Journal of University Medical & Dental College最新文献

{"title":"Three-Pronged Approach to Curb Cancer Metastasis","authors":"Jariya Kalsoom, Sadaf Naeem","doi":"10.37723/jumdc.v14i1.791","DOIUrl":"https://doi.org/10.37723/jumdc.v14i1.791","url":null,"abstract":"BACKGROUND & OBJECTIVE: Extracellular signal-regulated kinases 1 and 2 [ERK1/2] have been reported to promote cancer spread through receptor tyrosine kinase (RTK)/Ras/Raf/MEK/ERK1/2 pathway hyperactivation. The extracellular signal-regulated kinase ERK5 has also been linked to cancer. However, inhibition of ERK1/2 has been reported to cause compensatory hyperactivation of the ERK5 pathway. Therefore, there is a need for simultaneous inhibition of this trio by a common inhibitor. This study aimed to find a novel common inhibitor for ERK1, ERK2 and ERK5, with a special focus on phytochemicals. \u0000METHODOLOGY: All the available co-crystallized inhibitors of MEK1, ERK1/2 and ERK5 were used as references for 2D search across zillions of compounds. One hundred molecules with the best matching pharmacophores were extracted per virtual chemical space. A total of 20,000 new structurally diverse chemical entities with scaffold hopping ability were sifted out from these chemical spaces. Virtual screening of ERK1/2 and ERK5 was performed against these compounds. The successfully docked molecules with estimated affinities less than 500 nm were filtered. These filtered protein-molecule complexes of ERK1/2 and ERK5 were exported as Excel sheets, which were then compared to find any overlapping inhibitors. Four novel common/overlapping potential inhibitors were identified. Their pose views were generated, and binding interactions were analyzed. These novel compounds were compared for their absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) properties. \u0000RESULTS: The molecules m240690bcc215667167368734, rxn109fEMOL37110279EMOL314046334 and LIND027BT1904LN00213276AK0086 showed good binding affinities to the conventional ATP binding pockets of the kinases ERK1/2 and ERK5. \u0000CONCLUSION: These novel compounds may be proposed as potential common inhibitors of ERK1, 2 and 5. Further in silico analysis and in vitro testing of proteins are required to confirm their inhibitory potential.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115918367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of frequency of Hypoparathyroidism in Total Thyroidectomy (TT) versus Near-Total Thyroidectomy (NTT) patients","authors":"Sajid Rehman Randhawa, Muhammad Saleem Iqbal, Tayyaba Fatima, Iqra Khalid, Muhammad Sajid","doi":"10.37723/jumdc.v14i1.753","DOIUrl":"https://doi.org/10.37723/jumdc.v14i1.753","url":null,"abstract":"BACKGROUND & OBJECTIVE: Hypoparathyroidism in total thyroidectomy and near-total thyroidectomy is debatable. This study will determine the procedure of choice. Our objective is to compare the frequency of hypoparathyroidism in total thyroidectomy versus near-total thyroidectomy patients. \u0000METHODOLOGY: Prospective observational study was conducted at the Department of Surgery, Allied Hospital, Faisalabad. The study duration was six months. A total of 140 patients having multinodular goiter, 30-70 years of age, were selected. Patients were divided into two groups. In group A; patients underwent total thyroidectomy while in group B; patients were offered near-total thyroidectomy. All the parathyroid glands were preserved. In all patients, serum calcium levels and parathyroid hormone (PTH) levels were checked on 1st & the 2nd day after surgery. \u0000RESULTS: Mean age in group A was 48.06±8.21 years & in group B was 48.83 ± 7.0 years. The majority of patients, 88 (62.86%) were between 30 to 50 years of age. Out of these 140 patients, 37 (26.43%) were males & 103 (73.57%) were females, with the ratio of 1:2.8. Mean pre-operative serum Parathyroid hormone was 25.67±9.87 pg/mL. The mean postoperative serum Parathyroid hormone was 16.87±2.43 pg/mL. Mean pre-operative serum calcium levels were 11.32 ± 4.52 mg/dl and mean postoperative serum calcium levels were 9.4 ±0.45mg/dl. In this study, the frequency of Hypoparathyroidism in the total thyroidectomy group (28.57%) was significantly higher than near-total thyroidectomy (8.57%) (p=0.002). \u0000CONCLUSION: Hypoparathyroidism is more common after total thyroidectomy as compared to near-total thyroidectomy.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122714610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress levels among pre-clinical Medical students and their coping strategies","authors":"Muhammad Hasnat Akhtar, Anum Ashfaq, Ahmed Murtaz Khalid, Mukhtiar Baig","doi":"10.37723/jumdc.v14i1.783","DOIUrl":"https://doi.org/10.37723/jumdc.v14i1.783","url":null,"abstract":"BACKGROUND & OBJECTIVE: Stress is no doubt prevalent among medical students. Insight into how different personality types cope with this challenge might give the opportunity to healthcare authorities to devise a more standardized guideline for conducting a psychological aptitude test at the time of intake into medical school. Our objective is to look at the stress and anxiety among medical students and how different personality types cope with stress. \u0000METHODOLOGY: A Cross-sectional descriptive study was carried out at CMH Kharian Medical College from November 2020 to May 2021. Agha Khan University, Anxiety and Depression Scale was employed to assess stress and anxiety levels among medical students. Myers–Briggs Type Indicator (MBTI) was used to identify personality traits, and the “Brief COPE Inventory Scale” was employed to investigate stress coping styles(approach or avoidant) among students. SPSS was used to analyze the results. \u0000RESULTS: Out of 158 participants, 108(68.4%) were females, and 50(31.6%) were males. More than half of the preclinical medical students, 93(58.86%) were having stress [females 73(67.59%), males 20(40%)]. Personality types showed that 100(63.3%) students belonged to the introvert group, while 58(36.7%) students belonged to the extrovert group. Most participants, 144(91%) students, adopted approach coping styles rather than avoidant ones (14 (8.86%). Stress was significantly associated with personality types (p=0.021), coping style (p=0.007), and gender (female) (p=0.001). However, we did not find any association between personality types & coping styles (p=0.936). \u0000CONCLUSION: High level of stress and anxiety (58.86%) was found among students and was more prevalent among females and extroverted medical students. Both personality types (extroverts and introverts) used approach coping styles rather than avoidant trends.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"23 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131840642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of clinical manifestation of lumbar disc prolapse with magnetic resonance imaging findings among adult patients","authors":"Hamna Nasir, Muhammad Usman Sarwar, Sumair Nasim Qureshi, Manqoosh-ur-Rehman, Amjad Maqsood, Saba Saif","doi":"10.37723/jumdc.v13i4.764","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.764","url":null,"abstract":"BACKGROUND & OBJECTIVE: The most common cause of low back pain is disc prolapse. Disc prolapse occurs in both gender, but females are more prone to disc degenerative changes. The aim of this study was to determine the correlation between clinical findings and MRI findings of lumbar disc prolapse patients. \u0000METHODOLOGY: This study recruited 32 participants of either gender, between the ages of 19 to 65, in the Radiology department of Shalamar Hospital. This study was carried out in six months with follow-up. Only diagnosed patients with lumbar disc prolapse on MRI were recruited. NPRS was used to identify the intensity of pain. History and neurological examinations were done in all diagnosed patients. MRI reports of all these patients were reviewed. All these findings of MRI were correlated with the clinical findings at different levels of lumbar vertebrae. \u0000RESULTS: There was a statistically significant positive correlation of MRI findings with clinical findings in the presence of nerve root compression at the L1-L2 level of lumbar vertebrae. All abnormal findings on MRI did not correlate with clinical findings because some patients did not produce symptoms. According to the Pearson coefficient correlation, there was a positive but insignificant  (p-value≥0.05) correlation between clinical features (sensations, power and reflexes) and MRI findings at all the levels of lumbar vertebrae except L2 dermatome and myotome. \u0000CONCLUSION: There was a not good correlation between MRI findings and clinical findings of patients with lumbar disc prolapse except L2.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121856254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health care in Afghanistan: The need of the hour","authors":"Tauseef Ahmad, Iqra Mushtaque, Saba Tariq, Sundus Tariq","doi":"10.37723/jumdc.v13i4.793","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.793","url":null,"abstract":"The COVID-19 pandemic has seriously devastated the national, regional, and international health-care systems and thus opened some new windows for health-related issues and challenges. Afghanistan was one of the most affected countries during the COVID-19 crisis. Afghanistan is a landlocked country situated at the crossroads of Central and South Asia. In 2021, the country's population was over 40 million. The Afghan people suffered badly as a result of the United States' longest war. The United States military service members left Afghanistan on August 30, 2021 [1], declaring the end of the United States invasion of two decades. As a result of the United States war, the poor healthcare system and humanitarian crisis have significantly affected the mental health of Afghan people. Mental health has remained a significant and often discussed issue over the years. However, the COVID-19 pandemic, political instability, and the current earthquake have doubled the intensity of mental health issues in Afghanistan. Afghans suffering from mental illnesses seek treatment despite personal, cultural, and institutional barriers such as poverty, social marginalization, humiliation, gender discrimination, and ongoing violence [2]. The mental health of adolescents has been damaged by the ongoing violence in Afghanistan. In a sample of 1011 Afghan adolescents, 224 (22.2%) had emotional problems, 49 (4.9%) had behavioral issues, and 242 (23.9%) had posttraumatic stress disorder (PTSD). In Afghanistan, being younger was a risk factor for having poor mental health [3]. Depression and anxiety disorders are relatively common, particularly among women and children. Gender segregation (known as \"purdah\") in Afghanistan, sexual abuse against women, and war-related traumatic losses are all key risk factors for the development of depression and anxiety disorders in women. Exposure to war-related violence is thought to induce a high rate Most importantly, efforts must be made at a national or regional level to overcome barriers to accessing mental health care in Afghanistan. The mobile clinic, which is financed by USAID and WHO, administers important immunizations to children. Through outreach and education, the mobile health team improved the community's perspective on vaccines. After learning about the advantages of vaccinations, nearly all families vaccinate their children regularly [5]. There is a dire need for increased funding for mental health and to establish mobile mental health care facilities across the country on an urgent basis. International funding agencies, organizations, and governments should cooperate with the Afghan government to overcome this humanitarian crisis. https://doi.org/10.37723/jumdc.v13i4.793 J. Univ. Med. Dent. Coll.2022;Vol.13(4): v-vi ISSN (Print) 2221-7827, ISSN (Online) 2310-5542 https://www.jumdc.com","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130847981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Dentists regarding Brain Drain in Punjab, Pakistan: A Cross-sectional Survey","authors":"Arooj Ul Hassan, Naiha Muzamil, Mehrin Wajahat, Zunaira Iqbal, Obaid Bajwa","doi":"10.37723/jumdc.v13i4.726","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.726","url":null,"abstract":"BACKGROUND & OBJECTIVE: Brain drain is a term coined for the migration of highly skilled professionals from the country of their origin to more developed countries. As the trend of moving abroad is on a rise, ever since, it is causing a shortage of dental professionals in our country. The objective of our study is to determine the factors that would compel the dentists of Punjab, Pakistan, to move abroad and how to prevent this migration. \u0000METHODOLOGY: It was a cross-sectional survey. Data was collected through a self-constructed and validated questionnaire. The study was done in dental colleges in Punjab, and the duration of the study was one year. The questionnaire was distributed both by hand and via digital sources. \u0000RESULTS:  There were 155 (33.4%) participants, who were planning to go abroad for higher education, and 274 (59%) had not planned to go out of the country for further studies. Among the study participants, 50 (32.3%) participants were planning to move to the United Kingdom, whereas 23 (14.8%) participants were planning to go to Australia, 44 (28.3%) wanted to move to the US, 10 (6.4%) to Canada and the rest (18%) had plans to move to any other country. \u0000CONCLUSION: The majority of dental graduates wish to go abroad for their post-graduation. The dentists of Punjab were willing to serve their country, provided the economic and political situations improved.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121934588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Medicine: A new take on an old practice","authors":"Sumera Shahzad","doi":"10.37723/jumdc.v13i4.794","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.794","url":null,"abstract":"Comprehensive Primary health care in Pakistan is lagging behind the developed world because number of medical graduates choosing family medicine as a career is sparse. Majority of Pakistani population is without adequate access to the health care system. Family medicine is a field in which complete and comprehensive healthcare services are provided to the patients and their families. It deals with not only prevention and screening but also diagnosis and firsthand treatment of many acute and chronic health problems [1]. Family physician can provide health care for almost all sorts of problems encountered in ambulatory setting and can play a key role in integration of primary health care with secondary and tertiary health services [2].","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116327271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the frequency of Plummer Vinson Syndrome among patients having dysphagia presenting at district Bahawalpur","authors":"Nasir Wakeel, Masood Akhtar, Aasma Tariq, Iqra Gull, Hamna Hafeez, Nayab Anjum","doi":"10.37723/jumdc.v13i4.698","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.698","url":null,"abstract":"BACKGROUND & OBJECTIVE: Plummer Vinson syndrome (PVS) is a rare triad of dysphagia, iron deficiency, and esophageal webs. This study aims to assess the frequency of PVS in patients presenting with dysphagia. \u0000METHODOLOGY: A cross-sectional study was conducted at the Department of Otolaryngology from 1st April 2020 to 31st March 2021. A total of 164 patients having dysphagia for a minimum of two weeks duration were enrolled. The patient's data was recorded using a pre-designed questionnaire for PVS assessments, complete blood count, serum ferritin levels and barium swallow test results were obtained, and a radiologist was consulted for the upper esophageal web. \u0000RESULTS: The observed frequency of PVS among patients with dysphagia was 11(6.7%). Female gender turned out to be significantly associated with PVS occurrence (p=0.001), while age (p=0.748) and duration of dysphagia (p=1.00) showed no significant association with it. Among those with PVS, 72.7% of patients were >40 years of age, 90.9% were females, and 81.8% had a duration of dysphagia >4 weeks.  \u0000CONCLUSION: It is concluded that PVS is not very frequent among patients with dysphagia. But since it increases the risk of squamous cell carcinoma of the pharynx and the esophagus, therefore, such patients should be followed closely for the presence of PVS and treated promptly to avoid morbidity and mortality.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124864215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the use of intravenous iron sucrose with intravenous ferric Carboxymaltose for treatment of iron deficiency anaemia in pregnant patients","authors":"Khar Un-Nisa, Rukhsana Shaheen Afzal, Faiza Safdar, Noreen Majeed, Shabana Kalsoom, Irum Mushtaq","doi":"10.37723/jumdc.v13i4.766","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.766","url":null,"abstract":"BACKGROUND & OBJECTIVE: Iron deficiency results in major disabilities and death all over the world, about two billion people are suffering from anaemia at the moment. To compare intravenous iron sucrose with intravenous ferric carboxymaltose in terms of mean change in hemoglobin level and mean corpuscular volume (MCV) for treatment of iron deficiency anaemia in pregnant patients. \u0000METHODOLOGY: Prospective comparative study was conducted at the department of Obstetrics/ Gynecology of POF Hospital Wah Cantt and HIT Hospital Taxila Cantt. The study duration was 2 years, from January 2017-December 2018. A total of 80 patients were included in the study. Patients were randomly divided into two groups; in Group-A; 40 patients were given intravenous iron sucrose, and in Group B, 40 patients were given intravenous ferric carboxymaltose. Patients were observed for hemoglobin level and mean corpuscular volume (MCV). Data analysis was done with SPSS version 24. An Independent t-test was applied, and results with p-value ≤0.05 were found significant. \u0000RESULTS: Post-treatment hemoglobin means level in the iron sucrose group was 9.90±0.4SD, and in the intravenous ferric carboxymaltose group, post-treatment hemoglobin was 10.71±0.9SD (p≤0.001). In the iron sucrose group, the post-treatment mean corpuscular volume mean level was 81.94±6.0SD and in the intravenous ferric carboxymaltose group mean post-treatment mean corpuscular volume was 88.08±7.1SD (p≤0.001) \u0000CONCLUSION: Treatment with intravenous iron caboxymaltose is superior to intravenous iron sucrose with respect to hematological response, which seems to be safe, as very few severe side effects were observed.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126410137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Piperacillin-Tazobactam induced Hypersensitivity Reaction in Workers of Stallion’s Pharmaceutical Factory at Lahore","authors":"Anwar Ali Sulehri, Hafiz Muhammad Hammad Yaqub, Humayun Suqrat Hassan Imam, Uzma Sagheer, Muhammad Abubakar","doi":"10.37723/jumdc.v13i4.718","DOIUrl":"https://doi.org/10.37723/jumdc.v13i4.718","url":null,"abstract":"BACKGROUND & OBJECTIVE: Piperacillin is an antibiotic that belongs to the ureidopenicillin family. Piperacillin-tazobactam provides cover against gram-positive, gram-negative bacteria and some bacteria of anaerobic nature. It is an extended-spectrum antibiotic and is used along with tazobactam which is an inhibitor of beta-lactamase. The main objective of our research was to identify the hypersensitivity reactions of piperacillin-tazobactam in pharmaceuticals factory and office workers. \u0000METHODOLOGY: A Cross-sectional study was conducted at Stallion Pharmaceuticals (Pvt) Ltd located at Sundar Industrial Estate Lahore, Pakistan, from March to April 2018, after approval from the institutional research committee. All the workers, including factory workers and office workers at Stallion Pharmaceuticals (Pvt) Ltd were included in this study. Data was collected from each respondent by immediate-type skin testing. Data analysis was done by SPSS version 25, the demographic data was evaluated by descriptive statistics, Fisher Exact test was used for comparison and p≤0.05 was taken as significant. \u0000RESULTS: The results of the study presented that hypersensitivity reaction was present in (7.5%) of males and (3.8%) of females. It was also observed that (8.8%) of factory workers had hypersensitivity reactions when they are gone through skin tests, and only (2.5%) of office workers were skin test positive. From the above results (11.2%) of all the respondents developed hypersensitivity reactions and (88.8%) showed no reaction when they were gone through skin tests, which contain 0.1 ml of piperacillin and tazobactam. Fisher exact test was applied, and results showed no significant difference between hypersensitivity reactions among factory and office workers as the p-value was 01. \u0000CONCLUSION: Hypersensitivity reaction to piperacillin-tazobactam was minimal in the factory & office workers, and this was not significant.","PeriodicalId":178216,"journal":{"name":"Journal of University Medical & Dental College","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122533169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}