Klinische Monatsblatter fur Augenheilkunde最新文献

{"title":"Ocular Mucosal Pemphigoid: Diagnosis, Clinic and Therapy.","authors":"Uwe Pleyer","doi":"10.1055/a-2566-3860","DOIUrl":"https://doi.org/10.1055/a-2566-3860","url":null,"abstract":"<p><p>Ocular mucosal pemphigoid is a rare, chronically progressive autoimmune disease of the ocular surface. It belongs to a group of diseases whose common clinical correlate is the disruption of cohesion at the basement membrane. Recurrent inflammation with progressive fibrosis of the conjunctiva and damage to limbal stem cells are characteristic. If the course remains uncontrolled, severe morphological and functional damage can occur, up to blindness. Therefore, the critical perception of initially subtle findings and early diagnostic are of great importance. The aim of immune modulative therapy is to control the underlying inflammation and prevent the progression of fibrosis, in order to avoid serious complications.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"653-659"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycotic Keratitis - Signs, Diagnosis, Therapy.","authors":"Robert Bock, Mathias Roth, Gerd Geerling","doi":"10.1055/a-2598-5668","DOIUrl":"10.1055/a-2598-5668","url":null,"abstract":"<p><p>Mycotic keratitis is a rare but serious infection of the cornea that occurs particularly in wearers of contact lenses and in patients with systemic diseases, such as diabetes or immunosuppression. It is often caused by filamentous fungi such as Fusarium spp. and Aspergillus spp. or by yeasts, in particular Candida spp. The diagnosis of mycotic keratitis is challenging, as clinical signs are often non-specific. Diagnosis includes in vivo confocal microscopy, fungal cultures and histopathological examinations. Early and targeted diagnosis is crucial, in order to avoid serious complications. Treatment is based on the use of antimycotics such as natamycin and voriconazole. In refractory cases, early surgical intervention, usually by means of keratoplasty, is necessary. The aim of this article is to provide a comprehensive overview of the aetiology, diagnosis and treatment of mycotic keratitis and to provide clinical recommendations for the effective management of this challenging disease.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"636-642"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Inherited retinal disorders: clinical and molecular genetic diagnostic].","authors":"Ulrich Kellner, Kristina Pfau","doi":"10.1055/a-2274-5801","DOIUrl":"10.1055/a-2274-5801","url":null,"abstract":"<p><p>Inherited retinal dystrophies (IRD) are the most frequent cause for severe visual loss in the working age. The heterogeneous group of IRDs is associated with loss of visual function and has a severe impact on personal and familial life. Early diagnosis is of high relevance for patients and their families, to facilitate possible therapies and professional help for the individual situation. This review summarizes a diagnostic protocol for an efficient diagnosis of IRD including non-invasive retinal imaging, functional and molecular genetic testing as well as examination in specialized centers for IRD.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"677-697"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Besonders selten, besonders wichtig.","authors":"Philip Christian Maier, Berthold Seitz, Gerd Geerling","doi":"10.1055/a-2550-8448","DOIUrl":"https://doi.org/10.1055/a-2550-8448","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"627-628"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assistance Systems and Fitness to Drive in Case of Visual Field Defects - Statement of the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA). Status: 21 January 2025].","authors":"","doi":"10.1055/a-2576-5691","DOIUrl":"https://doi.org/10.1055/a-2576-5691","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"698-700"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevens Johnson Syndrome/Toxic Epidermal Necrolysis - Diagnostic Testing and Treatment for Ophthalmologists.","authors":"Philip Christian Maier, Thomas Reinhard","doi":"10.1055/a-2543-9811","DOIUrl":"https://doi.org/10.1055/a-2543-9811","url":null,"abstract":"<p><p>Epidermal necrolysis (EN) is a very rare, but life-threatening dermatological disease where the skin and various mucous membranes react to drugs (75%) or systemic infections (25%). If up to 10% of the body surface is affected, the disease is called Stevens Johnson syndrome (SJS); if more than 30% of the body surface is affected, it is called toxic epidermal necrolysis (TEN); if 10 - 30% of the body surface is affected, it is called SJS/TEN overlap. In the acute phase of the disease, 80% of cases show ophthalmic involvement (from mild conjunctivitis to total de-epithelialisation of the ocular surface). Therefore, patients should be seen by an ophthalmologist within 24 h after symptoms have started. Treatment of the acute ophthalmic problems has a very important impact on long-term eye complications. However, in the long run up to 50% of patients develop chronic sight threatening ocular surface disease which needs further intensive topical and surgical treatment (e.g. lubrification, topical anti-inflammatory agents, lid surgery, scleral lenses, corneal surgery). The indication for corneal transplantation (allogenic penetrating limbo-keratoplasty and keratoprostheses) should be given with due caution, as the prognosis is very poor.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"644-652"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acanthamoeba Keratitis: What is the Best Time for Keratoplasty in Patients with Resistance to Conservative Therapy?","authors":"Yaser Abu Dail, Elias Flockerzi, Nóra Szentmáry, Berthold Seitz, Loay Daas","doi":"10.1055/a-2558-8878","DOIUrl":"https://doi.org/10.1055/a-2558-8878","url":null,"abstract":"<p><p>Acanthamoebic keratitis (AK) is a sight-threatening infectious keratitis caused by Acanthamoeba. Timely and appropriate conservative treatment of AK can lead to a cure of the keratitis with good visual acuity, without the need for keratoplasty in the further course of the disease. In treatment-resistant cases, keratoplasty after intensive anti-amoebic therapy (AAT), so-called \"low-load keratoplasty\", appears to offer a better overall prognosis and earlier visual and psychological rehabilitation than actively delayed keratoplasty (optical/therapeutic). Further studies directly comparing early and delayed keratoplasty are needed to even better determine the optimal timing of corneal transplantation in AK.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 6","pages":"629-635"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprachoroidal Delivery of Corticosteroid Slow-Release Implants for the Treatment of Cystoid Macular Edema.","authors":"Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger","doi":"10.1055/a-2541-2444","DOIUrl":"10.1055/a-2541-2444","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"674-676"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle Changes in Aging and their Potential Impact on POAG.","authors":"Carl Erb, Clivia Erb, Avaz Kazakov, Gulnara Kapanova, Burkhard Weisser","doi":"10.1055/a-2372-3505","DOIUrl":"10.1055/a-2372-3505","url":null,"abstract":"<p><p>Primary open angle glaucoma is a primary mitochondrial disease with oxidative stress triggering neuroinflammation, eventually resulting in neurodegeneration. This affects many other areas of the brain in addition to the visual system. Aging also leads to inflammaging - a low-grade chronic inflammatory reaction in mitochondrial dysfunction, so these inflammatory processes overlap in the aging process and intensify pathophysiological processes associated with glaucoma. Actively counteracting these inflammatory events involves optimising treatment for any manifest systemic diseases while maintaining chronobiology and improving the microbiome. Physical and mental activity also provides support. This requires a holistic approach towards optimising neurodegeneration treatment in primary open angle glaucoma in addition to reducing intraocular pressure according personalised patient targets.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"661-670"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal and Epithelial Thickness Measurements: Comparability between two Different Ocular Coherence Tomography Devices.","authors":"Burcu Yakut, Anika Förster, Burkhard Dick, Suphi Taneri","doi":"10.1055/a-2558-8789","DOIUrl":"https://doi.org/10.1055/a-2558-8789","url":null,"abstract":"<p><strong>Background: </strong>Corneal and epithelial thickness maps obtained with high-frequency ultrasound were first used to diagnose keratoconus. Anterior segment OCT has recently become widely used in many conditions especially in preoperative planning before refractive surgery, keratoconus diagnosis, keratoconus progression monitoring, hydrops formation, and epithelial healing monitoring. We compare epithelial and pachymetric thickness-based parameters from two different Fourier-domain optical coherence tomography (OCT) devices as to whether they can be used interchangeably.</p><p><strong>Methods: </strong>Retrospective, comparative chart review. This study comprises 24 normal consecutive eyes and 32 consecutive post-SMILE eyes with corneal thickness and epithelial thickness maps obtained using two different OCT devices (Cirrus 5000, Carl Zeiss Meditec, Germany and Avanti RTVue 100, OptoVue Inc., USA). The following common parameters in the print-out of the two OCT devices were examined: minimum corneal thickness (Pachy min), minimum corneal thickness minus median corneal thickness (Pachy min-med), average corneal thickness of the superonasal octant minus the average corneal thickness of the inferotemporal octant (Pachy SN-IT), average corneal thickness of the superior octant minus average corneal thickness of the inferior octant (Pachy S-I), minimum epithelial thickness (Epi min), and maximum epithelial thickness (Epi max).</p><p><strong>Results: </strong>Pachy min and Epi max measurements matched well between the two devices (ICC at 0.906 and 0.839, respectively). We found a significant correlation in Pachy min (<i>p</i> = 0.040), Pachy min-med (<i>p</i> = 0.033), and Epi max (<i>p</i> < 0.001) in the normal eye group. Only Pachy min and Epi max measurements (<i>p</i> < 0.001 for both) exhibited a significant correlation between the two devices in the post-SMILE group.</p><p><strong>Conclusion: </strong>Anterior segment OCT is a valuable method for evaluating quantitative corneal and epithelial thickness measurements. However, measurements may differ between devices, and they should not be used interchangeably.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}