Clinical study on the effectiveness of laser combined with topical tranexamic acid in the treatment of melasma.

This study was conducted aimed at investigating the effectiveness of combined laser and topical tranexamic acid in the treatment of melasma. A total of 160 melasma patients treated in the dermatology department at the author's hospital from May 2021 to October 2022 were randomly assigned to a control group (laser treatment only, n = 80) and an observation group (combined laser and topical tranexamic acid, n = 80). General patient information was collected, and clinical analysis of melasma area and depth scores was performed before and after treatment. After treatment, the observation group showed significantly smaller melasma area and depth compared to the control group (P < 0.05). Skin quality scores post-treatment were higher in the observation group (P < 0.05). Upon re-examination at the 6th and 12th month, the observation group exhibited smaller melasma areas than the control group (P < 0.05), indicating superior long-term control. The observation group had a lower incidence of side effects (P < 0.05), higher rates of both very satisfied and totally satisfied patients (P < 0.05), and lower dissatisfaction rates (P < 0.05) than the control group. Combined laser and topical tranexamic acid treatment is significantly more effective than laser treatment alone in reducing melasma area and depth, minimizing side effects, and improving patient satisfaction.