An X-tra role for NFκB in gene regulation?

IF 3.2 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2025-01-10 DOI:10.1111/imcb.12850

Sara Berent, Rhys S Allan

引用次数: 0

Abstract

In this Research Highlight, we discuss recent research which shows that TCR-mediated activation and NF-κB signalling play an indispensable role in localising Xist RNA and its interactors to the inactive X chromosome (Xi) in T cells (left and middle). Inhibition of NF-κB disrupts this process, impairing the recruitment of silencing factors and jeopardizing the maintenance of X chromosome inactivation (right).

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NFκB在基因调控中的X-tra作用？

在本研究重点中，我们讨论了最近的研究，这些研究表明tcr介导的激活和NF-κB信号传导在T细胞中将Xist RNA及其相互作用物定位到失活的X染色体（Xi）中起着不可或缺的作用（左和中）。抑制NF-κB会破坏这一过程，损害沉默因子的募集，危及X染色体失活的维持（右）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.