Effect of Intense Pulsed Light Combined With 3% Tranexamic Acid for Facial Erythema Associated With Acne Vulgaris and Rosacea

IF 1.9 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2025-06-15 DOI:10.1002/lsm.70029

Xueping Liu, Xiaoyi Qi, Yufeng He, Linmei Xiang, Aoxue Wang

{"title":"Effect of Intense Pulsed Light Combined With 3% Tranexamic Acid for Facial Erythema Associated With Acne Vulgaris and Rosacea","authors":"Xueping Liu, Xiaoyi Qi, Yufeng He, Linmei Xiang, Aoxue Wang","doi":"10.1002/lsm.70029","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Current treatment options for facial erythema associated with acne and rosacea include oral and topical treatments. Physical modalities are also commonly used recently. Combination therapy usually works better than a single therapy. There are few studies on the therapeutic effect of IPL combined with TXA on facial erythema.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>To study the efficacy of intense pulsed light combined with 3% tranexamic acid in the treatment of facial erythema associated with acne and rosacea.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 56 patients were included in the study. They were randomly divided into the observation group and the control group, with 28 cases in each group. The observation group was treated with intense pulsed light combined with 3% tranexamic acid for external use, while the control group was treated with intense pulsed light only. The clinical efficacy, erythema degree, and skin disease quality of life index score before and after treatment were observed in the two groups, and the results were compared.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>After treatment, both groups showed improvement; the observation group exhibited a significantly higher overall effective rate than the control group (<i>p</i> < 0.05). The scores of erythema index and skin quality of life index in the observation group were lower than those in the control group, and the differences were statistically significant (<i>p</i> < 0.05). There were no obvious adverse reactions in both groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Intense pulsed light combined with 3% tranexamic acid can effectively improve the degree of acne and rosacea erythema without serious adverse effects.</p>\n </section>\n </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 6","pages":"490-495"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lasers in Surgery and Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/lsm.70029","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Current treatment options for facial erythema associated with acne and rosacea include oral and topical treatments. Physical modalities are also commonly used recently. Combination therapy usually works better than a single therapy. There are few studies on the therapeutic effect of IPL combined with TXA on facial erythema.

Objective

To study the efficacy of intense pulsed light combined with 3% tranexamic acid in the treatment of facial erythema associated with acne and rosacea.

Methods

A total of 56 patients were included in the study. They were randomly divided into the observation group and the control group, with 28 cases in each group. The observation group was treated with intense pulsed light combined with 3% tranexamic acid for external use, while the control group was treated with intense pulsed light only. The clinical efficacy, erythema degree, and skin disease quality of life index score before and after treatment were observed in the two groups, and the results were compared.

Results

After treatment, both groups showed improvement; the observation group exhibited a significantly higher overall effective rate than the control group (p < 0.05). The scores of erythema index and skin quality of life index in the observation group were lower than those in the control group, and the differences were statistically significant (p < 0.05). There were no obvious adverse reactions in both groups.

Conclusion

Intense pulsed light combined with 3% tranexamic acid can effectively improve the degree of acne and rosacea erythema without serious adverse effects.

查看原文本刊更多论文

强脉冲光联合3%氨甲环酸治疗寻常性痤疮和酒渣鼻面部红斑的疗效。

背景：目前与痤疮和酒渣鼻相关的面部红斑的治疗方案包括口服和局部治疗。最近，物理疗法也被广泛使用。联合疗法通常比单一疗法效果更好。IPL联合TXA治疗面部红斑的疗效研究较少。目的：探讨强脉冲光联合3%氨甲环酸治疗面部红斑合并痤疮、酒渣鼻的疗效。方法：共纳入56例患者。随机分为观察组和对照组，每组28例。观察组采用强脉冲光联合3%氨甲环酸外用治疗，对照组仅采用强脉冲光治疗。观察两组患者治疗前后的临床疗效、红斑程度、皮肤病生活质量指数评分，并进行比较。结果：两组治疗后均有改善；结论：强脉冲光联合3%氨甲环酸可有效改善痤疮、酒渣鼻红斑程度，且无严重不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.