Lab AnimalPub Date : 2024-11-12DOI: 10.1038/s41684-024-01475-3
Shuai Qiu, Jingyan Jia, Benlei Xu, Nan Wu, Huaqiang Cao, Shuangyi Xie, Jialong Cui, Ji Ma, Yi-Hsuan Pan, Xiao-Bing Yuan
{"title":"Development and evaluation of an autism pig model","authors":"Shuai Qiu, Jingyan Jia, Benlei Xu, Nan Wu, Huaqiang Cao, Shuangyi Xie, Jialong Cui, Ji Ma, Yi-Hsuan Pan, Xiao-Bing Yuan","doi":"10.1038/s41684-024-01475-3","DOIUrl":"10.1038/s41684-024-01475-3","url":null,"abstract":"Developing cost-effective and disease-relevant animal models is essential for advancing biomedical research into human disorders. Here we investigate the feasibility of a pig model for autism spectrum disorder (ASD) using embryonic exposure to valproic acid (VPA), an antiepileptic drug known to increase ASD risk. We established experimental paradigms to assess the behavioral characteristics of these pig models. Administration of VPA to Bama miniature pigs (Sus scrofa domestica) during critical embryonic stages resulted in abnormal gait, increased anxiety levels, reduced learning capabilities and altered social patterns, while largely preserving social preference of treated piglets. Notably, we detected significant neuroanatomical changes in cortical regions associated with ASD in the VPA-treated pigs, including cortical malformation, increased neuronal soma size, decreased dendritic complexity and reduced dendritic spine maturation. Transcriptome analysis of the prefrontal cortex of VPA-treated pigs further revealed substantial alterations in the expression of genes linked to ASD, especially genes of the dopamine signaling pathway, highlighting the model’s relevance and potential for shedding light on ASD’s underlying neuropathological and molecular mechanisms. These findings suggest that pig models could serve as a promising alternative to traditional rodent models and provide a more ethical substitute for the use of primates in translational research on neurodevelopmental disorders. This study describes a new pig model of autism induced by embryonic exposure to valproic acid. The pig model displays behavioral alterations, abnormal gait and increased anxiety, which recapitulate key features of autism.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"376-386"},"PeriodicalIF":5.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01475-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-11-12DOI: 10.1038/s41684-024-01474-4
Natascha Drude, Stefan Nagel-Riedasch, Stephan P. Rosshart, Andreas Diefenbach, The “Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium, Stefan Jordan
{"title":"A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin","authors":"Natascha Drude, Stefan Nagel-Riedasch, Stephan P. Rosshart, Andreas Diefenbach, The “Charité 3R Wildling Mouse Model in Health and Disease (C3R Wildling HeaD)” consortium, Stefan Jordan","doi":"10.1038/s41684-024-01474-4","DOIUrl":"10.1038/s41684-024-01474-4","url":null,"abstract":"Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"351-354"},"PeriodicalIF":5.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01474-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-10-29DOI: 10.1038/s41684-024-01470-8
Alexandra Le Bras
{"title":"Midkine links aging and breast cancer","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01470-8","DOIUrl":"10.1038/s41684-024-01470-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 11","pages":"305-305"},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01470-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-10-29DOI: 10.1038/s41684-024-01469-1
Alexandra Le Bras
{"title":"Pregnancy confers immune protection against influenza A virus infection","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01469-1","DOIUrl":"10.1038/s41684-024-01469-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 11","pages":"304-304"},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01469-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-10-29DOI: 10.1038/s41684-024-01461-9
Alexandra Le Bras
{"title":"Viral persistence in lungs","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01461-9","DOIUrl":"10.1038/s41684-024-01461-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 11","pages":"301-301"},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-10-29DOI: 10.1038/s41684-024-01463-7
Alexandra Le Bras
{"title":"Neuronal vulnerability in social dysfunction","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01463-7","DOIUrl":"10.1038/s41684-024-01463-7","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 11","pages":"301-301"},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2024-10-29DOI: 10.1038/s41684-024-01464-6
Alexandra Le Bras
{"title":"Gut–lung axis in birds","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01464-6","DOIUrl":"10.1038/s41684-024-01464-6","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 11","pages":"301-301"},"PeriodicalIF":5.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}