Immunology & Cell Biology最新文献_第7页

Affinity alone does not drive long-lived plasma cell differentiation 亲和力本身并不能驱动长寿命浆细胞分化。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-07 DOI: 10.1111/imcb.12770

Courtney E McDougal, Marion Pepper

引用次数: 0

Identification of the immune repertoire of γδ T-cell receptors in psoriasis 确定银屑病中 γδ T 细胞受体的免疫复合物。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-06 DOI: 10.1111/imcb.12765

Yuting Chen, Quanze Fu, Yinjiang Ma, Nan Wang, Ji Yang, Qing Liang, Kejia Wang, Lujuan Gao

{"title":"Identification of the immune repertoire of γδ T-cell receptors in psoriasis","authors":"Yuting Chen, Quanze Fu, Yinjiang Ma, Nan Wang, Ji Yang, Qing Liang, Kejia Wang, Lujuan Gao","doi":"10.1111/imcb.12765","DOIUrl":"10.1111/imcb.12765","url":null,"abstract":"The γδ T cells are a subpopulation of T cells that are abundantly found in the skin and mucous membranes. Their reactivity to self-antigens and ability to secrete various cytokines make them a key component in psoriasis development. Although the correlation between the immune repertoire (IR) of γδ T-cell receptors and the occurrence and severity of psoriasis remains incompletely explored, high-throughput sequencing of γδ T cells has led to a deeper understanding of IR in psoriasis. This study investigated the differences between γδ T cells in patients with psoriasis and healthy controls. The γδ T cells were identified via immunofluorescence staining and a correlation analysis was performed according to the psoriasis area and severity index (PASI) scores. The IR sequencing method was used to detect IR in the γδ T-cell receptors. The findings demonstrated more skin γδ T cells in patients with psoriasis, which were positively correlated with the PASI score. There were subtle differences in most variable (V), diversity (D) and joining (J) gene segments and VJ/VDJ combination segments between patients with psoriasis and healthy controls. However, a higher diversity of complementarity-determining region 3 (CDR3) was observed in patients with psoriasis. In summary, the IR of skin γδ T cells was significantly altered in patients with psoriasis, and the diversity in the cell's CDR3 population is a promising biomarker for assessment of psoriasis severity.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 7","pages":"570-577"},"PeriodicalIF":3.2,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A trainee's perspective on scientific conferences 学员对科学会议的看法。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-05 DOI: 10.1111/imcb.12772

Stefanie F Valbon, Vanessa de Carvalho Oliveira, Lauralie Short

引用次数: 0

Inclusive multisensory science and immunology books for blind, low-vision and diverse-needs audiences 为盲人、低视力和有不同需求的读者提供包容性的多感官科学和免疫学书籍。

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-05-03 DOI: 10.1111/imcb.12758

Stuart Favilla, Erica Tandori, James Marshall

{"title":"Inclusive multisensory science and immunology books for blind, low-vision and diverse-needs audiences","authors":"Stuart Favilla, Erica Tandori, James Marshall","doi":"10.1111/imcb.12758","DOIUrl":"10.1111/imcb.12758","url":null,"abstract":"This paper presents interdisciplinary research exploring the development of inclusive multisensory science books, communicating immunology data for blind, low-vision and diverse-needs audiences. The research adopted an inductive theory-building approach, practice-based art methods and music and design methods, leveraging the lived experience of a legally blind artist. The research also involved designers and scientists in a cocreation process, producing books that incorporate tactile artworks, Braille-inspired protein models, image sonification and interaction. Two multisensory book titles, “The Heroes Within You: A Multisensory Exploration of Infection and Immunity” and “My Goodness: A Multisensory Exploration of Nutrition and Immunity”, were developed for the Monash Sensory Science 2023 Exhibition Day. The books offer an innovative way to make science and art more accessible and engaging, addressing the limitations of traditional museum methods. Feedback from audiences has been positive, emphasizing the fascination, sensory engagement and ease of understanding. This paper highlights the potential for an interdisciplinary and inclusive approach to science and art, demonstrating the value of multisensory books as tools for science communication. The findings highlight the positive reception of this novel approach and suggest its potential for broader applications, promoting inclusivity and accessibility.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 5","pages":"358-364"},"PeriodicalIF":4.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlight of 2023: Tregs in the lungs 2023 年亮点：肺中的集落细胞

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-02 DOI: 10.1111/imcb.12771

Ntombizodwa Makuyana, Adrian Liston

引用次数: 0

Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapy 2023 年的亮点：挖掘自然杀伤细胞的治疗潜力--适应性功能、细胞工程和免疫疗法方面的进展。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-02 DOI: 10.1111/imcb.12769

Pui Yeng Lam, Fernando Souza-Fonseca-Guimaraes

引用次数: 0

Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease 2023 年亮点：CAR T 细胞推动自身免疫性疾病的精准治疗

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12766

Adrian YS Lee, Joanne H Reed

引用次数: 0

Constitutive Flt3 signaling impacts conventional dendritic cell function 连续的 Flt3 信号影响树突状细胞的常规功能。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12757

Kayla R Wilson, Christophe Macri, Jose A Villadangos, Justine D Mintern

{"title":"Constitutive Flt3 signaling impacts conventional dendritic cell function","authors":"Kayla R Wilson, Christophe Macri, Jose A Villadangos, Justine D Mintern","doi":"10.1111/imcb.12757","DOIUrl":"10.1111/imcb.12757","url":null,"abstract":"The development of dendritic cells (DCs) depends on signaling via the FMS-like tyrosine kinase 3 (Flt3) receptor. How Flt3 signaling impacts terminally differentiated DC function is unknown. This is important given the increasing interest in exploiting Flt3 for vaccination and tumor immunotherapy. Here, we examined DCs in mice harboring constitutively activated Flt3 (Flt3-ITD). Flt3ITD/ITD mice possessed expanded splenic DC subsets including plasmacytoid DC, conventional DC (cDC)1, cDC2, double positive (DP) cDC1 (CD11c+ CD8+ CD11b− CD103+ CD86+), noncanonical (NC) cDC1 (CD11c+ CD8+ CD11b− CD103− CD86−) and single positive (SP) cDC1 (CD11c+ CD8+ CD11b− CD103− CD86+). Outcomes of constitutive Flt3 signaling differed depending on the cDC subset examined. In comparison with wild type (WT) DCs, all Flt3ITD/ITD cDCs displayed an altered surface phenotype with changes in costimulatory molecules, major histocompatibility complex class I (MHC I) and II (MHC II). Cytokine secretion patterns, antigen uptake, antigen proteolysis and antigen presenting function differed between WT and Flt3ITD/ITD subsets, particularly cDC2. In summary, Flt3 signaling impacts the function of terminally differentiated cDCs with important consequences for antigen presentation.","PeriodicalId":179,"journal":{"name":"Immunology & Cell Biology","volume":"102 6","pages":"500-512"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlight of 2023: Unconventional T cells: recent insights on development, trafficking and target cell recognition 2023 年亮点：非常规 T 细胞：关于发育、贩运和靶细胞识别的最新见解。

IF 3.2 4区医学

Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12767

Sarah Pasquin

引用次数: 0

Art, science and inclusion: multisensory Sciart of immunology for blind, low-vision and diverse-needs audiences 艺术、科学与包容：为盲人、低视力和有不同需求的受众提供免疫学的多感官 Sciart。

IF 4 4区医学

Immunology & Cell Biology Pub Date : 2024-05-01 DOI: 10.1111/imcb.12759

Erica Tandori, Stuart Favilla

引用次数: 0