Klinische Monatsblatter fur Augenheilkunde最新文献

{"title":"[Behandlung durchgreifender Makulaforamina mittels ILM-Flap ohne Gastamponade].","authors":"Franziska Eckardt, Caroline Stueven, Barbara Sophie Brunner, Viktoria Deiters, Julian Klaas, Benedikt Schworm, Siegfried Georg Priglinger","doi":"10.1055/a-2984-1060","DOIUrl":"https://doi.org/10.1055/a-2984-1060","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Klinische und subjektive Ergebnisse nach beidseitiger Implantation einer IOL mit partiellem Fokusbereich].","authors":"Thomas Kohnen, Kerstin Petermann, Eva Hemkeppler, Christoph Lwowski, Myriam Böhm","doi":"10.1055/a-2976-1869","DOIUrl":"https://doi.org/10.1055/a-2976-1869","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Optic Perineuritis: Diagnostic Value of Visual Field and MRI.","authors":"Rafael Lucena, Arnas Urbonavicius, Gudrun Hanzo, Christoph Tappeiner, David Goldblum, Andreas Weinberger","doi":"10.1055/a-2969-7654","DOIUrl":"https://doi.org/10.1055/a-2969-7654","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Role of Intravitreal Chemotherapy in the Treatment of Retinoblastoma].","authors":"Cristina Rastoaca, Leyla Jabbarli, Tobias Kiefer, Philipp Rating, Nikolaos E Bechrakis, Eva Biewald","doi":"10.1055/a-2977-8635","DOIUrl":"https://doi.org/10.1055/a-2977-8635","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Outcomes of PRESERFLO MicroShunt Implantations With and Without Adjunctive Healaflow® Application in Glaucoma Patients: A Single-Center Experience.","authors":"Dominique Frédéric Waldmann, Konstantin Gugleta, Thomas Dervos, Tim J Enz, Oussama Habra","doi":"10.1055/a-2964-8392","DOIUrl":"https://doi.org/10.1055/a-2964-8392","url":null,"abstract":"<p><strong>Abstract: </strong>INTRODUCTION: This report describes our experience with PRESERFLO MicroShunt implantation with and without adjunctive subconjunctival Healaflow® as a modified bleb-forming filtration technique in glaucoma patients.</p><p><strong>Abstract: </strong>MATERIALS AND METHODS: A retrospective cohort analysis of 65 consecutive eyes undergoing single PRESERFLO MicroShunt implantation at a single center was performed. The Healaflow group (HG; <i>n</i> = 36, with Healaflow®) was operated between October 2024 and July 2025, and the control group (CG; <i>n</i> = 29, without Healaflow®) between October 2018 and December 2019. Medical records were reviewed for demographics, intraocular pressure (IOP), medication use and complications. IOP and topical medication were compared between groups preoperatively, on day 1, week 1, and at 1-3, 3-6, 6-12 and 12-18 months using unpaired t-tests and a two-way repeated-measures ANOVA.</p><p><strong>Abstract: </strong>RESULTS: Mean preoperative IOP was comparable between groups (24.4 ± 9.4 vs. 21.8 ± 8.2 mmHg; <i>p</i> = 0.24). IOP was significantly lower in the HG at 1-3 months (8.6 ± 4.0 vs. 14.0 ± 9.2; <i>p</i> = 0.007), 3-6 months (10.4 ± 5.4 vs. 14.9 ± 7.1; <i>p</i> = 0.031) and 6-12 months (11.0 ± 4.0 vs. 15.4 ± 5.3; <i>p</i> = 0.004), and remained nominally lower at 12-18 months (11.6 ± 6.0 vs. 13.8 ± 5.3; <i>p</i> = 0.254). The ANOVA showed a significant group-by-time interaction (<i>p</i> = 0.001) in favour of the HG. Topical medication was consistently lower in the HG (6-12 months: 0.41 vs. 1.38 compounds). Transient, self-limiting hypotony-related choroidal detachment/effusion occurred in 27.8% (HG) vs. 13.8% (CG); bleb revision was required in 8.3% vs. 13.8%.</p><p><strong>Abstract: </strong>DISCUSSION/CONCLUSION: PRESERFLO MicroShunt implantation with adjunctive subconjunctival Healaflow® may provide a greater and more sustained IOP reduction and a lower medication burden than MicroShunt with mitomycin C alone, at least in the early-to-mid postoperative period and in the absence of postoperative 5-fluorouracil. Transient hypotony was more frequent but reversible. Further, prospective and standardized comparisons are warranted.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Irisstromazyste mit Endothelzellverlust].","authors":"Clara E Englisch, Rosemarie Schlosser, Colya N Englisch, Clemens N Rudolph, Karl T Boden, Peter Szurman, Bert Bier, Philip Wakili","doi":"10.1055/a-2966-1331","DOIUrl":"https://doi.org/10.1055/a-2966-1331","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics, management and clinical outcomes in familial exudative vitreoretinopathy (FEVR): a multicentre retrospective cohort.","authors":"Tomasz Szeligowski, Amanda Ie, Peter Kiraly, Monica Hu, Tsveta Ivanova, Assad Jalil, Panagiotis Sergouniotis, Graeme Black, Sui Chien Wong, Chetan K Patel, Robert Henderson, Kanmin Xue","doi":"10.1055/a-2962-8394","DOIUrl":"10.1055/a-2962-8394","url":null,"abstract":"&lt;p&gt;&lt;p&gt;in English Background Familial exudative vitreoretinopathy (FEVR) is a group of inherited retinal diseases characterised by abnormal retinal angiogenesis and peripheral non-perfusion. While over 10 genes have been implicated in FEVR, genotype-phenotype correlations and their clinical significance are incompletely understood. Here we describe a retrospective cohort of FEVR patients and assess the impact of defined genetic variants on protein structure, disease severity, inter-ocular variability, as well as treatment choices and visual outcomes. Methods Retrospective cohort of 51 patients with FEVR across three UK paediatric retina centres. All data was obtained from routine clinical records. Standard FEVR staging system was used throughout. Identified genetic variants were checked against genomic databases (ClinVar, GnomAD, UniProt), and their structural impact was examined using in silico algorithms (MutationTaster and PolyPhen2) to determine the likelihood of pathogenicity. Results 51 patients were included, with variants identified in FZD4 (n=16), LRP5 (n=13), TSPAN12 (n=11), KIF11 (n=6), NDP (n=4), and CTNNB1 (n=1). In silico analysis identified 11 variants not previously reported in FEVR, seven of which were classified as likely pathogenic. NDP variants were associated with the most severe and asymmetrical disease. Management included conservative monitoring (45 eyes), retinal laser photocoagulation (39 eyes), and surgical interventions (12 eyes), with the majority of patients achieving stable or improved visual acuity in all treatment groups. Conclusion This study demonstrates significant diversity among FEVR patients with regards to genetic variants, clinical presentation, and visual outcomes. Understanding genotype-phenotype correlations in FEVR may be crucial for developing novel treatment strategies. ABSTRACT in German Hintergrund Die familiäre exsudative Vitreoretinopathie (FEVR) ist eine Gruppe erblicher Netzhauterkrankungen, die durch eine abnorme retinale Angiogenese und eine periphere Minderperfusion gekennzeichnet ist. Obwohl mehr als 10 Gene mit FEVR in Verbindung gebracht wurden, sind Genotyp-Phänotyp-Korrelationen und deren klinische Bedeutung nur unvollständig verstanden. In dieser Arbeit beschreiben wir eine retrospektive Kohorte von FEVR-Patienten und untersuchen den Einfluss definierter genetischer Varianten auf die Proteinstruktur, den Krankheitsschweregrad, die interokuläre Variabilität sowie auf Behandlungsentscheidungen und visuelle Ergebnisse. Methoden Retrospektive Kohorte von 51 Patienten mit FEVR aus drei pädiatrischen Netzhautzentren im Vereinigten Königreich. Alle Daten wurden aus routinemäßigen klinischen Aufzeichnungen gewonnen. Durchgehend wurde das Standard-FEVR-Staging-System verwendet. Die identifizierten genetischen Varianten wurden mit genomischen Datenbanken (ClinVar, GnomAD, UniProt) abgeglichen, und ihre strukturelle Auswirkung wurde mittels In-silico-Algorithmen (MutationTaster und PolyPhen2) unte","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Magnetic resonance imaging of the orbital cavity: indications and diagnostic possibilities].","authors":"Helena Posch, Katharina Erb-Eigner","doi":"10.1055/a-2899-7821","DOIUrl":"https://doi.org/10.1055/a-2899-7821","url":null,"abstract":"<p><strong>Abstract: </strong>Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated using case-based examples in the context of clinical findings.Vascular pathologies (such as capillary hemangioma and cavernous venous malformation), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Additionally, the role of MRI in acute clinical settings and trauma is discussed.The text explains technical aspects of MRI encompassing field strength and the utilization of receiver coils to optimize image quality and achieve high spatial resolution.Alongside common sequences (T1- and T2-weighted sequences) used in standard anatomic imaging (sAI), the article demonstrates the potential of \"multiparametric\" imaging techniques (diffusion-weighted imaging, DWI, and dynamic contrast-enhanced imaging, DCE). These innovative MRI sequences depict functional tissue characteristics in addition to morphology alone and thus facilitate radiological assessment.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of Dry Eye Disease - Current recommendations according to DEWS III report].","authors":"Christina Jacobi","doi":"10.1055/a-2641-1346","DOIUrl":"https://doi.org/10.1055/a-2641-1346","url":null,"abstract":"<p><strong>Abstract: </strong>Dry eye disease (DED) is one of the most common chronic disorders of the ocular surface. It is clinically relevant because it can cause pronounced complaints such as burning, pain, blurred vision, foreign body sensation, photophobia or severe visual disturbance. According to the current pathophysiological understanding, dry eye is a multifactorial, symptomatic disease characterised by a loss of homeostasis of the tear film and/or the ocular surface. Etiologically, tear film instability, hyperosmolarity, inflammatory mechanisms and neurosensory abnormalities play a decisive role.Treating dry eye is one of the most demanding tasks in ophthalmological practice. Patients often present with a high burden of suffering. The multifactorial origin of dry eye calls for a time-intensive, detailed history and differentiated diagnostic work-up. Treatment frequently poses a considerable challenge for the treating physicians and for the affected patients. Current diagnostic and therapeutic recommendations are based on the DEWS III (Dry Eye Workshop III) report of 2025. Therapy no longer follows a stepwise scheme exclusively; instead, an individualised, etiology-oriented, targeted combination therapy is recommended. Particular importance is attached to the recognition of systemic causes, to taking neuropathic pain components into account, and to interdisciplinary collaboration.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Herpes Simplex Virus and Varicella-Zoster Virus Keratitis].","authors":"Nóra Szentmáry, Maria Della Volpe Waizel, Ágnes Élő, Annekatrin Rickmann, Julian Kahlert, Fabian Norbert Fries, Roman Saternus, Berthold Seitz","doi":"10.1055/a-2857-9740","DOIUrl":"https://doi.org/10.1055/a-2857-9740","url":null,"abstract":"<p><strong>Abstract: </strong>Herpesvirus infections of the cornea are among the leading infectious causes of corneal vision loss worldwide. Both herpes simplex virus (HSV) and varicella-zoster virus (VZV) play a major role in the development of corneal disease. Following primary infection, both viruses establish lifelong latency in sensory ganglia and may be reactivated by triggering factors such as ultraviolet (UV) exposure, stress, fever, surgery, or immunosuppression. Clinically, ocular herpesvirus infections present with a broad spectrum of manifestations, and early differentiation between these entities is essential for appropriate diagnosis, treatment, and prognosis. HSV keratitis is characterized by a recurrent course and includes epithelial, stromal, endothelial, and neurotrophic forms. Epithelial HSV keratitis results from active viral replication and typically presents as dendritic or geographic keratitis. Non-necrotizing stromal keratitis is predominantly caused by immune-mediated inflammatory responses without significant viral replication, whereas necrotizing stromal keratitis is thought to involve significant viral replication in combination with an excessive immune response. In HSV endotheliitis, both viral and immune-mediated mechanisms play a role. These clinical manifestations may be associated with keratouveitis, secondary glaucoma, iris atrophy, or corneal neovascularization. Recurrent episodes frequently lead to damage of the subbasal corneal nerve plexus, resulting in neurotrophic keratopathy. Varicella-zoster virus may also cause severe ocular complications in patients with herpes zoster ophthalmicus (HZO), including keratitis, uveitis, elevated intraocular pressure, neurotrophic corneal disease, and retinitis. Elderly and immunocompromised individuals are at particularly high risk of severe disease and postherpetic neuralgia. Diagnosis is primarily based on clinical findings and may be supported by corneal esthesiometry, in vivo confocal microscopy, and PCR-based virological testing. Polymerase chain reaction (PCR) analysis of corneal tissue or aqueous humor is particularly valuable in atypical or treatment-resistant cases. Management includes topical and systemic antiviral agents such as acyclovir, valacyclovir, ganciclovir, and famciclovir. Immune-mediated stromal and endothelial keratitis additionally require anti-inflammatory therapy. Neurotrophic forms require regenerative therapies such as autologous serum eye drops, amniotic membrane transplantation, or the recombinant human nerve growth factor cenegermin. Although no licensed vaccine against HSV is currently available, recombinant herpes zoster vaccination provides effective protection against VZV-associated ocular complications.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}