实现对动物研究中 3R 原则的共同解释

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2024-11-15 DOI:10.1038/s41684-024-01476-2

Jan Lauwereyns, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery De Kock, Alisa Elezović, Sevilay Erden, Fernando Gonzalez-Uarquin, Yesim Isil Ulman, Orsolya Ivett Hoffmann, Maria Kitsara, Nikolaos Kostomitsopoulos, Winfried Neuhaus, Benoit Petit-Demouliere, Simone Pollo, Brígida Riso, Sophie Schober, Athanassia Sotiropoulos, Aurélie Thomas, Augusto Vitale, Doris Wilflingseder, Arti Ahluwalia

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引用次数: 0

摘要

许多科学突破都有赖于动物研究，然而围绕实验中使用动物的伦理问题长期以来一直引发着关于人道待遇和负责任的科学实践的讨论。由罗素和伯奇首次提出的 "3R "原则，即 "替代（Replacement）、减少（Reduction）和改进（Refinement）"，作为动物研究的基本准则得到了广泛认可。随着时间的推移，3R 原则已经超越了研究界，影响到政策决策、动物福利倡导和公众对动物实验的看法。尽管 3Rs 已被广泛接受，但对其的解释却大相径庭，影响着不同层面的法定框架，既有技术层面的，也有实践层面的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Toward a common interpretation of the 3Rs principles in animal research

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Toward a common interpretation of the 3Rs principles in animal research

Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.