Louisa M Bulirsch, Karin U Löffler, Matthias Marten Mauschitz, Martina C Herwig-Carl
{"title":"[Visual side effects of chemotherapeutic drugs].","authors":"Louisa M Bulirsch, Karin U Löffler, Matthias Marten Mauschitz, Martina C Herwig-Carl","doi":"10.1055/a-2563-4912","DOIUrl":"https://doi.org/10.1055/a-2563-4912","url":null,"abstract":"<p><p>Chemotherapeutic agents can lead to serious visual side effects in the eye, which can affect both the anterior and posterior segment. This article presents a selection of the most important chemotherapeutics causing ocular side effects. We will discuss side effects of chemotherapeutic agents that are applied directly to the eye for the treatment of an ocular neoplasia as well as side effects of systemically applied chemotherapeutic agents. Furthermore, the corresponding therapy and possible necessary adaptions of the chemotherapy are explained. Most importantly the ophthalmologist should stay in close contact with the other treating specialists.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Inherited retinal disorders: Current therapeutic options and future perspectives].","authors":"Kristina Pfau, Ulrich Kellner","doi":"10.1055/a-2521-4616","DOIUrl":"https://doi.org/10.1055/a-2521-4616","url":null,"abstract":"<p><p>Inherited retinal diseases (IRDs) represent a heterogeneous group of genetically driven conditions that frequently lead to progressive vision loss. Due to their complexity and the limited therapeutic options available, they pose a significant challenge for ophthalmology. This article provides a comprehensive overview of current evidence-based therapeutic approaches, including pharmacological strategies, gene therapy, and stem cell therapy, as well as innovative developments such as optogenetics and retinal implants. While gene therapies like Luxturna for <i>RPE65</i>-associated retinitis pigmentosa have paved the way for causal treatments, initial successes are also being observed in other retinal dystrophies, such as Stargardt disease and Usher syndrome. Rehabilitative measures and interdisciplinary care remain essential to improving the quality of life for affected individuals. Future research efforts focus on enhancing the efficacy and accessibility of therapies while addressing challenges such as inflammatory reactions, high costs, and genetic variability. The perspectives outlined highlight promising advancements in the treatment of genetic retinal diseases.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Dietrich Beckers, Florian Kretz, Fabian Höhn, Karen Glandorf, Detlev R H Breyer, Anke Messerschmidt-Roth, Lena Beckers
{"title":"[Visuelle Ergebnisse einer KLEx mit einer 7,7 mm optischer Zone].","authors":"David Dietrich Beckers, Florian Kretz, Fabian Höhn, Karen Glandorf, Detlev R H Breyer, Anke Messerschmidt-Roth, Lena Beckers","doi":"10.1055/a-2661-4897","DOIUrl":"https://doi.org/10.1055/a-2661-4897","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Grün, Kai Rothaus, Albrecht Peter Lommatzsch, Henrik Faatz
{"title":"[Erste Real-World-Erfahrungen mit Aflibercept 8 mg bei der Behandlung der neovaskulären AMD].","authors":"Michael Grün, Kai Rothaus, Albrecht Peter Lommatzsch, Henrik Faatz","doi":"10.1055/a-2655-8854","DOIUrl":"https://doi.org/10.1055/a-2655-8854","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johanna Wiedemann, Christopher Dicke, Björn O Bachmann, Lebriz Altay, Claus Cursiefen
{"title":"[Cystoid macular edema (CME) and immune responses after DMEK/Triple DMEK: Real-life data from Oregis].","authors":"Johanna Wiedemann, Christopher Dicke, Björn O Bachmann, Lebriz Altay, Claus Cursiefen","doi":"10.1055/a-2650-9712","DOIUrl":"https://doi.org/10.1055/a-2650-9712","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Patient selection for multifocal intraocular lenses].","authors":"Ramin Khoramnia, Tadas Naujokaitis","doi":"10.1055/a-2519-4324","DOIUrl":"10.1055/a-2519-4324","url":null,"abstract":"<p><p>Patient selection is the key to patient satisfaction with multifocal intraocular lenses (mIOLs). While multifocality provides spectacle independence, it is associated with potentially bothersome side effects inherent in multifocal optics. Photic phenomena such as halos and glare, as well as loss of contrast in low light environments, can be potentially problematic in visually demanding occupations and leisure activities. The use of mIOLs may also be disadvantageous in patients with certain comorbidities that affect vision or increase the risk of complications. In addition, unilateral mIOL implantation, preoperative myopia, postoperative ametropia, unrealistic patient expectations and certain personality traits may lead to lower patient satisfaction with mIOLs. Healthy, hyperopic patients with presbyopia or cataracts, a desire for spectacle independence and a willingness to compromise tend to achieve the highest satisfaction with mIOLs.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"767-780"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Wolfrum, Anna Maria Voigt, Katrin Lorenz, Bernhard M Stoffelns, Christina A Korb
{"title":"Real-world Efficacy, Safety, and the Impact of Spherical Equivalent on Intravitreal Anti-VEGF Therapy in Patients Affected by Myopic Choroidal Neovascularisation.","authors":"Peter Wolfrum, Anna Maria Voigt, Katrin Lorenz, Bernhard M Stoffelns, Christina A Korb","doi":"10.1055/a-2561-2847","DOIUrl":"10.1055/a-2561-2847","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse real-world clinical outcomes and influence of the spherical equivalent (SE) on anti-vascular endothelial growth factor (VEGF) therapy in patients affected by myopic choroidal neovascularisation (mCNV).</p><p><strong>Patients and methods: </strong>A retrospective investigation was conducted on treatment-naïve mCNV patients receiving anti-VEGF therapy at the Department of Ophthalmology, University Medical Center Mainz, Germany, between January 2018 and March 2024. Safety, functional and morphological changes in visual acuity (VA), central retinal thickness (CRT), and central retinal volume (CRV) were evaluated over a two-year period. Further, we analysed how baseline VA and CRT relate to it's final outcome measures. Finally, a subgroup analysis assessed the impact of SE above and below - 10 D.</p><p><strong>Results: </strong>Significant improvements in VA, CRT, and CRV were observed. VA improved from 0.5 ± 0.27 logMAR to 0.38 ± 0.31 logMAR (<i>p</i> = 0.005) at 6 months and remained stable at 2 years. CRT and CRV decreased from 344.4 ± 115.0 µm to 284.2 ± 45.2 µm (<i>p</i> < 0.001) and 0.27 ± 0.09 mm³ to 0.22 ± 0.04 mm³ (<i>p</i> < 0.001), respectively, four weeks after the initial injection, with stability maintained thereafter. Baseline VA correlated strongly with final VA, whereas CRT did not. No adverse events were reported. The subgroup analysis showed no significant outcome differences based on SE.</p><p><strong>Conclusion: </strong>Anti-VEGF therapy in mCNV patients proved to be safe and effective in our study with sustained improvement in functional and anatomical measures. Baseline VA strongly predicted final VA, whereas baseline and final CRT showed no association. No differences in treatment outcomes were observed as based on a varying SE.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"745-751"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retinal Nerve Fibre Layer OCT for Glaucoma Diagnosis - Gold Standard or Just a Piece of the Puzzle?","authors":"Leonie Bourauel, Karl Mercieca","doi":"10.1055/a-2501-8538","DOIUrl":"10.1055/a-2501-8538","url":null,"abstract":"<p><p>Early diagnosis and accurate monitoring are essential in treating glaucoma effectively and avoiding further irreversible loss of retinal ganglion cells. Glaucoma is a complex disease; initial progression is usually asymptomatic, and regular clinical and imaging examinations are extremely important. Imaging the retinal nerve fibre layer (RNFL) using spectral domain optical coherence tomography (SD-OCT) has established itself in recent years as an easy-to-perform and reproducible diagnostic method. This imaging technique allows precise analysis of the RNFL in monitoring retinal nerve fibre thickness. The present article will discuss the anatomical principles, changes to be expected in the RNFL with glaucoma compared to normal control scans, and options in analysing disease progression. We will also be discussing limitations to the method as well as additional OCT imaging techniques available. Awareness of potential sources of error makes it easier to achieve an accurate analysis of RNFL scans. Tips on interpreting RNFL scans should help ophthalmologists using the available data effectively towards reaching informed decisions on disease treatment and management in glaucoma patients.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"726-734"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Früherkennung des Glaukoms als eine der häufigsten Erblindungsursachen – Fortschritte durch moderne Diagnostik mit OCT.","authors":"Verena Prokosch, Carl Erb","doi":"10.1055/a-2579-7419","DOIUrl":"https://doi.org/10.1055/a-2579-7419","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":"242 7","pages":"711"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vera Kanlic, Andreas Guttmann, Andreas Wedrich, Domagoj Ivastinovic
{"title":"Patient Reported Outcomes of Retrobulbar versus Topical Anaesthesia in Cataract Surgery - a Prospective Observational Trial.","authors":"Vera Kanlic, Andreas Guttmann, Andreas Wedrich, Domagoj Ivastinovic","doi":"10.1055/a-2616-2773","DOIUrl":"10.1055/a-2616-2773","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this prospective clinical, monocentric observational study was to assess the pain perception of patients during cataract surgery.</p><p><strong>Methodology: </strong>Patients undergoing cataract surgery at the Department of Ophthalmology at the Medical University of Graz were recruited. Patients who received retrobulbar anaesthesia (RBA) were compared to those who received topical drop anaesthesia (TA) with (TAG) or without an anaesthetic gel. Exclusion criteria were complications during the cataract surgery requiring additional steps including anterior vitrectomy and the placement of a Malyugin ring. The patients were interviewed postoperatively regarding their perceived pain experience during cataract surgery, using the Numeric Rating Scale. Additionally, the mean intraoperative blood pressure was recorded for correlation with the subjective assessment of pain.</p><p><strong>Results: </strong>Overall, 201 patients could be enrolled. Among them, 105 patients underwent cataract surgery under RBA, 50 patients under TA and 46 patients under TAG. The average pain score under RBA was 0.35 ± 0.87, under TA 1.32 ± 1.22, and under TAG 0.89 ± 0.97. Statistical analysis revealed a significant difference between RBA and the two topical anaesthesia methods (p < 0.01). However, no significant difference was found between the two topically applied methods, TA and TAG (p = 0.64). The mean intraoperative blood pressure could be obtained for a total of 32 patients. The average difference in values before and during the operation was + 1.88 mmHg under RBA and + 3.33 mmHg under TAG (p > 0.05).</p><p><strong>Conclusion: </strong>Our results indicate that patients receiving RBA have significantly less pain intraoperatively than those with TA and TAG. The addition of an anaesthetic gel to TA showed a slight, but not significant, reduction in pain.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":"741-744"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}