Lasers in Surgery and Medicine最新文献

{"title":"Optical Coherence Tomography Enables the Depth-Resolved Measurement of Cilia Beat Frequency in Ex Vivo Human Fallopian Tubes.","authors":"Dilara J Long, Tian Xia, Photini F Rice, Deirdre M Scully, Makayla Johnson, Ryan Mistifer, Andrea Aguirre, John M Heusinkveld, Irina V Larina, Jennifer K Barton","doi":"10.1002/lsm.70049","DOIUrl":"https://doi.org/10.1002/lsm.70049","url":null,"abstract":"<p><strong>Objectives: </strong>The movement of cilia in the fallopian tubes (FTs) facilitates important processes involved in fertility, and abnormalities in cilia function are linked with diseases including endometriosis and pelvic inflammatory disease. For the first time, we demonstrate the use of optical coherence tomography (OCT) to create depth-resolved mapping of motile cilia locations and quantify cilia beat frequency (CBF) in human FT samples ex vivo.</p><p><strong>Methods: </strong>Segments of the FT ampulla were acquired from five patients following salpingectomy under an IRB approved protocol. The samples were longitudinally opened to expose the luminal surface for imaging. A sequence of at least 500 OCT images were acquired at 5-10 locations on each sample. To define the location of the motile cilia in the images, pixel-wise Fast Fourier Transform (FFT) analysis of intensity fluctuations with a sliding temporal window was performed on each image sequence. The frequencies corresponding to the physiological range of CBF (2-10 Hz) were selected for mapping, while the part of the FFT spectrum at higher frequencies (> 23 Hz) was used to define the noise threshold. The frequency with the highest FFT amplitude for each supra-threshold pixel was considered the CBF for this pixel and used to create a color-coded CBF map. The CBF map was overlaid with the OCT intensity image sequences to reveal cilia locations. Frequency histograms from the sliding window were examined to assess temporal consistency of the mapping and evaluate movement artifacts.</p><p><strong>Results: </strong>OCT image sequences clearly showed the structure of FT plicae. The ciliated epithelium was obvious as a \"shimmering\" (rapidly changing intensity) layer atop plicae. Colored pixels on CBF maps visually aligned to these shimmering regions. Frequency histograms revealed that the image sequence peak CBF could be robustly determined, even in the presence of outliers attributable to table vibrations or bulk sample movement.</p><p><strong>Conclusions: </strong>OCT can provide depth-resolved maps of CBF in human ex vivo FT tissue. Potentially, this technique can aid in understanding cilia dynamics in the normal human FT over the menstrual cycle and across age, as well as in diseases that affect the FTs. Future work will be directed toward in vivo implementation including miniaturization and robust motion compensation.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Cutaneous Collagenous Vasculopathy With Pulsed Dye Laser.","authors":"Hannah L Hanania, Isabella Camacho-Hubbard, Zeena Y Nawas","doi":"10.1002/lsm.70048","DOIUrl":"https://doi.org/10.1002/lsm.70048","url":null,"abstract":"<p><strong>Objectives: </strong>Cutaneous collagenous vasculopathy (CCV) is a rare, idiopathic microangiopathy marked by widespread telangiectasias and histologic vessel wall thickening. Due to its rarity and clinical overlap with other vascular conditions, CCV poses diagnostic and therapeutic challenges. This report highlights the successful use of pulsed dye laser (PDL) therapy in treating a case of extensive CCV.</p><p><strong>Methods: </strong>A 40-year-old woman with a decade-long history of progressive telangiectasias involving the extremities, trunk, and forearms underwent treatment with a 595-nm PDL. Six treatment sessions were conducted over 14 months.</p><p><strong>Results: </strong>The patient experienced significant improvement in erythema, telangiectasias, and associated discomfort, with sustained clinical response and substantial cosmetic benefit observed across all treated areas.</p><p><strong>Conclusion: </strong>PDL is a safe and effective treatment for CCV, offering both symptomatic relief and cosmetic improvement. This case adds to limited existing literature supporting its use and highlights the importance of individualized laser parameters for optimal outcomes.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Scalp Hair Appearance Following Treatment With a Non-Ablative Fractional Laser: A Retrospective Observational Study.","authors":"Marc R Avram, Dawn Queen, Jerry Shapiro, Girish Munavalli","doi":"10.1002/lsm.70044","DOIUrl":"https://doi.org/10.1002/lsm.70044","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) affects at least 80% of men and 50% of women by age 70. This study aimed to assess the efficacy of a non-ablative fractional laser (NAFL) in treating AGA and enhancing hair appearance on the scalp in male and female patients.</p><p><strong>Methods: </strong>This was a single-center, retrospective, observational study. Case files of all subjects, who were treated for improvement of scalp hair appearance using a 1565-nm NAFL at LaserMed Clinic (Lublin, Poland) between February 24, 2020, and January 31, 2023, were reviewed for study inclusion. The authors were not involved in the administration of treatments but reviewed the data that were obtained for the study. Digital images taken before and following laser treatment were gathered and blindly evaluated by non-treating physicians for quality of results. The study's primary efficacy endpoint was the proportion of image sets correctly classified as before and after treatment. Success was defined as correct identification of the posttreatment image as the image demonstrating scalp hair growth and clinical improvement by at least two out of three blinded reviewers. Safety was evaluated based on the incidence of adverse events or safety issues.</p><p><strong>Results: </strong>A total of 132 patients were included in the study, of whom 98 patients had photos of adequate quality for assessing device efficacy. The overall success rate of correct identification of before and after images among the 98a evaluable patients was 96.9% (95% confidence interval: 91.4%-98.5%) and remained consistently high (> 95%) across the evaluated subgroups (patients with AGA, patients with unknown type of alopecia, males and females). No adverse events were documented in the clinic records for the 132 subjects included.</p><p><strong>Conclusions: </strong>NAFL is a safe and effective method for promoting visible hair growth and improving the appearance of scalp hair.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image: Volume 57 Issue 6","authors":"Soha Yousuf,&nbsp;Mohamed Irfan Karukappadath,&nbsp;Azhar Zam","doi":"10.1002/lsm.70047","DOIUrl":"https://doi.org/10.1002/lsm.70047","url":null,"abstract":"<p>Cover micrograph: The cover image is based on the article Differentiation of Healthy Ex Vivo Bovine Tissues Using Raman Spectroscopy and Interpretable Machine Learning by Soha Yousuf et al., https://doi.org/10.1002/lsm.70031.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Trends and Future Directions of the Dual 1550-nm Erbium Glass Fiber and 1927-nm Thulium Fiber Non-Ablative Fractional Laser System.","authors":"Paul M Friedman, Jeffrey S Dover, Anne Chapas, Abby Jacobson","doi":"10.1002/lsm.70043","DOIUrl":"https://doi.org/10.1002/lsm.70043","url":null,"abstract":"<p><strong>Objectives: </strong>To synthesize current evidence and trends supporting the dual 1550-nm erbium glass fiber and 1927-nm thulium fiber non-ablative fractional laser system's mechanism of action and proven efficacy and safety profile in addressing aging skin concerns.</p><p><strong>Methods: </strong>A review of current evidence and expert consensus was conducted to evaluate the 1550/1927-nm dual laser system. The analysis focused on the 1550 and 1927-nm lasers' specific mechanisms of action and their applications in treating various skin conditions.</p><p><strong>Results: </strong>The 1550-nm laser effectively targets dyschromia, fine lines, and various types of scars, while the 1927-nm laser specifically addresses actinic keratoses, dyschromia, and pigmented lesions. Expert consensus has established standardized protocols while emphasizing personalized treatment approaches on the basis of factors including treatment area and Fitzpatrick skin type.</p><p><strong>Conclusion: </strong>The 1550/1927-nm dual laser system's ability to offer customizable settings positions it as a versatile tool in the growing field of esthetic medicine, particularly for addressing the multiple components of skin aging.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Approaches for Seborrheic Keratosis Treatment: Curettage Versus 532-nm Lithium Borate Laser Versus Cryotherapy: A Prospective Interventional Study.","authors":"Vanessa Timmermann, Sven Krengel, Petra Mrowka, Ozan Haase","doi":"10.1002/lsm.70042","DOIUrl":"https://doi.org/10.1002/lsm.70042","url":null,"abstract":"<p><strong>Background: </strong>Seborrheic keratosis (SK) is the most prevalent benign skin tumor associated with aging, posing esthetic concerns and potential discomfort. The rising demand for cosmetic interventions prompts the exploration of effective removal methods. This study compares three treatment modalities: curettage, 532 nm laser, and propane-butane cryotherapy.</p><p><strong>Methods: </strong>A prospective interventional clinical study was conducted with 30 subjects, treating 123 SK using curettage, 532 nm laser, and propane-butane cryotherapy. Randomized allocation and evaluations at 0, 4, 8, and 12 weeks were employed. Objective measures included clearance rates (assessed by a dermatologist) and blinded cosmetic ratings by 125 observers. Subjective outcomes encompassed patient-reported pain (VAS), side effects, satisfaction, and preferences.</p><p><strong>Results: </strong>Curettage achieved the highest clearance rate (87.5% vs. laser: 55%, cryotherapy: 50%; p < 0.01). However, patients perceived complete healing most frequently with laser (90% vs. curettage: 87%, cryotherapy: 53%). Despite lower efficacy, 67% favored laser for future treatments, valuing minimal bleeding and no dressings. Observers rated curettage's cosmetic outcomes superior (50% vs. laser: 22.5%). Laser caused the fewest side effects (mean 0.93/lesion) but highest pain (VAS: 4.62 vs. cryotherapy: 3.85). Cryotherapy showed efficacy comparable to laser (50% vs. 55%) but more adverse events.</p><p><strong>Conclusion: </strong>Curettage remains optimal for thick, hyperkeratotic SKs, enabling histopathological confirmation. The 532 nm laser, preferred subjectively for convenience, may suit small, non-hyperkeratotic lesions but warrants further validation. Propane-butane cryotherapy offers a cost-effective alternative. The discordance between patient preferences (prioritizing convenience) and clinical efficacy underscores the need for personalized treatment strategies balancing outcomes, tolerability, and cosmetic expectations.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Photodynamic Therapy in Diabetic Amputation Ulcers: Case Series Evaluating Wound Healing Quality","authors":"Priscilla Farias Chagas,&nbsp;Thais Barbosa dos Santos,&nbsp;Gesiane dos Santos Trivino,&nbsp;Sandra Kalil Bussadori,&nbsp;Cinthya Cosme Gutierrez Duran,&nbsp;Kristianne Porta Santos Fernandes,&nbsp;Rebeca Boltes Cecatto,&nbsp;Anna Carolina Ratto Tempestini Horliana,&nbsp;Raquel Agnelli Mesquita-Ferrari","doi":"10.1002/lsm.70037","DOIUrl":"10.1002/lsm.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Diabetic foot ulcers affect approximately 15% of individuals with diabetes, compromising their quality of life and placing an additional burden on the public health system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to evaluate the effects of the antimicrobial photodynamic therapy (aPDT) in tissue repair through the analysis of two case studies involving individuals with diabetes-related foot lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>aPDT was performed using 1% methylene blue, a cluster of four red lasers (660 nm) with an average radiant power of 100 mW, and radiant energy per emitter of 6 J. The exposure time was 1 min, resulting in a total radiant energy per session of 24 J. Patients were evaluated on sessions 1, 3, 5, 10, and 30 days after the completion of treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Using the Bates-Jensen Wound Assessment Tool (BWAT) scale as a tool to assess wound progression, Patient 1 had an initial score of 37 points, which reduced to 24 points by the end of treatment, resulting in a decrease of 13 points on the scale. Patient 2 started with 36 points and finished with 14 points, achieving complete healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Treatment led to improved wound quality, evidenced by a reduction in BWAT scores, a 74.9% decrease in wound area in patient 1 with consistent healing progress, and complete wound closure in patient 2. Although limited by its case-series design, this study contributes preliminary clinical evidence suggesting the potential benefits of antimicrobial photodynamic therapy (aPDT) in the management of diabetic foot ulcers and highlights the need for larger, controlled trials to validate its efficacy. In conclusion, aPDT was effective across all evaluated outcomes in these two reported cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>NCT06416462 (initial release: 09/23).</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 6","pages":"457-465"},"PeriodicalIF":2.2,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoporfin-Mediated Photodynamic Therapy-Caused Skin Barrier Damage and Triggered Dermatitis in Port-Wine Stains.","authors":"Kai Chen, Yan-Yan Hu, Shan-Shan Qian, Jin-Zhao Wu, Li-Juan Cao, Lin-Lin Wang, Meng Li, Yu-Xin Xia, Qian Jiang, Hong-Ying Chen, Liu-Qing Chen, Dong-Sheng Li","doi":"10.1002/lsm.70036","DOIUrl":"https://doi.org/10.1002/lsm.70036","url":null,"abstract":"<p><strong>Background: </strong>Hemoporfin-mediated photodynamic therapy (PDT) is a high efficacy treatment alternative for port-wine stains (PWS) patients, and PDT also induced eczematous dermatitis in treated areas. However, the effect of PDT treatment on the prevalence and risk of dermatitis in patients with PWS have not been reported.</p><p><strong>Purpose: </strong>To assess the association between PDT and dermatitis incidence and to investigate the mechanism of PDT-triggered dermatitis in PWS patients.</p><p><strong>Patients and methods: </strong>A total of 512 PWS patients who received hemoporfin-mediated PDT treatment between June 2020 and September 2022 at the dermatology department of Wuhan No.1 Hospital were recruited in this study. Clinical images were used to calculate the percentage of dermatitis in treated areas. The arithmetic mean roughness (Ra), the average depth of roughness (Rz) and the mean square roughness (Rq) were used to assess the change of surface roughness. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and total lipid content (TLC) were used to analyze the skin barrier function.</p><p><strong>Results: </strong>After treatment, we found that 27.15% (139/512) of PWS patients developed dermatitis on the treated areas, and the percentage of dermatitis was closely related to the treatment times and age of the patient. Moreover, these treated areas also exhibited markedly increased skin roughness (Ra, Rz, Rq; p < 0.05) and impaired barrier function, evidenced by significantly elevated TEWL and TLC (p < 0.05) and reduced SCH (p < 0.05).</p><p><strong>Conclusion: </strong>PDT caused skin barrier dysfunction in PWS patients, which may lead to increased permeability of the epidermis and contribute to the dermatitis development.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninsulated Microneedle Radiofrequency for Skin Rejuvenation: A Histological, Transcriptomic and Clinical Study.","authors":"Jiayi Feng, Lvping Huang, Jun Qi, Shize Ma, Ling Zhang","doi":"10.1002/lsm.70041","DOIUrl":"https://doi.org/10.1002/lsm.70041","url":null,"abstract":"<p><strong>Background: </strong>The efficacy and safety of microneedle radiofrequency (MRF) for antiaging skin treatment has already been demonstrated. This study aims to, for the first time, comprehensively interpret the short and long-term effects of MRF by combining histology, high-throughput molecular analysis, and clinical evaluation.</p><p><strong>Methods: </strong>At 1, 3, and 6 months after MRF in different parameters, the skin samples were taken for HE staining, Masson staining, and Victoria blue staining to observe the overall histological changes. Real-time PCR and WB were used to evaluate the quantitative changes of collagen I and III, MMP-2 and TGF-β1 at the different time periods. After transcriptome sequencing, bioinformatics analysis was performed to identify important biological processes related to skin after MRF treatment. At the same time, patients who had undergone facial MRF treatment in our department between 2020 and 2023 were collected for clinical review within half a year after treatment. Patient satisfaction score and Global Aesthetic Improvement Scale (GAIS) were collected.</p><p><strong>Results: </strong>The histological sections showed that collagen and elastic fibers regenerated and the density increased after MRF. The mRNA and protein levels of collagen in each treatment group also showed an upward trend after treatment, especially in Group A. However, there was no significant difference among the treatment groups and compared with the blank control group. Transcriptome analysis showed that the differentially expressed genes were significantly enriched in collagen regeneration-related pathways at 1 month after treatment, then gradually decreased at 6 months. The clinical data showed that after MRF treatment, patients mainly rated the effect of skin rejuvenation as \"3 - satisfied.\" The GAIS score showed that the long-term effect after MRF was better than the short-term effect (p = 0.040).</p><p><strong>Conclusions: </strong>MRF can stimulate collagen rearrangement and rejuvenation in facial rejuvenation. The long-term rejuvenation effect of MRF can last at least 6 months and is better than the short-term effect.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Intense Pulsed Light Combined With 3% Tranexamic Acid for Facial Erythema Associated With Acne Vulgaris and Rosacea","authors":"Xueping Liu,&nbsp;Xiaoyi Qi,&nbsp;Yufeng He,&nbsp;Linmei Xiang,&nbsp;Aoxue Wang","doi":"10.1002/lsm.70029","DOIUrl":"10.1002/lsm.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Current treatment options for facial erythema associated with acne and rosacea include oral and topical treatments. Physical modalities are also commonly used recently. Combination therapy usually works better than a single therapy. There are few studies on the therapeutic effect of IPL combined with TXA on facial erythema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To study the efficacy of intense pulsed light combined with 3% tranexamic acid in the treatment of facial erythema associated with acne and rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 56 patients were included in the study. They were randomly divided into the observation group and the control group, with 28 cases in each group. The observation group was treated with intense pulsed light combined with 3% tranexamic acid for external use, while the control group was treated with intense pulsed light only. The clinical efficacy, erythema degree, and skin disease quality of life index score before and after treatment were observed in the two groups, and the results were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After treatment, both groups showed improvement; the observation group exhibited a significantly higher overall effective rate than the control group (<i>p</i> &lt; 0.05). The scores of erythema index and skin quality of life index in the observation group were lower than those in the control group, and the differences were statistically significant (<i>p</i> &lt; 0.05). There were no obvious adverse reactions in both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Intense pulsed light combined with 3% tranexamic acid can effectively improve the degree of acne and rosacea erythema without serious adverse effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 6","pages":"490-495"},"PeriodicalIF":2.2,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}