Lasers in Surgery and Medicine最新文献

{"title":"A Comparitive Study Between Early Outcomes of Laser and Lay-Open Technique in Management of Simple Pilonidal Sinus.","authors":"Mostafa Seif El Deen, Youssef Mohamed Hassan, Magdy Akel Sorour, Hany El Hadad, Mohamed Wael","doi":"10.1002/lsm.70008","DOIUrl":"https://doi.org/10.1002/lsm.70008","url":null,"abstract":"<p><strong>Background: </strong>Pilonidal sinus (PS) predominantly impacts adolescent and young adult males. This condition may be asymptomatically or escalate to painful acute abscesses and recurrent discharge.</p><p><strong>Objective: </strong>To evaluate the early postoperative outcomes of laser therapy compared to the lay-open technique in the treatment of chronic pilonidal sinus disease.</p><p><strong>Methods: </strong>Prospective randomized comparative study including 40 patients, divided into two equal groups: (a) The SiLaT group: PS treated with diode laser therapy (SiLaT) and (b) the lay-open group: PS treated with lay-open (sinotomy). Postoperative outcomes such as operative time, hospital stay, pain scores, healing time, complications, and recurrence rates were analyzed.</p><p><strong>Results: </strong>Operative time was significantly shorter in the SiLaT group (18.4 ± 2.1 min vs. 26.2 ± 3.7 min, p = 0.022). Hospital stay was shorter in the SiLaT group (6.60 ± 1.47 h vs. 15.10 ± 5.52 h, p < 0.001). Pain scores were lower in the SiLaT group (2.30 ± 0.92 vs. 4.80 ± 1.01, p < 0.001). Wound healing was significantly faster in the SiLaT group (10.1 ± 2.7 days vs. 34.1 ± 15.1 days, p < 0.0001). Recurrence rates (p = 0.998) and surgical site infection (p = 1.00) were comparable among both groups.</p><p><strong>Conclusion: </strong>Sinus laser therapy (SiLaT) demonstrated superior early outcomes, including faster recovery, reduced pain, and fewer complications with earlier resumption of daily activities compared to the lay-open technique. However, recurrence rates remain similar, necessitating long-term studies to evaluate its effectiveness as a first-line treatment. These findings support the use of SiLaT as a day-case surgical procedure, for treating simple PS disease, particularly in young active patients seeking rapid recovery with minimal morbidity.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Number of Recommended Sessions and Influential Factors of Hematoporphyrin Monomethyl Ether Photodynamic Therapy for Pulsed Dye Laser-Resistant Facial Port-Wine Stain.","authors":"Yating Lv, Luan Yang, Shufang Wei, Xiaoying Xiangli, Xiaorong Yang, Xianjun Zhang, Hua Zhong","doi":"10.1002/lsm.70003","DOIUrl":"https://doi.org/10.1002/lsm.70003","url":null,"abstract":"<p><strong>Objectives: </strong>Some patients with port-wine stain (PWS) who have undergone several sessions of pulsed dye laser (PDL) treatment desire further improvement through hematoporphyrin monomethyl ether (HMME) photodynamic therapy (PDT). We attempted to analyse a possible number of recommended sessions and factors influencing the efficacy of multiple sessions of HMME-PDT for facial PDL-resistant PWSs.</p><p><strong>Methods: </strong>Forty-eight patients with facial PDL-resistant PWSs who underwent at least three HMME-PDT sessions were included in this study. All patients received an intravenous injection of HMME (5 mg/kg) followed by 532-nm light-emitting diode green light therapy. Cumulative improvement scores and single improvement scores were obtained after each session to evaluate the degree of improvement.</p><p><strong>Results: </strong>The excellent improvement rates of patients were 0% (0/48), 8.3% (4/48), 29.2% (14/48), 38.5% (10/26), and 50.0% (8/16) after 1-5 HMME-PDT sessions, respectively. A significant difference was observed in the cumulative improvement scores (p < 0.0001). Moreover, there were significant differences between any two sessions in the first four HMME-PDT sessions (p = 0.003). The improvement after the first HMME-PDT session was more obvious than that after each subsequent session (p = 0.004). A PWS less than or equal to 1% of the body surface area (OR = 9.05; 95% CI, 1.42-57.57; p = 0.020) and 5-10 sessions of previous PDL treatment (OR = 8.06; 95% CI, 2.01-32.33; p = 0.003) were positive influential factors for PDL-resistant PWS.</p><p><strong>Conclusions: </strong>We propose that at least 4 HMME-PDT sessions could be recommended for patients with PDL-resistant PWSs, and the improvement after the first HMME-PDT session was the most evident compared with that after each subsequent treatment. Moreover, greater erythema and a greater number of previous PDL session were associated with poor HMME-PDT efficacy.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Protocol for Dermatology Service Learning for Medical Students: Supporting Laser Tattoo Removal for Adults Impacted by the Justice-System","authors":"Victoria D. Ojeda,&nbsp;Hong-An Nguyen,&nbsp;Saisha Nandamuri,&nbsp;Spencer Chau,&nbsp;Jose Luis Burgos,&nbsp;Laura Romero,&nbsp;Arisa Ortiz","doi":"10.1002/lsm.70005","DOIUrl":"10.1002/lsm.70005","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Medical students are interested in participating in dermatology-based service learning programs that address social justice issues. This article describes a novel volunteer program in dermatology with a focus on laser medicine.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We developed a service-learning program that is embedded in a tattoo removal program that serves adults who have interacted with the criminal justice system. The program is designed to ensure that student participation is appropriate to their training while allowing volunteers to: (1) gain exposure to dermatological clinical settings, (2) strengthen communication skills with diverse patients that medical students typically do not typically interact with during their first and second years, (3) build relationships with dermatology residents and faculty and work in multi-disciplinary teams, (4) observe laser procedure and physicians' approaches to the bedside manner, and (5) support the clinical team with patient education postprocedure. Lastly, the program is designed to facilitate peer mentorship by encouraging second-year students to transition into a leadership role and co-mentor first-year students. Evaluation survey data of the first two student cohorts (&lt;i&gt;n&lt;/i&gt; = 6 students, 75% response rate) were collected in January, 2025 and results are summarized.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Student volunteers participate in the following activities: consent form preparation, patient check-in, rooming, consent form collection, shadow procedure, assist with postprocedure tasks (e.g., apply skin ointment and provide sun protection supplies) and patient education as needed. The program is in its second year and has been piloted with eight students with the number of sessions attended ranging between 1 and 13. Evaluation data indicate that all students had prior work experience in clinical settings. Motivations for working in the clinic primarily included interest in providing medical services to adults impacted by the justice system (100%) followed by interest in gaining experience in dermatology to potentially support a career in this discipline. Students felt the program would prepare them to serve underserved communities and for a career in dermatology (33% for each). All students reported being very satisfied with the program's training activities and the majority were able to partake in most activities. Most students reported being confident or very confident in their abilities to carry-out the activities assigned to volunteers and build relationships with students and clinicians. Areas for program improvement include streamlin","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"284-290"},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inaugural Editorial by the New Editor-in-Chief","authors":"Bahman Anvari PhD","doi":"10.1002/lsm.70006","DOIUrl":"10.1002/lsm.70006","url":null,"abstract":"","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"235"},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Topical 5-Aminolevulinic Acid Photodynamic Therapy With the Loop Electrosurgical Excision Procedure for Patients With Cervical High-Grade Squamous Intraepithelial Neoplasia: A Prospective and Propensity-Matched Analysis","authors":"Yao Yang,&nbsp;Bingying Sun,&nbsp;Dan Cao,&nbsp;Ying Xu,&nbsp;Yi Chen,&nbsp;Dan Wu","doi":"10.1002/lsm.70004","DOIUrl":"10.1002/lsm.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (PDT) for high-grade squamous intraepithelial lesions of the cervix associated with high-risk human papillomavirus (HPV) infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, 120 patients who received treatment for high-grade squamous intraepithelial lesions of the cervix from March 2023 to March 2024 were followed up prospectively, which were categorized into the PDT and loop electrosurgical excision procedure (LEEP) groups and matched 1:1 using a propensity score. The regression rate of the lesions and the HPV clearance rate were compared between the groups at 6 and 12 months. Factors affecting the clearance rate were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the 6- and 12-month follow-ups, no significant difference was observed in the rate of lesion regression between the PDT (86.7%, 91.7%) and LEEP groups (85.0%, 93.3%) (<i>p</i> &gt; 0.05), nor the HPV clearance rate (55.0%, 76.7% vs. 65.0%, 78.3%) (<i>p</i> &gt; 0.05). Neither group had any lesions that progressed to Grade 3 or invasive cervical carcinoma at follow-up. According to regression analysis, thinprep cytology test (TCT) results influenced lesion regression in the PDT group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared to the LEEP, 5-aminolevulinic acid PDT had a similar rate of lesion regression and HPV clearance for the treatment of high-grade squamous intraepithelial lesions of the cervix; thus, PDT offers an alternative and effective minimally invasive approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"276-283"},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Vaginal Er:YAG Laser Therapy on Pelvic Floor Symptoms in Women With Stress Urinary Incontinence: A Single-Center Cohort Study","authors":"Massimiliano Lia,&nbsp;Pavel Pilát,&nbsp;Laura Weydandt,&nbsp;Kaven Baessler,&nbsp;Tom Kempe,&nbsp;Bahriye Aktas","doi":"10.1002/lsm.70001","DOIUrl":"10.1002/lsm.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To examine the effect of vaginal erbium:yttrium-aluminum-garnet (Er:YAG) laser therapy on pelvic floor symptoms in women with stress urinary incontinence (SUI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a prospective, single-arm interventional study applying three Er:YAG laser treatments to patients with SUI. The German version of the validated Australian Pelvic Floor Questionnaire was used to quantify pelvic floor symptoms (bladder function, bowel function, sexual function, pelvic organ prolapse) over different time points (baseline, posttreatment, 3 months, and 6 months after treatment). Subgroups were compared to examine which factors influenced symptom development after the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 50 women received three Er:YAG laser treatments and had their symptoms evaluated at all time points of the study. All symptom complex scores, especially bladder function and sexual function, showed statistically significant improvements lasting for the whole study period. However, score improvements of bowel function and prolapse symptoms were likely not clinically meaningful, as they were below the minimal important difference (MID) of this questionnaire. Moreover, sexual function scores improved less when women additionally had urgency symptoms (i.e., mixed urinary incontinence [MUI]; <i>p</i> = 0.036).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Vaginal Er:YAG laser therapy has the potential to improve pelvic floor symptoms linked to bladder function and sexual function in women with SUI. However, the positive effect on sexual function was lower if the women had MUI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"265-275"},"PeriodicalIF":2.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Efficacy and Safety of a Novel Monopolar Radiofrequency Device for Skin Tightening: A Prospective Randomized Controlled Study","authors":"Zhongshuai Wang,&nbsp;Li Li,&nbsp;Xiaofeng Zhang,&nbsp;Zhenzhen Li,&nbsp;Yan Yan","doi":"10.1002/lsm.70002","DOIUrl":"10.1002/lsm.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of a novel monopolar RF device for skin tightening and rejuvenation treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty participants were enrolled in the study. Subjects randomized to the treatment group received a single treatment with the novel RF device (YOUMAGIC), whereas the control group received regular RF treatment (Thermage CPT; Solta Medical). Digital photographs and Antera 3D photographs were taken at baseline, 1-, 3-, and 6-month posttreatment. The depression volume of nasolabial folds (NLFs) in each visit was evaluated using the Antera 3D imaging program. The pain was evaluated by pain measurement scales immediately after treatment. Any procedure-related side effects were documented and examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Posttreatment results were compared with the baseline; statistically significant mean depression volume (MDV) changes of NLFs were found at 1, 3, and 6 months posttreatment. No significant MDV changes were found between the treatment and control groups. No severe adverse events were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study demonstrates that the novel monopolar RF device is clinically safe and effective for skin tightening in the lower face area, and is not inferior to the regular RF therapeutic device.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"259-264"},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Intense Pulsed Light With Nonablative Fractional Laser and Picosecond Alexandrite Laser With Diffractive Lens Array for Noninvasive Facial Rejuvenation","authors":"Jiafang Zhu,&nbsp;Rui Chang,&nbsp;Yue Han,&nbsp;Qianwen Xi,&nbsp;Shutian Jiang,&nbsp;Ying Shang,&nbsp;Dongze Lyu,&nbsp;Wenxin Yu,&nbsp;Xiaoxi Lin","doi":"10.1002/lsm.23879","DOIUrl":"10.1002/lsm.23879","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Both nonablative fractional (NAFL) laser combined with intense pulsed light (IPL) and picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) have been documented for their efficacy in facial rejuvenation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To observe the safety and efficacy of PSAL-DLA and IPL-NAFL in the rejuvenation of Chinese individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Each subject (<i>n</i> = 18) received three treatments on half of their face, with 1-month interval between treatments. One side of the face was randomly treated with PSAL-DLA, and the other side with IPL-NAFL. Quantitative data of wrinkles, pores, brown spots, and red areas were calculated using the VISIA-CR imaging system 3 months after the final treatment. Secondary outcomes included a 10-point VAS for patient-rated pain sensation, incidence of post-inflammatory hyperpigmentation (PIH), erythema and edema, and overall satisfaction. Adverse events were recorded after each treatment and at each follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 17 Chinese female patients aged 28.2 ± 4.3 years completed the study and the 3-month follow-up. The IPL-NAFL side showed a statistically significant improvement in pores compared to baseline (<i>p</i> &lt; 0.05); the PSAL-DLA side showed a statistically significant improvement in brown spots compared to baseline (<i>p</i> &lt; 0.01). Compared to PSAL-DLA, the improvement in enlarged pores was better for IPL-NAFL (81.8 ± 128.1 vs. 20.8 ± 132.4, <i>p</i> &lt; 0.01). In terms of pain, IPL-NAFL was more painful than PSAL-DLA (6 ± 1 vs. 4 ± 1, <i>p</i> &lt; 0.01), a longer recovery time for erythema and edema (5 ± 1 vs. 2 ± 1, <i>p</i> &lt; 0.001), and a higher incidence of PIH (58.8% vs. 23.5%, <i>p</i> &lt; 0.05). Patient satisfaction was higher for PSAL-DLA than for IPL-NAFL (3 ± 1 vs. 4 ± 0.5, <i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study results indicated that both IPL-NAFL and PSAL-DLA could improve the photoaging, but within the same number of treatments, IPL-NAFL was slightly more effective for enlarged pores than PSAL-DLA, while PSAL-DLA was more effective for brown spots than IPL-NAFL. Patients were more satisfied with PSAL-DLA, with a shorter postoperative recovery period and a lower incidence of PIH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 2","pages":"195-203"},"PeriodicalIF":2.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Effectiveness of a Thermo-Mechanical Fractional System at Low Settings for the Treatment of Photodamage","authors":"Eric F. Bernstein,&nbsp;Maggie Wang,&nbsp;Jennifer Wang,&nbsp;J. Lee Pannell","doi":"10.1002/lsm.70000","DOIUrl":"10.1002/lsm.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of a thermo-mechanical fractional device for the treatment of photodamaged skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Materials</h3>\u0000 \u0000 <p>Twenty-five subjects received three thermo-mechanical fractional device treatments at monthly intervals. Low treatment settings of a 5 ms pulse duration and 100 μm tip protrusion were administered in 1–2 passes. Digital images were evaluated for improvement on the Fitzpatrick Wrinkle Classification Score 3 months after the final treatment. Secondary efficacy endpoints included ratings on a Global Aesthetic Improvement Score and Subject SatIsfaction Questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-eight percent of subjects demonstrated a ≥ 1 score improvement in the Fitzpatrick Wrinkle Classification Score, and 96% of subjects demonstrated a good to excellent Global Aesthetic Improvement Score. Sixty-eight percent of subjects were “satisfied” to “very satisfied” with treatment results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The thermo-mechanical fractional device at low settings is safe and effective for improving signs of photodamage with minimal patient discomfort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 3","pages":"252-258"},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Non-Ablative Erbium Laser Therapy on Recurrent Vaginal Candidiasis","authors":"Adrian Gaspar,&nbsp;Alicia Calderon,&nbsp;Josue Vargas Mora,&nbsp;Joaquin Silva,&nbsp;Juan Fernando Bojanini,&nbsp;Maria Jose Araujo,&nbsp;Leticia Lazzaleta Geada,&nbsp;Elena Ivanova,&nbsp;Yeksin Helvacioglu,&nbsp;Pedro Peña Coello,&nbsp;Delfina Zelaschi,&nbsp;Maria Fernanda Lucas,&nbsp;Larissa Mitraud,&nbsp;Virginia Carneiro,&nbsp;Mariela Cogorno,&nbsp;Aleksandra Novakov Mikić,&nbsp;Mihaela Vasilescu","doi":"10.1002/lsm.23880","DOIUrl":"10.1002/lsm.23880","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the effect of non-ablative Er:YAG laser therapy on the symptoms and microbiological conditions of women with recurrent vulvovaginal candidiasis (RVVC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>One hundred and sixty-seven women (mean age 34.1 ± 8.57 years) participated in this cohort study. Women diagnosed with RVVC received four vaginal laser therapies within 4 months. At baseline, 3 months, and 9 months after the last laser therapy microbiological assessment, improvement of five bothersome symptoms related to vaginal infection (burning, itching, dyspareunia, dysuria, and abnormal discharge), and the safety of the laser therapy and overall patient satisfaction were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Non-ablative vaginal Er:YAG laser therapy resulted in improvements of all bothersome symptoms and was statistically significant at 3 and 9 months following the therapy. A complete resolution in symptoms (VAS = 0) was observed in 38%–74% of women, depending on the symptom. Nine months after therapy, the prevalence of <i>Candida albicans</i> dropped from 80% to 30%, and a complete elimination of pathogens was detected in 64% of the women. The laser therapy appeared to be effective in the elimination of non-albicans Candida species. A total of 86% of the patients reported being satisfied or very satisfied with the therapy. Only minor and transient adverse effects were recorded during the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Non-ablative vaginal Er:YAG laser therapy proved to be a promising treatment for RVVC in women. The effect was achieved by improving their vaginal health by lowering the load of pathogenic yeast and by promoting the restoration of a favorable environment for normal microflora.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 2","pages":"187-194"},"PeriodicalIF":2.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}