Klinische Monatsblatter fur Augenheilkunde最新文献

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Comparison of Analytical Methods for the Validation of the Sterility of Autologous Serum Eye Drops. 自体血清滴眼液无菌性验证分析方法的比较。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2468-5416
Frank Blaser, Isabelle Meneau, Jana Schneider, Jürg Wiedler, Hanspeter Hinrikson, Daniel Barthelmes, Sandrine Zweifel, Anahita Bajka, Sadiq Said, Maximilian Robert Justus Wiest
{"title":"Comparison of Analytical Methods for the Validation of the Sterility of Autologous Serum Eye Drops.","authors":"Frank Blaser, Isabelle Meneau, Jana Schneider, Jürg Wiedler, Hanspeter Hinrikson, Daniel Barthelmes, Sandrine Zweifel, Anahita Bajka, Sadiq Said, Maximilian Robert Justus Wiest","doi":"10.1055/a-2468-5416","DOIUrl":"https://doi.org/10.1055/a-2468-5416","url":null,"abstract":"<p><strong>Purpose: </strong>For specific samples, there are different methods and requirements for testing sterility. Blood and blood products are analyzed using automated blood culture methods, while pharmacopeial sterility is assessed using membrane filtration or direct inoculation according to the European Pharmacopoeia (Ph. Eur. 2.6.1.) to detect microbial growth. As autologous serum eye drops (ASEDs) may be viewed as both a blood product and a classical drug, the Swiss legislator has classified these as non-standardizable drugs, and thus, the pharmacopeial requirements apply. This study investigates ASED preparations with respect to the performance of a common automated blood culture system, BD BACTEC, in detecting aerobic and anaerobic bacteria and fungi in ASED preparations, with pharmacopeial sterility testing using agar plate cultures.</p><p><strong>Methods: </strong>Based on the European Pharmacopoeia, we inoculated sterile filtered blood serum with BioBalls of the six reference strains at a low concentration of three colony-forming units per milliliter (CFU/mL). A test battery of three different BD BACTEC culture media (hereafter referred to as Trio-BACTEC : BD BACTEC Plus Aerobic/F-Medium, BD BACTEC Lytic/10 Anaerobic/F-Medium, BD BACTEC Mycosis IC/F-Medium) and three agar plates [Tryptic Soy Agar (TSA), Chocolate Blood Agar, Sabouraud's Dextrose Agar] were inoculated per strain. We incubated the Trio- BACTEC in the BD BACTEC Blood Culture System at 35 °C for 5 days, the TSA and Chocolate plates at 35 °C for 5 days, and the Sabouraud plates at 25 °C for 7 days. We confirmed positive growth signals by microscopy or MALDI-ToF mass spectrometry and included negative controls.</p><p><strong>Results: </strong>We detected all reference strains using BACTEC and agar plates. No growth was observed in the negative controls. Overall, growth detection by BACTEC and agar plates was comparable, except for <i>Aspergillus brasiliensis</i> and <i>Candida albicans</i>, which was detected after 1 day on solid media and after 2 days on BACTEC.</p><p><strong>Conclusion: </strong>This study demonstrates the comparability of sensitivity and detection speed using the automated blood culture method and agar plates for sterility validation of ASED, even at low bacterial and fungal contamination levels.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes after Implantation of KeraNatural, a Sterile Corneal Allograft Intrastromal Ring Segment (CAIRS), in Eyes with Keratoconus.
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2526-2105
Evelyn-Elisa Benz, Christoph Tappeiner, David Goldblum, Dimitrios Kyroudis
{"title":"Outcomes after Implantation of KeraNatural, a Sterile Corneal Allograft Intrastromal Ring Segment (CAIRS), in Eyes with Keratoconus.","authors":"Evelyn-Elisa Benz, Christoph Tappeiner, David Goldblum, Dimitrios Kyroudis","doi":"10.1055/a-2526-2105","DOIUrl":"https://doi.org/10.1055/a-2526-2105","url":null,"abstract":"<p><strong>Purpose: </strong>To assess and describe the outcomes of corneal allograft intrastromal ring segment (CAIRS) implantation in eyes with keratoconus.</p><p><strong>Methods: </strong>In this retrospective analysis, we examined the early postoperative results of CAIRS (KeraNatural) implantation after cutting a corneal tunnel with a femtosecond laser device (Ziemer Z6) in patients with keratoconus. Outcome measures included best-corrected distance visual acuity (BCDVA), spherical equivalent (SE), maximal keratometry (K<sub>max</sub>), refractive astigmatism (RA), higher-order aberrations (HOAs), and root mean square total aberrations (total RMS), evaluated both before and a variable time after surgery, ranging from at least 30 days to 338 days, with a mean follow-up time of 141.1 ± 79.9 days postoperatively.</p><p><strong>Results: </strong>A total of 17 eyes with keratoconus of 16 patients (mean age of 36.2 ± 17.3 years) were treated. In one eye, previous corneal UVA cross-linking (CXL) was reported in the medical history, and 9 eyes underwent adjunctive CXL at least 1 month postoperatively due to previously documented progressive disease. BCDVA (mean ± SD) improved from preoperative values of 0.43 ± 0.16 logMAR to 0.19 ± 0.14 logMAR postoperatively (p < 0.001). Furthermore, the results show a significant decrease in spherical and astigmatic refraction, with the mean SE decreasing from - 2.9 ± 4.7 D to - 0.7 ± 3.6 D (p = 0.004). Mean RA slightly changed from - 3.42 ± 2.18 D to - 2.51 ± 2.31 D (p = 0.13). Additionally, mean K<sub>max</sub> significantly decreased from 57.3 ± 5.5 D to 51.4 ± 5.7 D (p < 0.001). In the comparison of pre- to postoperative HOA and total RMS values at 4, 5, and 6 mm, a slight tendency for improvement was found; however, these changes were not statistically significant (p > 0.05, each).</p><p><strong>Conclusion: </strong>CAIRS implantation reduced corneal ectasia and improved BCDVA in patients with keratoconus. This highlights its potential as an effective visual rehabilitation strategy, particularly for patients who are intolerant to wearing contact lenses.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-assessment of Knowledge vs. Real Reactions in Simulated Emergency Situations among Contact Lens Wearers in Switzerland. 瑞士隐形眼镜佩戴者在模拟紧急情况下对知识与真实反应的自我评估。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2493-9342
Philipp Perschak, Sadiq Said, Simone Metzler, Sandrine Zweifel, Daniel Barthelmes, Dominique Hermann, Didier Herrmann, Farhad Hafezi, Léonard Kollros, Martina Monika Bosch, Frank Blaser
{"title":"Self-assessment of Knowledge vs. Real Reactions in Simulated Emergency Situations among Contact Lens Wearers in Switzerland.","authors":"Philipp Perschak, Sadiq Said, Simone Metzler, Sandrine Zweifel, Daniel Barthelmes, Dominique Hermann, Didier Herrmann, Farhad Hafezi, Léonard Kollros, Martina Monika Bosch, Frank Blaser","doi":"10.1055/a-2493-9342","DOIUrl":"https://doi.org/10.1055/a-2493-9342","url":null,"abstract":"<p><strong>Background: </strong>If used properly, contact lenses (CLs) provide a safe and effective alternative to eyeglasses for refractive error correction. However, often due to patient noncompliance, CL-related complications may occur, such as discomfort, dry eye, as well as serious conditions like infectious keratitis. Our study aimed to assess the perceived knowledge and behavior of CL wearers in Switzerland regarding the handling of CLs and associated ocular health risks.</p><p><strong>Methods: </strong>This investigator-initiated, cross-sectional, qualitative, multicenter study was conducted in Switzerland from August 2023 to August 2024. After verbal consent, CL wearers were interviewed using a structured survey. The questionnaire explored participants' demographics, their perceived knowledge of the overall handling of CLs and associated health risks, as well as their behavior in two emergency scenarios involving monocular redness or pain. The descriptive statistical analysis was performed using Microsoft Excel (Microsoft Corp., Redmond, WA, USA). Figures were created with Prism version 10.2.3 (GraphPad Software, San Francisco, CA, USA).</p><p><strong>Results: </strong>A total of 172 participants with a median (IQR [range]) age of 39 (27 to 54 [10 to 82]) years were interviewed, whereby 81 (47.1%) were female. Myopia (61.0%) and keratoconus (30.2%) were the most reported indications for CL use. In terms of overall CL handling, 91.3% of participants felt well or sufficiently informed, whereas this was the case of 66.3% regarding CL-related health risks. In the scenario involving eye redness during CL use, 135 of 175 (77.1%) responses did not mention seeking professional advice, while 25 (14.3%) indicated visiting an ophthalmologist within 1 day of symptom onset. In the event of monocular pain, 67 of 179 (37.4%) responses did not consider seeking professional care, whereas 86 (48.0%) included consulting an ophthalmologist.</p><p><strong>Conclusion: </strong>This study provides insight into the unmet educational need of CL wearers, especially regarding CL-related complications. Participants generally felt better informed about overall CL handling than about the potential health risks. This information discrepancy is reflected by their responses to scenarios involving monocular redness or pain, where a considerable number of participants failed to react adequately. Further studies are warranted to explore effective, practical strategies for improving patient awareness and behavior.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous Regression of Postoperative Paracentral Posterior Retinal Folds after Vitrectomy for Rhegmatogenous Pseudophakic Retinal Detachment. 风湿性假性视网膜脱离玻璃体切割术后视网膜中央后皱褶的自然消退
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2521-4013
Amr Saad, Karin Fröse, Gabor Mark Somfai, Matthias Becker
{"title":"Spontaneous Regression of Postoperative Paracentral Posterior Retinal Folds after Vitrectomy for Rhegmatogenous Pseudophakic Retinal Detachment.","authors":"Amr Saad, Karin Fröse, Gabor Mark Somfai, Matthias Becker","doi":"10.1055/a-2521-4013","DOIUrl":"https://doi.org/10.1055/a-2521-4013","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The 2023 Activity Report of the Tissue Transplantation and Biotechnology Section of the German Ophthalmological Society]. [德国眼科学会组织移植和生物技术分会 2023 年活动报告]。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2521-3969
Helga Reinshagen, Daniel Böhringer, Jan Schroeter, Philip Christian Maier
{"title":"[The 2023 Activity Report of the Tissue Transplantation and Biotechnology Section of the German Ophthalmological Society].","authors":"Helga Reinshagen, Daniel Böhringer, Jan Schroeter, Philip Christian Maier","doi":"10.1055/a-2521-3969","DOIUrl":"https://doi.org/10.1055/a-2521-3969","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Outcome of Congenital Obstruction of the Nasolacrimal Duct]. [先天性鼻泪管梗阻的预后]。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2511-6524
Bardh Mulaj, Sarah Patzelt, Karla Chaloupka, Christina Gerth-Kahlert
{"title":"[Outcome of Congenital Obstruction of the Nasolacrimal Duct].","authors":"Bardh Mulaj, Sarah Patzelt, Karla Chaloupka, Christina Gerth-Kahlert","doi":"10.1055/a-2511-6524","DOIUrl":"https://doi.org/10.1055/a-2511-6524","url":null,"abstract":"<p><strong>Background: </strong>Congenital nasolacrimal duct obstruction, a common condition in newborns, is characterised by narrowing of the tear drainage system, often at the nasolacrimal duct. In most cases, the tear duct opens spontaneously within the first year of life, assisted by massage. In cases where there is no improvement, surgical probing may be required. This study aimed to analyse the presentation and outcomes of surgically treated tear duct obstructions in children at our clinic.</p><p><strong>Patients and methods: </strong>A retrospective analysis was conducted using electronic medical records of patients under 18 years of age who were treated for congenital nasolacrimal duct obstruction between 2011 and 2023. Data collected included demographic information, symptoms, stenosis location, surgical therapy, and outcomes. Additionally, parents of the patients were surveyed regarding the postoperative condition and symptomatology. The study was approved by the Cantonal Ethics Commission Zurich (BASEC2022-00830).</p><p><strong>Results: </strong>Of a total of 147 identified patients (39 female, 62 male), 69% could be analysed with available consent. The age at initial examination ranged from 8 months to 12 years (median 27 months). Unilateral stenosis was observed in 69% of cases and bilateral stenosis in 31%. The most common symptoms were epiphora (95%), matted eyelashes (68%), mucous discharge (23%), and redness of the eyelids/conjunctiva (19%). Malformations were identified intraoperatively in 11% of cases. A second probing was necessary in 10% of cases, with ages ranging from 18 to 69 months (median 38 months). Dacryocystorhinostomy was performed in 4% of cases (age 92 - 145 months, median 113 months). Postoperatively, 70.5% reported subjective and/or objective symptom resolution, 22.7% experienced persistent epiphora, and 6.8% had recurrent matted eyelashes. Of the 101 patients surveyed, 77 responded to the questionnaire. Among them, 92% reported that tearing was no longer present, 96% no longer required therapy, 97% reported uncomplicated surgery, 17% experienced recurrent tearing, and 6% required additional non-lacrimal treatments.</p><p><strong>Conclusion: </strong>In most cases, probing and irrigation alone are sufficient for healing. Temporary stent placement is more frequently necessary in older children. An intervention after 18 months of age does not negatively impact healing.</p>","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buckle Dislocation Mimicking Eyelid Tumor. 模拟眼睑肿瘤的扣位脱位。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2506-9381
Eleftherios Chatzimichail, Peter Meyer, Zisis Gatzioufas, Alexandra Steinemann-Inauen
{"title":"Buckle Dislocation Mimicking Eyelid Tumor.","authors":"Eleftherios Chatzimichail, Peter Meyer, Zisis Gatzioufas, Alexandra Steinemann-Inauen","doi":"10.1055/a-2506-9381","DOIUrl":"https://doi.org/10.1055/a-2506-9381","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Toxic Keratopathy Associated with Hydrogen Peroxide.
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2511-6475
Eleftherios Chatzimichail, Alexandra Steinemann-Inauen, Konstantin Gugleta, Nicolas Feltgen, Zisis Gatzioufas
{"title":"Bilateral Toxic Keratopathy Associated with Hydrogen Peroxide.","authors":"Eleftherios Chatzimichail, Alexandra Steinemann-Inauen, Konstantin Gugleta, Nicolas Feltgen, Zisis Gatzioufas","doi":"10.1055/a-2511-6475","DOIUrl":"https://doi.org/10.1055/a-2511-6475","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Toxicity of Anticancer Drugs: A Case Series. 抗癌药物的视网膜毒性:病例系列。
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-27 DOI: 10.1055/a-2521-4104
Nicolò Bartolomeo, Alexandre Déglise, Yannic Pannatier Schuetz, Daniela Gallo Castro, Anna Chiara Nascimbeni, Aude Ambresin
{"title":"Retinal Toxicity of Anticancer Drugs: A Case Series.","authors":"Nicolò Bartolomeo, Alexandre Déglise, Yannic Pannatier Schuetz, Daniela Gallo Castro, Anna Chiara Nascimbeni, Aude Ambresin","doi":"10.1055/a-2521-4104","DOIUrl":"https://doi.org/10.1055/a-2521-4104","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suprachoroidal delivery of corticosteroid slow release implants for the treatment of cystoid macular edema.
IF 0.8 4区 医学
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-02-17 DOI: 10.1055/a-2541-2444
Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger
{"title":"Suprachoroidal delivery of corticosteroid slow release implants for the treatment of cystoid macular edema.","authors":"Ben Asani, Jakob Siedlecki, Julian Klaas, Siegfried Georg Priglinger","doi":"10.1055/a-2541-2444","DOIUrl":"https://doi.org/10.1055/a-2541-2444","url":null,"abstract":"","PeriodicalId":17904,"journal":{"name":"Klinische Monatsblatter fur Augenheilkunde","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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