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Prospective International Registry for Treatment Exit Options in Uveitis (TOFU) - the First Five Years. Uveitis （TOFU）治疗退出选择国际登记前景-头五年。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-02 DOI: 10.1055/a-2529-0057
Carsten Heinz, David J Fink, Jennifer Dell, Moritz Berger, Matthias Schmid, Robert P Finger
{"title":"Prospective International Registry for Treatment Exit Options in Uveitis (TOFU) - the First Five Years.","authors":"Carsten Heinz, David J Fink, Jennifer Dell, Moritz Berger, Matthias Schmid, Robert P Finger","doi":"10.1055/a-2529-0057","DOIUrl":"10.1055/a-2529-0057","url":null,"abstract":"<p><p>Uveitis diseases are generally rare and therefore often pose a significant challenge in treatment. In developed countries, non-infectious uveitis is one of the most common causes of severe functional impairment and even blindness. The current guidelines provide information on when and how to initiate treatment, but do not include recommendations on when and how to reduce or discontinue treatment. The Treatment Exit Options for Uveitis Register (TOFU) was initiated over five years ago, with the aim of improving the evidence for therapy reduction and termination. Over the past five years, the register has been established nationally with funding from the German Federal Ministry of Education and Research (BMBF), the Eye Foundation and industry partners and has since been expanded in individual European countries. The registry is under the auspices of the Uveitis Section of the German Ophthalmological Society (DOG). The analysis of baseline data from around 1000 patients shows that, in the prospectively documented patient population, intermediate uveitis is most common, followed by posterior uveitis, panuveitis and retinal vasculitis. The disease was bilateral in 75.9% of cases. The mean visual acuity was 0.22 ± 0.36 logMAR. Patients with panuveitis had the worst visual acuity, with 0.27 ± 0.39 logMAR. Severe visual impairment (> 1.0 logMAR) was observed in only 1% of patients at baseline. The continuation and European expansion will ensure the continuous generation of high-quality data in the coming years and thus help to develop recommendations on the end of therapy.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[21-Year-old Patient with Paracentral Scotoma after Drug Abuse]. [21岁药物滥用后并发中央旁暗斑患者]。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-03-31 DOI: 10.1055/a-2570-2993
David Dietrich Beckers, Lena Beckers, Ulrich Schaudig, Birthe Stemplewitz
{"title":"[21-Year-old Patient with Paracentral Scotoma after Drug Abuse].","authors":"David Dietrich Beckers, Lena Beckers, Ulrich Schaudig, Birthe Stemplewitz","doi":"10.1055/a-2570-2993","DOIUrl":"10.1055/a-2570-2993","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"671-673"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ocular Mucosal Pemphigoid: Diagnosis, Clinic and Therapy. 眼粘膜类天疱疮的诊断、临床和治疗。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1055/a-2566-3860
Uwe Pleyer
{"title":"Ocular Mucosal Pemphigoid: Diagnosis, Clinic and Therapy.","authors":"Uwe Pleyer","doi":"10.1055/a-2566-3860","DOIUrl":"https://doi.org/10.1055/a-2566-3860","url":null,"abstract":"<p><p>Ocular mucosal pemphigoid is a rare, chronically progressive autoimmune disease of the ocular surface. It belongs to a group of diseases whose common clinical correlate is the disruption of cohesion at the basement membrane. Recurrent inflammation with progressive fibrosis of the conjunctiva and damage to limbal stem cells are characteristic. If the course remains uncontrolled, severe morphological and functional damage can occur, up to blindness. Therefore, the critical perception of initially subtle findings and early diagnostic are of great importance. The aim of immune modulative therapy is to control the underlying inflammation and prevent the progression of fibrosis, in order to avoid serious complications.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"653-659"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycotic Keratitis - Signs, Diagnosis, Therapy. 真菌性角膜炎-体征，诊断，治疗。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-04-30 DOI: 10.1055/a-2598-5668
Robert Bock, Mathias Roth, Gerd Geerling
{"title":"Mycotic Keratitis - Signs, Diagnosis, Therapy.","authors":"Robert Bock, Mathias Roth, Gerd Geerling","doi":"10.1055/a-2598-5668","DOIUrl":"10.1055/a-2598-5668","url":null,"abstract":"<p><p>Mycotic keratitis is a rare but serious infection of the cornea that occurs particularly in wearers of contact lenses and in patients with systemic diseases, such as diabetes or immunosuppression. It is often caused by filamentous fungi such as Fusarium spp. and Aspergillus spp. or by yeasts, in particular Candida spp. The diagnosis of mycotic keratitis is challenging, as clinical signs are often non-specific. Diagnosis includes in vivo confocal microscopy, fungal cultures and histopathological examinations. Early and targeted diagnosis is crucial, in order to avoid serious complications. Treatment is based on the use of antimycotics such as natamycin and voriconazole. In refractory cases, early surgical intervention, usually by means of keratoplasty, is necessary. The aim of this article is to provide a comprehensive overview of the aetiology, diagnosis and treatment of mycotic keratitis and to provide clinical recommendations for the effective management of this challenging disease.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"636-642"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Inherited retinal disorders: clinical and molecular genetic diagnostic]. 遗传性视网膜疾病：临床和分子遗传学诊断。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-01-14 DOI: 10.1055/a-2274-5801
Ulrich Kellner, Kristina Pfau
{"title":"[Inherited retinal disorders: clinical and molecular genetic diagnostic].","authors":"Ulrich Kellner, Kristina Pfau","doi":"10.1055/a-2274-5801","DOIUrl":"10.1055/a-2274-5801","url":null,"abstract":"<p><p>Inherited retinal dystrophies (IRD) are the most frequent cause for severe visual loss in the working age. The heterogeneous group of IRDs is associated with loss of visual function and has a severe impact on personal and familial life. Early diagnosis is of high relevance for patients and their families, to facilitate possible therapies and professional help for the individual situation. This review summarizes a diagnostic protocol for an efficient diagnosis of IRD including non-invasive retinal imaging, functional and molecular genetic testing as well as examination in specialized centers for IRD.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"677-697"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Besonders selten, besonders wichtig. 非常罕见，非常重要。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1055/a-2550-8448
Philip Christian Maier, Berthold Seitz, Gerd Geerling
{"title":"Besonders selten, besonders wichtig.","authors":"Philip Christian Maier, Berthold Seitz, Gerd Geerling","doi":"10.1055/a-2550-8448","DOIUrl":"https://doi.org/10.1055/a-2550-8448","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"627-628"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Assistance Systems and Fitness to Drive in Case of Visual Field Defects - Statement of the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA). Status: 21 January 2025]. 在视野缺陷情况下的辅助系统和驾驶适应性-德国眼科学会（DOG）和德国眼科专业协会（BVA）的声明。状态：2025年1月21日]。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1055/a-2576-5691
{"title":"[Assistance Systems and Fitness to Drive in Case of Visual Field Defects - Statement of the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA). Status: 21 January 2025].","authors":"","doi":"10.1055/a-2576-5691","DOIUrl":"https://doi.org/10.1055/a-2576-5691","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"698-700"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stevens Johnson Syndrome/Toxic Epidermal Necrolysis - Diagnostic Testing and Treatment for Ophthalmologists. 史蒂文斯约翰逊综合征/中毒性表皮坏死松解-眼科医生的诊断测试和治疗。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1055/a-2543-9811
Philip Christian Maier, Thomas Reinhard
{"title":"Stevens Johnson Syndrome/Toxic Epidermal Necrolysis - Diagnostic Testing and Treatment for Ophthalmologists.","authors":"Philip Christian Maier, Thomas Reinhard","doi":"10.1055/a-2543-9811","DOIUrl":"https://doi.org/10.1055/a-2543-9811","url":null,"abstract":"<p><p>Epidermal necrolysis (EN) is a very rare, but life-threatening dermatological disease where the skin and various mucous membranes react to drugs (75%) or systemic infections (25%). If up to 10% of the body surface is affected, the disease is called Stevens Johnson syndrome (SJS); if more than 30% of the body surface is affected, it is called toxic epidermal necrolysis (TEN); if 10 - 30% of the body surface is affected, it is called SJS/TEN overlap. In the acute phase of the disease, 80% of cases show ophthalmic involvement (from mild conjunctivitis to total de-epithelialisation of the ocular surface). Therefore, patients should be seen by an ophthalmologist within 24 h after symptoms have started. Treatment of the acute ophthalmic problems has a very important impact on long-term eye complications. However, in the long run up to 50% of patients develop chronic sight threatening ocular surface disease which needs further intensive topical and surgical treatment (e.g. lubrification, topical anti-inflammatory agents, lid surgery, scleral lenses, corneal surgery). The indication for corneal transplantation (allogenic penetrating limbo-keratoplasty and keratoprostheses) should be given with due caution, as the prognosis is very poor.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"644-652"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acanthamoeba Keratitis: What is the Best Time for Keratoplasty in Patients with Resistance to Conservative Therapy? 棘阿米巴角膜炎：对保守治疗有抵抗的患者进行角膜移植的最佳时机是什么？
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1055/a-2558-8878
Yaser Abu Dail, Elias Flockerzi, Nóra Szentmáry, Berthold Seitz, Loay Daas
{"title":"Acanthamoeba Keratitis: What is the Best Time for Keratoplasty in Patients with Resistance to Conservative Therapy?","authors":"Yaser Abu Dail, Elias Flockerzi, Nóra Szentmáry, Berthold Seitz, Loay Daas","doi":"10.1055/a-2558-8878","DOIUrl":"https://doi.org/10.1055/a-2558-8878","url":null,"abstract":"<p><p>Acanthamoebic keratitis (AK) is a sight-threatening infectious keratitis caused by Acanthamoeba. Timely and appropriate conservative treatment of AK can lead to a cure of the keratitis with good visual acuity, without the need for keratoplasty in the further course of the disease. In treatment-resistant cases, keratoplasty after intensive anti-amoebic therapy (AAT), so-called \"low-load keratoplasty\", appears to offer a better overall prognosis and earlier visual and psychological rehabilitation than actively delayed keratoplasty (optical/therapeutic). Further studies directly comparing early and delayed keratoplasty are needed to even better determine the optimal timing of corneal transplantation in AK.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"629-635"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suprachoroidal Delivery of Corticosteroid Slow-Release Implants for the Treatment of Cystoid Macular Edema. 脉络膜上给药皮质类固醇缓释植入治疗黄斑囊样水肿。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1055/a-2541-2444
Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger
{"title":"Suprachoroidal Delivery of Corticosteroid Slow-Release Implants for the Treatment of Cystoid Macular Edema.","authors":"Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger","doi":"10.1055/a-2541-2444","DOIUrl":"10.1055/a-2541-2444","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"674-676"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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