Lasers in Medical Science最新文献

{"title":"Multilayered numerical modelling of bio-thermal aspects during laser assisted treatment of internal haemorrhoid developed in rectum.","authors":"Jaideep Dutta","doi":"10.1007/s10103-025-04355-5","DOIUrl":"https://doi.org/10.1007/s10103-025-04355-5","url":null,"abstract":"<p><p>Haemorrhoids are swollen blood vessels developed around the anus. Internal haemorrhoids are generally not visible from outside due to its growth inside the rectum and it is generally considered as painless. However, a prolapsed internal haemorrhoid may cause discomfort, pain and irritation. For the treatment of internal haemorrhoid, laser assisted therapy would be helpful due to its rooted advantages such as post-surgery minimal pain, lesser bleeding, quicker healing, shorter recovery period, shorter surgical and overall treatment duration, lower risk of recurrence and least risk of post-surgical infections. The genesis of present research work deals with the development of mathematical modelling to capture the bio-thermal response during laser assisted therapy of internal haemorrhoid developed in the rectum. The explicit form of finite difference method is employed as numerical tool for the mathematical study and the physical domain is considered as multilayered tissue (three different layers of rectum: muscle, submucosa and mucosa). A Gaussian laser beam is considered as heat source to destroy the abnormal growth inside the rectum. Temperature variation in multi-layered tissue is investigated for laser heat input and absorption radius along the temporal and spatial coordinate. Temperature drop has been evidenced in the interfaces of multi-layered rectum tissue. The research outcome is verified with the published numerical model with negligible variation.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"105"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial photodynamic therapy using gold nanoparticles conjugated with 1,9-dimethyl-methylene blue for treating Staphylococcus skin infections.","authors":"Anildo Alves de Brito Júnior, Pedro Jorge Louro Crugeira, Wellington Luis Reis Costa, Andressa Vollono Barbosa, Susana Carla Pires Sampaio de Oliveira, Maria Cristina Teixeira Cangussu, Jean Nunes Dos Santos, Juliana Monteiro Azevedo, Antonio Luiz Barbosa Pinheiro","doi":"10.1007/s10103-025-04367-1","DOIUrl":"https://doi.org/10.1007/s10103-025-04367-1","url":null,"abstract":"<p><p>This study aims to assess the effectiveness of Antimicrobial Photodynamic Therapy (aPDT) using phenothiazine photosensitizer (PS) combined with gold nanoparticles (DMMB-AuNPs) in treating S. aureus-contaminated wounds on the dorsum of rats. Twelve Wistar rats were divided into four groups: Control, LED, DMMB-AuNPs, and DMMB-AuNPs + LED. DMMB-AuNPs were prepared using DMMB (300 ng/mL) and 5 nm diameter AuNPs (~ 5.5E + 13 particles/mL). The light source was a red LED (12 J/cm², λ630 ± 20 nm, CW, 125 mW, 192s). Following the procedures, samples were plated on an agar medium specific to S. aureus to count the colony-forming units (CFU/mL). Statistical analysis using unidirectional ANOVA and Tukey's test revealed that the aPDT group (DMMB-AuNPs + LED) exhibited a 99.999% (5 log reduction) microbial reduction with a significant statistical difference (p < 0.0001) compared to the Control group, demonstrating a bactericidal effect. The in vivo findings unequivocally demonstrate the effectiveness of DMMB-AuNPs-mediated aPDT as an alternative therapy for staphylococcal infections.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"103"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of color Doppler ultrasound in the treatment of infantile hemangioma by applying timolol combined with Cynergy dual-wavelength laser : Application of color Doppler ultrasound in the treatment of infantile hemangioma.","authors":"Shubin Liang, Xia Li, Qian Wu, Bohe Wang, Ping Chen","doi":"10.1007/s10103-025-04356-4","DOIUrl":"https://doi.org/10.1007/s10103-025-04356-4","url":null,"abstract":"&lt;p&gt;&lt;p&gt;To assess the utility of color Doppler ultrasound in guiding the treatment of infantile hemangiomas using a combination of topically applied timolol and Cynergy dual-wavelength laser. We selected 92 hemangioma patients from our outpatient clinic between March 2022 and September 2023. According to the Guidelines for Diagnosis and Treatment of Hemangiomas and Vascular Malformations (2019 edition), laser therapy is suitable for superficial localized or sporadic lesions, combined treatment or natural resolution of residual skin hemangioma lesions, remaining loose and uneven skin.All the patients in our group met the guidelines for Diagnosis and Treatment of hemangiomas and vascular malformations (2019 edition). The risk grade was medium risk and low risk, medium risk: hemangiomas on both sides of the face, scalp, hands and feet, with disfigurement risk and low risk of functional impairment; Hemangiomas in the body folds (neck, perineum, underarm), with a high risk of ulcer formation; Segmental hemangiomas &gt; 5 cm- risk of ulcer formation on trunk, limbs, and skin, and permanent remains. Low risk: Trunk, limbs (not obvious), low risk of disfigurement and functional impairment. According to guidelines for moderate risk hemangiomas: Treat them early. Early and weak lesions can be given topical β-blockers, or pulsed dye laser; In the course of treatment, if the tumor growth cannot be controlled, the high-risk hemangioma treatment regimen should be followed. Low-risk hemangioma: If it is stable, follow up or try topical drugs; If the tumor is growing rapidly, the medium risk hemangioma treatment regimen is followed.These patients were divided into two groups, A and B. In group A, color Doppler ultrasonography was conducted, and patients were categorized into three groups based on their blood flow signals identified through color ultrasound. Among the 70 cases in group A with distinct blood flow signals, laser parameters were adjusted, and topical timolol was administered. In group B, the family members of the patients were reluctant to accept color ultrasound examination due to poor family conditions and the patient's uncooperation during color ultrasound examination,22 cases received direct treatment with topical timolol and Cynergy dual-wavelength laser upon hospital admission without undergoing ultrasound. The time gap between these treatments was one month. Both groups were followed up for one month to compare treatment effectiveness, adverse effects, and treatment durations. A total of 92 patients were included in this study, with 70 cases in group A (average age 4.05 ± 2.51 months) and 22 cases in group B (average age 4.00 ± 2.33 months). Hemangioma blood flow signals in group A were categorized as follows: no blood flow, sparse blood flow, and moderate blood flow in groups A1, A2, and A3, respectively. The effectiveness rate in group A was significantly higher than that in group B (90.0% vs. 72.7%, U = 637, P = 0.044). Group A exhibited lower ","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"101"},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphoton tomographic analysis of hyaluronic acid delivery: comparison of carbon dioxide laser and 1927 nm thulium laser over time.","authors":"Lynhda Nguyen, Christian Mess, Stefan W Schneider, Volker Huck, Katharina Herberger","doi":"10.1007/s10103-025-04363-5","DOIUrl":"10.1007/s10103-025-04363-5","url":null,"abstract":"<p><p>Hyaluronic acid injections, known as skin quality boosters (SQB), improve skin hydration and quality. Laser-assisted delivery using ablative (AFL) and non-ablative fractional lasers (NAFL) enhances the uptake of topical drugs and cosmeceuticals. This study aims to compare the biodistribution of SQB as well as the morphologic and metabolic cellular changes following CO₂ and thulium (Tm) laser treatments. Healthy male and female volunteers were assigned to either the CO₂ laser or the Tm laser treatment group. Areas on their forearm were marked for following treatments: laser with SQB application, laser monotherapy, topical SQB monotherapy, and untreated control. Measurements were carried out 30 min and 30 days post-treatment using multiphoton-tomography equipped with fluorescence lifetime imaging (MPT-FLIM). Eleven volunteers were included in each group. SQB penetration reached the upper dermal layer in both groups, with larger aggregates after CO₂ treatment. The CO₂ laser induced a higher level of inflammation, which persisted as subclinical inflammation even 30 days post-treatment. In contrast, skin treated with the Tm laser showed a metabolic state similar to the untreated control after 30 days. Both CO₂ laser and Tm laser enhance cutaneous uptake of the SQB, potentially improving skin hydration and quality. While the CO₂ laser may be more effective in delivering SQB, the Tm laser may be a treatment option with minimal downtime. MPT-FLIM proved to be a suitable tool for monitoring treatment outcomes.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"100"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-action approach to oral cancer therapy: integrating HDAC inhibition and photodynamic therapy with LXD191.","authors":"Anahas Perianaika Matharasi Antonyraj, Dhanraj Ganapathy","doi":"10.1007/s10103-025-04359-1","DOIUrl":"https://doi.org/10.1007/s10103-025-04359-1","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"99"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical effects and skin histological changes induced by a novel insulated radiofrequency microneedle: a pilot study.","authors":"Meng Wang, Yi Li, Xiaodong Lai, Congqi Shi, Yan Yan","doi":"10.1007/s10103-025-04354-6","DOIUrl":"https://doi.org/10.1007/s10103-025-04354-6","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Radiofrequency microneedle (RFMN) could mechanically penetrates the epidermis and emits radiofrequency energy to the target skin layer. This innovative system offers the capability to deliver precisely controlled radiofrequency energy at varying depths within the skin in a single insertion. We hypothesized that the new RFMN could improve both pore size and skin laxity simultaneously by single insertion and multiple discharges, thus reducing the number of treatment passes and improving the treatment efficiency. Therefore, we carried out this pilot study to confirm the clinical effects and corresponding histological changes. In clinical part, 3 subjects received a single RFMN treatment. Subjects' faces were randomly divided into superficial base-energy and deep high-energy side or superficial high-energy and deep base-energy side. Facial characteristics were documented using standardized photographic techniques at various points in the study. In animal experiment, the abdomen of Bama miniature pig was divided into 4 treatment zones: the blank control group; superficial base-energy and deep high-energy group; superficial high-energy and deep base-energy group; no energy control group. Skin samples were collected immediately and 1 month post-treatment for histological analysis to observe the corresponding histological changes. Immediately after treatment, we found that the severity of erythema and petechiae may be related to the parameter settings. 1 month after treatment, improvement in skin laxity and facial pore size on both sides of the face was observed. The treatment resulted in a more significant improvement in relaxation on the superficial base-energy and deep high-energy side, but the pore improvement appeared to be more pronounced on the superficial high-energy and deep base-energy side. A trend of decreasing intensity in vascular dilatation was observed across the treatment groups, with the superficial high-energy and deep base-energy group exhibiting the most pronounced dilation. Histological observations immediately after treatment revealed that 2 seperated injury zones, which was caused by the same needle discharged electric twice, and one charge in the deep and one in the shallow. Immediate post-treatment dilation of blood vessels in all treatment groups was observed. A trend of decreasing intensity in vascular dilatation was observed across the treatment groups, with the superficial high-energy and deep base-energy group exhibiting the most pronounced dilation. 1 month post-treatment, histological analysis revealed an increase in dermal thickness, elastin, collagen fiber thickness and density, perivascular inflammatory cell infiltration across all treatment groups. Overall, our study demonstrated that variations in energy delivered at different depths by a new RFMN could induce distinct histological changes and corresponding clinical efficacy. This finding holds promise for optimizing the clinical application of RFMN. By tailori","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"98"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucosa cues for regeneration using Photobiomodulation.","authors":"Larissa Fassarela Marquiore, Rafaela Ferrer Oliveira, Luiza Almeida Queiroz Ferreira, Natália Aparecida Gomes, Milena Martins Olavo de Souza, Beatriz Gomes Lucardians, João Victor Reis Cruvinel, Ana Luísa Morais Perdigão, Ricardo Alves Mesquita, Tarcília Aparecida Silva, Sara Santos Bernardes, Marina Gonçalves Diniz, Ivana Marcia Alves Diniz","doi":"10.1007/s10103-025-04343-9","DOIUrl":"https://doi.org/10.1007/s10103-025-04343-9","url":null,"abstract":"<p><p>Photobiomodulation therapy (PBMT) is gaining recognition as an effective method for repairing damaged tissues, particularly in skin and mucosa injuries. Despite its growing use, there remains a significant gap in understanding the interaction of ectomesenchymal components during light therapy. This study explored various near-infrared light parameters on stressed skin keratinocytes (KC) cultured alone or in association with oral fibroblasts (FB) using a transwell system. Reactive oxygen species (ROS) levels were quantified, alongside observations of cell viability/proliferation, migration, and pro-resolutive gene expression in KC cultivated conventionally (at 1, 5, and 50 J/cm²; 1.4, 7 and, 70 s; 0.03, 0.14, and 1.4 J, respectively; 0.71 W/cm²; 20 mW) and co-cultured with FB (at 5 J/cm²). Murine tongue fragments were also treated at 5 J/cm² for three days. The results revealed increased ROS levels in stressed cells. PBMT enhanced cell viability/proliferation and migration of KC in vitro, while pro-inflammatory cytokines were predominantly suppressed following irradiation. All energy densities and culture models showed upregulation of amphiregulin. In the co-culture system, PBMT notably upregulated interleukin 1 - receptor antagonist and vascular endothelial growth factor genes while downregulating transforming growth factor-β1 expression. In ex vivo tongue fragments, PBMT significantly increased lamina propria thickness and spindle-shaped cell counts compared to non-irradiated samples. Overall, near-infrared PBMT demonstrated pro-regenerative effects by modulating inflammation. The activation of pro-resolutive molecules and the dampening of cytokines may favor early tissue remodeling in the dermis counterpart.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"97"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser versus rhomboid flap for sacrococcygeal pilonidal sinus: multi-centre comparative study.","authors":"Alaa Alwadess, Abdulzahra Hussain, Emad Geddoa, Ali Younus Altamimi, Tamer Habeeb, Sahl Jafer, Samer Al-Hakkak","doi":"10.1007/s10103-025-04341-x","DOIUrl":"https://doi.org/10.1007/s10103-025-04341-x","url":null,"abstract":"<p><p>Pilonidal sinus is a condition affecting young people. Several management methods are available. The two popular approaches are laser ablation and open techniques. This study aims to assess the recurrence rate after both techniques. This is a government and private hospital setting. Patients are included if they are diagnosed with pilonidal sinus, between the ages of 16 and 70, and have never had surgery before. Diabetic patients and patients with immune deficiency status who are younger than 16 or older than 70 are excluded. The operations are done by senior consultant surgeons. Patients are seen for 4 weeks or 3 months and discharged if there are no complications. 190 and 184 patients were selected for the laser and open groups, respectively. There are 142 men and 42 women in the open group compared to 140 men and 50 women in the laser group, with p-value: of 0.472. There was no significant difference in age, body mass index, or obesity between the two groups. There is a significantly higher recurrence rate in the laser group value: <0.00001. No significant difference in the recurrence rate for one or more than one opening disease within the open group. The laser technique is associated with a higher recurrence rate compared to the open rhomboid flap technique. One opening pilonidal sinus is significantly showing better results within the laser group but no significant difference in the open group.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"93"},"PeriodicalIF":2.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of quantum hyperlight technology in photobiomodulation on stem cells: an experimental in vitro study.","authors":"Gülsemin Çiçek, Fatma Öz Bağcı, Tahsin Murad Aktan, Selçuk Duman","doi":"10.1007/s10103-025-04358-2","DOIUrl":"10.1007/s10103-025-04358-2","url":null,"abstract":"<p><p>Human umbilical cord matrix Wharton's jelly mesenchymal stem cells (WJ-MSCs) are commonly utilized in regenerative medicine due to their therapeutic benefits. However, the microenvironmental stress present in patients with hyperglycemia can significantly reduce mesenchymal stem cell (MSC) viability under high-glucose conditions in the body, ultimately reducing their therapeutic effectiveness. Enhancing the survival rate of MSCs following cell transplantation remains a crucial challenge. This study investigates whether Quantum Hyperlight (QHL) can counteract the detrimental effects of high glucose (HG), thereby improving MSC survival, proliferation, and mitochondrial function. We aimed to evaluate the effect of QHL on cellular viability, proliferation, and mitochondrial activity in WJ-MSCs exposed to HG. MSCs were cultured in a medium containing normal glucose (NG) (1 g/L) and HG (4.5 g/L). MSCs in the HG medium were exposed to QHL for 90 s or 180 s with an energy density of 2.4 Joules/cm²/minute and an average power density of 40 mW/cm². Then, proliferating cell nuclear antigen (PCNA), MTT assays, and Mitotracker Green staining were performed to evaluate cell viability and proliferation. The viability of MSCs was significantly increased in the QHL-treated groups (84% in QHL-90 s and 86% in QHL-180 s) compared to the untreated HG group (65%, p < 0.001). PCNA expression in QHL-90 s and QHL-180 s groups showed significant increases (p < 0.001) compared to the untreated HG group. MitoTracker staining intensity was significantly higher in the QHL-treated groups compared to the untreated HG group (p < 0.001). The HG environment reduced viability, proliferation, and mitochondrial staining. In the context of the NG environment, MSCs exhibited notable differences. However, the viability, proliferation, and mitochondrial staining rates of MSCs were significantly higher in the HG conditions when treated with QHL compared to the group that did not receive QHL. This study introduces QHL as a novel approach to enhance the therapeutic potential of WJ-MSCs under HG conditions, demonstrating its ability to improve cellular viability, proliferation, and mitochondrial activity. This study highlights its potential as a pretreatment to improve clinical outcomes in regenerative medicine.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"96"},"PeriodicalIF":2.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effectiveness and safety of photobiomodulation on low-to-moderate myopia.","authors":"Jun Ren, Jiang-Ning Xu, Yu-Zhen Liu, Xian-Liang Gu, Yi Wang","doi":"10.1007/s10103-024-04119-7","DOIUrl":"https://doi.org/10.1007/s10103-024-04119-7","url":null,"abstract":"<p><p>To find and assess the effectiveness and safety of short-term Photobiomodulation (PBM) treatment in children with low-to-moderate myopia. Children with low-to-moderate myopia were recruited and divided into PBM or control groups based on whether they received PBM treatment. The PBM group underwent a three-month treatment with a 650 nm low-energy semiconductor laser, while the control group did not receive any therapeutic intervention. At the end of the trial, the changes in spherical equivalent refractive (SER) and axial length (AL) before and after treatment were compared between the PBM group and the control group to evaluate the effectiveness of PBM in preventing myopia. The best corrected visual acuity (BCVA), nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), central point retinal thickness (CPRT), 3-mm subfield central retinal thickness (3 mm-CRT), superficial retinal vascular density (SCP), and central choroid thickness (CCT) were self-compared to assess the safety of PBM. A total of 57 subjects were prospectively followed from October 2020 to September 2021, comprising 28 participants (56 eyes) in the PBM group and 29 participants (58 eyes) in the control group. After three months of treatment, the AL decreased by 0.07 ± 0.11 mm, and the SER decreased by -0.12 ± 0.39 D in the PBM group. However, both SER and AL increased in the control group. Furthermore, there were statistically significant differences between the PBM and control groups (p < 0.01). The BCVA, RNFLT, GCLT, CPRT, and 3 mm-CRT remained almost unchanged in the PBM group; The SCP decreased from 0.37 ± 0.03 to 0.35 ± 0.02 in the PBM group with a statistically significant difference before and after treatment (p = 0.045). The CCT increased from 255 ± 41 µm to 274 ± 29 µm in the PBM group without any significant difference before and after treatment. The administration of PBM significantly suppresses the elevation of AL and SER following a three-month duration. No significant adverse effects were observed on visual function and retinal morphology.Trial Registration: This study is registered at https://clinicaltrials.gov/ (registration number: NCT04604405).</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"95"},"PeriodicalIF":2.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}