肾类器官：揭示原发性和复发性FSGS通透性因素的三维工具

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2025-04-18 DOI:10.1016/j.kint.2025.02.013

Federica Casiraghi , Giuseppe Remuzzi

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引用次数: 0

摘要

原发性局灶节段性肾小球硬化症是一种肾小球疾病，移植后复发的风险很高。有确凿证据表明存在循环渗透因子，但这些因子的身份仍然难以确定。在本期《国际肾脏》（Kidney International）杂志上，Gupta 等人提出，在局灶节段性肾小球硬化症患者中，肾脏类器官可对这些因素做出反应，并可作为预测疾病复发的潜在平台。未来的研究需要确定驱动局灶节段性肾小球硬化复发的关键因素，并开发一个用于预测临床结果的标准化类器官平台。

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Kidney organoids: a 3-dimensional tool to unmask permeability factors in primary and recurrent FSGS

Primary focal segmental glomerulosclerosis is a glomerular disorder associated with a high risk of recurrence after transplantation. Compelling evidence supports the existence of circulating permeability factors whose identity remains elusive. In the current issue of Kidney International, Gupta et al. propose that kidney organoid can respond to these factors in patients with focal segmental glomerulosclerosis and may serve as a potential platform for predicting disease recurrence. Future studies are required to identify the critical factors driving focal segmental glomerulosclerosis recurrence and to develop a standardized organoid platform for predicting clinical outcome.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.