Lab AnimalPub Date : 2026-06-30DOI: 10.1038/s41684-026-01769-8
Alexandra Le Bras
{"title":"A new sensor for monitoring autophagic flux in vivo","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01769-8","DOIUrl":"10.1038/s41684-026-01769-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 7","pages":"243-243"},"PeriodicalIF":6.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2026-06-23DOI: 10.1038/s41684-026-01750-5
Roberta Giusti Schran, Patrícia Rodrigues, Gabriela Trevisan, Juliano Ferreira
{"title":"Analgesic drug efficacy in mouse postoperative pain: a systematic review and meta-analysis","authors":"Roberta Giusti Schran, Patrícia Rodrigues, Gabriela Trevisan, Juliano Ferreira","doi":"10.1038/s41684-026-01750-5","DOIUrl":"10.1038/s41684-026-01750-5","url":null,"abstract":"The management of postoperative pain is a critical ethical concern and a challenge in laboratory animal research, particularly for mice. Surgical procedures are routinely conducted in mice, but the use of analgesic drugs is underreported and the assessment of their efficacy is limited. This systematic review assesses the efficacy of analgesic drugs for postoperative pain in mice, addressing the influence of various factors, including sex, surgical invasiveness, pain modalities and analgesic classes. A systematic literature search resulted in 48 eligible studies included in the qualitative analysis and 43 in the quantitative analysis. The overall pooled standardized mean difference (SMD) for analgesic drugs was 0.46 (95% confidence interval 0.31 to 0.60), indicating a positive pain-reducing effect. Subgroup analysis revealed that analgesic treatment was significantly more effective in male (SMD 0.84; 0.60 to 1.08) than in female mice, in mild (SMD 0.57; 0.38 to 0.75) than in severe surgical procedures and in reducing evoked pain (SMD 1.12; 0.83 to 1.41) than in reducing spontaneous pain. In addition, almost all analgesic drug classes tested, including opioids, nonsteroidal anti-inflammatory drugs, acetaminophen and local anesthetics were effective in reducing evoked pain but not spontaneous pain (SMD 0.12; −0.03 to 0.27). However, most studies present limitations that could produce a high risk of bias. Taken together, our results indicate that, although analgesic drugs can reduce postoperative pain in mice, their efficacy is reduced in females, severely invasive surgeries and spontaneous pain. Thus, high-quality studies are still needed to answer ethical concerns and to guarantee full analgesia in laboratory mice submitted to surgical procedures. This study systematically reviews analgesic efficacy for postoperative pain in mice, showing overall pain reduction but reduced effects in females, severe surgeries and spontaneous pain, stressing the need for higher-quality studies.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 9","pages":"334-343"},"PeriodicalIF":6.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01750-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2026-06-04DOI: 10.1038/s41684-026-01730-9
Sergio Díaz-Fernández, Matilde Aleluia, Margarida Saraiva, Pablo Soldevilla, Jordi B. Torrelles, Riti Sharan, Frank A. W. Verreck, Angelo Izzo, Maria Vidal, Ana C. Moreira, Bernat Pérez de Val, Francisco Jose Roca, Madalina Preda, Eduard Torrents, Esther Julián, José Domínguez, Irene Latorre
{"title":"The study of immunological markers in tuberculosis across animal models and its translation to human research","authors":"Sergio Díaz-Fernández, Matilde Aleluia, Margarida Saraiva, Pablo Soldevilla, Jordi B. Torrelles, Riti Sharan, Frank A. W. Verreck, Angelo Izzo, Maria Vidal, Ana C. Moreira, Bernat Pérez de Val, Francisco Jose Roca, Madalina Preda, Eduard Torrents, Esther Julián, José Domínguez, Irene Latorre","doi":"10.1038/s41684-026-01730-9","DOIUrl":"10.1038/s41684-026-01730-9","url":null,"abstract":"Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis, remains one of the major causes of death from infection worldwide, with over a million associated deaths each year. The study of biomarkers for TB is critical for advancing our understanding and management of the disease. Biomarkers, defined as measurable indicators of biological states or conditions, are invaluable for the diagnosis, prognosis and treatment monitoring of TB. Clinical studies have provided critical knowledge on the matter but are also notoriously constrained by economical, ethical and sampling limitations. The use of animal models provides a simpler, more controllable, cost-effective setting with great potential for translation to humans. They also allow the evaluation of biomarkers within the respiratory compartment, when available, which is of particular interest due to the nature of TB pathogenesis. This Review focuses on the current landscape of TB biomarker discovery in several animal models, from invertebrates to large mammals. Here we summarize the basics of host–pathogen immune interaction, describe the main methodological approaches used and highlight the most substantial findings for each animal model studied. Furthermore, we discuss the advantages, challenges and limitations associated with species-specific differences in animal models. We conclude that integrating the data obtained from animal models and human studies is absolutely required to advance the TB field to accelerate the management of this disease. This Review summarizes tuberculosis biomarker discovery across animal models, outlining immune mechanisms, methods and important findings, while stressing how integrating animal and human data is essential to advance tuberculosis diagnosis and management.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 7","pages":"248-266"},"PeriodicalIF":6.8,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-026-01730-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lab AnimalPub Date : 2026-06-03DOI: 10.1038/s41684-026-01757-y
Jorge Ferreira
{"title":"New platform to study Huntington’s disease","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01757-y","DOIUrl":"10.1038/s41684-026-01757-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 6","pages":"196-196"},"PeriodicalIF":3.9,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148147285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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