Magnetic Resonance Materials in Physics, Biology and Medicine最新文献

{"title":"Metabolic modelling and time-resolved mapping of glucose oxidative metabolism in the rat brain by indirect deuterium detection with ¹H-FID-MRSI at 9.4 T.","authors":"Alessio Siviglia, Gianna Nossa, Brayan Alves, Fabian Niess, Anna Duguid, Zenon Starčuk, Wolfgang Bogner, Bernhard Strasser, Cristina Cudalbu, Bernard Lanz","doi":"10.1007/s10334-026-01363-6","DOIUrl":"10.1007/s10334-026-01363-6","url":null,"abstract":"<p><strong>Object: </strong>This study exploits newly developed dynamic indirect ¹H-[²H]-FID-MRSI at 9.4 T, combined with a dedicated metabolic model, to enable regional and quantitative characterization of glucose oxidative metabolism flux in the rat brain with minimal metabolic assumptions, by measuring both ²H-labelled Glx turnover and pool size along a controlled ²H-Glc infusion protocol.</p><p><strong>Materials and methods: </strong>Seven rats underwent dynamic 2D ¹H-FID-MRSI during a 2-h infusion of [6,6'-²H₂] glucose. Consecutive 13-min acquisitions quantified Glx-C4 ¹H-signal decay, converted to ²H-Glx concentrations using baseline metabolite pool sizes. A four-pool kinetic model including ²H-label loss was fitted to regional turnover curves to estimate oxidative flux (V_gt) and pyruvate dilution (Kdil). Model performance and parameter robustness were assessed with Monte-Carlo simulations.</p><p><strong>Results: </strong>In vivo ²H-Glx turnover showed a saturated exponential rise (~ 60 min), with a labelling plateau higher in striatum (1.85 μmol/g) than hippocampus (1.55 μmol/g). Metabolic modelling provided region-specific oxidative fluxes: V_gt = 0.53 ± 0.15 μmol/g/min (hippocampus) and V_gt = 0.81 ± 0.12 μmol/g/min (striatum), with consistent Kdil across regions. Simulations confirmed a good model robustness in retrieving V_gt over a large range of experimental conditions.</p><p><strong>Discussion: </strong>This work shows the potential of indirect dynamic ¹H-[²H]-FID-MRSI for quantitative metabolic flux mapping of cerebral glucose oxidative metabolism.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"381-393"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148032070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of regional metabolic alteration using 7T deuterium metabolic imaging in MRI-negative, ¹⁸FDG-PET-positive epilepsy patients.","authors":"Narjes Ahmadian, Romy Buijs, Mark Gosselink, Igrid Otto, Kiki Tesselaar, Jeanine J Prompers, Pieter van Eijsden, Nicole van Klink, Dennis W Klomp, Evita C Wiegers","doi":"10.1007/s10334-026-01334-x","DOIUrl":"10.1007/s10334-026-01334-x","url":null,"abstract":"<p><strong>Objective: </strong>Identifying presumed epileptogenic region (PER) in MRI-negative epilepsy patients is crucial for successful surgical outcomes. This study aims to determine whether dynamic deuterium metabolic imaging (DMI) at 7Tesla can detect region-specific metabolic alterations in MRI-negative, ¹⁸FDG-PET-positive temporal-lobe epilepsy.</p><p><strong>Methods: </strong>Five drug-resistant MRI-negative, ¹⁸FDG-PET-positive epilepsy patients underwent dynamic DMI. 3D ²H FID-MRSI scans (11:44 min each) were acquired at 7T over ~ 100 min following oral [6,6'-²H₂]glucose intake. Venous plasma glucose and ²H glucose atom percent enrichment (APE) were measured in blood samples taken during scanning. Plasma glucose and ²H-glucose APE were analyzed using a General Linear Model with Repeated measures. From DMI, brain ²H-glucose and ²H glutamate/glutamine levels were analyzed using a two-level linear mixed model (factors: time and tissue type) comparing the PER and contralateral (contra-PER), hippocampus and temporal pole regions.</p><p><strong>Results: </strong>Plasma glucose and ²H-Glucose (Glc) atom-percent excess rose within 40 min post ingestion and then stabilized. Brain ²H-Glc and ²H-glutamate/glutamine (Glx) increased over time (p < 0.001). For ²H-Glc, regional differences were small, with only a modest elevation in hippocampus-PER relative to temporal-contra (p = 0.04). In contrast, ²H-Glx showed clear regional variation (p < 0.001), with the highest levels in hippocampus-PER, significantly exceeding PER, Temporal-PER, and Temporal-Contra (p ≤ 0.01). These findings remained consistent when averaging the final four time points.</p><p><strong>Conclusions: </strong>Ultra-high-field DMI revealed elevated hippocampal glutamatergic turnover in MRI negative epilepsy patients, with the highest levels in the epileptogenic hippocampus. These findings indicate the presence of subtle metabolic alterations in hippocampal tissue, supporting the potential of DMI to capture pathophysiological changes that remain invisible to conventional imaging.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"453-461"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of T₁ and T₂ relaxation times of deuterium (²H) labeled resonances in the human liver and kidney using k-space reordered 3D concentric ring trajectory sampling at 7T.","authors":"Viola Bader, Bernhard Strasser, Lukas Hingerl, Johannes J Kovarik, Sabina Frese, Lorenz Pfleger, Anna Duguid, Aaron Osburg, Martin Krššák, Thomas Scherer, Wolfgang Bogner, Fabian Niess","doi":"10.1007/s10334-025-01320-9","DOIUrl":"10.1007/s10334-025-01320-9","url":null,"abstract":"<p><strong>Objective: </strong>Deuterium metabolic imaging (DMI) is an emerging MR technique providing non-invasive insights into glucose metabolism. Reliable concentration estimation depends on knowledge of tissue specific relaxation times. This study reports T₁ and T₂ relaxation time constants of deuterium-labeled water (HDO) and glucose (Glc) from the human liver and kidney at 7T.</p><p><strong>Materials and methods: </strong>Twelve healthy volunteers (6f/6 m) were examined using k-space-reordered inversion-recovery and spin-echo DMI with non-Cartesian concentric-ring trajectory (CRT) sampling. Seven volunteers underwent oral ²H-Glc (0.8 g/kg body weight) administration. Data were averaged over organ-specific masks before spectral fitting. One volunteer was measured after oral D₂O (0.5 ml/kg body weight) administration.</p><p><strong>Results: </strong>Faster longitudinal relaxation but similar transversal relaxation were observed for ²H-labeled Glc in the liver compared to kidney tissue (T₁^liver/kidney = 60 ± 4 ms/85 ± 18 ms, p = 0.016; T₂^liver/kidney = 31 ± 6 ms/35 ± 2 ms, p = 0.283). HDO exhibited significantly shorter liver relaxation times (T₁^liver/kidney = 218 ± 24 ms/324 ± 34 ms, p < 0.001; T₂^liver/kidney = 28 ± 4 ms/39 ± 6 ms, p < 0.001). D₂O loading improved voxelwise SNR enabling renal T₁/T₂ mapping of HDO.</p><p><strong>Discussion: </strong>Hepatic and renal glucose homeostasis is often impaired in several pathophysiological conditions such as tumors, diabetes and metabolic dysfunction-associated steatotic liver disease. Using organ-specific ²H relaxation times increases the accuracy of concentration estimation and can help to improve the understanding of underlying metabolic processes in future abdominal DMI studies, which can help to push abdominal DMI towards clinical application.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"499-512"},"PeriodicalIF":3.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Net zero emission MR imaging using a permanent 0.4 T magnet.","authors":"Hans-Martin Klein","doi":"10.1007/s10334-026-01385-0","DOIUrl":"https://doi.org/10.1007/s10334-026-01385-0","url":null,"abstract":"<p><strong>Objectives: </strong>Radiology, particularly superconducting MRI, accounts for a significant share of healthcare energy consumption. We aimed to achieve zero-emission MR imaging by combining a permanent-magnet MRI with a solar energy system.</p><p><strong>Material/methods: </strong>We installed a 30-kW peak rooftop solar array on an energy-efficient building. We used a permanent-magnet MRI system with a 0.4 T field strength, 25 mT gradients, and a 55 T/m/s slew rate. We installed a 22 kWh LiFePO4 battery for short-term energy storage. A smart consumer controller routed solar energy as the primary source. Surplus solar energy was fed into the power grid. If solar production was too low, energy was purchased from the grid. In the event of a grid failure with no available solar energy, a high-voltage DC generator would supply grid energy. Energy consumption and solar energy production were analyzed from January 2024 to December 2025.</p><p><strong>Results: </strong>Total energy consumption in 2025 was 22,992 kWh. Total energy production in 2025 was 30,823 kWh. Total grid feed in 2025 was 16,364 kWh. Total energy retrieved from the grid in 2025 was 8948 kWh. From May to August 2025, the practice operated grid independent for more than 94% of the time. The practice's energy balance was positive (negative CO₂ emissions) at 7416 kWh (- 2692 kg CO₂).</p><p><strong>Conclusion: </strong>A permanent-magnet MRI, combined with a solar power system, enabled grid-independent operation with net negative CO₂ emissions.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the diffusion time dependence of the IVIM effect based on realistic capillary flow simulations in mouse brain.","authors":"Franciszek Hennel, Manuel Fernández López, Franca Schmid","doi":"10.1007/s10334-026-01382-3","DOIUrl":"https://doi.org/10.1007/s10334-026-01382-3","url":null,"abstract":"<p><strong>Introduction: </strong>The intra-voxel incoherent motion (IVIM) effect is an additional signal attenuation in in-vivo diffusion-weighted MRI due to blood microcirculation. The dependence of this effect on diffusion time is of high interest because it may inform about the architecture of blood vessels in perfusion studies and help optimizing diffusion scans to avoid the IVIM bias. This dependence is derived here using capillary blood trajectories obtained by realistic flow simulations in capillary bed samples of mouse brain cortex derived from two-photon microscopy.</p><p><strong>Methods: </strong>Using the gaussian phase approximation, NMR signal attenuation due to IVIM is derived for pulsed-gradient diffusion sequences at different diffusion times and for sequences with flow-compensated gradient shapes by calculating the product of the gradient moment spectra with the spectral density of the simulated blood velocity autocorrelation function.</p><p><strong>Results and discussion: </strong>The results suggest that the microcirculation underlying the IVIM effect in the brain cannot be faithfully depicted by the commonly used models of diffusive or ballistic flow, but rather as a correlated random motion with a correlation time in the range of 60-120 ms. Consequently, the correlation time appears to be an interesting, MRI-accessible endpoint to characterize microcirculation. Further, the flow compensation as a means of suppressing the IVIM effect in diffusion measurements may not be fully effective.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of brain volume and cortical thickness measurement at 0.55 T.","authors":"Anand A Joshi, Sophia X Cui, Chin-Cheng Chan, Hao-Ting Kung, Jonas T Kaplan, Krishna S Nayak, Richard M Leahy, Justin P Haldar","doi":"10.1007/s10334-026-01380-5","DOIUrl":"10.1007/s10334-026-01380-5","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the feasibility of anatomical neuroimaging studies using 0.55 T MRI.</p><p><strong>Methods: </strong>MPRAGE images with 1 mm isotropic resolution were acquired from a cohort of five healthy subjects using both 0.55 T and 3 T scanners, including repeat scans of each subject at each field strength. The 0.55 T images were denoised to mitigate the effects of high resolution and low-field strength. All scans were analyzed using BrainSuite and FreeSurfer image analysis software, which performs operations including tissue classification, region segmentation/labeling, and thickness/volume measurements for different brain regions. Regional cortical thickness measurements and regional brain volume measurements were compared, and test-retest repeatability at each field strength was evaluated.</p><p><strong>Results: </strong>For both image analysis software tools, we observed reasonably good correlations between field strengths for cortical thickness measures and regional brain volume measures. Test-retest repeatability analysis suggests that experimental variability was generally higher at 0.55 T than at 3 T, although the amount of difference was dependent on the specific measure being considered and the software tool that was used.</p><p><strong>Conclusion: </strong>While our sample size was small which limits the strength of the conclusions we can draw, this small-scale pilot study suggests the potential feasibility of certain types of anatomical neuroimaging studies at 0.55 T (especially those involving volume measurements), assuming that appropriate adjustments are made to account for increased experimental variability at this field strength.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of gadolinium-based contrast agent (GBCA) on the diffusion weightings of breast lesions: an intra-patient analysis.","authors":"Kay J J van der Hoogt, Robert-Jan Schipper, Leon C Ter Beek, Ronni Wessels, Hedda J van der Hulst, Arjan Te Boekhorst, Regina G H Beets-Tan, Ritse M Mann","doi":"10.1007/s10334-026-01381-4","DOIUrl":"10.1007/s10334-026-01381-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the influence of gadolinium-based contrast agent (GBCA) administration on breast lesions' signal intensities on diffusion-weighted images and its derived ADC maps acquired 2 min after GBCA administration.</p><p><strong>Materials and methods: </strong>An intra-patient analysis was performed. 110 lesions > 5 mm in 93 patients, visible on screening and pre-operative MRI scans at 1.5 T and 3.0 T, were included. Pre-contrast and post-contrast DWI were acquired with single-shot spin-echo echo-planar imaging (SSh-SE-EPI) with b0, b50, b150, and b800 diffusion weightings. 2D regions of interest were drawn. Each b value was separately analyzed regarding signal intensities on DWI. Furthermore, ADC values were compared based on the pairs b0-b800 and b150-b800. The comparison between pre- and post-contrast DWIs was investigated within and between different groups (overall, malignant/benign, and at 1.5/3.0 T). The Wilcoxon-signed rank test and independent Student T test were used when appropriate. P < 0.01 was considered as statistically significant.</p><p><strong>Results: </strong>Overall, and for malignant and benign lesions separately, a significant change after contrast administration in signal intensity was observed at each specific b value, irrespective of the use of 1.5 T or 3.0 T. The effect of contrast administration was overall notably different when comparing b0 (+ 9.4%) vs. b800 (+ 11.8%), but this was not observed between b150 (11.4%) and b800 (11.8%) (P = 0.10). In malignant lesions, specifically, all b value pairs, except b0-b50, showed significant differences in GBCA effects. This translates into a pre-post-contrast difference of the ADC value of 3.2% (P = 0.02) when based on b0-b800 and 0.9% (P = 0.11) when using b150-800.</p><p><strong>Conclusions: </strong>There is a limited, but significant effect of contrast administration on DW signal intensities measured 2 min after contrast administration. This effect is not the same for each b value. Signal change is stronger for high than for low b values, which leads to a larger change in measured ADC values after contrast administration when b0 and b50 are incorporated in the calculation. As a consequence, ADC calculations obtained from b150-b800 seem to be more robust than those obtained from b0-b800.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black-blood dynamic contrast-enhanced MRI of abdominal aortic aneurysms.","authors":"Wilhelm Stehling, Eva Aalbregt, Myrte Wennen, Eric Schrauben, Kak Khee Yeung, Aart J Nederveen, Oliver J Gurney-Champion","doi":"10.1007/s10334-026-01386-z","DOIUrl":"https://doi.org/10.1007/s10334-026-01386-z","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a dynamic contrast-enhanced (DCE) MRI protocol for imaging the aortic wall of abdominal aortic aneurysms (AAAs), and to investigate the repeatability and clinical correlation of novel biomarkers for rupture risk assessment.</p><p><strong>Methods: </strong>A dedicated DCE protocol with black-blood contrast was applied to 20 patients with AAA, of which 16 underwent a second scan 6 months later. Semiquantitative DCE-derived parameters in the aneurysm wall were calculated, assessed for test-retest repeatability using within-subject coefficient of variation (wCV), and correlated with clinical measures (aneurysm diameter and growth rate) using Spearman's rank correlation.</p><p><strong>Results: </strong>The developed protocol allows for accurate delineation of the aortic wall and calculation of semiquantitative DCE-derived parameters. The maximum enhancement (ME) and area under the curve (AUC) demonstrated good stability with wCVs of 14% and 18%, respectively. No significant correlations were found between DCE-derived parameters and clinical measures.</p><p><strong>Conclusion: </strong>The derived DCE protocol enables repeatable assessment of semiquantitative parameters of the aortic wall in AAA patients. No correlation was found between DCE-derived parameters and clinical markers of aneurysm progression.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hazards associated with superconducting magnet quench events: system requirements, application and consequences.","authors":"Michael Steckner","doi":"10.1007/s10334-026-01373-4","DOIUrl":"https://doi.org/10.1007/s10334-026-01373-4","url":null,"abstract":"<p><p>The magnetically induced displacement force on nearby ferromagnetic objects has injured and killed people. The \"quench\" button dissipates the magnetic field by forcing the wire from the superconducting to the resistive state and its use in such situations should be unquestioned. Unfortunately, recent events demonstrate a reluctance to initiate a quench, perhaps because of the expense and down-time involved and the shock of confronting a rare and dire situation. Reports from various adverse incidents involving quenches also suggest a need to improve the awareness of what might happen during a quench. This review highlights relevant attributes of superconducting magnets (e.g. possible reasons for a quench, field attributes during the quench, various failure mechanisms that may occur etc.), the quench button, quench pipe, cryogen safety, and the quench sequence of events. Furthermore, it is necessary to be prepared for a rare gaseous helium release, including a nearby second safety-trained assistant, as people have been injured, incapacitated, or killed either by physical contact with a super-cooled object, hypoxia, or asphyxiation. In this regard, the development of \"cryogenless\" magnets demonstrates significant safety benefits. A selection of Food and Drug Administration (FDA) \"Manufacturer and User Facility Device Experience\" (MAUDE) incident reports illustrate these various situations, and device recalls also identify and resolve various potential, or realized, hazards, such as magnet explosions due to over-pressure and accidental cryogen release mechanisms. All users of MRI equipment must recognize when it is necessary to initiate a quench, what happens when a quench goes awry, and be prepared with quick decisions and actions. However, with small ferromagnetic objects or other non-critical situations, there may be alternative non-quench solutions. Understanding prior incidents prepares us for what might happen in a future incident and is a motivation for additional safety procedure development and training activities.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bi- and tri-component approaches for the analysis of short-T₂^* tissues in the presence of fat: application to the Achilles tendon.","authors":"Peter Latta, Veronika Janacova, Martin Kojan, Lubomir Vojtíšek, Aneta Malá, Zenon Starčuk, Siegfried Trattnig, Vladimir Juras","doi":"10.1007/s10334-026-01383-2","DOIUrl":"https://doi.org/10.1007/s10334-026-01383-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate how data acquisition and post-processing choices influence ultrashort echo time (UTE)-based characterization of the short-T₂^* compositional structure of the Achilles tendon.</p><p><strong>Methods: </strong>Ten healthy volunteers (33.3 ± 6.9 years) underwent Achilles tendon MRI using a multi-echo, time-interleaved UTE sequence. T₂^* data were analyzed with and without fat suppression using two models: (i) a bi-component decay with two water pools and (ii) a tri-component decay including two water components and one fat component. The effect of magnitude versus complex fitting on compositional estimates was also assessed. Three Achilles tendon regions were analyzed: insertion (INS), mid-portion (MID), and muscle-tendon junction (MTJ).</p><p><strong>Results: </strong>Estimated short vs. long T₂^* components differed significantly depending on the use of fat suppression (p < 0.001 for all tendon regions) and fitting method (magnitude vs. complex) (p_INS = 0.002, p_MID < 0.001, p_MTJ < 0.001). T₂^* time constants were comparatively stable, particularly in the MID part (p > 0.05). The fitting method affected short T₂^* component in the MTJ (p_MTJ = 0.032) and long T₂* component in the INS and MTJ (p_INS = 0.025, p_MTJ < 0.017).</p><p><strong>Discussion: </strong>Non-fat-suppressed vs. fat-suppressed (FS) strategy and fitting approach substantially affect bi-component T₂^* quantification of the Achilles tendon, limiting comparability of UTE-based metrics. Tri-component modeling provides a more realistic description of tendon signal and may improve sensitivity to pathological changes. Further studies in patients are needed.</p>","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}