Quantitative Analysis of Choroidal Vascular Remodeling after Cataract Surgery: Correlation with Preoperative Lens Opacity Grading.

IF 0.7 4区医学 Q4 OPHTHALMOLOGY

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-08-01 Epub Date: 2025-08-21 DOI:10.1055/a-2644-4687

Lars H B Mackenbrock, An Ting L Xu, Grzegorz Łabuz, Victor A Augustin, Timur M Yildirim, Gerd U Auffarth, Ramin Khoramnia

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引用次数: 0

Abstract

Background: Cataract surgery has been shown to induce choroidal remodeling, but the underlying mechanisms remain poorly understood. This study investigates the relationship between preoperative lens opacity and postoperative changes in choroidal vascularity following phacoemulsification.

Methods: This prospective study included 46 eyes from 46 patients undergoing routine cataract surgery. Choroidal vascularity was assessed using optical coherence tomography angiography (OCTA) before surgery and at 1, 4, and 12 weeks postoperatively. The choroidal vascularity index (CVI) was calculated using a custom computer script. Preoperative lens opacity was quantified using anterior segment optical coherence tomography (AS-OCT). Correlations between CVI changes and various surgical and anatomical parameters were analyzed.

Results: The CVI decreased significantly, from 0.584 ± 0.036 preoperatively to 0.569 ± 0.037 at 12 weeks postoperatively (p = 0.003). There was a significant negative correlation between the change in CVI and preoperative lens density (r = - 0.333, p = 0.036), as well as nuclear density (r = - 0.328, p = 0.039). No significant correlations were found between CVI change and cumulative dissipated energy, phacoemulsification time, fluid usage, or intraocular pressure change.

Conclusion: Cataract surgery induces a significant decrease in choroidal vascularity that persists for at least three months postoperatively. This decrease correlates with preoperative cataract density, suggesting that increased light transmission following lens replacement may lead to choroidal remodeling. Consequently, objective measurement of lens opacity may contribute to the decision-making process for timing cataract surgery; however, further studies are needed to evaluate its potential role in minimising short- and long-term complications, such as macular oedema or age-related macular degeneration.

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白内障术后脉络膜血管重构的定量分析：与术前晶状体混浊分级的相关性。

背景：白内障手术已被证明可诱导脉络膜重塑，但其潜在机制尚不清楚。本研究探讨术前晶状体混浊与超声乳化术术后脉络膜血管变化的关系。方法：本前瞻性研究纳入46例常规白内障手术患者的46只眼。术前、术后1周、4周和12周采用光学相干断层扫描血管造影（OCTA）评估脉络膜血管性。脉络膜血管指数（CVI）计算使用自定义的计算机脚本。术前使用前段光学相干断层扫描（AS-OCT）量化晶状体混浊。分析CVI变化与各种手术及解剖参数的相关性。结果：CVI由术前0.584±0.036降至术后12周0.569±0.037 （p = 0.003）。CVI变化与术前晶状体密度（r = - 0.333, p = 0.036）、核密度（r = - 0.328, p = 0.039）呈显著负相关。CVI变化与累积耗散能、超声乳化时间、液体用量或眼压变化无显著相关性。结论：白内障手术引起脉络膜血管的明显减少，这种减少至少持续术后3个月。这种下降与术前白内障密度有关，提示晶状体置换术后光透射增加可能导致脉络膜重塑。因此，客观测量晶状体混浊可能有助于白内障手术时机的决策过程；然而，需要进一步的研究来评估其在减少短期和长期并发症（如黄斑水肿或年龄相关性黄斑变性）方面的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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