Lasers in Surgery and Medicine最新文献

{"title":"Improved Ex-Vivo Bond Quality Monitoring of Plasmonic Metal Oxide Biomaterials Mediated Laser Tissue Soldering Process Using Fast Noninvasive Optical Tomographic Imaging.","authors":"Sweta Satpathy, Abhishek Banerjee, Ishita Banerjee, Raju Poddar","doi":"10.1002/lsm.70023","DOIUrl":"https://doi.org/10.1002/lsm.70023","url":null,"abstract":"<p><strong>Background and objectives: </strong>Laser tissue soldering (LTS) offers an innovative, suture-free approach to wound closure. However, challenges such as limited tensile strength and prolonged soldering time need solutions. This work combines BSA with PEG to enhance mechanical properties and introduces silver and titanium dioxide nanoparticles to accelerate soldering via localized surface plasmon resonance (LSPR). Real-time SS-OCT monitoring ensures precise evaluation of the soldering process, advancing LTS applications for diverse tissue.</p><p><strong>Study design/materials and methods: </strong>Four solder compositions (C1-C4) are prepared using combinations of BSA, PEG, silver nanoparticles (AgNP) and titanium dioxide nanoparticles (TiNP). Ex-vivo samples of chicken breast, chicken skin, and goat skin were incised in 1 cm incision with 0.45 mm width and soldered using a 980 nm, 5 W laser. Tensile strength was measured using a tensiometer, while cytotoxicity was assessed using HEK293 cells. SS-OCT captured real-time scattering coefficient changes during soldering, providing insight into coagulation dynamics.</p><p><strong>Results: </strong>Combining bovine serum albumin (BSA) with PEG and nanoparticles (silver and titanium dioxide), tensile strength in ex-vivo tissue samples increased significantly-by 27% in chicken breast (0.4980 to 0.6366 N/cm²), 28% in chicken skin (0.6080 to 0.7840 N/cm²), and 23% in goat skin (0.6220 to 0.7666 N/cm²). Nanoparticle incorporation reduced soldering time by 33%, achieving complete fusion within 3 min using a laser of optical power of 5 W, central wavelength 980 nm and duty cycle of 50%. Real-time monitoring with Swept-Source Optical Coherence Tomography (SS-OCT) quantified the scattering coefficient changes during soldering, validating efficient bonding. Results demonstrate PEG's contribution to tensile strength, nanoparticles' role in reducing soldering time, and SS-OCT's utility for precision monitoring, supporting LTS as a promising wound closure method.</p><p><strong>Conclusion: </strong>The study validates PEG's biomechanical reinforcement and nanoparticles' role in efficient LTS. The integration of SS-OCT enables precise, real-time assessment, confirming the clinical potential of this enhanced LTS method for rapid and robust tissue closure.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety Assessment of a 1940 nm Tm:YAP Laser for Fractional Skin Ablation in a Swine Model.","authors":"Yuval Ramot, Michal Steiner, Udi Vazana, Rotem Nahear, Neria Suliman, David J Friedman, Salman Noach, Abraham Nyska","doi":"10.1002/lsm.70022","DOIUrl":"https://doi.org/10.1002/lsm.70022","url":null,"abstract":"<p><strong>Objectives: </strong>This exploratory study was aimed to evaluate the safety and preliminary efficacy of Epicare, a 1940 nm thulium-doped yttrium aluminum perovskite (Tm:YAP) laser, for fractional skin ablation in a swine model. The goal was to assess collagen remodeling and tissue responses across varied laser settings to optimize skin resurfacing applications.</p><p><strong>Materials and methods: </strong>Two female domestic swine were subjected to controlled fractional laser ablation using Epicare across 52 marked abdominal sites with varying energy settings. Macroscopic examinations of ablated sites were conducted immediately following ablation and at 1, 3, 7, 14, 22, and 29 days postablation. Histopathological evaluation was conducted immediately posttreatment, and at 1, 7, and 29 days postablation. Observed parameters included epidermal regeneration, dermal remodeling, inflammation, and collagen deposition.</p><p><strong>Results: </strong>Macroscopic evaluations revealed a fractional, clear, and immediate impact of ablation, consisting primarily of erythema and edema, which resolved without complications by Day 14. Histopathological analysis indicated focal, cylinder-like structures associated with necrotic epidermis and dermis, which healed progressively (i.e. from day 1), transitioning to complete epidermal regeneration by Day 7 for most energy settings. By Day 29, advanced collagen deposition and no residual inflammation indicated effective dermal remodeling, consistent with rapid healing and minimal adverse reactions.</p><p><strong>Conclusions: </strong>Epicare demonstrated a favorable safety profile and effective tissue ablation. These findings support the laser's potential for dermatologic applications while emphasizing the need for further investigation to confirm its efficacy and optimal settings in human clinical trials.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Study of Picosecond Alexandrite Laser Treatment for Acquired Bilateral Nevus of Ota-Like Macules in Children.","authors":"Wenwen Zhao, Hedan Yang, Xing Liu, Wanting Jiang, Sanjing Chen, Tong Lin, Yiping Ge, Yan Zong","doi":"10.1002/lsm.70021","DOIUrl":"https://doi.org/10.1002/lsm.70021","url":null,"abstract":"<p><strong>Background: </strong>Picosecond lasers have been increasingly applied to the treatment of acquired bilateral nevus of Ota-like macules (ABNOMs), and proved safe and effective for adult patients. But there has been limited data concerned with their use in children.</p><p><strong>Objective: </strong>To analyze the efficacy, safety, and correlative influencing factors of a 755 nm picosecond alexandrite laser in treating ABNOMs in children.</p><p><strong>Methods: </strong>We retrospectively analyzed children with ABNOMs from January 2017 to July 2023 who received the treatment using a 755 nm picosecond alexandrite laser. Treatment parameters used were as follows: 750 ps pulse duration, 2.34-4.07 J/cm² fluence, and 2.5-3.3 mm spot size. The mean treatment interval was 7 months. The efficacy was evaluated based on a five-point scale according to the percentage of pigmentation clearance.</p><p><strong>Results: </strong>A total of 49 pediatric patients were included in this retrospective study. The average age at the beginning of treatment was 16.87 months old (range of 4 months to 59 months). These patients received an average of two treatments, achieving an average of 76% pigment clearance, which corresponded to excellent improvement (75%-94%). After the first treatment, six cases reached clinical clearance, and an average of pigment clearance was 61%. The initial efficacy was positively correlated with Fitzpatrick type (p < 0.05). Patients with Fitzpatrick III skin type responded better than patients with Fitzpatrick IV skin type. Besides, the initial efficacy was negatively correlated with the first treatment age and disease duration (p < 0.05). Eight cases developed postinflammatory hyperpigmentation, accounting for 16.3% of the cases.</p><p><strong>Conclusion: </strong>The 755 nm picosecond alexandrite laser is safe and effective in treating ABNOMs in children. Being younger at the initial treatment, having Fitzpatrick III skin type, and experiencing a shorter disease duration are beneficial for initial efficacy.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Nonablative Er-YAG Laser on Human Endometrial Stromal Cells (hESCs): A Pilot Study.","authors":"Cemal Tamer Erel, Duygu Neccar, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Elif Guzel Meydanli","doi":"10.1002/lsm.70020","DOIUrl":"https://doi.org/10.1002/lsm.70020","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the thermo-chemical effects of nonablative Er:YAG laser on human endometrial stromal cells (hESCs).</p><p><strong>Materials and methods: </strong>In this laboratory based study, for the hESCs cultures, endometrial tissue biopsy samples were obtained from three fertile women in the late proliferative phase. In this laboratory-based study, seven experimental groups were created: Estradiol (E₂) group, E₂ + Sham (S) group, E₂ + P₄ group, E₂ + Laser (L) group, E₂ + P₄ + L group, hESC group and hESC+L group. Cell cultures reaching confluence on the matrigel-coated petri dishes in all groups were incubated for 12, 24, 48, and 72 h after laser irradiation, respectively. Nonablative Er:YAG laser irradiation was performed to the hESCs culture. The main outcome of this study involves assessing the alterations in MMP-2, TNF-α, IL-6, VEGF-A, and IGFBP-1 levels within conditioned media of hESC cultures subsequent to the Er:YAG laser irradiation.</p><p><strong>Results: </strong>Median MMP-2 levels significantly differed between groups at the 12th, 24th, 48th, and 72nd hour (p = 0.012, p = 0.045, p = 0.021, and p = 0.032, respectively). All media of hESCs irradiated with Er-YAG laser had higher median MMP-2 values. At the 48th hour, the groups showed significant differences in terms of median TNF-α levels (p = 0.029), which were lower in the groups that received Er-YAG laser. At the 12th hour, median IL-6 levels differed significantly between the groups (p = 0.011), being higher in the groups that received Er-YAG laser. At the 72nd hour, lower median VEGF-A values were observed for the groups that received Er-YAG laser (p = 0.021). A statistically significant difference existed in terms of median IGFBP-1 levels between the groups at the 24th hour, with higher levels in the groups which received Er-YAG laser (p = 0.041).</p><p><strong>Conclusion: </strong>Our findings demonstrated that the non-ablative Er-YAG laser induces tissue remodeling, modulates immune responses by favoring Th2 cell activity and suppresses Th1 cell activity in hESCs. Additionally, it exerts favorable impact on decidualization.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom-Induced Hyperpigmentation.","authors":"Alanoud A Alhadyani, Christen Samaan, Girish S Munavalli","doi":"10.1002/lsm.70019","DOIUrl":"https://doi.org/10.1002/lsm.70019","url":null,"abstract":"<p><strong>Objectives: </strong>This case series reports the use of the 730-nm picosecond titanium-sapphire laser in the treatment of kratom-induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood.</p><p><strong>Methods: </strong>A series of patients with kratom-induced hyperpigmentation were treated using the 730-nm picosecond titanium-sapphire laser. Treatment outcomes were documented by assessing the degree of pigmentation improvement and noting the occurrence of any adverse effects or recurrence of hyperpigmentation.</p><p><strong>Results: </strong>All patients showed significant improvement in the appearance of hyperpigmentation following treatment. No adverse effects or recurrence of hyperpigmentation were observed during the follow-up period.</p><p><strong>Conclusions: </strong>This case series represents the first documented use of the 730-nm picosecond titanium-sapphire laser for treating kratom-induced hyperpigmentation. The laser's precision and minimal tissue disruption suggest it as a promising treatment option for this challenging dermatological side effect.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Two Laser-Assisted Epidermal Ablation Techniques on the Efficacy of Autologous Non-Cultured Epidermal Cell Suspension Transplantation Plus Narrowband Ultraviolet B Phototherapy for the Treatment of Stable Vitiligo: A Retrospective Study.","authors":"Bing Han, Yuanyuan Liu, Yang Song, Henan Si, Shanshan Li, Lei Yao","doi":"10.1002/lsm.70018","DOIUrl":"https://doi.org/10.1002/lsm.70018","url":null,"abstract":"<p><strong>Objectives: </strong>Autologous non-cultured epidermal cell suspension (NECS) transplantation is an effective therapeutic approach for managing stable vitiligo, and laser-assisted epidermal ablation is a common recipient area preparation procedure before NECS transplantation. We sought to compare the efficacy and safety of two different lasers used in NECS transplantation combined with narrowband ultraviolet B (NB-UVB) therapy for treatment of stable vitiligo.</p><p><strong>Materials and methods: </strong>In this retrospective study, 63 white macules in 54 patients with stable vitiligo were assessed for the repigmentation rate and any adverse effects associated with NECS transplantation combined with NB-UVB therapy at 1, 3, and 6 months post-transplantation. The epidermis was ablated using either a Kinglaser CO2 fractional laser used in the fully ablative mode at 100% coverage (KL) or an ultra-pulse CO2 laser (UL).</p><p><strong>Results: </strong>At the 6-month follow-up, the repigmentation rates in the KL group were graded as excellent in 28.6%, good in 9.5%, fair in 42.9%, and poor in 19.0%, giving an effective rate of 38.1%. In the UL group, the rates were graded as 73.8%, 14.3%, 7.1%, and 4.8%, respectively, giving an effective rate of 88.1% (p < 0.001). The Visual Analog Scale score for pain during the laser-assisted epidermal ablation was higher in the UL group than in the KL group (p < 0.0001). The UL group had a significantly higher incidence of mild to moderate persistent erythema at 1 month post-transplantation than the KL group (p = 0.002).</p><p><strong>Conclusions: </strong>UL can achieve better repigmentation efficacy than KL when used for epidermal ablation during NECS transplantation plus NB-UVB therapy in patients with stable vitiligo. However, regarding adverse events, the UL procedure is more painful and has a higher incidence of mild to moderate persistent erythema during the early postoperative period. Larger studies are required to assess the impacts of various laser de-epidermalization techniques on the efficacy of NECS transplantation for stable vitiligo.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Effects of Low-Level Laser Therapy (LLLT) on the Nuclear Factor (NF)-κB Signaling Pathway in Traumatized Muscle.","authors":"","doi":"10.1002/lsm.70015","DOIUrl":"https://doi.org/10.1002/lsm.70015","url":null,"abstract":"<p><strong>Retraction: </strong>C. F. Rizzi, J. L. Mauriz, D. S. F. Corrêa, et al., \"Effects of Low-Level Laser Therapy (LLLT) on the Nuclear Factor (NF)-κB Signaling Pathway in Traumatized Muscle,\" Lasers in Surgery and Medicine 38, no. 7 (2006): 704-713, https://doi.org/10.1002/lsm.20371. The above article, published online on 23 June 2006 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Bahman Anvari; and Wiley Periodicals, LLC. Concerns were raised by a third party regarding image overlap in the histology panels of Figure 2. This was confirmed by the publisher's investigation and acknowledged by the authors as an error in figure preparation. Investigators also found evidence of duplication of numerous western blot bands in Figures 5, 6, and 7. The authors were unable to provide sufficient original data for these experiments, and they were unable to provide satisfactory explanations for the concerns raised. The retraction has been agreed by the parties because of concerns that the images were manipulated, affecting the interpretation of the data and results presented. The authors disagree with this decision.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Temperature-Controlled Radiofrequency in Treating Vulvar Lichen Sclerosus: A Pilot Study.","authors":"Nengxiu Wu, Ying Li, Chaoqin Lin","doi":"10.1002/lsm.70016","DOIUrl":"https://doi.org/10.1002/lsm.70016","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy and safety of transcutaneous temperature-controlled radiofrequency (TTCRF) in the treatment of female vulvar lichen sclerosus (VLS).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on VLS patients treated with TTCRF at our hospital between May 2021 and May 2023. Each patient underwent ten TTCRF sessions, spaced 1 week apart. Complications were monitored throughout the treatment, and efficacy was assessed using the Cattaneo scoring system and the Patient Global Impression of Change (PGI-C) questionnaire at 1 and 6 months Posttreatment.</p><p><strong>Results: </strong>A total of 40 patients were included in the study, with a mean age of 44.98 ± 11.14 years and a mean BMI of 22.78 ± 2.62 kg/m². Follow-up results at 1 and 6 months Posttreatment showed significant improvements in pruritus degree, skin elasticity, and skin color compared to baseline (p < 0.05), although no significant change in lesion scope was observed. According to the PGI-C questionnaire, 75% (30/40) of patients reported improvement or significant improvement at 1 month Posttreatment, which decreased to 60% (24/40) at 6 months. No adverse reactions were reported during the treatment or follow-up periods.</p><p><strong>Conclusion: </strong>TTCRF is an effective and safe treatment for female VLS, offering significant short-term symptom relief. However, further research is needed to confirm long-term benefits.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Debulking With Excimer Laser Coronary Angioplasty Versus Balloon Angioplasty in Patients With in Stent Restenosis (ELDISR Study): A Randomized Controlled Trial","authors":"Pan He,&nbsp;Haiwei Chen,&nbsp;Junjie Yang,&nbsp;Lei Gao,&nbsp;Jun Guo,&nbsp;Yundai Chen,&nbsp;Qi Wang","doi":"10.1002/lsm.70013","DOIUrl":"10.1002/lsm.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Excimer laser coronary angioplasty (ELCA) is a safe and effective method for lesion preparation. However, its impact on clinical outcomes in patients with in-stent restenosis (ISR) undergoing drug-coated balloon (DCB) angioplasty remains unclear. This study aims to evaluate the effect of ELCA-based lesion preparation on the clinical outcomes of ISR patients treated with standard DCB angioplasty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective, single-center, randomized controlled trial, patients with ISR were randomized 1:1 to either ELCA (+) or ELCA (−). The ELCA (+) group received ELCA for lesion preparation followed by standard DCB angioplasty, while the ELCA (−) group received standard DCB angioplasty alone. The primary endpoint was the rate of target lesion revascularization (TLR) within 1 year. Safety was also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 110 patients were randomized to either the ELCA (+) group (<i>n</i> = 55) or the ELCA (−) group (<i>n</i> = 55). The mean age of the study participants was 64.5 years, 89 (80.9%) were men and 51 (46.4%) had diabetes mellitus. The procedure was successful in all patients. The primary endpoint event occurred in five patients (cumulative incidence, 9.1%) in the ELCA (+) group and in 13 patients (cumulative incidence, 23.6%) in the ELCA (−) group (HR, 0.38; 95% CI, 0.15–0.95; <i>p</i> = 0.038).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Lesion preparation with ELCA before DCB angioplasty is a safe and effective strategy for patients with ISR, associated with a lower incidence of TLR compared to standard DCB angioplasty alone. However, due to the limited sample size and single-center design, these findings should be considered hypothesis-generating. Future validation requires confirmation through multicenter studies with larger patient populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Unique identifier: ChiCTR2300068962.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 4","pages":"329-338"},"PeriodicalIF":2.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-diffuse Reflectance Spectroscopy Combined With Machine Learning Method for Oral Mucosal Disease Identification","authors":"Limin Zhang,&nbsp;Qing Chang,&nbsp;Qi Zhang,&nbsp;Siyi Zou,&nbsp;Dongyuan Liu,&nbsp;Feng Gao,&nbsp;Chenlu Liu","doi":"10.1002/lsm.70011","DOIUrl":"10.1002/lsm.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) is the sixth-highest incidence of malignant tumors worldwide. However, early diagnosis is complex owing to the impracticality of biopsying every potentially premalignant intraoral lesion. Here, we present a sub-diffuse reflectance spectroscopy combined with a machine learning method for oral mucosal disease identification. This method provides a noninvasive cost-effective identification option for early signs of malignancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sub-diffuse spectra of three oral sites (hypoglottis, buccal, and gingiva) from healthy subjects and three types of mucosal lesions (oral lichen planus, OLP, oral leukoplakia, OLK, and OSCC) from patients were collected by using a home-made sub-diffuse reflectance spectroscopy prototype system, and three features including spectra ratio (SR), first-order derivative(DE) of the spectra and optical parameters (OP) were derived from the original spectra to enhance the insights into the optical properties of the oral mucosal tissues. To accurately classify the spectral features, a support vector machine (SVM) and probabilistic neural network (PNN) were employed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Most of the statistical distributions of the spectral features demonstrated obvious differences and the two classification methods exhibited comparable performances. For the classification in the oral sites of healthy subjects, the OP-based classification results were unsatisfactory, while the classification results utilizing DR, SR, and DE achieved a least accuracy of 0.8289, sensitivity of 0.8495, sensitivity of 0.9311, and Matthews correlation coefficient of 0.8085. Comparatively, the classification results between OLP, OLK, OSCC, and normal tissue obtained achieved high indexes even using the OP feature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Integrating sub-diffuse reflectance spectroscopy measurement and suitable machine learning methods can obtain remarkable precision in differentiating different sites of oral mucosa and identifying different types of oral mucosal diseases, especially based on DE features. It is of great help in detecting OSCC and is expected to be a highly sensitive, time-sensitive, and accurate method for oral disease detection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 4","pages":"339-351"},"PeriodicalIF":2.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}