盘状红斑狼疮伴无瘤样抗体的低色素病变的进行性再色素沉着：附2例报告。

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Lupus Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI:10.1177/09612033251345017

Margot Hulin, Agathe Le Seac'h, Léa Jaume, Julien Seneschal, Katia Boniface, Annick Barbaud, Alexis Mathian, Zahir Amoura, François Chasset

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引用次数: 0

摘要

我们报告了两例难治性盘状红斑狼疮（DLE）和深色皮肤光型患者，他们在无瘤单抗治疗下经历了脱色病变的进行性滤泡周围重新色素沉着，持续改善超过18个月。这些观察结果强调了anfrolumab对DLE瘢痕性色素沉着的潜在新作用。这种效果可能是一种有价值的治疗选择，特别是对于深色皮肤类型的患者。

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Progressive repigmentation of hypopigmented lesions in discoid lupus erythematosus with anifrolumab: A report of two cases.

We report two cases of patients with refractory discoid lupus erythematosus (DLE) and dark skin phototypes who experienced progressive perifollicular repigmentation of depigmented lesions under anifrolumab therapy, with sustained improvement over 18 months. These observations highlight a potential novel effect of anifrolumab on cicatricial dyspigmentation in DLE. This effect may represent a valuable therapeutic option for DLE-related damage, particularly in patients with darker skin types.

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来源期刊

Lupus 医学-风湿病学

CiteScore

4.20

自引率

11.50%

发文量

225

审稿时长

1 months

期刊介绍： The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…