Helga Reinshagen, Daniel Böhringer, Jan Schroeter, Philip Christian Maier
{"title":"[The 2023 Activity Report of the Tissue Transplantation and Biotechnology Section of the German Ophthalmological Society].","authors":"Helga Reinshagen, Daniel Böhringer, Jan Schroeter, Philip Christian Maier","doi":"10.1055/a-2521-3969","DOIUrl":"https://doi.org/10.1055/a-2521-3969","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger
{"title":"Suprachoroidal delivery of corticosteroid slow release implants for the treatment of cystoid macular edema.","authors":"Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger","doi":"10.1055/a-2541-2444","DOIUrl":"https://doi.org/10.1055/a-2541-2444","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inflammatory Choroidal Neovascularization in Pediatric Uveitis: A Case Series.","authors":"Amandine Gauderon, Chiara Eandi, Aikaterini Koryllou, Florence Hoogewoud, Katerina Theodoropoulou, Yan Guex-Crosier","doi":"10.1055/a-2467-1804","DOIUrl":"https://doi.org/10.1055/a-2467-1804","url":null,"abstract":"<p><strong>Background: </strong>The aim of our study is to describe clinical features, therapy, and outcome of children with inflammatory choroidal neovascularization (CNV).</p><p><strong>Methods: </strong>Retrospective case series of children seen at the Jules-Gonin Eye Hospital between 2000 and 2024 with macular choroidal neovascularisation secondary to ocular inflammation.</p><p><strong>Results: </strong>Four children (one male, three females) developed a retro-foveolar neovascular membrane after a median time of 2.5 months (range 1 - 16 months) following uveitis onset. The median age at presentation was 12 years (range 5 - 12 years). The CNV presentation was unilateral in all four cases, with three patients having posterior uveitis and one panuveitis. Two patients had idiopathic bilateral granulomatous uveitis while the other two had suspected toxoplasmosis chorioretinitis. Idiopathic cases were treated with oral steroids, with one patient being additionally treated with adalimumab. Toxoplasmosis cases were managed with antibiotics and oral steroids. CNV treatment involved a single anti-VEGF injection in two cases, six injections in one case, and no injection in one case due to CNV inactivity. Median follow-up period was 4.25 years (range 0.75 to 11 years) and the median final best-corrected visual acuity was 0.9 (range 0.6 - 1.25). No recurrence of CNV was observed, despite uveitis reactivation in two cases.</p><p><strong>Conclusion: </strong>Anti-VEGF therapy is safe even in young children with minimal injections required to control the disease. Treating the underlying cause of uveitis with appropriate therapy is also crucial.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does Axial Length Influence the Dose Effect of Horizontal Strabismus Surgery?","authors":"Hatice Uecelehan, Anja Palmowski-Wolfe","doi":"10.1055/a-2511-3537","DOIUrl":"https://doi.org/10.1055/a-2511-3537","url":null,"abstract":"<p><strong>Background: </strong>Dose effect (DE) of strabismus surgery is thought to decrease with increasing axial length (AL), and it has been suggested that this effect may be more important in hyperopes over + 2 D. Here, we analyse the influence of AL on the DE of horizontal strabismus surgery in regard to its clinical relevance.</p><p><strong>Methods: </strong>Retrospective chart analysis of patients who had undergone horizontal strabismus surgery between 2020 and 2023.</p><p><strong>Statistical analysis: </strong>descriptive analysis and ANOVA (R 4.1.2).</p><p><strong>Results: </strong>There were 65 patients (34 male and 31 female) included; mean age: 18.0 years (range 5 - 74). Mean AL was 23.50 mm (range: 20.80 - 28.50 mm). At the 3-month follow-up, 83.1% of patients demonstrated binocularity. Mean DE was 2.36 PD/mm at distance and 2.60 in near vision. There was no significant influence of AL on the DE of surgery (p = 0.30). However, DE was significantly higher in esotropia (n = 32) than exotropia (n = 33) in distant and near vision (p = 0.0 000 403) and in both groups, patients with positive binocularity had a significantly greater DE than patients without binocularity (p = 0.0032).</p><p><strong>Conclusion: </strong>Our data showed no significant correlation between AL and the DE of surgery, while the type of strabismus and binocularity had a significant influence on the DE of surgery. However, AL is still important for surgical planning, in particular, to assess the risk of a deviating muscle path or thin sclera in high myopia.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giacomo Edoardo Bravetti, Matteo Mandrioli, Luca Cappuccini, Giorgio Enrico Bravetti
{"title":"Effect of Foveal Herniation on Surgical Outcomes of Idiopathic Epiretinal Membrane Peeling: A Challenging Presentation.","authors":"Giacomo Edoardo Bravetti, Matteo Mandrioli, Luca Cappuccini, Giorgio Enrico Bravetti","doi":"10.1055/a-2511-6405","DOIUrl":"https://doi.org/10.1055/a-2511-6405","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this report is to describe the visual symptoms and spectral-domain optical coherence tomography (SD-OCT) findings associated with foveal herniation with epiretinal membrane and to evaluate the postoperative visual, anatomical, and surgical outcomes.</p><p><strong>Background: </strong>Foveal herniation occurs when neuroretinal tissue protrudes through and above the level of an epiretinal membrane. The pathogenesis of foveal herniation is still unknown, though it is likely attributable to the centripetal contraction of the epiretinal membrane (ERM). Moreover, thinning of the prefoveolar internal limiting membrane (ILM) may further exacerbate this process by reducing the structural support for the retina in that area. In the literature, foveal herniation with ERM is rare and usually described as unilateral. Most cases present a good visual outcome after surgical intervention.</p><p><strong>Case description: </strong>We describe the case of a 37-year-old Caucasian male patient, without any previous ocular history, who presented with metamorphopsia and a sustained reduction visual acuity to his left eye that had persisted for several months. The baseline best-corrected visual acuity (BCVA) was recorded as 0.05 decimals. Anterior segment examination was unremarkable, while dilated fundoscopy revealed an ERM with a concentric ring of foveal tissue prolapse. SD-OCT showed the foveal tissue protruding through and above the ERM, demonstrating the severe foveal herniation. A diagnosis of idiopathic ERM with foveal herniation was established based on these findings. Subsequently, the patient was scheduled for surgical intervention to undergo pars-plana vitrectomy with ERM peeling. After the surgery, the patient experienced progressive restoration of the foveal anatomy and an improvement of vision to 0.6 decimals from baseline at 3 months.</p><p><strong>Conclusion: </strong>This case report shows a rare finding of foveal herniation with ERM. This atypical presentation is of important clinical relevance in drawing clinicians' attention to the possibility of these findings, with the goal to prevent erroneous diagnosis and unnecessary treatments. We demonstrate the visual improvement and gradual resolution of foveal herniation with SD-OCT images after ERM removal, and the images show that it may take a few months for the foveal bulge to decrease in height. When the outer retinal layers are normal, visual recovery, though delayed, is appreciable.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yannik Laich, Stefan J Lang, Andreas Glatz, Navid Farassat, Felicitas Bucher, Simone Nuessle, Daniel Böhringer, Wolf Alexander Lagrèze, Spyridon Sideris, Peter Maloca, Clemens Lange, Thomas Reinhard, Hansjürgen Agostini, Michael Reich
{"title":"Morphology of Retinal Hemangioblastoma in von Hippel-Lindau Disease Revealed by Optical Coherence Tomography Angiography.","authors":"Yannik Laich, Stefan J Lang, Andreas Glatz, Navid Farassat, Felicitas Bucher, Simone Nuessle, Daniel Böhringer, Wolf Alexander Lagrèze, Spyridon Sideris, Peter Maloca, Clemens Lange, Thomas Reinhard, Hansjürgen Agostini, Michael Reich","doi":"10.1055/a-2501-8628","DOIUrl":"https://doi.org/10.1055/a-2501-8628","url":null,"abstract":"<p><strong>Background: </strong>To characterize different growth patterns of retinal hemangioblastomas (RHs) in patients with von Hippel-Lindau disease (VHLD) using swept-source optical coherence tomography angiography (SS-OCTA).</p><p><strong>Methods: </strong>Single-center observational cross-sectional study. SS-OCTA B-scans were centered over primary treatment-naïve RHs to display the perfusion in the inner, middle, and outer areas (IA, MA, OA). Distinctive growth patterns were characterized using K-means cluster analysis of the flow signal.</p><p><strong>Results: </strong>Annual screening of 201 patients with VHLD revealed 49 patients with 85 RHs (41 recurrent, 44 primary treatment-naïve RHs). High-quality SS-OCTA images were available for 24 primary RHs and were pooled with scans of the treatment-naïve form of 6 recurrent RHs, which were taken at a prior visit, for further analysis. Out of 30 primary RHs, 18 were located juxtapapillary (jRH) and 12 peripherally (pRH). K-means cluster analysis distinguished seven exophytic (23.3%, 2 jRH, 5 pRH), nine endophytic (30%, 6 jRH, 3 pRH), and fourteen sessile (46.7%, 10 jRH, 4 pRH) growth patterns. Fractions of the flow signal in the IA, MA, and OA were 7.3 ± 3.3%, 89.3 ± 5.0%, and 3.4 ± 3.5% for exophytic RHs, 22.2 ± 7.4%, 65.6 ± 7.3%, and 12.1 ± 8.2% for sessile RHs, and 65.4 ± 5.7%, 26.6 ± 4.9%, and 8.0 ± 6.1% for endophytic RH.</p><p><strong>Conclusion: </strong>OCTA contributes to further elucidating the morphology of RHs as a useful complementary diagnostic tool that can help to provide customized therapeutic approaches in the future and thus improve the effectiveness of RH treatment.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}