Improvement in Scalp Hair Appearance Following Treatment With a Non-Ablative Fractional Laser: A Retrospective Observational Study.

Background: Androgenetic alopecia (AGA) affects at least 80% of men and 50% of women by age 70. This study aimed to assess the efficacy of a non-ablative fractional laser (NAFL) in treating AGA and enhancing hair appearance on the scalp in male and female patients.

Methods: This was a single-center, retrospective, observational study. Case files of all subjects, who were treated for improvement of scalp hair appearance using a 1565-nm NAFL at LaserMed Clinic (Lublin, Poland) between February 24, 2020, and January 31, 2023, were reviewed for study inclusion. The authors were not involved in the administration of treatments but reviewed the data that were obtained for the study. Digital images taken before and following laser treatment were gathered and blindly evaluated by non-treating physicians for quality of results. The study's primary efficacy endpoint was the proportion of image sets correctly classified as before and after treatment. Success was defined as correct identification of the posttreatment image as the image demonstrating scalp hair growth and clinical improvement by at least two out of three blinded reviewers. Safety was evaluated based on the incidence of adverse events or safety issues.

Results: A total of 132 patients were included in the study, of whom 98 patients had photos of adequate quality for assessing device efficacy. The overall success rate of correct identification of before and after images among the 98a evaluable patients was 96.9% (95% confidence interval: 91.4%-98.5%) and remained consistently high (> 95%) across the evaluated subgroups (patients with AGA, patients with unknown type of alopecia, males and females). No adverse events were documented in the clinic records for the 132 subjects included.

Conclusions: NAFL is a safe and effective method for promoting visible hair growth and improving the appearance of scalp hair.