Lab Animal最新文献_第7页

Cauterization of the root of the left coronary artery as a straightforward, large and reproducible ischemic injury model in neonatal mice 灼烧左冠状动脉根部作为新生小鼠缺血损伤模型简单、大且可重复

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-10-22 DOI: 10.1038/s41684-024-01443-x

Tianyuan Hu, Bernd K. Fleischmann, Mona Malek Mohammadi

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引用次数: 0

The continued importance of animals in biomedical research 动物在生物医学研究中的持续重要性

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-10-14 DOI: 10.1038/s41684-024-01458-4

Michael C. J. Chang Ph.D., Franziska B. Grieder DVM, Ph.D.

引用次数: 0

Efficacy of mucosal vaccines in nonhuman primates 非人灵长类动物粘膜疫苗的功效。

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01452-w

Alexandra Le Bras

引用次数: 0

Space radiation increases risk taking 太空辐射增加了冒险性。

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01447-7

Jorge Ferreira

引用次数: 0

Effect of Sprouty triple deletion in adult mice 成年小鼠 Sprouty 三重缺失的影响

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01449-5

Jorge Ferreira

引用次数: 0

Spared ulnar nerve injury results in increased layer III–VI excitability in the pig somatosensory cortex 幸免的尺神经损伤会导致猪躯体感觉皮层 III-VI 层兴奋性增加。

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01440-0

Suzan Meijs, Andrew J. Hayward, Thomas Gomes Nørgaard Dos Santos Nielsen, Carsten Reidies Bjarkam, Winnie Jensen

{"title":"Spared ulnar nerve injury results in increased layer III–VI excitability in the pig somatosensory cortex","authors":"Suzan Meijs, Andrew J. Hayward, Thomas Gomes Nørgaard Dos Santos Nielsen, Carsten Reidies Bjarkam, Winnie Jensen","doi":"10.1038/s41684-024-01440-0","DOIUrl":"10.1038/s41684-024-01440-0","url":null,"abstract":"This study describes cortical recordings in a large animal nerve injury model. We investigated differences in primary somatosensory cortex (S1) hyperexcitability when stimulating injured and uninjured nerves and how different cortical layers contribute to S1 hyperexcitability after spared ulnar nerve injury. We used a multielectrode array to record single-neuron activity in the S1 of ten female Danish landrace pigs. Electrical stimulation of the injured and uninjured nerve evoked brain activity up to 3 h after injury. The peak amplitude and latency of early and late peristimulus time histogram responses were extracted for statistical analysis. Histological investigations determined the layer of the cortex in which each electrode contact was placed. Nerve injury increased the early peak amplitude compared with that of the control group. This difference was significant immediately after nerve injury when the uninjured nerve was stimulated, while it was delayed for the injured nerve. The amplitude of the early peak was increased in layers III–VI after nerve injury compared with the control. In layer III, S1 excitability was also increased compared with preinjury for the early peak. Furthermore, the late peak was significantly larger in layer III than in the other layers in the intervention and control group before and after injury. Thus, the most prominent increase in excitability occurred in layer III, which is responsible for the gain modulation of cortical output through layer V. Therefore, layer III neurons seem to have an important role in altered brain excitability after nerve injury. Meijs et al. perform an electrophysiological investigation of cortical responses in a pig nerve injury model, showing the role of layer III–VI neurons in altered primary somatosensory cortex excitability after nerve injury.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"287-293"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01440-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A real-world setting for H1N1 transmission in ferrets 甲型 H1N1 流感在雪貂间传播的真实环境。

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01451-x

Alexandra Le Bras

引用次数: 0

Spotlight on pig models 聚焦猪模。

IF 5.9 3区农林科学

Lab Animal Pub Date : 2024-09-30 DOI: 10.1038/s41684-024-01455-7

引用次数: 0

Two x two for USDA semiannual inspections 美国农业部每半年检查一次，每次 2 x 2。

IF 5.9 3区农林科学