Lupus最新文献

{"title":"Impact of parenting on patient-reported outcomes in female patients with systemic lupus erythematosus: A cross-sectional study of the LUNA registry.","authors":"Dai Kishida, Takanori Ichikawa, Yasuhiro Shimojima, Nobuyuki Yahima, Ken-Ei Sada, Yoshia Miyawaki, Ryusuke Yoshimi, Shigeru Ohno, Kunihiro Ichinose, Ayuko Takatani, Shuzo Sato, Hiroshi Kajiyama, Michio Fujiwara, Takashi Kida, Yusuke Matsuo, Keisuke Nishimura, Akira Onishi, Takahisa Onishi, Nao Oguro, Masao Katsushima, Tomoaki Ida, Kei Ikeda, Hirofumi Miyake, Yoshiki Sekijima","doi":"10.1177/09612033261474991","DOIUrl":"10.1177/09612033261474991","url":null,"abstract":"<p><p>ObjectivesAlthough pregnancy and childbirth are critical for patients with systemic lupus erythematosus (SLE), patients who continue to parent their children during treatment have received little attention. In this study, we aimed to investigate the impact of parenting on the quality of life (QoL) of patients with SLE.MethodsThis cross-sectional study used data from the Lupus Registry of Nationwide Institutions. The participants were females with SLE. The exposure was parenting, categorized according to the children's age (including young children [0-5 years] and school-aged children [6-18 years]). The primary outcome was QoL, which was measured using the Lupus Patient-Reported Outcomes (LupusPRO) scale. Multiple regression analysis was performed to assess the association between parenting and QoL adjusted for patient age, number of children, disease activity, disability, living with a spouse, caregiving, and glucocorticoid dosage as confounding factors.ResultsOverall, 630 patients (median age, 44 years; median disease duration, 12 years) were included: 71 with young children, 50 with school-aged children only, and 509 without children. None of the LupusPRO scores were significantly lower in patients with children than in patients without children. Patients with young children had significantly better cognitive scores (memory and concentration) than those without children (regression coefficient: 12.16, 95% confidence interval: 0.97-23.35, <i>p</i> = 0.033).ConclusionParenting of young children did not worsen QoL in patients with SLE; rather, it was associated with better cognitive function. These findings may help reduce anxiety or hesitation regarding parenting among patients with SLE who wish to become mothers.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1345-1353"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation and reliability of the Arabic version of the LupusQoL questionnaire (Ar-LupusQoL) in Egyptian patients with systemic lupus erythematosus.","authors":"Omima Ahmed El-Farra, Yasmeen Abdelhakim Abdelnaby, Ahmed Adel Abdel Azim, Gamal Saeed Gamal, Amal Mohamed Elmesiry, Nermeen Mohammed Elmenayar, Shereen R Kamel, Manal Hassanien, Shaimaa Moustafa Hafez, Wedad Mahmoud Ghazy","doi":"10.1177/09612033261477825","DOIUrl":"10.1177/09612033261477825","url":null,"abstract":"<p><p>IntroductionSystemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease associated with impaired health-related quality of life (HRQoL). The LupusQoL is a disease-specific instrument designed to capture SLE-related HRQoL domains; however, a validated Arabic version remains unavailable.ObjectiveTo evaluate the reliability and validity of the Arabic version of LupusQoL (Ar-LupusQoL) in SLE Egyptian patients.MethodsIn this multicenter cross-sectional study, 156 patients with SLE completed the Arabic LupusQoL and Short Form-36 (SF-36). Disease activity and damage were assessed using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR-DI), respectively. Internal consistency was assessed using Cronbach's alpha, and test-retest reliability using intraclass correlation coefficients. Construct validity was examined through item-total correlations and correlations with corresponding SF-36 domains. Discriminant validity was also evaluated.ResultsThe mean age was 33.37 ± 10.71 years, and 98.1% were female. The cohort demonstrated a high level of disease activity (87.2% with SLEDAI >4; mean SLEDAI 19.52 ± 16.20). Internal consistency was high across domains (α = 0.78-0.98). Item-total correlations were strong (r > 0.30, <i>p</i> < 0.001). Significant correlations with corresponding SF-36 domains supported convergent validity (r = 0.668-0.829, p < 0.05). The Ar-LupusQoL effectively discriminated between active and inactive disease (<i>p</i> < 0.001). Ceiling effects were observed in selected domains, with no significant floor effects.ConclusionThe Arabic version of the LupusQoL is a reliable and valid instrument for assessing HRQoL in Egyptian patients with SLE. The high disease activity observed, likely reflecting recruitment from tertiary referral centers, may limit generalizability to patients with milder disease.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1407-1414"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neutrophil-to-lymphocyte ratio with disease activity in systemic lupus erythematosus: A meta-analysis.","authors":"Young Ho Lee, Gwan Gyu Song","doi":"10.1177/09612033261481122","DOIUrl":"10.1177/09612033261481122","url":null,"abstract":"<p><p>ObjectiveThis study aimed to assess the relationship between the neutrophil-to-lymphocyte ratio (NLR) and systemic lupus erythematosus (SLE), with specific focus on the association between NLR and disease activity, including lupus nephritis (LN), and evaluating the correlation between NLR and the SLE Disease Activity Index (SLEDAI).MethodsA systematic search of MEDLINE, Embase, and Web of Science from database inception through August 2025 was conducted. Meta-analyses compared NLR values between SLE patients and healthy controls, between active and inactive SLE, and between active LN and non-LN subgroups, with stratification by ethnicity, sample size, and publication year. Correlation coefficients between NLR and SLEDAI were pooled to assess the strength of this association.ResultsThirty-one studies comprising 4,006 SLE patients and 2,576 healthy controls were included. The combined analysis showed significantly increased NLR in SLE patients versus controls (SMD = 1.051, 95% CI = 0.817-1.286, <i>p</i> < 0.001). Significantly higher NLR was observed in European, Asian, and Arab SLE patients relative to healthy controls within each respective subgroup, by showing significantly higher NLR in European (SMD = 1.058, 95% CI = 0.402-1.713, <i>p</i> = 0.002), Asian (SMD = 1.058, 95% CI = 0.839-1.278, <i>p</i> < 0.001), and Arab (SMD = 1.127, 95% CI = 0.707-1.547, <i>p</i> < 0.001) populations. Comparing disease activity, active SLE patients had notably higher NLR than those with inactive disease (SMD = 1.134, 95% CI = 0.252-2.017, <i>p</i> = 0.012). However, the difference in NLR between active LN and non-LN groups was not statistically significant (SMD = 0.467, 95% CI = -0.045-0.979, <i>p</i> = 0.074). NLR showed a significant positive correlation with SLEDAI (correlation coefficient = 0.354, 95% CI = 0.256-0.444, <i>p</i> < 0.001). Subgroup analysis revealed significant correlations in Asian (correlation coefficient = 0.358, 95% CI = 0.246-0.461, <i>p</i> < 0.001) and Arab (correlation coefficient = 0.525, 95% CI = 0.382-0.644, <i>p</i> < 0.001) populations.ConclusionsThis meta-analysis demonstrates that NLR is significantly increased in SLE patients compared to healthy controls, and that NLR is associated with greater disease activity, supported by its positive correlation with SLEDAI.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1415-1425"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial palladin is associated with tubulointerstitial chronicity and adverse outcomes in patients with lupus nephritis.","authors":"Naoki Yamamoto, Norihiko Sakai, Shiori Nakagawa, Daichi Kaikoi, Takahiro Matsuno, Taku Kobayashi, Akihiko Koshino, Keisuke Sako, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Yuta Yamamura, Megumi Oshima, Satoshi Hara, Kiyoaki Ito, Akinori Hara, Miho Shimizu, Takashi Wada, Yasunori Iwata","doi":"10.1177/09612033261479120","DOIUrl":"10.1177/09612033261479120","url":null,"abstract":"<p><p>BackgroundTubulointerstitial lesions predict kidney prognosis in lupus nephritis (LN), but the molecular features of interstitial fibrosis remain incompletely defined. We previously showed that palladin, an actin-associated protein, drives kidney fibrosis through actin dynamics. This study examined whether interstitial palladin expression is associated with histopathology and prognosis in LN.MethodsWe retrospectively analyzed Japanese patients with biopsy-proven LN at Kanazawa University Hospital between 1990 and 2018. Palladin-positive area was quantified by immunohistochemistry and log2-transformed (log2 palladin). The colocalization of palladin and α-smooth muscle actin (αSMA) was investigated by immunofluorescence. Associations with modified NIH activity and chronicity indices were assessed using Spearman correlation. Event-free survival for renal replacement therapy (RRT) initiation or all-cause death was evaluated by Kaplan-Meier analysis.ResultsThirty-four patients were included. Palladin was predominantly expressed in the kidney interstitium and colocalized with αSMA-positive cells. Log2 palladin correlated with the modified NIH chronicity index (ρ = 0.61, <i>p</i> < 0.01), tubular atrophy (ρ = 0.53, <i>p</i> < 0.01), interstitial fibrosis (ρ = 0.56, <i>p</i> < 0.01), and interstitial inflammation (ρ = 0.55, <i>p</i> < 0.01), but not with the total activity index (ρ = 0.24, <i>p</i> = 0.16). During a median follow-up of 10.1 years (IQR, 3.3-17.5), seven patients reached the composite outcome. The composite outcome occurred in five patients in the high-palladin group and two patients in the low-palladin group, and high palladin expression was associated with poorer event-free survival by Kaplan-Meier analysis (log-rank <i>p</i> = 0.04).ConclusionInterstitial palladin expression may reflect tubulointerstitial chronicity and be associated with poor outcomes in LN; however, its independent prognostic value could not be established due to the limited number of events.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1433-1439"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircSMURF2 alleviates cell apoptosis by binding DIABLO promote ubiquitination and its expression level and clinical significance in lupus nephritis.","authors":"Xin Yuan, Lushan Xiao, Qin Huang, Hao Wang, Weinan Lai","doi":"10.1177/09612033261474989","DOIUrl":"10.1177/09612033261474989","url":null,"abstract":"<p><p>BackgroundLupus nephritis (LN) is an autoimmune disease that affects kidneys and is considered one of the most prevalent complications of systemic lupus erythematosus (SLE). We screened differentially expressed circRNAs through circRNA sequencing in peripheral blood molecular cells (PBMC) of LN patients and verified that circSMURF2 was downregulated  and its correlation with laboratory indicators.Our study reveals for the first time that circSMURF2 was downregulated in LN patients and mediated cell apoptosis in HK2s by modulating DIABLO ubiquitination.MethodsThe expression and function of circSMURF2 were detected by qRT-PCR and FISH. The interactions between circSMURF2 and DIABLO were analyzed by RNA pull-down assay, Mass Spectrometry and RNA Immunoprecipitation. HK2s treated with lentivirus overexpression of circSMURF2 was applied for  experiments.ResultFunctionally, circSMURF2 promoted proliferation and inhibited apoptosis in Human renal cortex proximal tubule epithelial cells (HK2). Mechanistically, circRNA pull-down analysis showed that circSMURF2 functions in HK2s by binding to DIABLO protein and negatively regulating its expression through accelerating its ubiquitination.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1333-1344"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated <i>Nocardia pseudobrasiliensis</i> infection in a case of juvenile systemic lupus erythematosus on immunosuppressive therapy.","authors":"Kaustav Bhowmick, Angan Karmakar, Dipendranath Ghosh, Geetabali Sircar, Parasar Ghosh","doi":"10.1177/09612033261477905","DOIUrl":"10.1177/09612033261477905","url":null,"abstract":"<p><p>Nocardiosis is an uncommon infection that presents as a chronic, debilitating illness with radiographic manifestations simulating lung cancer or tuberculosis. Immunocompromised hosts may develop a fulminant disease resembling acute bacterial pneumonia or disseminated disease. We report a case of a juvenile lupus who developed disseminated <i>Nocardia pseudobrasilienisis</i> infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe, following inadvertent hiking of steroids after a minor organ flare. This case was successfully treated with intravenous meropenem, amikacin, and oral cotrimoxazole therapy for 6 weeks which lead to resolution of pneumonia, and partial resolution of of the cutaneous and CNS lesion. As the patient was immunosuppressed, and had disseminated nocardiosis, we planned to put her on oral cotrimoxazole for the next 1 year.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1440-1443"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal autoimmune connective tissue disease and cardiac structure and function in the newborn.","authors":"Terese Frellesen Neumann, Sarah Sofie Andersen, Sofie Dannesbo, Anne-Sophie Sillesen, Ruth Ottilia Birgitta Vøgg, Anton Friis Mariager, Amanda Rønne Wright, Heather Allison Boyd, Niels Vejlstrup, Karen Schreiber, Kasper Karmark Iversen, Henning Bundgaard, Anna Axelsson Raja","doi":"10.1177/09612033261477295","DOIUrl":"10.1177/09612033261477295","url":null,"abstract":"<p><p>IntroductionNewborns of mothers with autoimmune systemic connective tissue disease (CTD) have a higher incidence of major congenital heart defects (CHDs) compared to unexposed newborns. Less is known about the association between maternal CTD and less severe cardiac abnormalities in the newborn.MethodsWe analysed prospectively collected echocardiographic data from the Copenhagen Baby Heart Study (CBHS), comparing newborns exposed to maternal CTD with those who were not exposed. Maternal autoimmune CTD diagnoses were identified through the National Patient Register and validated by medical record review. Outcome measures included minor CHDs (atrial and ventricular septal defects, bicuspid aorta valve and patent ductus arteriosus), as well as cardiac dimensions and function.ResultsIn total 25,590 newborns underwent echocardiography in the CBHS, of whom 57 (0.22%) were born to mothers with CTD. When comparing newborns of mothers with overall CTD to non-exposed newborns, we found no differences in structural and functional cardiac parameters. Minor CHDs were more common in newborns born to mothers with Sjögren's disease (n = 3, 33.3%) than in unexposed newborns (n = 1,945, 7.6%, p = 0.03).ConclusionsIn this large population-based study, we did not observe consistent associations between overall maternal CTD and cardiac structure or function in the infant, although minor CHD were more common in newborns exposed to maternal Sjögren's disease. Findings should be interpreted with caution, considering the small sample size of exposed newborns and potential underrepresentation of major CHD due to standard clinical management practices.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1395-1406"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus.","authors":"Jing Wang, Qian-Qian Zhou, Yu-Jie Du, Lei Zhang, Lin Cheng, Ya-Qin Zhang, Yi-Yuan Wang, Zhang-Wei Lu, Xue Jin, Yang-Guang Cao, Ya-Ting He, Li-Lan Zhang, Long Qian, Bao-Zhu Li","doi":"10.1177/09612033261477298","DOIUrl":"10.1177/09612033261477298","url":null,"abstract":"<p><p>ObjectivesSystemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is not clear.MethodsGut microbiota profiling was performed using 16S rRNA gene sequencing of fecal samples, and functional prediction was conducted using PICRUSt. Plasma lipidomics was performed using LC-MS. Associations between differentially abundant microbial taxa and differential lipids were assessed using Spearman's rank correlation.ResultsWe found obvious abnormalities in lipid metabolism in SLE patients. Sphingolipid metabolism and glycerophospholipid metabolism were the most significantly dysregulated pathways in these patients. There is an obvious intestinal flora imbalance in SLE patients, the <i>Becteroides</i> and <i>Lachnoclostridium</i> is the most important genus to distinguish SLE case groups from control groups. Some differential metabolites in the plasma of SLE patients were correlated with some differential bacteria in the stool. Most of the bacteria associated with lipid changes belonged to <i>Firmicutes</i>, <i>Bacteroidetes, Actinobacteriaceae, Peptostreptococcaceae,</i> Bacteroidetes, <i>Gordonibacter</i>, <i>Romboutsia</i>, etc.ConclusionOur findings illustrate the disruption of the gut microbiome and lipid group in SLE patients, which may facilitate the development of new SLE interventions.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1382-1394"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with primary antiphospholipid syndrome and \"single\" antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (\"registry\").","authors":"Silvia Grazietta Foddai, Irene Cecchi, Massimo Radin, Laura Bertolaccini, Danieli de Andrade, Maria Tektonidou, Vittorio Pengo, Chary Lopez-Pedrera, Diana Paredes-Ruiz, Howard Michael Belmont, Paul R Fortin, Denis Wahl, Ware Branch, Maria Gerosa, Guilherme de Jesus, Zhouli Zhang, Tatsuya Atsumi, Maria Efthymiou, Laura Andreoli, Esther Rodriguez, Michelle Petri, Ricard Cervera, Bahar Artim-Esen, Rosana Quintana, Jason S Knight, Rohan Willis, Reyhan Kose Cobanoglu, Hannah Cohen, Doruk Erkan, Savino Sciascia","doi":"10.1177/09612033261479899","DOIUrl":"10.1177/09612033261479899","url":null,"abstract":"<p><p>ObjectiveWhile triple antiphospholipid antibody (aPL) positivity is associated with a higher risk of thrombosis, the clinical significance of single aPL positivity remains unclear. This study aimed to assess the prevalence, clinical characteristics, and cardiovascular disease (CVD) risk profile of persistently single aPL-positive primary antiphospholipid syndrome (PAPS) patients.MethodsWe conducted a retrospective analysis for APS patients from the APS ACTION registry with confirmed persistent single aPL positivity (after testing for lupus anticoagulant [LA], anticardiolipin [aCL] IgG/IgM, or anti-β₂-glycoprotein I [aβ₂GPI] IgG/IgM), defined by the Revised Sapporo APS Classification Criteria. Triple aPL-tested single aPL-positive patients with no APS classification were used as a control group. Demographics, clinical characteristics, aPL profiles, and adjusted Global APS Score (aGAPSS) were compared between two groups.ResultsAmong 233 PAPS patients tested, 84 (36%) had single aPL positivity: 67 (79%) LA positive, eight (10%) aCL IgG or IgM positive, and 9 (11%) aβ₂GPI IgG or IgM positive. Among 97 aPL-positive patients with no APS classification, 22 (22.7%) had single aPL-positivity: nine LA positive, eight aCL IgG or IgM positive, and 5 aβ₂GPI IgG or IgM positive. Single LA positivity was significantly more common in PAPS patients, whereas aCL IgM or aβ₂GPI IgM positivity were significantly more common in those without APS classification. Historical thrombosis recurrence was observed in 26% of single aPL-positive PAPS patients, predominantly among those with LA positivity (86%).ConclusionsIn this international cohort of persistently aPL-positive individuals, 36% had single aPL positivity, mostly positive LA test. Although \"single\" aPL-positivity is traditionally considered as a lower-risk profile, findings highlight the importance of differentiating between single LA-positivity and single aCL/aβ₂GPI positivity, and the need for individualized risk stratification.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1426-1432"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence and associated factors of metabolic syndrome in patients with systemic lupus erythematosus: A systematic review and meta-analysis.","authors":"Sandeep Samethadka Nayak, Shahriar Ghodous, Narsimha Rao Keetha, Anoop Gurram, Negin Letafatkar, Prashant Ahlawat, Arman Habibi, Srinivasa Ramanujan Boora, Seyed Mohammad Hashemi, Sivaramakrishna Cheetirala, Mohammad Amouzadeh-Lichahi, Sarpong Boateng, Maryam Jafari, Madhu Ponnala, Asal Khorami, Simran Joshi, Ilya Saberi, AmirAli Moodi Ghalibaf, Antony Arumairaj, Ehsan Amini-Salehi, Nishant Sharma","doi":"10.1177/09612033261477274","DOIUrl":"10.1177/09612033261477274","url":null,"abstract":"<p><p>BackgroundSystemic lupus erythematosus (SLE) is characterized by chronic systemic inflammation, frequent corticosteroid exposure, and heightened cardiometabolic vulnerability. Metabolic syndrome (MetS) has become a clinically significant comorbidity among individuals with SLE. We performed an updated systematic review and meta-analysis to better understand the prevalence and identify the factors associated with the occurrence of MetS in SLE.MethodsPubMed, Scopus, and Web of Science were systematically searched through January 4, 2026 to identify observational studies reporting the prevalence of MetS among individuals with SLE. Random-effects meta-analytic models were applied to calculate pooled prevalence estimates and evaluate the associations with potential risk factors.ResultsThe overall pooled prevalence of MetS in patients with SLE was estimated at 0.27 (95% CI: 0.24-0.30). Sex-stratified analyses showed a prevalence of 0.36 (95% CI: 0.25-0.47) in male patients and 0.27 (95% CI: 0.23-0.30) in female patients. Across continents, the highest prevalence was observed in Africa (0.36, 95% CI: 0.30-0.41), followed by South America (0.32, 95% CI: 0.24-0.40), Asia (0.27, 95% CI: 0.22-0.32), Europe (0.23, 95% CI: 0.18-0.28), and North America (0.21, 95% CI: 0.14-0.30). Regarding medication use, hydroxychloroquine was associated with a significantly reduced risk of MetS (OR = 0.66, 95% CI: 0.52-0.83; P < 0.01), whereas cyclophosphamide (OR = 1.39, 95% CI: 1.06-1.81; P = 0.02), azathioprine (OR = 1.25, 95% CI: 1.00-1.55; P = 0.04), and mycophenolate mofetil (OR = 1.13, 95% CI: 1.03-1.23; P = 0.01) were each associated with a significant increased risk of MetS. No significant associations were found for steroids (OR = 1.34, 95% CI: 0.97-1.83; P = 0.07), methotrexate (OR = 1.07, 95% CI: 0.78-1.47; P = 0.84), or cyclosporine use (OR = 1.19, 95% CI: 0.64-2.21; P = 0.33). The analysis also identified several risk factors for MetS in SLE patients. Patients with MetS were older (Hedges' g = 0.47; P < 0.01), had higher BMI (Hedges' g = 0.88; P < 0.01), and higher total cholesterol (Hedges' g = 0.39; P < 0.01) and LDL levels (Hedges' g = 0.41; P < 0.01) than those without MetS.ConclusionMetS is prevalent among individuals with SLE and is influenced by demographic, clinical, and treatment-related factors. These findings highlight the need for targeted monitoring and management strategies to reduce the cardiometabolic risk in this population.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1354-1381"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}