Lab Animal最新文献

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Metformin and monkeys: what can we learn about delaying aging? 二甲双胍和猴子:我们能从延缓衰老中学到什么?
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-28 DOI: 10.1038/s41684-024-01492-2
José Pedro Castro
{"title":"Metformin and monkeys: what can we learn about delaying aging?","authors":"José Pedro Castro","doi":"10.1038/s41684-024-01492-2","DOIUrl":"10.1038/s41684-024-01492-2","url":null,"abstract":"A new study reveals that metformin, a widely prescribed diabetes medication, can significantly improve health parameters in aged male cynomolgus monkeys — possibly by slowing the aging process. The findings represent an important step toward understanding how pharmaceutical interventions might, in the future, extend the healthspan and delay age-related diseases in humans.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 1","pages":"7-8"},"PeriodicalIF":5.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-speed injection in C. elegans elegans 的高速注射
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01485-1
Alexandra Le Bras
{"title":"High-speed injection in C. elegans","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01485-1","DOIUrl":"10.1038/s41684-024-01485-1","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"356-356"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twenty-first century mouse genetics is again at an inflection point 二十一世纪小鼠遗传学再次迎来拐点
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01491-3
Zhuoqing Fang, Gary Peltz
{"title":"Twenty-first century mouse genetics is again at an inflection point","authors":"Zhuoqing Fang, Gary Peltz","doi":"10.1038/s41684-024-01491-3","DOIUrl":"10.1038/s41684-024-01491-3","url":null,"abstract":"The laboratory mouse has been the premier model organism for biomedical research owing to the availability of multiple well-characterized inbred strains, its mammalian physiology and its homozygous genome, and because experiments can be performed under conditions that control environmental variables. Moreover, its genome can be genetically modified to assess the impact of allelic variation on phenotype. Mouse models have been used to discover or test many therapies that are commonly used today. Mouse genetic discoveries are often made using genome-wide association study methods that compare allelic differences in panels of inbred mouse strains with their phenotypic responses. Here we examine changes in the methods used to analyze mouse genetic models of biomedical traits during the twenty-first century. To do this, we first examine where mouse genetics was before the first inflection point, which was just before the revolution in genome sequencing that occurred 20 years ago, and then describe the factors that have accelerated the pace of mouse genetic discovery. We focus on mouse genetic studies that have generated findings that either were translated to humans or could impact clinical medicine or drug development. We next explore how advances in computational capabilities and in DNA sequencing methodology during the past 20 years could enhance the ability of mouse genetics to produce solutions for twenty-first century public-health problems. Mouse genetic studies are essential for our understanding of genotype–phenotype relationships. Here the authors discuss the technological advances that have accelerated the pace of mouse genetic discovery during the twenty-first century.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 1","pages":"9-15"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01491-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating cancer with a new smart drug delivery system 用新型智能给药系统治疗癌症
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01480-6
Jorge Ferreira
{"title":"Treating cancer with a new smart drug delivery system","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01480-6","DOIUrl":"10.1038/s41684-024-01480-6","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"355-355"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the role of the cGAS/STING pathway in killifish aging 阐明 cGAS/STING 通路在鳉鱼衰老过程中的作用
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01490-4
Alexandra Le Bras
{"title":"Elucidating the role of the cGAS/STING pathway in killifish aging","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01490-4","DOIUrl":"10.1038/s41684-024-01490-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"357-357"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut–brain axis in Drosophila aging 果蝇衰老过程中的肠脑轴
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01482-4
Alexandra Le Bras
{"title":"Gut–brain axis in Drosophila aging","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01482-4","DOIUrl":"10.1038/s41684-024-01482-4","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"356-356"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic DNA confers cell-specificity 合成 DNA 赋予细胞特异性
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01484-2
Alexandra Le Bras
{"title":"Synthetic DNA confers cell-specificity","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01484-2","DOIUrl":"10.1038/s41684-024-01484-2","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"356-356"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drosophila model for tau trafficking 果蝇的 tau 贩卖模型
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01479-z
Jorge Ferreira
{"title":"Drosophila model for tau trafficking","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01479-z","DOIUrl":"10.1038/s41684-024-01479-z","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"355-355"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of adipocyte ATF3 in metabolic disorders 脂肪细胞 ATF3 在代谢紊乱中的作用
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01487-z
Jorge Ferreira
{"title":"Role of adipocyte ATF3 in metabolic disorders","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01487-z","DOIUrl":"10.1038/s41684-024-01487-z","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"359-359"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01487-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amantadine improves POCD symptoms 金刚烷胺可改善 POCD 症状
IF 5.9 3区 农林科学
Lab Animal Pub Date : 2024-11-26 DOI: 10.1038/s41684-024-01478-0
Jorge Ferreira
{"title":"Amantadine improves POCD symptoms","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01478-0","DOIUrl":"10.1038/s41684-024-01478-0","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"355-355"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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