Klinische Monatsblatter fur Augenheilkunde最新文献

{"title":"[Between Monofocal and Multifocal: Extended Depth of Focus (EDOF) Intraocular Lenses in Clinical Practice].","authors":"Lukas M Möhwald, Alexander Lukas Rattunde, David Muallah, Ricardo Elsner, Jasmin Abu Arif, Sabine Popa, Tim Rüterhenke, Reem Alshammari, Joris De Keersmaecker, Jessica Stabel, Ramin Khoramnia, Eckart Bertelmann","doi":"10.1055/a-2950-4028","DOIUrl":"10.1055/a-2950-4028","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The 2024 Activity Report of the Section on Tissue Transplantation-Association of German Cornea Banks of the German Ophthalmologic Society].","authors":"Jill Rena Ramroth, Sebastian Thaler, Jan Schroeter, Philip Christian Maier","doi":"10.1055/a-2932-5895","DOIUrl":"https://doi.org/10.1055/a-2932-5895","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory and Metabolic Indices in Pseudoexfoliation Syndrome and Glaucoma: The Role of Pan-Immune-Inflammation Value and Triglyceride-Glucose Index.","authors":"Muge Toprak, Hayati Yılmaz","doi":"10.1055/a-2947-6724","DOIUrl":"10.1055/a-2947-6724","url":null,"abstract":"<p><strong>Abstract: </strong>PURPOSE: To determine whether the pan-immune-inflammation value (PIV) and triglyceride-glucose (TyG) index reflect a graded systemic inflammatory and metabolic burden across the pseudoexfoliation spectrum and to compare their discriminatory performance with conventional hematologic ratios.</p><p><strong>Abstract: </strong>METHODS: This retrospective cross-sectional study included 170 adults classified as controls (<i>n</i> = 60), pseudoexfoliation syndrome (PEXS; <i>n</i> = 60), or pseudoexfoliation glaucoma (PEXG; <i>n</i> = 50). Demographic variables, comorbidities, complete blood count parameters, and fasting triglyceride and glucose values were extracted from medical records. PIV and TyG indices were calculated using established formulas.</p><p><strong>Abstract: </strong>RESULTS: Both PIV and the TyG index demonstrated a significant, stepwise increase across groups (Control < PEXS < PEXG; <i>p</i> < 0.001). All pairwise comparisons were significant, with the highest values observed in the PEXG group. The neutrophil-lymphocyte ratio was elevated in the PEXS and PEXG groups versus controls (<i>p</i> ≤ 0.005) but did not differ significantly between PEXS and PEXG. The platelet-lymphocyte ratio and monocyte-lymphocyte ratio showed no significant group differences. Routine metabolic parameters, including fasting glucose and triglycerides, were comparable among groups.</p><p><strong>Abstract: </strong>CONCLUSIONS: PIV and the TyG index appear to sensitively reflect the systemic inflammatory-metabolic gradient across the pseudoexfoliation spectrum and showed stronger discriminatory performance than traditional hematologic ratios in this cross-sectional cohort. Given their simplicity, low cost, and accessibility, these indices represent promising candidate biomarkers for the pseudoexfoliation spectrum.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Relative Scotoma an Artefact?","authors":"Friedrich Hoffmann, Thilo Knacke, Fabian Müller, Christian Meltendorf","doi":"10.1055/a-2944-0749","DOIUrl":"https://doi.org/10.1055/a-2944-0749","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Direct Ophthalmoscopy Teaching of Medical Students Based on a Standardized Simulator-based Procedure Versus the Classic Ophthalmoscope\".","authors":"Thiago Gonçalves Dos Santos Martins","doi":"10.1055/a-2944-0812","DOIUrl":"https://doi.org/10.1055/a-2944-0812","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Findings of Epithelial Invasion after Arcuate and Radial Keratotomies.","authors":"Alexandra Serfözö, Fidelis Flockerzi, Tim Berger, Adrien Quintin, Berthold Seitz","doi":"10.1055/a-2457-6977","DOIUrl":"10.1055/a-2457-6977","url":null,"abstract":"<p><strong>Abstract: </strong>BACKGROUND: Complications after arcuate (АKs) and radial keratotomies (RKs) may include infection, delayed wound healing, and epithelial invasion.</p><p><strong>Abstract: </strong>PURPOSE: To assess the histopathologic findings of epithelial invasion following АK/RK.</p><p><strong>Abstract: </strong>METHODS: The study included patients who underwent penetrating keratoplasty (PK) after previous АK or RK treatment. In corneas with histologically confirmed epithelial invasion, the following parameters were examined: invasion depth (µm), width (µm) in the superficial, middle, and deep stroma, and the ratio of invasion depth to corneal thickness. The time between АK/RK and PK was compared for corneas with and without detectable epithelial invasion.</p><p><strong>Abstract: </strong>RESULTS: Out of 31 excised corneas, 7 (22%) showed epithelial invasion 2 to 19 years (median 6 years) after АK/RK. Histological examination revealed different invasion patterns, with a mean depth of 315 (231 to 395) µm or 57% (46 to 66%) of corneal thickness. The mean width in the superficial stroma was 291 (75 to 789) µm, in the middle stroma 210 (33 to 422) µm, and in the deep stroma 164 (19 to 324) µm. No significant association was found between the presence of the epithelial invasion and the time after PK (p = 0.83).</p><p><strong>Abstract: </strong>CONCLUSION: In almost a quarter of the eyes after АK or RK, epithelial invasion could be detected. The potential biomechanical instability associated with this should be considered in cases of trauma as well as in the context of planning cataract surgery or PK, particularly in the hands of less experienced surgeons. Nonmechanical contact-free excimer laser trephination may be helpful in PK.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"930-936"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Macular Telangiectasia Type 2 (MacTel) - Therapeutic Options and New Developments].","authors":"Julia Harten, Kristin Raming, Lukas Goerdt, Frank Holz, Kristina Pfau","doi":"10.1055/a-2936-8879","DOIUrl":"10.1055/a-2936-8879","url":null,"abstract":"<p><strong>Abstract: </strong>Macular telangiectasia type 2 (MacTel) is a rare, bilateral neurodegenerative disease of the macula associated with secondary vascular alterations. Pathophysiologically, Müller cell dysfunction plays a central role. Their loss leads to progressive degeneration of central cone photoreceptors and may secondarily contribute to the development of macular neovascularization (MNV), which affects approximately 10% of patients.</p><p><strong>Abstract: </strong>A major pathophysiologic mechanism is a disturbance in serine and sphingolipid metabolism. Patients with MacTel have significantly lower blood serine levels, leading to increased synthesis of neurotoxic deoxysphingolipids, which are elevated by approximately 84% in affected individuals compared with healthy controls. These toxic lipids damage Müller cells, photoreceptors, and retinal ganglion cells. Oral serine supplementation is discussed as a promising causal therapeutic approach. Initial animal studies have shown reversible retinal changes under serine therapy; a phase 3 study of supplementation in patients with MacTel is currently in preparation.</p><p><strong>Abstract: </strong>Clinically, optical coherence tomography (OCT) shows hyporeflective cavities and loss of the ellipsoid zone (EZ) as markers of photoreceptor atrophy, while fundus autofluorescence demonstrates loss of macular pigment. Fluorescein angiography reveals telangiectatic capillaries temporal to the fovea in the early phase and diffuse leakage in the late phase. Symptomatically, patients primarily report reading difficulties, metamorphopsia, and paracentral scotomas; marked impairment of central visual acuity usually occurs only in advanced disease stages.</p><p><strong>Abstract: </strong>Therapeutically, intravitreal anti-VEGF therapy is considered the standard treatment for exudative MNV but has no benefit in nonproliferative MacTel and may even adversely affect the disease course. A milestone is the Encelto implant (revakinagene taroretcel-lwey), approved by the FDA in March 2025. The implant contains allogeneic RPE cells that continuously produce and secrete ciliary neurotrophic factor (CNTF) and is considered the first disease-modifying therapy for MacTel. In two parallel phase 3 studies (NTMT-03-A/B), the implant reduced EZ loss by approximately 55% and 31%, respectively, compared with sham treatment. European approval by the EMA is still pending. This review systematically presents current and future therapeutic options for macular telangiectasia type 2.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"911-921"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Acute Cystoid Macular Edema After Penetrating Keratoplasty and Endothelial Keratoplasty.","authors":"Ibrahim Qozat, Yazan Abubaker, Pranav Vasu, Isabella Wagner, Conner Lentz, Emily Dorairaj, Abhimanyu Ahuja, Darby Miller, Michael Stewart, Syril Dorairaj","doi":"10.1055/a-2932-7648","DOIUrl":"10.1055/a-2932-7648","url":null,"abstract":"<p><strong>Abstract: </strong>INTRODUCTION: Cystoid macular edema (CME) is a recognized complication associated with penetrating keratoplasty (PK) and Endothelial Keratoplasty (EK). The purpose of this study was to determine the incidence of acute CME within the first 6 months after PK, Descemet stripping automated EK, or Descemet's membrane EK.</p><p><strong>Abstract: </strong>METHODS: A retrospective cohort analysis of the TriNetX United States collaborative database was conducted. Patients with a diagnosis of Fuchs dystrophy or keratoconus who underwent PK or EK between January 1, 2004 and August 30, 2024 were included. Those with a history of uveitis, retinal vascular occlusion, diabetic macular edema, or prior vitrectomy were excluded. Outcomes and diagnoses were defined using current procedural terminology and International Classification of Diseases, Tenth edition (ICD-10) codes. Cohorts were stratified based on a history of prior PK or EK with >6 months follow-up. Propensity score matching was performed on both cohorts to control for age at index, sex, race, ethnicity, and the diagnosis of Fuchs dystrophy and keratoconus. The incidence of acute CME during a 6-month postoperative follow-up period was assessed. Odds ratios were calculated between cohorts.</p><p><strong>Abstract: </strong>RESULTS: A total of 2516 eyes were included in the study (PK: 1258; EK: 1258). At six months postoperatively, the incidence of acute CME in the EK cohort (46 of 1258) was significantly higher than in the PK cohort (20 of 1258) (<i>P</i> = 0.0012) (OR 0.426, 95% confidence interval 0.25-0.72).</p><p><strong>Abstract: </strong>CONCLUSIONS: Our findings suggest that the incidence of acute CME is higher in patients undergoing EK compared to PK.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"922-926"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Makuläre Teleangiektasien.","authors":"Sandra Liakopoulos, Martin Zinkernagel","doi":"10.1055/a-2754-9337","DOIUrl":"https://doi.org/10.1055/a-2754-9337","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"243 9","pages":"892-893"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Optical coherence tomography angiography].","authors":"Michael Grün, Henrik Faatz","doi":"10.1055/a-2729-1450","DOIUrl":"10.1055/a-2729-1450","url":null,"abstract":"<p><strong>Abstract: </strong>Optical coherence tomography angiography (OCTA) has become increasingly established as a diagnostic procedure in clinical practice in recent years. In the field of medical retina in particular, it serves as a useful aid to the morphological assessment of vascular diseases such as neovascular age-related macular degeneration and diabetic retinopathy. Technically speaking, it is a further development of optical coherence tomography (OCT) and therefore offers the advantage of being non-invasive. Even though other imaging modalities still need to be used for certain clinical matters, OCTA offers a suitable alternative to invasive procedures in some situations or can be a helpful supplement in cases of unclear findings. In addition, OCTA has led to a better understanding of the pathophysiology and course of vascular diseases in a scientific context. Recent developments have already reduced or eliminated some of the limitations of OCTA and further improvements for use in clinical practice can be expected in the future.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"945-958"},"PeriodicalIF":1.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}