Magnetic Resonance Materials in Physics, Biology and Medicine最新文献_第6页

Gadobenate dimeglumine-enhanced MRI at hepatobiliary phase can predict liver regeneration after partial hepatectomy in fibrotic rats. 肝胆道期磁共振增强Gadobenate - dimeglumin可以预测肝部分切除后纤维化大鼠的肝再生。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-08-01 Epub Date: 2026-01-20 DOI: 10.1007/s10334-026-01325-y

Jiaying Bao, Yuanyuan Li, Gongzheng Wang, Pengyu Zhang, Jin Cui, Suhong Duan, Chengyong Qin, Min Huang, Xinya Zhao

{"title":"Gadobenate dimeglumine-enhanced MRI at hepatobiliary phase can predict liver regeneration after partial hepatectomy in fibrotic rats.","authors":"Jiaying Bao, Yuanyuan Li, Gongzheng Wang, Pengyu Zhang, Jin Cui, Suhong Duan, Chengyong Qin, Min Huang, Xinya Zhao","doi":"10.1007/s10334-026-01325-y","DOIUrl":"10.1007/s10334-026-01325-y","url":null,"abstract":"Objective: Liver regeneration after partial hepatectomy (PH) is markedly impaired in liver fibrosis, leading to serious complications. Non-invasive imaging methods for predicting regenerative capacity are crucial for preoperative planning and risk assessment. Gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI at hepatobiliary phase has recently shown promise for assessing liver function. This study investigated the predictive value of Gd-BOPTA-enhanced MRI at hepatobiliary phase for liver regeneration in fibrotic rats.Materials and methods: Thirty male Sprague-Dawley rats with experimentally induced liver fibrosis underwent Gd-BOPTA-enhanced MRI. The relative enhancement ratios of liver parenchyma (REL) and biliary system (REB) were quantified during the hepatobiliary phase. After 70% PH, the liver regeneration rate (LRR) was calculated on day 3 and 5. Stepwise multivariable linear regression was conducted to identify imaging and biochemical determinants of LRR.Results: In fibrotic rats, the mean LRRs were 0.80 ± 0.10 (range, 0.64-1.01) and 1.06 ± 0.09 (range, 0.89-1.17) on day 3 and 5 after PH, respectively. Multivariable analysis identified REL (p = 0.002), REB (p = 0.026), and alanine aminotransferase (ALT; p = 0.040) as the strongest determinants of LRR on day 3 (Predicted LRR on day 3 = 0.368 + 1.332 × REL + 0.105 × REB - 0.001 × ALT(IU/l)). On day 5, REL (p < 0.001) and REB (p = 0.023) remained significant determinants of LRR (Predicted LRR on day 5 = 1.107 + 2.601 × REL - 0.173 × REB).Discussion: Gd-BOPTA-enhanced MRI at hepatobiliary phase can effectively predict LRR on day 3 and 5 after partial hepatectomy in fibrotic rats.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":"619-630"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging. 修正：铁与富铁灰质核在衰老过程中的平均峰度之间的关系。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-08-01 DOI: 10.1007/s10334-026-01393-0

Jason Langley, Kitzia Solis, Vala Masjedizadeh, Murphy Shao, Ilana J Bennett, Xiaoping P Hu

引用次数: 0

Correction: Detection of regional metabolic alteration using 7T deuterium metabolic imaging in MRI-negative, ¹⁸FDG-PET-positive epilepsy patients. 更正：mri阴性、18fdg - pet阳性癫痫患者的7T氘代谢成像检测区域代谢改变。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-08-01 DOI: 10.1007/s10334-026-01360-9

Narjes Ahmadian, Romy Buijs, Mark Gosselink, Igrid Otto, Kiki Tesselaar, Jeanine J Prompers, Pieter van Eijsden, Nicole van Klink, Dennis W Klomp, Evita C Wiegers

引用次数: 0

Differentiation between glioblastomas and solid brain metastases using amide proton transfer-weighted (APTw) MRI with and without fluid suppression. 用酰胺质子转移加权（APTw） MRI鉴别胶质母细胞瘤和实体脑转移瘤有无液体抑制。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-30 DOI: 10.1007/s10334-026-01389-w

Malte Knutsson, Tim Salomonsson, Anina Seidemo, Anna Rydelius, Xavier Saenz Sarda, Patrick Liebig, Mattias Belting, Johan Bengzon, Peter C M van Zijl, Linda Knutsson, Pia C Sundgren

{"title":"Differentiation between glioblastomas and solid brain metastases using amide proton transfer-weighted (APTw) MRI with and without fluid suppression.","authors":"Malte Knutsson, Tim Salomonsson, Anina Seidemo, Anna Rydelius, Xavier Saenz Sarda, Patrick Liebig, Mattias Belting, Johan Bengzon, Peter C M van Zijl, Linda Knutsson, Pia C Sundgren","doi":"10.1007/s10334-026-01389-w","DOIUrl":"https://doi.org/10.1007/s10334-026-01389-w","url":null,"abstract":"Object: Accurate differentiation between glioblastomas (GBM) and solitary brain metastases (MET) is crucial for treatment planning. This study evaluated the ability of amide proton transfer-weighted (APTw) MRI with and without fluid suppression (FS) to distinguish between GBM and MET.Method: Thirty-two patients with histopathologically confirmed GBM (n = 24) or MET (n = 8) were included. Post-processing included creation of APTw maps without FS, with patient-specific FS based on the patient's white matter values and with a fixed-factor FS. Regions of interest (ROIs) were segmented in the contrast-enhanced tumour, peritumoural oedema, necrosis and the normal-appearing white matter (NAWM). The min, max and mean signals were extracted for each ROI and normalised to NAWM, creating normalised APTw (nAPTw) values. Group differences were determined with t test and Mann-Whitney U test. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis.Results: Both FS methods significantly reduced nAPTw values in tumour regions. Patient-specific FS showed highest performance in distinguishing GBM from MET in the necrotic (AUC 0.921) and oedematous regions (AUC 0.698). Fixed FS provided minor to intermediate improvements.Conclusion: Patient-specific fluid suppression increased the diagnostic performance of APTw imaging in differentiating GBM from MET, particularly in oedematous and necrotic regions.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On z-shimming of non-linear and inhomogeneous through-slice field variations: insights from numerical simulations. 非线性和非均匀通片场变化的z-闪烁：来自数值模拟的见解。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-27 DOI: 10.1007/s10334-026-01394-z

Jürgen Finsterbusch

{"title":"On z-shimming of non-linear and inhomogeneous through-slice field variations: insights from numerical simulations.","authors":"Jürgen Finsterbusch","doi":"10.1007/s10334-026-01394-z","DOIUrl":"https://doi.org/10.1007/s10334-026-01394-z","url":null,"abstract":"Objective: T2*-weighted acquisitions used for functional neuroimaging suffer from signal losses in the presence of field inhomogeneities due to through-slice dephasing that can be ameliorated with so-called z-shim gradient pulses in the slice direction. Determining the z-shim settings from the negative linear field component in the slice direction seems to be reasonable but the performance of this approach in the presence of non-linear field variations is unclear.Materials and methods: Here, numerical simulations are performed for different through-slice field variations and echo times (TE) in order to determine the optimum z-shim setting that maximises the signal amplitude.Results and discussion: They demonstrate that the optimum z-shim compensation gradient field, i.e. the gradient pulse time integral divided by TE, differs from the negative linear field component and depends on TE. The results also indicate that non-linear field inhomogeneities may cause a spatial weighting of the signal within the slice that is modulated with the z-shim. Furthermore, it is shown that these findings also hold for a region-of-interest composed of voxels with purely linear field variations that differ between voxels. Thus, deriving z-shim values from the linear field component(s) of a voxel or region-of-interest will, in general, not provide the maximum signal amplitude.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actuated dose delivery and physiological monitoring of ¹²⁹Xe MRI: implications for improving repeatability. 129Xe MRI的驱动剂量传递和生理监测：对提高可重复性的意义。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-23 DOI: 10.1007/s10334-026-01398-9

Drew Clements, Suphachart Leewiwatwong, Anna Costelle, Seth Lee, Andrew Dummer, David Mummy, Bastiaan Driehuys

{"title":"Actuated dose delivery and physiological monitoring of 129Xe MRI: implications for improving repeatability.","authors":"Drew Clements, Suphachart Leewiwatwong, Anna Costelle, Seth Lee, Andrew Dummer, David Mummy, Bastiaan Driehuys","doi":"10.1007/s10334-026-01398-9","DOIUrl":"10.1007/s10334-026-01398-9","url":null,"abstract":"Objective: Identify and quantify physiological sources of variability in hyperpolarized 129Xe gas-exchange MRI and present a dose-delivery workflow that promotes repeatable lung inflation and alveolar pressure during imaging.Theory and methods: A modular 129Xe dose-delivery and monitoring system was developed with two configurations: a remotely actuated flow/volume-monitoring device used to evaluate pre-dose lung inflation, and a pressure-sensing mouthpiece used with conventional delivery to estimate alveolar pressure during breath-hold. In Cohort A (n = 12), standard coaching was evaluated by quantifying how pre-dose lung volumes deviated from the target of functional residual capacity (FRC). In Cohort B (n = 14), 129Xe spectroscopy under normal, Mueller, and Valsalva breath-hold maneuvers was used to quantify the extent to which alveolar pressure modulates RBC:Membrane (RBC:M) and RBC oscillation amplitude.Results: In Cohort A, coaching drove subjects in 70% of tests to exhale below FRC prior to dose delivery. Reduced lung volume is known to increase membrane and RBC signals beyond healthy-reference ranges. In Cohort B, changing alveolar pressure inversely affected RBC:M; Mueller increased RBC:M by 4.4% and Valsalva decreased it by 7%. Both maneuvers reduced RBC oscillation amplitude by ~20-25% of the original amplitude.Conclusion: Variations in lung inflation and alveolar pressure are significant drivers of variability in critical 129Xe metrics. Integrating actuated delivery and real-time monitoring into dose delivery workflows offers a practical pathway to improving repeatability and standardization of quantitative spectroscopy and gas-exchange imaging.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of skin sodium content via ²³Na magnetic resonance imaging at 3 T using a single-loop surface transmit/receive coil. 利用单回路表面发射/接收线圈在3t下通过23Na磁共振成像估计皮肤钠含量。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-15 DOI: 10.1007/s10334-026-01390-3

Jonathan Richard Birchall, Joshua Daniel Kaggie, Frank Riemer, Viknesh Selvarajah, Kathleen Connolly, Martin John Graves, Ian Wilkinson, Ferdia Aiden Gallagher, Mary Anne McLean

{"title":"Estimation of skin sodium content via 23Na magnetic resonance imaging at 3 T using a single-loop surface transmit/receive coil.","authors":"Jonathan Richard Birchall, Joshua Daniel Kaggie, Frank Riemer, Viknesh Selvarajah, Kathleen Connolly, Martin John Graves, Ian Wilkinson, Ferdia Aiden Gallagher, Mary Anne McLean","doi":"10.1007/s10334-026-01390-3","DOIUrl":"https://doi.org/10.1007/s10334-026-01390-3","url":null,"abstract":"Objective: To assess the feasibility of performing quantitative in vivo tissue sodium concentration measurements in the skin with MRI using a sodium-tuned single-loop transmit/receive surface coil at 3 T.Materials and methods: Proton and sodium imaging of skin at the lower back was performed in 17 healthy volunteers on a clinical 3 T system using an anisotropic (1 x 1 x 10 mm) 3D cones sequence. B1 mapping via the double-angle method was used to account for spatial variation in transmit and receive sensitivity. Apparent tissue sodium concentration (aTSC) was estimated relative to a concurrently imaged phantom of known concentration.Results: The mean and standard deviation of B1-corrected aTSC across all subjects were 28 ± 7 mM, approximately 63% higher than previously published studies at 3 T. Although the study was not originally powered to detect gender or racial differences, a higher aTSC was observed in males relative to females (31 ± 5 mM vs. 23 ± 7 mM, distribution 11M/6F).Discussion: The skin aTSC values recorded were slightly higher than in some previous studies, which possibly arose from the higher spatial resolution and coil sensitivity utilised here. The recorded values remain lower than those measured at 7 T or via direct tissue sampling. Sex-linked differences in 23Na-MRI-derived aTSC are consistent with biopsy results described in the literature. A scan duration of ~40 minutes was considered clinically acceptable.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal cardiac phase selection using motion-sensitive cine imaging improves T2w-STIR image quality in cardiac MRI. 利用运动敏感电影成像优化心脏相位选择，提高心脏MRI T2w-STIR图像质量。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-11 DOI: 10.1007/s10334-026-01391-2

Yoshihiko Tachikawa, Chisato Ando, Risa Ishikawa, Yasuhiro Fujiwara

{"title":"Optimal cardiac phase selection using motion-sensitive cine imaging improves T2w-STIR image quality in cardiac MRI.","authors":"Yoshihiko Tachikawa, Chisato Ando, Risa Ishikawa, Yasuhiro Fujiwara","doi":"10.1007/s10334-026-01391-2","DOIUrl":"https://doi.org/10.1007/s10334-026-01391-2","url":null,"abstract":"Objective: Cardiac T2-weighted short-tau inversion recovery (T2w-STIR) is highly susceptible to myocardial motion, and acquisition at inappropriate cardiac phases can cause myocardial signal loss and inhomogeneity. This study investigated whether cardiac phase selection based on motion-sensitive (MoSe) cine imaging improves T2w-STIR image quality compared with conventional ECG-synchronized acquisition at the longest trigger delay corresponding to end-diastole.Materials and methods: Twelve healthy volunteers underwent 1.5T cardiac MRI. MoSe cine imaging with ECG and peripheral pulse unit (PPU) synchronization was used to visually identify phases with minimal myocardial motion. Short-axis T2w-STIR images were acquired at Conv[ECG-l] (longest ECG trigger delay at end-diastole), MoSe[ECG-S] (MoSe-determined systolic phase with ECG), and MoSe[PPU-D] (MoSe-determined diastolic phase with PPU). Quantitative assessments were myocardium-to-spleen ratio (MSR) and inter- and intra-slice MSR coefficient of variation (CV). Overall image quality was scored on a 4-point scale.Results: MoSe[PPU-D] yielded higher MSR and lower inter- and intra-slice CVs than Conv[ECG-l] (p < 0.05), and higher MSR and lower intra-slice CV than MoSe[ECG-S] (p < 0.05). Qualitative scores were higher for MoSe[PPU-D] than for Conv[ECG-l] and MoSe[ECG-S] (p < 0.05).Conclusion: Cardiac T2w-STIR images acquired at the MoSe-identified optimal diastolic phase with PPU synchronization provide superior image quality compared with conventional ECG-synchronized approach.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of salts on phase transition in native tendon collagen - an NMR study. 盐对天然肌腱胶原相转变的影响-核磁共振研究。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-11 DOI: 10.1007/s10334-026-01388-x

Alexander M Panich

引用次数: 0

Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism using ¹H-MRS. 利用1H-MRS评价高脂饮食诱导的iBAT脂质代谢损伤。

IF 3.1 4区医学

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2026-07-11 DOI: 10.1007/s10334-026-01392-1

Anantharaj Rengaraj, Giang Thi Thu Le, Chandan Dharmashekar, Melvin Khee-Shing Leow, Houchun H Hu, Chandan Shivamallu, Johan G Eriksson, S Sendhil Velan, Balasubramaniem Ashokkumar, Jadegoud Yaligar

{"title":"Evaluation of high-fat diet-induced metabolic impairments in iBAT lipid metabolism using 1H-MRS.","authors":"Anantharaj Rengaraj, Giang Thi Thu Le, Chandan Dharmashekar, Melvin Khee-Shing Leow, Houchun H Hu, Chandan Shivamallu, Johan G Eriksson, S Sendhil Velan, Balasubramaniem Ashokkumar, Jadegoud Yaligar","doi":"10.1007/s10334-026-01392-1","DOIUrl":"https://doi.org/10.1007/s10334-026-01392-1","url":null,"abstract":"Background: High-fat diet (HFD) feeding impairs interscapular brown adipose tissue (iBAT) mitochondrial function, leading to lipid accumulation and insulin resistance.Objective: To evaluate HFD-induced metabolic impairments in iBAT lipid metabolism using 1H-MRS and to determine whether chronic cold exposure can restore mitochondrial lipid oxidation.Materials and methods: Male Wistar rats (n = 20) were fed either chow diet (CD) or HFD for eight weeks followed by maintained thermoneutral or cold-exposed conditions for two weeks. Lipid content in iBAT was quantified by localized 1H-MRS on 7 Tesla (Bruker), using 72-mm volume transmit coil and a 2 × 2 phased array receive only cardiac coil and water suppressed PRESS sequence. Systemic insulin sensitivity and mRNA expression of functional genes were quantified to assess thermogenesis, lipolysis, fatty acid oxidation, and mitochondrial functions.Results: At thermoneutrality, HFD-fed animals showed increased iBAT lipid fraction (75.3 ± 2% vs. 63.3 ± 1.7%, p < 0.05), elevated plasma glucose and insulin and downregulated UCP1, ATGL, CPT1, and PGC-1α (p < 0.01), indicating impaired oxidative metabolism. Cold exposure significantly reduced iBAT lipid in both CD and HFD groups (p < 0.01) and upregulated functional genes (p < 0.001), restoring mitochondrial functions, lipid oxidation, and thermogenic activity.Conclusion: HFD feeding caused insulin resistance and impaired iBAT mitochondrial functions and thermogenic activity, due to lipid accumulation. Chronic cold exposure improved insulin sensitivity and restored iBAT oxidative metabolism and mitochondrial functions.","PeriodicalId":18067,"journal":{"name":"Magnetic Resonance Materials in Physics, Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0