Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran

IF 1.8 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids Pub Date : 2024-01-29 DOI:10.1002/lipd.12386

Monireh Sadat Seyyedsalehi, Maryam Hadji, Giulia Collatuzzo, Hamideh Rashidian, Bahareh Sasanfar, Inge Huybrechts, Veronique Chajes, Paolo Boffetta, Kazem Zendehdel

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引用次数: 0

Abstract

High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case–control study of Iran (IROPICAN study). We used multivariate logistic regression models to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between PUFAs intake and CRC risk. Our results showed that gamma-linolenic acid (18:3 n-6, GLA), arachidonic acid (20:4n-6, ARA), a-linolenic acid (Cis-18:3n-3, ALA), eicosapentaenoic acid (20:5n-3, EPA), docosahexaenoic acid (22:6n-3, DHA) consumption was not associated with the risk of CRC. However, the OR of linoleic acid (18: 2n-6, LA) intake was 1.47 (95% CI 1.01–2.14, p = 0.04) for proximal colon and that of docosapentaenoic acid (22:5n-3, DPA) intake was 1.33 (95% CI 1.05–1.69, p = 0.01) for rectum. This study indicates a high level of LA is associated with an increased risk of proximal colon cancer, and DPA intake was positively associated with rectum cancer risk. Furthermore, our study noted a high intake of n-6 (from vegetable oils) compared to n-3 PUFAs (from fish and seafood) in this population. Public awareness and government support is needed to increase fish and seafood production and consumption in Iran.

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伊朗人膳食中特定多不饱和脂肪酸 (PUFA) 摄入量对结直肠癌风险的影响。

高脂肪饮食与结直肠癌（CRC）风险有关，而据报道，多不饱和脂肪酸（PUFAs）的作用因 PUFAs 的长度而异。我们探讨了膳食中欧米茄-6 和欧米茄-3 PUFAs 摄入量与 CRC 之间的关系。我们分析了伊朗一项病例对照研究（IROPICAN 研究）中的 865 例 CRC 患者和 3206 例对照者。我们使用多变量逻辑回归模型来计算 PUFAs 摄入量与 CRC 风险之间关系的几率比（OR）和 95% 的置信区间（CI）。结果显示，γ-亚麻酸（18:3 n-6，GLA）、花生四烯酸（20:4 n-6，ARA）、a-亚麻酸（顺式-18:3 n-3，ALA）、二十碳五烯酸（20:5 n-3，EPA）、二十二碳六烯酸（22:6 n-3，DHA）的摄入量与 CRC 风险无关。然而，亚油酸（18:2n-6，LA）摄入量的 OR 值在近端结肠为 1.47（95% CI 1.01-2.14，p = 0.04），摄入二十二碳五烯酸（22:5n-3，DPA）的 OR 值在直肠为 1.33（95% CI 1.05-1.69，p = 0.01）。这项研究表明，高水平的 LA 与近端结肠癌风险增加有关，而 DPA 摄入量与直肠癌风险呈正相关。此外，我们的研究还发现，与 n-3 PUFAs（来自鱼类和海产品）相比，该人群的 n-6（来自植物油）摄入量较高。伊朗需要提高公众意识和政府支持，以增加鱼类和海产品的生产和消费。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids 生物-生化与分子生物学

CiteScore

4.20

自引率

5.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Lipids is a journal of the American Oil Chemists'' Society (AOCS) that focuses on publishing high-quality peer-reviewed papers and invited reviews in the general area of lipid research, including chemistry, biochemistry, clinical nutrition, and metabolism. In addition, Lipids publishes papers establishing novel methods for addressing research questions in the field of lipid research.