Lab Animal最新文献

筛选
英文 中文
Effects of volume management on free flap perfusion and metabolism in a large animal model study 在一项大型动物模型研究中,容量管理对游离皮瓣灌注和新陈代谢的影响
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-09 DOI: 10.1038/s41684-024-01410-6
Daniel G. E. Thiem, Daniel Stephan, Alexander Ziebart, Robert Ruemmler, Julian Riedel, Shankeeth Vinayahalingam, Bilal Al-Nawas, Sebastian Blatt, Peer W. Kämmerer
{"title":"Effects of volume management on free flap perfusion and metabolism in a large animal model study","authors":"Daniel G. E. Thiem, Daniel Stephan, Alexander Ziebart, Robert Ruemmler, Julian Riedel, Shankeeth Vinayahalingam, Bilal Al-Nawas, Sebastian Blatt, Peer W. Kämmerer","doi":"10.1038/s41684-024-01410-6","DOIUrl":"10.1038/s41684-024-01410-6","url":null,"abstract":"Free flap failure represents a substantial clinical burden. The role of intraoperative volume management remains controversial, with valid studies lacking. Here, using a large animal model, we investigated the influence of volume management on free flap perfusion and metabolism. Autotransfer of a musculocutaneous gracilis flap was performed on 31 German domestic pigs, with arterial anastomosis and catheterization of the pedicle vein for sequential blood sampling. Flap reperfusion was followed by induction of a hemorrhagic shock with maintenance for 30 min and subsequent circulation stabilization with crystalloid solution, crystalloid solution and catecholamine, autotransfusion or colloidal solution. Flap perfusion and oxygenation were periodically assessed using hyperspectral imaging. Flap metabolism was assessed via periodic blood gas analyses. Hyperspectral imaging revealed no difference in either superficial or deep tissue oxygen saturation, tissue hemoglobin or tissue water content between the test groups at any time point. Blood gas analyses showed that lactate levels were significantly increased in the group that received crystalloid solution and catecholamine, after circulatory stabilization and up to 2 h after. We conclude that, in hemorrhagic shock, volume management impacts acid–base balance in free flaps. Crystalloid solutions with norepinephrine increase lactate levels, yet short-term effects on flap perfusion seem minimal, suggesting that vasopressors are not detrimental. Free flap is widely used in head and neck reconstructive surgery, but fluid management of surgical patients remains controversial. Here, Thiem et al. used a pig model to monitor the effects of volume management on free flap perfusion and metabolism.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"268-275"},"PeriodicalIF":5.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01410-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic stress in acute kidney injury 急性肾损伤的肝脏压力
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01415-1
Jorge Ferreira
{"title":"Hepatic stress in acute kidney injury","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01415-1","DOIUrl":"10.1038/s41684-024-01415-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"191-191"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humidity and heat cause anxiety in mice 潮湿和高温会导致小鼠焦虑。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01418-y
Alexandra Le Bras
{"title":"Humidity and heat cause anxiety in mice","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01418-y","DOIUrl":"10.1038/s41684-024-01418-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"192-192"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New guidelines for rodent cancer models 啮齿动物癌症模型新指南。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01419-x
Alexandra Le Bras
{"title":"New guidelines for rodent cancer models","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01419-x","DOIUrl":"10.1038/s41684-024-01419-x","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"192-192"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Snakebites-on-a-chip 芯片上的蛇咬伤
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01421-3
Jorge Ferreira
{"title":"Snakebites-on-a-chip","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01421-3","DOIUrl":"10.1038/s41684-024-01421-3","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"193-193"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01421-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving transgenesis in zebrafish 改进斑马鱼的转基因技术。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01417-z
Alexandra Le Bras
{"title":"Improving transgenesis in zebrafish","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01417-z","DOIUrl":"10.1038/s41684-024-01417-z","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"192-192"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New evidence linking serotonin and memory 将血清素与记忆联系起来的新证据
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01423-1
Alexandra Le Bras
{"title":"New evidence linking serotonin and memory","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01423-1","DOIUrl":"10.1038/s41684-024-01423-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"195-195"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01423-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validated learning paradigm for cichlid fish 经过验证的慈鲷学习范式。
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01414-2
Jorge Ferreira
{"title":"Validated learning paradigm for cichlid fish","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01414-2","DOIUrl":"10.1038/s41684-024-01414-2","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"191-191"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-irradiation protein alterations 辐照后蛋白质改变
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01413-3
Jorge Ferreira
{"title":"Post-irradiation protein alterations","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01413-3","DOIUrl":"10.1038/s41684-024-01413-3","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"191-191"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary emulsifiers impact mouse health 膳食乳化剂对小鼠健康的影响
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-08-01 DOI: 10.1038/s41684-024-01420-4
Alexandra Le Bras
{"title":"Dietary emulsifiers impact mouse health","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01420-4","DOIUrl":"10.1038/s41684-024-01420-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 8","pages":"192-192"},"PeriodicalIF":5.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信