Life Sciences in Space Research最新文献

{"title":"Corrigendum to ‘RadLab: An open science resource for radiation studies relevant to human spaceflight’ Life Sciences in Space Research Volume 43, November 2024, Pages 29-34","authors":"Kirill A. Grigorev , Jack Miller , Livio Narici , Sylvain V. Costes","doi":"10.1016/j.lssr.2024.11.002","DOIUrl":"10.1016/j.lssr.2024.11.002","url":null,"abstract":"","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"44 ","pages":"Page 9"},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls","authors":"Takayuki Hattori ,&nbsp;Sayoko Hishii-Higuchi ,&nbsp;Hiroko Inoue ,&nbsp;Takehide Kato ,&nbsp;Takashi Hashimoto ,&nbsp;Kazuyuki Wakabayashi ,&nbsp;Takayuki Hoson ,&nbsp;Kouichi Soga","doi":"10.1016/j.lssr.2024.11.001","DOIUrl":"10.1016/j.lssr.2024.11.001","url":null,"abstract":"<div><div>The mechanism by which gravity affects the growth anisotropy of plant organs is an important issue for the cultivation of plants under microgravity conditions in space. This study aimed to examine the roles of KATANIN1 (KTN1), a microtubule-severing enzyme, in the modification of the direction of cortical microtubules (CMTs) and growth anisotropy in Arabidopsis hypocotyls induced by gravity using hypergravity conditions that can be created on Earth. The <em>KTN1</em> mutants (<em>ktn1^P393S, ktn1^R465Q,</em> and <em>ktn1^S342F</em>) exhibited shorter and thicker hypocotyls than the wild type (ecotype Columbia-0). Hypergravity at 300 <em>g</em> modified growth anisotropy in wild-type hypocotyls; hypergravity inhibited elongation but stimulated lateral growth. In contrast, hypergravity-induced modification of growth anisotropy was suppressed in hypocotyls of the three mutants. The wild type had an abundance of CMTs in transverse orientation (between 0° and 30°) under 1 <em>g</em> conditions and a tendency toward increased CMTs in longitudinal orientation under hypergravity conditions (between 60° and 90°). However, hypergravity-induced reorientation was not observed in hypocotyls of <em>ktn1</em> mutants. The transcript level of the <em>KTN1</em> gene in wild-type hypocotyls increased within 1 h of onset of hypergravity treatment and promptly decreased to the same level as the 1 <em>g</em> control. These findings suggest that the reorientation of CMTs is mediated by KTN1, which is regulated by transient expression upregulation, which is responsible for the modification of growth anisotropy induced by hypergravity in Arabidopsis hypocotyls.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"45 ","pages":"Pages 170-175"},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spaceflight associated dry eye syndrome (SADES): Radiation, stressors, and ocular surface health","authors":"Ryung Lee ,&nbsp;Joshua Ong ,&nbsp;Ethan Waisberg ,&nbsp;Andrew G. Lee","doi":"10.1016/j.lssr.2024.08.007","DOIUrl":"10.1016/j.lssr.2024.08.007","url":null,"abstract":"<div><div>Crewed spaceflight missions require careful scrutinization of the health risks including alterations to the tear film lipid layer in astronauts. We review the current literature and prior published work on tear film lipid layer biophysics and secondary spaceflight-associated dry eye syndrome (SADES). We define the term spaceflight-associated dry eye syndrome to describe the collection of ocular surface signs and symptoms experienced by astronauts during spaceflight. Our review covers the ocular surface and lipidomics in the spaceflight environment. From our literature review, we extrapolate biophysical principles governing the tear film layer to determine the changes that may arise from the harsh conditions of spaceflight and microgravity. Our findings provide vital information for future long-duration spaceflight, including a return to the Moon and potential missions to Mars.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 75-81"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting meniscus tissue onboard the International Space Station","authors":"George J. Klarmann ,&nbsp;Aaron J. Rogers ,&nbsp;Kristin H. Gilchrist ,&nbsp;Vincent B. Ho","doi":"10.1016/j.lssr.2024.09.004","DOIUrl":"10.1016/j.lssr.2024.09.004","url":null,"abstract":"<div><div>We bioprinted meniscus tissue on the International Space Station (ISS) using the onboard BioFabrication Facility (BFF). The three dimensional (3D) printing bioink, cells, culture media and fixative were delivered to the ISS on NG-18 and SpX-27 vehicles and stored prior to the printing operation. The meniscus tissue was fabricated from ink composed of collagens type I and II, chondroitin sulfate and mesenchymal stem cells. Following printing, the meniscus tissue was cultured for 2 weeks in growth media, then stored at 4 °C and returned to earth for analysis. The print showed good overall shape fidelity, and dimensions were comparable to control meniscus tissue printed on Earth. Young's modulus of the ISS printed meniscus was approximately 4-fold lower than the control. Histologic evaluation showed good cell distribution within the print. Though logistical challenges were encountered during payload delivery to the ISS and operational challenges limited the cell culture portion of this study, this investigation demonstrated the feasibility for 3D printed musculoskeletal tissue in microgravity. The completed meniscus tissue print is the largest tissue engineered model 3D printed on the ISS to date, the first to be 3D bioprinted using an ink similar in composition to native tissue, and the first to be fabricated on the ISS in an anatomically relevant shape. These experiments help advance the field of tissue engineering in low or microgravity where 3D bioprinting may have a role in future long term space flight or extraterrestrial habitation.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 82-91"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RadLab: An open science resource for radiation studies relevant to human spaceflight","authors":"Kirill A. Grigorev ,&nbsp;Jack Miller ,&nbsp;Livio Narici ,&nbsp;Sylvain V. Costes","doi":"10.1016/j.lssr.2024.10.001","DOIUrl":"10.1016/j.lssr.2024.10.001","url":null,"abstract":"<div><div>In response to the growing need of the space life sciences community for a publicly available single access point for radiation physics data relevant to human space exploration, an open data repository and analysis platform, RadLab, has been developed. RadLab consists of a database and a user-friendly data retrieval, visualization, and analysis toolkit, including a graphical user interface (GUI) and an application programming interface (API). RadLab complements the space biology data in the NASA Open Science Data Repository (OSDR) and aims to provide open, centralized access to radiation physics data relevant to spaceflight. Analysis tools contained in RadLab will facilitate intercomparison among different detectors and radiation data sets to better understand the radiation environment in spacecraft and planetary habitats, and facilitate the use of space radiation data by space biology investigators and radiation instrument developers.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 29-34"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprint of: From the desk of the Editor-in-Chief","authors":"Tom K. Hei","doi":"10.1016/j.lssr.2024.10.003","DOIUrl":"10.1016/j.lssr.2024.10.003","url":null,"abstract":"","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Page 3"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different spectrum of space radiation induced cognitive impairments in radiation-naïve and adapted rats","authors":"Richard A. Britten ,&nbsp;Arriyam S. Fesshaye ,&nbsp;Alyssa Tidmore ,&nbsp;Ella N. Tamgue ,&nbsp;Paola A. Alvarado-Arriaga","doi":"10.1016/j.lssr.2024.09.001","DOIUrl":"10.1016/j.lssr.2024.09.001","url":null,"abstract":"<div><div>NASA's decision to resume manned deep space mission, first to the Moon and then Mars, necessitated a detailed assessment of the potential health effects that astronauts may experience on long-duration missions. Multiple studies suggest that there may be significant space radiation (SR)-induced impairment of neurocognitive processes, including advanced executive functions. However, given the multitude of SR-induced changes in the CNS, it is possible that completely different SR-induced sequelae will be induced in previously exposed individuals. Thus, current risk estimates are likely to be pertinent only for the early stages of a deep space mission, and even then only for astronauts that have no previous experience in space.</div><div>In this study, rats that maintained high attentional set shifting (ATSET) performance after an initial exposure to 10 cGy of SR (either 250 MeV/n He or GCRsim), were exposed to an additional dose of 10 cGy GCRsim and their ATSET performance reassessed. The re-irradiated rats exhibited significant impairment of ATSET performance, however, the performance decrements differed in two important aspects from those typically observed after single exposures. First, the decrements were manifested when the rats were required to perform set shifting, specifically in the IDR and EDS stages of the ATSET test. Secondly, the main performance decrement was in a loss of processing speed, which in the IDR stage resulted in the re-irradiated rats taking 2-fold more time to solve the problem than did Sham rats. The functional consequence of this decrement was that compared to Sham rats, 20 % fewer SR-exposed rats solved the IDS and EDR problems within 20 s.</div><div>These data suggests that prior SR exposure alters nature of ATSET impairments from that observed in radiation-naïve individuals. Risk estimates derived from studies that use radiation naïve rats may thus not fully reflect the incidence and nature of ATSET performance deficits that could occur over the entire duration of a mission to Mars, or in astronauts who return to deep space on multiple occasions. It would thus be germane to conduct in-flight monitoring for cognitive performance decrements observed in both radiation naïve and exposed rats during the mission, and ensure that the crew has sufficient overlapping skill sets to minimize the operational impact of these additional cognitive impairments.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 68-74"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles","authors":"Shengli Zhang ,&nbsp;Shenke Zhang ,&nbsp;Zhen Wang ,&nbsp;Takuya Adachi ,&nbsp;Yukari Yoshida ,&nbsp;Akihisa Takahashi","doi":"10.1016/j.lssr.2024.08.004","DOIUrl":"10.1016/j.lssr.2024.08.004","url":null,"abstract":"<div><div>The days of returning to the Moon and landing on Mars are approaching. These long-duration missions present significant challenges, such as changes in gravity, which pose serious threats to human health. Maintaining muscle function and health is essential for successful spaceflight and exploration of the Moon and Mars. This study aimed to observe the adaptation of rat hindlimb muscles to partial gravity conditions by simulating the gravity of space (microgravity (µ<em>G</em>)), Moon (1/6<em>G</em>), and Mars (3/8<em>G</em>) using our recently invented ground-based apparatus. A total of 25 rats were included in this study. The rats were divided into five groups: control (1<em>G</em>), sham (1<em>G</em>), simulated Mars (3/8<em>G</em>), simulated Moon (1/6<em>G</em>), and simulated Space (µ<em>G</em>). Muscle mass, fiber proportion, and fiber cross-sectional area (CSA) of four types of hindlimb muscles were measured: gastrocnemius (GA), tibialis anterior (TA), extensor digitorum longus (EDL), soleus (Sol). Sol and GA exhibited the most significant alterations in response to the changes in gravity after 10 days of the experiment. A notable decline in muscle mass was observed in the simulated µ<em>G</em>, Moon, and Mars groups, with the µ<em>G</em> group exhibiting the most noticeable decline. In Sol, a noteworthy decline in the proportion of slow-twitch type I fibers, CSA of slow-twitch type I fibers, and average CSA of the whole muscle fibers was observed in the simulated groups. The GA red, mixed, and white portions were examined, and the GA mixed portion showed significant differences in fiber proportion and CSA. A notable increase in the proportion of slow-twitch type I fibers was observed in the simulated groups, with a significant decrease in CSA of type IIb. In EDL or TA, no discernible changes in muscle mass, fiber proportion, or fiber CSA were observed in any of the five groups. These findings indicate that weight-bearing muscles, such as Sol and GA, are more sensitive to changes in partial gravity. Furthermore, partial gravity is insufficient to preserve the normal physiological and functional properties of the hindlimb muscles. Therefore, targeted muscle interventions are required to ensure astronauts' health and mission success. Furthermore, these findings demonstrate the viability and durability of our ground-based apparatus for partial gravity simulation.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 54-67"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress, neuroinflammation, and the blood-brain barrier biomarkers on the brain response to spaceflight","authors":"Xiao Wen Mao,&nbsp;Michael J Pecaut,&nbsp;Seta Stanbouly,&nbsp;Gregory Nelson","doi":"10.1016/j.lssr.2024.08.001","DOIUrl":"10.1016/j.lssr.2024.08.001","url":null,"abstract":"<div><div>Prolonged spaceflight can induce physiologic and pathologic abnormalities in the central nervous system (CNS). Our knowledge of the adaptive and/or detrimental effects of spaceflight on the structure and function of the nervous system is limited. Substantial effort has been devoted to identifying and developing reliable indicators to characterize and predict CNS injury and dysfunction associated with prolonged exposure to major components of the space environment including microgravity, physiological/psychological stress, and radiation from galactic cosmic rays (GCR) and solar particle events (SPEs) outside of low earth orbit (LEO). The blood-brain barrier (BBB) is a semi-permeable membrane that is essential to maintain homeostasis of the brain microenvironment. Oxidative stress or other environmental stressors may disrupt BBB integrity and increase permeability leading to immune cell infiltration and undesirable neuroinflammation. The focus of this review article is on BBB damage associated with spaceflight and space radiation in rodent and human studies. We will highlight potential biomarkers for this damage, including site-specific and circulating neuroinflammatory factors, BBB structural and brain parenchyma proteins, and neuroimaging tools for BBB damage evaluation. These knowledge will help to understand the risks associated with space travel and are also critical for novel countermeasure development to mitigate the space flight risk to astronaut performances.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 22-28"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrochemistry: The study of chemical processes in space","authors":"Ankan Das","doi":"10.1016/j.lssr.2024.10.005","DOIUrl":"10.1016/j.lssr.2024.10.005","url":null,"abstract":"<div><div>The formation of our solar system occurred approximately 4.6 billion years ago as a result of the gravitational collapse of a small portion of a giant molecular cloud. The origin of life on Earth is yet to be fully understood. Astrochemistry plays a crucial role in unraveling this mystery. It is an interdisciplinary field that mainly encompasses astronomy and astrophysics, focusing on studying molecules in the universe and their interactions with radiation. A substantial portion of the universe can be called the “Molecular Universe.” These molecules serve as valuable diagnostic tracers in the regions where they are observed. Recent progress in observational, experimental, and computational facilities has significantly enhanced our understanding of the molecular universe. This review aims to delve into this captivating field’s current state of the art.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"43 ","pages":"Pages 43-53"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}