Magnetic Resonance Materials in Physics, Biology and Medicine最新文献

{"title":"Agreement of image quality metrics with radiological evaluation in the presence of motion artifacts.","authors":"Elisa Marchetto, Hannah Eichhorn, Daniel Gallichan, Julia A Schnabel, Melanie Ganz","doi":"10.1007/s10334-025-01266-y","DOIUrl":"10.1007/s10334-025-01266-y","url":null,"abstract":"<p><strong>Objective: </strong>Reliable image quality assessment is crucial for evaluating new motion correction methods for magnetic resonance imaging. We compare the performance of common reference-based and reference-free image quality metrics on unique datasets with real motion artifacts, and analyze the metrics' robustness to typical pre-processing techniques.</p><p><strong>Materials and methods: </strong>We compared five reference-based and five reference-free metrics on brain data acquired with and without intentional motion (2D and 3D sequences). The metrics were recalculated seven times with varying pre-processing steps. Spearman correlation coefficients were computed to assess the relationship between image quality metrics and radiological evaluation.</p><p><strong>Results: </strong>All reference-based metrics showed strong correlation with observer assessments. Among reference-free metrics, Average Edge Strength offers the most promising results, as it consistently displayed stronger correlations across all sequences compared to the other reference-free metrics. The strongest correlation was achieved with percentile normalization and restricting the metric values to the skull-stripped brain region. In contrast, correlations were weaker when not applying any brain mask and using min-max or no normalization.</p><p><strong>Discussion: </strong>Reference-based metrics reliably correlate with radiological evaluation across different sequences and datasets. Pre-processing significantly influences correlation values. Future research should focus on refining pre-processing techniques and exploring approaches for automated image quality evaluation.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dedicated phantom for exploring the interplay of fat and paramagnetic substances in quantitative susceptibility mapping.","authors":"Simon Graf, Josefine Trapp, Maik Rothe, Alexander Gussew, Walter A Wohlgemuth, Andreas Deistung","doi":"10.1007/s10334-025-01261-3","DOIUrl":"10.1007/s10334-025-01261-3","url":null,"abstract":"<p><strong>Objective: </strong>Accurate quantitative tissue characterization in organs with considerable fat content, like the liver, requires thorough understanding of fat's influence on the MR signal. To continue the investigations into the use of quantitative susceptibility mapping (QSM) in abdominal regions, we present a dedicated phantom that replicates liver-like conditions in terms of effective transverse relaxation rates (R₂*) and proton density fat fractions.</p><p><strong>Materials and methods: </strong>The spherical agar phantom consists of nine smaller spheres (diameter: 3 cm) doped with a paramagnetic substance (iron nanoparticles or manganese chloride) and fat (peanut oil), embedded in a large agar sphere (diameter: 14 cm), ensuring no barriers exist between the enclosed spheres and their surrounding medium. Concentrations were selected to represent both healthy and pathologic conditions. 3T MRI measurements for relaxometry, fat-water imaging, and QSM were conducted with the head coil and for ¹H-spectroscopy with the knee coil at three time points, including a scan-rescan assessment and a follow-up measurement 14 months later.</p><p><strong>Results: </strong>The phantoms' relaxation and magnetic properties are in similar range as reported for liver tissue. Substantial alterations in local field and susceptilibty maps were observed in regions with elevated fat and iron content, where fat correction of the local field via chemical shift-encoded reconstruction effectively reduced streaking artifacts in susceptibility maps and substantially increased susceptibility values. Linear regression analysis revealed a consistent linear relationship between R₂* and magnetic susceptibility, as well as iron concentration and magnetic susceptibility. The relaxation, fat, and susceptibility measurements remained stable across scan-rescan assessment and long-term follow-up.</p><p><strong>Discussion: </strong>We developed a versatile phantom to study fat-iron interactions in abdominal imaging, facilitating the optimization and comparison of susceptibility processing methods in future research.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial Hadamard-encoded ¹⁹F-MRI.","authors":"Kian Tadjalli Mehr, Johannes Fischer, Felix Spreter, Simon Reiss, David Boll, Ali Caglar Özen, Deepa Gunashekar, Constantin von Zur Mühlen, Alexander Maier, Michael Bock","doi":"10.1007/s10334-025-01254-2","DOIUrl":"https://doi.org/10.1007/s10334-025-01254-2","url":null,"abstract":"<p><strong>Objectives: </strong>Developing a ¹⁹F imaging method to acquire images of the molecular inflammation tracer perfluorooctyl bromide (PFOB) without chemical shift artifacts.</p><p><strong>Materials and methods: </strong>PFOB is a molecular tracer that can be used to track the response of myeloid cells. However, imaging of PFOB with ¹⁹F-MRI is challenging due to its complex spectrum which leads to unwanted chemical shift artifacts. Spectral HE allows for separate reconstructions of each peak of the PFOB spectrum, which was combined into a single image after resonance shift correction. In this work, a Hadamard-encoded (HE) radial 3D UTE sequence was tested in phantoms and in vivo in a pig, measuring the ¹⁹F signal in the spleen at different times after injection.</p><p><strong>Results: </strong>Chemical shift artifacts were effectively suppressed with HE, and an SNR > 100 was observed for the ¹⁹F signal in the spleen 2 days after injection. The signal decreased over time, and 7 days after injection it was reduced by 30%.</p><p><strong>Discussion: </strong>Chemical shift artifact correction using HE allowed for in vivo ¹⁹F PFOB imaging of labeled monocytes with a high SNR. Compared to spectrally selective excitation, HE increased the PFOB ¹⁹F-MRI signal by 10%, and the simple HE-algorithm could be directly integrated into the image reconstruction of the MRI system.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating spatial resolution in prostate MR images: the utility of the ladder method.","authors":"Tomokazu Takeuchi, Norio Hayashi, Yusuke Sato, Kouichi Ujita, Ayako Taketomi-Takahashi, Hiromi Hirasawa, Aya Takase, Terutaka Yoshihara, Takayuki Yokota, Takayuki Suto, Yoshito Tsushima","doi":"10.1007/s10334-025-01264-0","DOIUrl":"https://doi.org/10.1007/s10334-025-01264-0","url":null,"abstract":"<p><strong>Background: </strong>Evaluating prostate MRI resolution is challenging due to motion artifacts caused by body movement or intestinal gas, which can degrade image quality. One simple approach to resolution assessment is the ladder method, but reports of its application to clinical images remain limited. This study aimed to compare the ladder method with visual evaluation to assess its utility.</p><p><strong>Methods: </strong>T2-weighted images of the prostate in healthy volunteers and a ladder phantom at various resolutions with altered pixel sizes (0.5, 0.7, 0.9 and 1.1 mm) were acquired. Three radiologists conducted visual evaluations of the prostate images. Correlation coefficients between the visual evaluation scores and the ladder index (LI) obtained from the ladder method were compared.</p><p><strong>Results: </strong>Average visual evaluation scores were 7.7, 5.9, 3.8, and 2.1, while the spatial frequencies corresponding to LI = 0.5 (50%LI) were 0.86, 0.81, 0.54, and 0.42 cycles/mm for each pixel size ranging from 0.5 to 1.1 mm, demonstrating higher values at smaller pixel sizes. The correlation coefficients exceeded 0.7 at most spatial frequencies, indicating a strong correlation. Inter-reader agreement was high (Kendall's W = 0.87), indicating consistent evaluation among radiologists.</p><p><strong>Conclusions: </strong>Spatial resolution for prostate MRI could be evaluated objectively using the ladder method.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-stage framework for segmentation of the brain anatomical regions with high accuracy.","authors":"Peyman Sharifian, Alireza Karimian, Hossein Arabi","doi":"10.1007/s10334-025-01233-7","DOIUrl":"10.1007/s10334-025-01233-7","url":null,"abstract":"<p><strong>Objective: </strong>This study presents a novel deep learning-based framework for precise brain MR region segmentation, aiming to identify the location and the shape details of different anatomical structures within the brain.</p><p><strong>Materials and methods: </strong>The approach uses a two-stage 3D segmentation technique on a dataset of adult subjects, including cognitively normal participants and individuals with cognitive decline. Stage 1 employs a 3D U-Net to segment 13 brain regions, achieving a mean DSC of 0.904 ± 0.060 and a mean HD95 of 1.52 ± 1.53 mm (a mean DSC of 0.885 ± 0.065 and a mean HD95 of 1.57 ± 1.35 mm for smaller parts). For challenging regions like hippocampus, thalamus, cerebrospinal fluid, amygdala, basal ganglia, and corpus callosum, Stage 2 with SegResNet refines segmentation, improving mean DSC to 0.921 ± 0.048 and HD95 to 1.17 ± 0.69 mm.</p><p><strong>Results: </strong>Statistical analysis reveals significant improvements (p-value < 0.001) for these regions, with DSC increases ranging from 1.3 to 3.2% and HD95 reductions of 0.06-0.33 mm. Comparisons with recent studies highlight the superior performance of the performed method.</p><p><strong>Discussion: </strong>The inclusion of a second stage for refining the segmentation of smaller regions demonstrates substantial improvements, establishing the framework's potential for precise and reliable brain region segmentation across diverse cognitive groups.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"299-315"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial assessment of PNS safety for interventionalists during image-guided procedures.","authors":"Feng Jia, Axel Vom Endt, Philipp Amrein, Maximilian Frederik Russe, Heiko Rohdjess, Martino Leghissa, Maxim Zaitsev, Sebastian Littin","doi":"10.1007/s10334-025-01228-4","DOIUrl":"10.1007/s10334-025-01228-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates peripheral nerve stimulation (PNS) safety thresholds for health professionals performing MRI procedures and the variation of arm rotations in close vicinity to the magnet bore.</p><p><strong>Methods: </strong>Employing two posable human body models, this research utilized quasi-static electromagnetic calculations and neurodynamic simulations to assess PNS thresholds. Different arm rotations are compared for standing interventionalist's posture assuming the supine patient position, typical for medical interventions inside MRI devices.</p><p><strong>Results: </strong>This study reveals that arm rotations in standing postures result in variations in PNS thresholds. However, for all the arm poses considered, the threshold was at least 2.4 times higher compared to the patient position. Differences in PNS thresholds and electric field distributions were observed between male and female models.</p><p><strong>Conclusions: </strong>The findings suggest that when the PNS thresholds for imaging subjects are not exceeded, it is likely that a subject leaning into the bore will also not experience PNS. However, variations in PNS thresholds due to arm movements highlight the importance of considering body posture in MRI safety protocols.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"239-251"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of fully automated cartilage transverse relaxation time (T2) and thickness analysis using quantitative DESS magnetic resonance imaging.","authors":"Wolfgang Wirth, Simon Herger, Susanne Maschek, Anna Wisser, Oliver Bieri, Felix Eckstein, Annegret Mündermann","doi":"10.1007/s10334-025-01227-5","DOIUrl":"10.1007/s10334-025-01227-5","url":null,"abstract":"<p><strong>Objective: </strong>To clinically validate a fully automated cartilage segmentation technique from quantitative double-echo steady-state (qDESS) MRI supporting simultaneous estimation of cartilage T2 and morphology. Here, we test whether laminar (superficial and deep layer) T2 results from convolutional neural network (CNN) segmentations are consistent with those from manual expert segmentations.</p><p><strong>Materials and methods: </strong>The 3D qDESS sequence was acquired using 3 T MRI (resolution: 0.3125 × 0.3125x1.5 mm) in both knees of 37 subjects with unilateral anterior cruciate ligament (ACL) injury and 48 uninjured controls. Automated femorotibial cartilage (FTJ) segmentation was based on a 2D U-Net. Laminar T2 and cartilage thickness across the FTJ) were compared between ACL-injured and contralateral knees, and between ACL-injured and control knees. Effect sizes of these differences were measured using non-parametric Cohen's d (d_n-p).</p><p><strong>Result: </strong>Significant differences were observed only in deep T2, with longer T2 in ACL-injured knees than in contralateral and healthy control knees in most of the comparisons and with similar effect sizes for automated and manual segmentations (range d_n-p automated/manual: 0.58-1.04/0.58-0.74). No significant differences were observed in superficial T2 or cartilage thickness.</p><p><strong>Discussion: </strong>Fully-automated, CNN-based analysis showed similar sensitivity to differences in laminar cartilage T2 as manual segmentation, allowing automated qDESS-analyses to be applied to larger datasets.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"285-297"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic evaluation of adhesives for implant fixation in multimodal functional brain MRI.","authors":"Anna Zsófia Szinyei, Bastian Maus, Jonas Q Schmid, Matthias Klimek, Daniel Segelcke, Esther M Pogatzki-Zahn, Bruno Pradier, Cornelius Faber","doi":"10.1007/s10334-024-01220-4","DOIUrl":"10.1007/s10334-024-01220-4","url":null,"abstract":"<p><strong>Objective: </strong>Invasive multimodal fMRI in rodents is often compromised by susceptibility artifacts from adhesives used to secure cranial implants. We hypothesized that adhesive type, shape, and field strength significantly affect susceptibility artifacts, and systematically evaluated various adhesives.</p><p><strong>Materials and methods: </strong>Thirty-one adhesives were applied in constrained/unconstrained geometries and imaged with T2*-weighted EPI at 7.0 and 9.4 T to assess artifact depths. Spherical and flat patch shapes, both unconstrained geometries, were compared for artifact depth in vitro and in vivo. Adhesion strength was assessed on post-mortem mouse crania. Finally, an integrative scoring system rated adhesive properties, including artifact depth, handling, and adhesion strength.</p><p><strong>Results: </strong>Susceptibility artifacts were two times larger at 9.4 than at 7.0 T (p < 0.001), strongest at the patch edges, and deeper with spherical than flat patches (p < 0.05). Artifact size depended more on shape and volume after curing than adhesive type. Our integrative scoring system showed resins, bonding agents, and acrylics offered the best overall properties, while silicones and cements were less favorable.</p><p><strong>Discussion: </strong>Adhesive selection requires balancing handling, curing time, strength, and artifact depth. To minimize artifacts, adhesives should be applied in a spread-out, flat and thin layer. Our integrative scoring system supports classification of future classes of adhesives.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"191-205"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New physiological insights using multi-TE ASL MRI measuring blood-brain barrier water exchange after caffeine intake.","authors":"Amnah Mahroo, Mareike Alicja Buck, Simon Konstandin, Jörn Huber, Daniel Christopher Hoinkiss, Jochen Hirsch, Matthias Günther","doi":"10.1007/s10334-024-01219-x","DOIUrl":"10.1007/s10334-024-01219-x","url":null,"abstract":"<p><strong>Objectives: </strong>Caffeine, a known neurostimulant and adenosine antagonist, affects brain physiology by decreasing cerebral blood flow. It interacts with adenosine receptors to induce vasoconstriction, potentially disrupting brain homeostasis. However, the impact of caffeine on blood-brain barrier (BBB) permeability to water remains underexplored. This study investigated the water exchange via the BBB in a perturbed physiological condition caused by caffeine ingestion, using the multiple echo time (multi-TE) arterial spin labeling (ASL) technique.</p><p><strong>Material and methods: </strong>Ten healthy, regular coffee drinkers (age = 31 ± 9 years, 3 females) were scanned to acquire five measurements before and six measurements after caffeine ingestion. Data were analyzed with a multi-TE two-compartment model to estimate exchange time (Tex), serving as a proxy for BBB permeability to water. Additionally, cerebral blood flow (CBF), arterial transit time (ATT), and intravoxel transit time (ITT) were investigated.</p><p><strong>Results: </strong>Following caffeine intake, mean gray matter CBF showed a significant time-dependent decrease (P < 0.01). In contrast, Tex, ATT, and ITT did not exhibit significant time-dependent change. However, a non-significant decreasing trend was observed for Tex and ITT, respectively, while ATT showed an increasing trend over time.</p><p><strong>Discussion: </strong>The observed decreasing trend in Tex after caffeine ingestion suggests a potential increase in water flux across the BBB, which may represent a compensatory mechanism to maintain brain homeostasis in response to the caffeine-induced reduction in CBF. Further studies with larger sample sizes are needed to validate and expand upon these findings.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"207-219"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143039443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study.","authors":"Martin B Schilder, Stefano Mandija, Sarah M Jacobs, Jordi P D Kleinloog, Hanna Liu, Oscar van der Heide, Beyza Köktaş, Federico D'Agata, Vera C W Keil, Evert-Jan P A Vonken, Jan Willem Dankbaar, Jeroen Hendrikse, Tom J Snijders, Cornelis A T van den Berg, Anja G van der Kolk, Alessandro Sbrizzi","doi":"10.1007/s10334-025-01237-3","DOIUrl":"10.1007/s10334-025-01237-3","url":null,"abstract":"<p><strong>Objective: </strong>To report T₁/T₂-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, and to explore relaxometry behavior in a brain tumor and in a multiple sclerosis patient.</p><p><strong>Methods: </strong>MR-STAT was acquired in 49 participants (39 patients with neurological pathologies, age range: 21-79 years) at 3 T. Mean T₁/T₂-values were computed for: normal and normal appearing grey matter (NGM/NAGM)/white matter (NWM/NAWM)/thalamus/putamen/caudate nucleus (CN)/globus pallidus (GP). Differences between sex, brain lobes, and left/right were assessed. The age-dependency of T₁/T₂-values in N(A)BTs was investigated. Relaxometry analysis was performed in two clinical case examples.</p><p><strong>Results: </strong>Mean (standard deviation) T₁/T₂-values were measured in N(A)GM = 1086(73)/74(9) ms; N(A)WM = 658(24)/48(3) ms; thalamus = 783(51)/42(4) ms; putamen = 863(40)/46(3) ms; CN = 1042(97)/63(9) ms; GP = 652(36)/36(3) ms. Differences between sex were not significant. T₁/T₂-values between the left/right parietal lobe and the left/right temporal lobe were significantly different. The quadratic age-dependency of T₁-values in the CN (p = 0.00039) and GP (p = 0.00037), and of T₂-values in the thalamus (p = 0.00044) and GP (p = 0.003) were significant. Pathological tissues could be discerned from NABTs using T₁/T₂-values.</p><p><strong>Discussion: </strong>T₁/T₂-values and data trends agree with literature, supporting the validity of MR-STAT as a clinical option for fast relaxometry despite the relatively low number of subjects in the study. Future work should aim to include healthy participants of a wider age-range and to include B₁-field corrections.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"333-345"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}