Lasers in Medical Science最新文献

{"title":"Application of Z-scan technique in detecting circulating free DNA for prostate cancer diagnosis and monitoring.","authors":"Sarah Alves, Charles Silva Junior, Guilherme Muniz, Luiz Silva, Renata Zortea, Vagner Lima, Glaucia Veiga, Beatriz Alves, Fernando Fonseca","doi":"10.1007/s10103-025-04357-3","DOIUrl":"10.1007/s10103-025-04357-3","url":null,"abstract":"<p><p>Prostate cancer diagnosis relies on methods like PSA testing, digital rectal exams, and biopsies. The Z-scan technique, a nonlinear optical method, may provide a new, non-invasive approach to detecting circulating free DNA (ccfDNA) in serum, offering potential improvements in cancer diagnosis and monitoring. The aim of this study is to evaluate whether the Z-scan technique can serve as an alternative or complementary diagnostic tool to existing prostate cancer tests. The Z-scan technique was applied to detect apoptotic and necrotic ccfDNA fragments in the serum or plasma of prostate cancer patients. This technique measures the nonlinear refractive index's dispersive and absorptive components and was compared with laboratory data, such as PSA levels and cancer progression indicators. The study found a correlation between Z-scan-derived θ values and PSA levels, suggesting its utility in identifying cancer relapse. However, no correlation was observed with the Gleason scale. The Z-scan technique shows promise as a diagnostic and monitoring tool for prostate cancer, offering a potential non-invasive alternative to traditional methods.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"114"},"PeriodicalIF":2.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warm irrigation fluid effect on Thulium fiber laser (TFL) ablation of uroliths.","authors":"Andrei D Cumpanas, Nitesh Katta, Thao N Vu, Yi Xi Wu, Antonio R H Gorgen, Mariah C Hernandez, Kelvin Vo, Sohrab N Ali, Zachary E Tano, Pengbo Jiang, Roshan M Patel, Thomas Milner, Jaime Landman, Ralph V Clayman","doi":"10.1007/s10103-024-04253-2","DOIUrl":"https://doi.org/10.1007/s10103-024-04253-2","url":null,"abstract":"<p><p>Prior laser studies have demonstrated that as the temperature of a medium increases, the amount of energy delivered to the target increases. We sought to investigate the role of irrigation fluid temperature on Thulium fiber laser (TFL) urolith ablation. 360 calculi were divided in vitro according to chemical composition: calcium oxalate monohydrate (COM), cystine (CYS), struvite (STR), calcium phosphate (CAP), uric acid (UA), and calcium oxalate dihydrate (COD). A 200 μm TFL was placed directly on each stone, while immersed in 0.9% NaCl at four different temperatures (25 C, 37 C, 44 C, 60 C) and a single laser pulse administered at distinct energy settings (0.1 J, 0.5 J, 1.5 J). Optical coherence tomography assessed the resulting ablation cone volume. Mean stone volume and porosity were evaluated through ANOVA and Tukey post-hoc analysis. A multivariate generalized model for each composition accounted for the impact of fluid temperature and laser energy on stone ablation. Warmer fluid temperatures yielded greater ablation cone volumes for most energy settings, excluding UA stones. When accounting for chemical composition, higher tensile strength stones (COM, CYS) benefited most from warmer fluid in comparison to frangible stones (CAP, STR). The effects of increasing fluid temperature are modest relative to laser pulse energy as a large temperature increase (i.e. 7ºC) is equivalent to a minor energy increase (i.e. 0.1 J). For non-UA stones, TFL ablation efficiency increases with warmer irrigation fluid. The effect, albeit modest compared to laser pulse energy, was most notable for COM and CYS stones.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"112"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and parameterization of low-level laser therapy in diabetic ulcers: an umbrella review of systematic reviews and meta-umbrella.","authors":"Mariana Bezerra Miranda, Rayana Fontenele Alves, Rebeca Barbosa da Rocha, Vinicius Saura Cardoso","doi":"10.1007/s10103-025-04366-2","DOIUrl":"https://doi.org/10.1007/s10103-025-04366-2","url":null,"abstract":"<p><p>This study aimed to systematically verify the available systematic reviews and meta-analyses of Low-level laser therapy (LLLT) in diabetic foot ulcer (DFUs) to identify the effects and optimal parameters of LLLT in the management of DFUs. This umbrella review was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) report items and registered in the International Prospective Register of Systematic Review (PROSPERO). The search for articles was performed in the Pubmed, Scopus, Web of Science and Embase databases. The following terms were used: Diabetic Foot, Diabetic Neuropathies, Peripheral Vascular Diseases, Peripheral Neuropathy, Diabetic Foot Ulcer, LASER Therapy, Low-Level Light Therapy, LLLT, LASER Biostimulation, Low Intensity LASER Irradiation, Low Power LASER Irradiation, Low Intensity LASER Therapy, Low Power LASER Therapy. A search was performed in the references section of the included studies. The systematic review (SR) included studies that compared LLLT with non-therapeutic doses (parameters considered low to modify healing), sham irradiation, and conventional DFU treatment. The interventions were performed using red and infrared wavelengths. Although two studies included in the SR used wavelengths below 600 nm, these were combined with diodes with infrared wavelengths within the same device. Another study performed a comparative analysis of LLLT at different wavelengths (632 nm and 904 nm), with area reduction rates of 63.7% and 56.8%, respectively, with no statistically significant difference. This is study indicated that, compared with standard treatment and non-irradiation treatments, the use of photobiomodulation (PBM) with different parameters was effective in promoting UPD healing. Further studies are warranted to determine the ideal parameters for improving patient outcomes. (International Prospective Register of Systematic Review Registration number: CRD42022362447).</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"109"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lasers for treatment of androgenetic alopecia: an in-depth analysis.","authors":"Aditya K Gupta, Daniel Taylor, Keyvan Nouri","doi":"10.1007/s10103-025-04365-3","DOIUrl":"https://doi.org/10.1007/s10103-025-04365-3","url":null,"abstract":"<p><p>With recent developments in laser technologies and growing demand for alternative treatments, laser therapy has been increasingly studied as a treatment for androgenetic alopecia (AGA). Low-level laser therapy (LLLT) and fractional laser therapies have been marketed as safe and effective options for treating AGA in comparison with traditional drug therapies, which are associated with unwanted side effects. We discuss the history of development and implementation of laser devices for treatment of hair loss and outline the proposed mechanism of action for LLLT and fractional lasers. Additionally, we summarize the evidence of efficacy for LLLT and fractional laser monotherapies in the treatment of AGA and assess potential risk of bias in available clinical studies. While evidence is still mounting, there exists some congruency in proposed mechanisms for the stimulation of hair follicles by laser therapy. Laser light is believed to foster a supportive microenvironment for the hair follicle, through improved vascularization and modulation of inflammation, and directly stimulate growth signaling in the follicle. As for evidence of clinical efficacy, studies of LLLT and fractional laser monotherapies have reported improvement in AGA markers from baseline values. However, these studies have a relatively small sample size and our risk of bias assessment suggests some concerns in procedural design. Although laser therapy represents a safe alternative treatment option for AGA, its evidence of efficacy is hindered by a lack of large-scale, high-quality clinical trials, susceptibility to bias, and a wide range of devices, treatment protocols and parameters.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"108"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polywave LEDs increase the degree of conversion of composite resins, but not adhesive systems: a systematic review and meta-analysis of in vitro studies.","authors":"Amanda Corrêa, Giovane Moro, Luis Eduardo Cechin, Luciano Gonçalves, Rachel O Rocha, Fabio Zovico Maxnuck Soares","doi":"10.1007/s10103-025-04368-0","DOIUrl":"https://doi.org/10.1007/s10103-025-04368-0","url":null,"abstract":"<p><p>This study aimed to systematically review the literature for laboratory studies that evaluated the influence of mono- and polywave light-emitting diode (LED) devices on the degree of conversion (DC) of composite resins and adhesive systems. A search of three electronic databases (PubMed, Web of Science, Scopus) and using Google Scholar was conducted through June 2024 to identify eligible studies that compared monowave and polywave LED devices on the DC of composite resins and adhesive systems. Studies that evaluated DC using indirect methods, material other than composite resin and adhesive system, and missing DC values as mean and standard deviation were excluded. Meta-analysis was performed at a significance level of ≤ 0.05 comparing DC values (mean and standard deviation) produced by LEDs. Heterogeneity was quantified using I² values. 79 potentially relevant studies were identified from online databases, 27 were selected for full-text assessment, and 22 were included in this systematic review. Eighteen of the included studies had a high risk of bias and four had a moderate risk of bias. Polywave LEDs significantly improved the DC of composite resins (p ≤ 0.5) and did not affect on adhesive systems (p = 0.18). Despite the high risk of bias and the heterogeneity of the included studies, the available evidence may support the conclusion that polywave LED devices improve the DC of composite resins. Monowave or polywave LED devices did not affect the DC of adhesive systems.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"111"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ethical considerations of artificial intelligence hallucination and misinformation in dermatological and medical laser documentation.","authors":"Ryan Scheinkman, Lea Tordjman, Sheila Sharifi, Keyvan Nouri","doi":"10.1007/s10103-025-04364-4","DOIUrl":"https://doi.org/10.1007/s10103-025-04364-4","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"110"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends and hotspots of laser therapy in hemangioma: a bibliometric and visualization analysis.","authors":"Jing Nie, Xiaoyang Dong, Dilinur Tasimeti, Yalin Zhu","doi":"10.1007/s10103-025-04312-2","DOIUrl":"10.1007/s10103-025-04312-2","url":null,"abstract":"<p><p>This bibliometric analysis aimed to analyze global research trends in laser therapy for hemangiomas, a common benign vascular tumor in children from 1977 to 2024. Publications in laser therapy for hemangiomas from 1977 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database, and only articles published in English were analyzed. Bibliometric and visual analyses were performed using VOSviewer, CiteSpace, and the R package \"bibliometrix.\" A total of 1,028 publications from 66 countries and 4,199 authors were analyzed, showing an annual growth rate of 5.61%. The United States led with 365 articles and 11,713 citations. Major contributors included the University of California System and Harvard Medical School, and key journals were Lasers in Surgery and Medicine and Dermatologic Surgery. Pulsed dye laser (PDL) was the most studied laser type. Research focused on optimizing treatment safety, effectiveness, and management, especially in children. The rise of propranolol as a keyword highlighted its increasing role in hemangioma therapy, and the keyword like \"classification\" and \"vascular anomalies\" underlining the importance of accurate diagnosis and classification. This study highlights the growing importance of laser therapies for hemangiomas. Future research should explore combining propranolol with laser treatments and the role of precise diagnosis in improving treatment outcomes.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"107"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of phthalocyanine, methylene blue and toluidine blue photosensitizers on the adhesive interface of fiber posts: a confocal laser microscopy study.","authors":"Tuba Gök, Gamze Er Karaoglu, Hulde Korucu","doi":"10.1007/s10103-025-04369-z","DOIUrl":"10.1007/s10103-025-04369-z","url":null,"abstract":"<p><p>Phthalocyanine (Pc) is a promising photosensitizer for photodynamic therapy (PDT), offering advantages such as high light stability, strong absorption, efficient singlet oxygen production, and low dark toxicity. This study evaluated the effects of PDT with different photosensitizers on the penetration depth and area of self-adhesive resin cement into dentinal tubules. Forty single-canal, round-shaped lower premolar teeth were prepared using the ProTaper Next system. After root canals were filled with the single cone technique, samples were stored for 7 days. Post spaces were created, and samples were divided into four groups: control, methylene blue (MB), toluidine blue (TB), and Pc groups. PDT was performed using photosensitizers combined with light-emitting diodes (LEDs). 1.0 mm ± 0.1 axial sections were taken from the 1, 5, and 8 mm levels from the orifice. The penetration depth and area of self-adhesive resin cement into dentinal tubules were analyzed using a confocal laser microscope. Statistical analyses were conducted using ANOVA and Tukey's test. Cement penetration depth decreased from coronal to apical sections in all groups. At the 1 mm level, MB showed a greater penetration area than Pc, while at the 5 mm level, MB showed a lower penetration area than the control group (p < 0.05). No significant differences were found at the 8 mm level. This study showed that while adhesive penetration depth did not differ significantly among groups, penetration area varied at 1 mm and 5 mm sections. Methylene blue exhibited a higher penetration area at 1 mm compared to phthalocyanine, whereas toluidine blue showed consistent penetration across sections. In terms of penetration depth and area findings, the findings showed that PC can be used as an alternative photosensitizer in PDT application in endodontics, showing generally similar findings with MB and TB.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"106"},"PeriodicalIF":2.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoangiogenetic potential of Nd:YAG 1064 nm photobiomodulation in non-surgical healing of trauma induced periapical bone defects: a clinicalprospective pilot study.","authors":"Jagruti Mutalikdesai, Rhythm Bains, Aseem P Tikku, Ramesh Bharti, Vijay Kumar Shakya, Sukriti Kumar, Promila Verma","doi":"10.1007/s10103-025-04360-8","DOIUrl":"https://doi.org/10.1007/s10103-025-04360-8","url":null,"abstract":"<p><p>To evaluate Nd: YAG 1064 nm photobiomodulation as a therapeutic adjunct for non-surgical management of trauma-induced periapical bone defects. The present study was a parallel-group, double arm, single-centre clinical, prospective, pilot study. Thirty systematically healthy individuals with radiographic evidence of trauma-induced periapical bone defects in anterior teeth were recruited. Twenty-four patients meeting the inclusion criteria were selected and randomly placed in two treatment groups. Group A: Non-surgical endodontic treatment with intracanal calcium hydroxide-iodoform paste (CH-I), and Group B: Non-surgical endodontic treatment with intracanal calcium hydroxide and adjunctive extracanal Nd:YAG 1064 nm photobiomodulation therapy (PBMT). Improvement in vascular perfusion, reduction in size, volume, area and echogenicity of the lesion was assessed with ultrasound and colour Doppler imaging. The peak systolic velocity increased statistically significantly (p < 0.05) from baseline to 3 and 6 months, suggesting PBMT as a facilitator of neoangiogenesis. Compared to the calcium hydroxide group, the PBM group showed a more significant mean reduction in size, volume, and surface area of the periapical lesion and lower post-operative pain scores, though not statistically significant. Also, the PBM group presented with more remarkable hard tissue development, as seen by an improvement in echogenicity from hypoechoic to predominantly hyperechoic or hyperechoic. Results suggest that PBMT with Nd: YAG can accelerate healing, enhance perfusion of periapical lesions, provide analgesia, and reduce the need for pharmacological drugs. Although the sample size is limited, this research offers a foundation for further clinical studies with larger sample sizes to evaluate the additional benefits of laser therapy in periapical healing. The study was submitted to the Clinical Trails Registry-India (CTRI), under reference no/2023/02/063428, with a registration number/2023/09/057848, before the commencement of the study.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"102"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of pain perception and surgical wound healing after lower labial frenectomy with diode laser technique: pilot study.","authors":"Ricardo Roberto de Souza Fonseca, Michelle Leal de Oliveira, Erich Brito Tanaka, Rhaisa Vasconcelos da Graça, Rogério Valois Laurentino, Luiz Fernando Almeida Machado, Silvio Augusto Fernandes de Menezes","doi":"10.1007/s10103-025-04370-6","DOIUrl":"https://doi.org/10.1007/s10103-025-04370-6","url":null,"abstract":"<p><p>The aim of this study was to evaluate the postoperative period of diode laser frenectomies of the lower labial frenulum (LLF) with anomalous insertions and the perceptions of postoperative pain and wound healing. This cross-sectional pilot study evaluated 3 patients who underwent mandibular labial frenectomy with a diode laser between April 2024 and July 2024. Individuals were divided into two groups according LLF insertion type and the parameters evaluated were gender, age, traumatic brushing, dentin hypersensitivity (DH), traumatic brushing, postoperative pain presence, healing, analgesic use and periodontal parameters, with follow-up occurring up to 90 days after frenectomy. Statistical analyses were performed by frequency of categorical variables, Fisher's exact test and G test were used for intra and intergroup comparisons and the Wilcoxon test was used to compare different postoperative times, with the level of significance set at 0.05 (p < 0.05). The mean age of the sample was 34.6 years and there was a predominance of female participants (n = 2/ 66.6%), we verified that 2 (66.6%) patients presented a bifurcated frenulum insertion and 100% presented mild to intense DH and gingival recession. In the postoperative period, 100% of individuals reported pain and visual dissatisfaction with the scar until the 4th day of follow-up and after 30 days of follow-up only 1 individual remained with pain and visual dissatisfaction with the scar and no evaluated parameter showed statistical significance. Diode laser frenectomy proved to be effective in controlling postoperative pain, improving healing and reducing bleeding.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"104"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}