Kidney international最新文献

{"title":"Urinary C-X-C-motif ligand 9 (CXCL9) in immune checkpoint inhibitor-associated acute interstitial nephritis.","authors":"Shruti Gupta, Kavita Mistry, Firasat M Alikhan, Sherley M Mejia, Sagar Sadarangani, Andrew Cao, Sophia L Wells, Emma Koval, Cathleen Liang, Jessica L Ortega, Leyre Zubiri, Joie Sun, Aleigha R Lawless, Alexa C Peterkin, Isabela J Kernin, Roya Best, Thomas J Otten, Karla Sofia Yamada, Wassim Obeid, Ryan Sullivan, Harriet Kluger, Elizabeth I Buchbinder, Kerry L Reynolds, Alexandra-Chloé Villani, Chirag R Parikh, Dennis G Moledina, Meghan E Sise","doi":"10.1016/j.kint.2025.05.029","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.029","url":null,"abstract":"<p><strong>Introduction: </strong>Immune checkpoint inhibitor-associated acute interstitial nephritis presents significant clinical challenges. There are no reliable non-invasive biomarkers and kidney biopsy remains the gold standard for diagnosis. Prior studies have shown that urinary C-X-C-motif ligand 9 (CXCL9) is upregulated in patients with acute interstitial nephritis. However, its utility, specifically in patients with cancer treated with immune checkpoint inhibitors, is not well-understood.</p><p><strong>Methods: </strong>We used proteomics followed by sandwich immunoassay to analyze urinary proteins among a multicenter cohort of prospectively enrolled participants with and without immune checkpoint inhibitor-associated acute interstitial nephritis.</p><p><strong>Results: </strong>Among 79 participants receiving immune checkpoint inhibitors, proteomics identified urine CXCL9 as the top-performing urinary biomarker differentiating 38 patients with biopsy-proven acute interstitial nephritis from other forms of acute kidney injury. We validated these results using immunoassay in an expanded cohort of 116 patients, observing higher CXCL9 levels in immune checkpoint inhibitor-associated acute interstitial nephritis compared to several control groups. Urinary CXCL9 was strongly associated with immune checkpoint inhibitor-associated acute interstitial nephritis, with a receiver operating characteristic curve of 0.84, inter quartile range [0.74, 0.93] when compared to other forms of acute kidney injury, and an even higher discrimination when compared with all control groups (0.90, [0.83-0.96]).</p><p><strong>Conclusions: </strong>Urinary CXCL9 demonstrated high discrimination for differentiating acute interstitial nephritis from other forms of acute kidney injury in participants on immune checkpoint inhibitor therapy. Our findings demonstrate the significant potential of this biomarker for non-invasive diagnosis of immune checkpoint inhibitor-associated acute interstitial nephritis.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease.","authors":"Xinyue Mao, Lu Li, Geoffray Lee, Ewud Agborbesong, Julie Xia Zhou, James P Calvet, Xiaogang Li","doi":"10.1016/j.kint.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.027","url":null,"abstract":"<p><strong>Introduction: </strong>Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, life threatening inherited kidney diseases. In the kidney, senescence is accumulated in different renal cells, which are in a state of permanent cell cycle arrest and the development of a senescence-associated secretory phenotype (SASP) in response to stresses. However, the role of cellular senescence in ADPKD remains elusive.</p><p><strong>Methods: </strong>Here, using different senescence markers, sendolytic drugs, and transgenic INK-ATTAC mice, we define the role of senescence in ADPKD. Additionally, we identify SASP by using our single-cell RNA sequencing database to monitor differential gene expressions in mutant and control mouse kidneys.</p><p><strong>Results: </strong>Senescence is increased in Pkd1 mutant mice and human ADPKD kidneys. Treatment with D-galactose, an inducer of senescence, promotes cyst progression, whereas treatment with senolytic drugs, including dasatinib (D), quercetin (Q), and D plus Q, delay disease progression in Pkd1 mutant kidneys. Clearance of p16^Ink4a positive senescent cells delayed cyst growth in Pkd1^RC/RC:INK-ATTAC mice, supporting a direct role of those cells in promoting cystogenesis in ADPKD. The secretion of SASP from senescent Pkd1 mutant cells induces senescence in neighboring cells and increases kidney epithelial cell proliferation and the activation of fibroblasts. We identify AKR1B1 (aldose reductase) as one of the Pkd1 gene mutation-associated SASP factors. Targeting AKR1B1 with its non-competitive and reversible inhibitor epalrestat, delayed cyst growth in Pkd1 mutant mouse kidneys.</p><p><strong>Conclusions: </strong>Our study supports the idea that senescence-targeting interventions including senolytics, removal of p16 positive senescent cells, and inhibition of AKR1B1 are promising therapeutic strategies to delay cyst growth in ADPKD.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medium chain fatty acids are potent binding competitors to improve protein-bound uremic toxin clearance during hemodialysis.","authors":"Laure-Anne Raillon, Nans Florens, Florine Payelle, Marie Martin, Laurent Soulère, Dan Yi, Zoé Simon-Onfroy, Stéphane Chambert, Marie Legras, Laurence Chardon, Griet Glorieux, Fitsum Guebre-Egziabher, Christophe O Soulage","doi":"10.1016/j.kint.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.kint.2025.06.004","url":null,"abstract":"<p><strong>Introduction: </strong>Protein-bound uremic toxins (PBUTs) remain a concerning burden in patients with kidney failure since their removal during hemodialysis is limited due to their tight binding to albumin. Here, we test whether medium chain fatty acids (MCFAs), potent ligands of human serum albumin (HSA), could be used as binding competitors of PBUTs to increase their removal during a hemodialysis session.</p><p><strong>Methods: </strong>A simulated hemodialysis session was performed using bovine blood spiked with PBUTs in the presence of various MCFAs. Blood was sampled serially to measure the concentrations of PBUTs indoxyl sulfate (IS) and p-cresyl sulfate (p-CS).</p><p><strong>Results: </strong>The binding of MCFAs to HSA was investigated in silico and using fluorescent probe displacement. The free fraction of IS and p-CS were measured after ultrafiltration of HSA solutions and uremic plasma in the presence of MCFAs (0.25-3 mmol/L). Among the five MCFAs tested, octanoate and decanoate were the most prone to interact with HSA Sudlow site II, one of two main binding sites on HSA. The in vitro incubation of HSA solutions and uremic plasma with MCFAs increased the free fraction of IS and p-CS. The per-dialytic infusion of octanoate significantly improved the fractional removal of p-CS from 38% to 88% and IS from 36% to 91%.</p><p><strong>Conclusions: </strong>MCFAs can effectively compete with PBUTs for binding to HSA. The per-dialytic administration of octanoate, which strikingly increased the removal of PBUTs, could constitute an efficient and cost-effective strategy to improve the possible clearance of these compounds and prevent their accumulation in patients with kidney failure.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and perspective for rare genetic kidney diseases","authors":"Chen Xiaoyi, Burgun Anita, Boyer Olivia, Knebelmann Bertrand, Garcelon Nicolas","doi":"10.1016/j.kint.2025.03.033","DOIUrl":"https://doi.org/10.1016/j.kint.2025.03.033","url":null,"abstract":"The integration of big data and artificial intelligence (AI) has revolutionized biomedicine, enhancing our understanding of diseases and healthcare practices. While AI has shown remarkable success in some medical fields, its application in nephrology faces challenges due to the complex disease mechanisms and intricate physiology. These obstacles are further compounded in rare diseases, affecting fewer than 1 in 2000 people, where data scarcity and clinical complexities create additional challenges for AI in accurate disease characterization and prediction.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"26 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscription Information","authors":"","doi":"10.1016/S0085-2538(25)00356-4","DOIUrl":"10.1016/S0085-2538(25)00356-4","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Page A2"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The authors reply","authors":"Rebecca Preston ,&nbsp;Mychel R.P.T. Morais ,&nbsp;Leo Zeef ,&nbsp;Qing-Jun Meng ,&nbsp;Rachel Lennon","doi":"10.1016/j.kint.2025.03.001","DOIUrl":"10.1016/j.kint.2025.03.001","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Pages 151-152"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid management in acute kidney injury should be liberal when needed","authors":"Kathleen D. Liu","doi":"10.1016/j.kint.2025.02.003","DOIUrl":"10.1016/j.kint.2025.02.003","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Pages 24-27"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4-related tubulointerstitial nephritis with negative contrast-enhanced computed tomography: diagnostic insights from 18F-fluorodeoxyglucose–positron emission tomography/computed tomography","authors":"Rina Tanaka ,&nbsp;Satoshi Hara ,&nbsp;Hideaki Aihara ,&nbsp;Takumi Toishi ,&nbsp;Mari Ikeda ,&nbsp;Atsuro Kawaji ,&nbsp;Masatoshi Matsunami ,&nbsp;Tomo Suzuki","doi":"10.1016/j.kint.2025.02.031","DOIUrl":"10.1016/j.kint.2025.02.031","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Page 154"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALECT2 amyloidosis in a patient with myeloma cast nephropathy","authors":"Lihong Bu ,&nbsp;Samar M. Said ,&nbsp;Matthew T. Howard ,&nbsp;Samih H. Nasr","doi":"10.1016/j.kint.2024.12.024","DOIUrl":"10.1016/j.kint.2024.12.024","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Page 155"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Q fever endocarditis and glomerulonephritis","authors":"Wanyin Hou ,&nbsp;Yuxuan Yao ,&nbsp;Dandan Dun ,&nbsp;Yulong Xia ,&nbsp;Xiaojuan Yu ,&nbsp;Xu Zhang ,&nbsp;Lei Jiang ,&nbsp;Suxia Wang ,&nbsp;Meng Tan ,&nbsp;Zhao Cui ,&nbsp;Zhiying Li ,&nbsp;Xihui Li ,&nbsp;Fude Zhou","doi":"10.1016/j.kint.2024.12.023","DOIUrl":"10.1016/j.kint.2024.12.023","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 1","pages":"Page 156"},"PeriodicalIF":14.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}