fatty acid composition of serum lipids was assessed using gas chromatography. The T-statistic and regression were used for statistical evaluations. Minor allele T carriers in both SNPs had significant lower level of palmitic acid (16:0, phospholipids) and arachidonic acid (20:4[n-6], phospholipids) in both sexes. In girls, we found a significant positive association between minor allele T carriers and eicosadienoic acid (20:2[n-6], cholesteryl esters) in both SNPs. Being a minor allele T carrier was significantly positively associated with dihomo-γ-linolenic acid (20:3[n-6], phospholipids) in boys in both SNPs. SNPs (including rs174546, rs174537) in the FADS gene cluster should have impacted desaturase activity, which may contribute to different efficiency of PUFA synthesis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 5","pages":"499-508"},"PeriodicalIF":1.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lipd.12317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39119905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A₂. 人IIA, V和X组分泌磷脂酶A2水解甘油磷酸胆碱环氧化物。

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 Epub Date: 2021-07-18 DOI: 10.1002/lipd.12320

Arnis Kuksis, Waldemar Pruzanski

{"title":"Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A2.","authors":"Arnis Kuksis, Waldemar Pruzanski","doi":"10.1002/lipd.12320","DOIUrl":"https://doi.org/10.1002/lipd.12320","url":null,"abstract":"This study was prompted by recent reports that epoxyeicosatrienoic (EET) and epoxyeicosatetraenoic (EEQ) acids accelerate tumor growth and metastasis by stimulation of angiogenesis, while eicosapentaenoic (EPA) and epoxydocosapentaenoic (EDP) acids inhibit angiogenesis, tumor growth, and metastasis. Cytochrome P450 epoxygenases convert arachidonic to EET, eicosapentaenoic acid to EEQ, and docosahexaenoic acid to EDP, which are found both in free form and esterified to glycerophosphocholine (GPC). Both free and esterified epoxy (EP) acids are also formed during lipid autoxidation. For biological activity, the GPC-EP requires hydrolysis, which we presumed could occur by sPLA2 s located in proximity of lipoproteins carrying the lipid epoxides. The plasma lipoproteins were isolated by ultracentrifugation and analyzed by LC/ESI-MS. The GPC-EPs were identified by reference to standards and to retention times of phospholipid masses. The GPC-EP monoepoxides (corrected for isobaric ether overlaps) in stored human LDL, HDL, HDL3 , or APHDL ranged from 0 to 1 nmol/mg protein, but during 4-h incubation at 37°C increased to 1-5 nmol/mg protein. An incubation of autoxidized LDL, HDL, or HDL3 with 1 μg/ml of group V or X sPLA2 resulted in complete hydrolysis of diacyl GPC epoxide esters. Group IIA sPLA2 at 1 μg/ml failed to produce significant hydrolysis in 4 h, but at 2.5 μg/ml in 8 h yielded almost 80% hydrolysis, which represented complete diacyl GPC-EP hydrolysis. The present study shows that group IIA, V, and X sPLA2 s are capable of extensive hydrolysis of PtdCho epoxides of autoxidized plasma lipoproteins. Therefore, all three human sPLA2 s were potentially capable of inducing epoxide biological activity in vivo.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 5","pages":"521-535"},"PeriodicalIF":1.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lipd.12320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39197587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Growth and fatty acid composition of Acutodesmus obliquus under different light spectra and temperatures. 不同光谱和温度下斜尖齿蚌的生长和脂肪酸组成。

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 Epub Date: 2021-06-26 DOI: 10.1002/lipd.12316

Mark Helamieh, Annkathrin Gebhardt, Marco Reich, Friedericke Kuhn, Martin Kerner, Klaus Kümmerer

{"title":"Growth and fatty acid composition of Acutodesmus obliquus under different light spectra and temperatures.","authors":"Mark Helamieh, Annkathrin Gebhardt, Marco Reich, Friedericke Kuhn, Martin Kerner, Klaus Kümmerer","doi":"10.1002/lipd.12316","DOIUrl":"https://doi.org/10.1002/lipd.12316","url":null,"abstract":"The combined impact of temperature and light spectra on the fatty acid (FA) composition in microalgae has been sparsely investigated. The aim of this study was to investigate the interactions of light and temperature on the FA composition in Acutodesmus obliquus. For this purpose, A. obliquus was cultivated with different temperatures (20, 30, and 35°C), as well as broad light spectra (blue, green, and red light). Growth and FA composition were monitored daily. Microalgal FA were extracted, and a qualitative characterization was done by gas chromatography coupled with electron impact ionization mass spectrometry (GC-EI/MS). Compared to red light, green and blue light caused a higher percentage of the polyunsaturated fatty acids (PUFA) 16:4, 18:3, and 18:4, at all temperatures. The highest total percentage of these PUFA were observed at the lowest cultivation temperature and blue and green light. These data imply that a combination of lower temperatures and blue-green light (450-550 nm) positively influences the activity of specific FA-desaturases in A. obliquus. Additionally, a lower 16:1 trans/cis ratio was observed upon green and blue light treatment and lower cultivation temperatures. Remarkably, green light treatment resulted in a comparably high growth under all tested conditions. Therefore, a higher content of green light, compared to blue light might additionally lead to a higher biomass concentration. Microalgae cultivation with low temperatures and green light might therefore result in a suitable FA composition for the food industry and a comparably high biomass production.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 5","pages":"485-498"},"PeriodicalIF":1.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lipd.12316","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39029116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The plasma phospholipidome of Tursiops truncatus: From physiological insight to the design of prospective tools for managed cetacean monitorization. 截尾鲸的血浆磷脂组:从生理学的洞察力到管理鲸类监测的前瞻性工具的设计。

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 Epub Date: 2021-05-25 DOI: 10.1002/lipd.12307

João P Monteiro, Elisabete Maciel, Tânia Melo, Carla Flanagan, Nuno Urbani, João Neves, Maria Rosário Domingues

{"title":"The plasma phospholipidome of Tursiops truncatus: From physiological insight to the design of prospective tools for managed cetacean monitorization.","authors":"João P Monteiro, Elisabete Maciel, Tânia Melo, Carla Flanagan, Nuno Urbani, João Neves, Maria Rosário Domingues","doi":"10.1002/lipd.12307","DOIUrl":"https://doi.org/10.1002/lipd.12307","url":null,"abstract":"Plasma biochemical analysis remains one of the established ways of monitoring captive marine mammal health. More recently, complementary plasma lipidomic analysis has proven to be a valid tool in disease diagnosis and prevention, with the potential to validate and complement common biochemical analysis, providing a more integrative approach. In this study, we thoroughly characterized the plasma polar lipid content of Tursiops truncatus, the most common cetacean species held under human care. Our results showed that phosphatidylcholine, lysophosphatidylcholine, and sphingomyelins (CerPCho) are the most represented phospholipid classes in T. truncatus plasma. Palmitic, oleic, and stearic acids are the major fatty acid (FA) present esterified to the plasma polar lipids of this species, although some n-3 species are also remarkably present, namely eicosapentaenoic and docosahexaenoic acids. The polar lipidome identified by HILIC LC-MS allowed identifying 304 different lipid species. These species belong to the phosphatidylcholine (103 lipid species), lysophosphatidylcholine (35), phosphatidylethanolamine (71), lysophosphatidylethanolamine (20), phosphatidylglycerol (13), lysophosphatidylglycerol (5), phosphatidylinositol (15), lysophosphatidylinositol (3), phosphatidylserine (6) lysophosphatidylserine (1), and sphimgomyelin (32) classes. This was the first time that the dolphin plasma phospholipid profile was characterized, providing a knowledge that will be important to further understand lipid metabolism and physiological regulation in small cetaceans. Furthermore, this study proved the practicability of the use of plasma lipid profiling for health assessment in marine mammals under human care.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 5","pages":"461-473"},"PeriodicalIF":1.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lipd.12307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39017932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The ratio of triglycerides to high-density lipoprotein cholesterol is associated with the risk of chronic kidney disease in Korean men. 甘油三酯与高密度脂蛋白胆固醇的比率与韩国男性慢性肾脏疾病的风险相关。

IF 1.9 4区医学

Lipids Pub Date : 2021-09-01 Epub Date: 2021-06-05 DOI: 10.1002/lipd.12314

Joungyoun Kim, Yoon-Jong Bae, Sang-Jun Shin, Hyo-Sun You, Jae-Woo Lee, Hee-Taik Kang

{"title":"The ratio of triglycerides to high-density lipoprotein cholesterol is associated with the risk of chronic kidney disease in Korean men.","authors":"Joungyoun Kim, Yoon-Jong Bae, Sang-Jun Shin, Hyo-Sun You, Jae-Woo Lee, Hee-Taik Kang","doi":"10.1002/lipd.12314","DOIUrl":"https://doi.org/10.1002/lipd.12314","url":null,"abstract":"Dyslipidemia is nephrotoxic and can result in the development of chronic kidney disease (CKD). The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is well-correlated with insulin resistance and cardiovascular events. The aim of this study is to examine the association between the TG/HDL-C ratio and CKD in Korean adults. This study was retrospectively designed based on the National Health Insurance Service-National Health Screening cohort. Seventy three thousand and fifty-two participants aged between 40 and 79 years old at baseline (2009-2010) were included in the final analyses. The study population was classified into three tertile groups (T1 , T2 , and T3 ) according to the TG/HDL-C ratio by sex. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD were calculated using Cox proportional hazard regression models. The median follow-up duration was 5.9 years. Higher tertile groups of the TG/HDL-C ratio had lower estimated glomerular filtration rates in both sexes. The cumulative incidence of CKD of T1 , T2 , and T3 was 11.89%, 12.90%, and 12.91%, respectively, in men and 10.17%, 10.61%, and 14.87%, respectively, in women (all p values < 0.001). Compared with T1 of the TG/HDL-C ratio, the HRs (95% CIs) of T2 and T3 for CKD were 1.212 (1.118-1.315) and 1.183 (1.087-1.287), respectively, in men and 0.895 (0.806-0.994) and 1.038 (0.937-1.150), respectively, in women after being fully adjusted. Higher TG/HDL-C ratios were positively associated with CKD development in men, while middle levels of TG/HDL ratios reduced the CKD incidence in women.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"56 5","pages":"475-483"},"PeriodicalIF":1.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/lipd.12314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39061731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Lipids最新文献