An S. De Vriese , Sanjeev Sethi , Fernando C. Fervenza
{"title":"The authors reply","authors":"An S. De Vriese , Sanjeev Sethi , Fernando C. Fervenza","doi":"10.1016/j.kint.2025.01.030","DOIUrl":"10.1016/j.kint.2025.01.030","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 5","pages":"Pages 937-938"},"PeriodicalIF":14.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Hanna , Matthew L. Basiaga , Justin T. Kastl , Tiffany N. Caza , Sanjeev Sethi , Samih H. Nasr
{"title":"PCSK6-associated membranous nephropathy in an adolescent with Sjögren disease","authors":"Christian Hanna , Matthew L. Basiaga , Justin T. Kastl , Tiffany N. Caza , Sanjeev Sethi , Samih H. Nasr","doi":"10.1016/j.kint.2024.12.022","DOIUrl":"10.1016/j.kint.2024.12.022","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 5","pages":"Pages 940-942"},"PeriodicalIF":14.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibroblast growth factor (FGF) 23 and FGF receptor 4 induced cardiac mitochondrial dysfunction as a new target in CKD?","authors":"Dieter Haffner , Maren Leifheit-Nestler","doi":"10.1016/j.kint.2025.02.017","DOIUrl":"10.1016/j.kint.2025.02.017","url":null,"abstract":"<div><div>Chronic kidney disease is associated with excessive cardiovascular mortality, which is promoted by the phosphaturic hormone fibroblast growth factor 23 (FGF23). Increased FGF23 levels result in left ventricular hypertrophy via activation of the FGF receptor 4 activation. Fuchs <em>et al.</em> now demonstrate, using bioengineered cardiobundles, neonatal rat ventricular myocytes, and mice with chronic kidney disease, that FGF23–FGF receptor 4 activation is a potential mechanism of cardiac mitochondrial dysfunction and metabolic remodeling as early complications of chronic kidney disease, preceding structural cardiac changes.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 5","pages":"Pages 782-784"},"PeriodicalIF":14.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From MC1R to MC5R, a new horizon for the podoprotective effect of melanocortin","authors":"Hua Sun","doi":"10.1016/j.kint.2025.01.026","DOIUrl":"10.1016/j.kint.2025.01.026","url":null,"abstract":"<div><div>The successful use of adrenocorticotropic hormone in treating proteinuric glomerulopathies attached new importance to the melanocortin receptors. While MC1R was originally identified as the receptor mediating melanocortins’ podoprotection, Chen <em>et al.</em>’s work in this issue highlights the role of MC5R in maintaining podocyte integrity in the face of stressors, by modulating glycogen synthase kinase-3 β signaling. These findings fill in a gap about melanocortin signaling in podocytes, supporting the therapeutic potential of MC5R agonism, while prompting questions for discussion.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 5","pages":"Pages 779-781"},"PeriodicalIF":14.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kidney organoids: a 3-dimensional tool to unmask permeability factors in primary and recurrent FSGS","authors":"Federica Casiraghi , Giuseppe Remuzzi","doi":"10.1016/j.kint.2025.02.013","DOIUrl":"10.1016/j.kint.2025.02.013","url":null,"abstract":"<div><div>Primary focal segmental glomerulosclerosis is a glomerular disorder associated with a high risk of recurrence after transplantation. Compelling evidence supports the existence of circulating permeability factors whose identity remains elusive. In the current issue of <em>Kidney International</em>, Gupta <em>et al.</em> propose that kidney organoid can respond to these factors in patients with focal segmental glomerulosclerosis and may serve as a potential platform for predicting disease recurrence. Future studies are required to identify the critical factors driving focal segmental glomerulosclerosis recurrence and to develop a standardized organoid platform for predicting clinical outcome.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 5","pages":"Pages 785-787"},"PeriodicalIF":14.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}