Barnaby Hole,Rachael Walker,Nicole Scholes-Robertson,Rachael L Morton,Lucy E Selman
{"title":"Patient preferences for kidney failure treatments.","authors":"Barnaby Hole,Rachael Walker,Nicole Scholes-Robertson,Rachael L Morton,Lucy E Selman","doi":"10.1016/j.kint.2025.05.035","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.035","url":null,"abstract":"This review considers what is important to people making decisions about their kidney failure care. We begin by introducing the concept of preferences and how preference-sensitive decision-making is central to person-centered care. Next, we explore the preferences that patients have in relation to kidney failure care and the attributes of available treatments. We examine how decisions are made about kidney failure treatments and consider whether preference-sensitive care is widespread. Finally, we make recommendations regarding how kidney services could be reshaped to ensure that people's preferences guide the healthcare they receive. We conclude that people's preferences can guide decisions between treatments for kidney failure only if clinicians and systems facilitate this. The best treatment for a person is the one that fits best with what is important to them. The science of nephrology involves optimal delivery of treatments that prolong life, preserve and replace organ function. The art lies in shaping this care to the person.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"53 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Critique of “Repression of PGC-1α leads to loss of mitochondrial homeostasis, contributing to maladaptive kidney repair”","authors":"Javeria Kashaf Zain , Iftikhar Khan , Sozen Rehman , Aisha Nayab Babar","doi":"10.1016/j.kint.2025.04.020","DOIUrl":"10.1016/j.kint.2025.04.020","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Page 329"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes","authors":"Laith F. Al-Rabadi , Laurence H. Beck Jr.","doi":"10.1016/j.kint.2025.05.009","DOIUrl":"10.1016/j.kint.2025.05.009","url":null,"abstract":"<div><div>Proteases, such as A disintegrin and metalloproteinase 10, can cleave the extracellular domains of transmembrane proteins and trigger a subsequent regulated intramembrane proteolysis step that releases the cytosolic domain into the cell. In this issue, Rosenbaum <em>et al.</em> unraveled the role of A disintegrin and metalloproteinase 10 in the podocyte by showing that it can release the ectodomains of the membranous nephropathy target antigens phospholipase A2 receptor 1 and thrombospondin type 1 domain–containing 7A as well as the adhesion molecule β-dystroglycan.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 176-178"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the Mayo prediction tool for MGRS ready for prime time?","authors":"Jack F. Wetzels","doi":"10.1016/j.kint.2025.05.010","DOIUrl":"10.1016/j.kint.2025.05.010","url":null,"abstract":"<div><div>Kidney disorders caused by a monoclonal Ig (monoclonal gammopathy of renal significance) are now considered treatable kidney diseases. Because chronic kidney disease and monoclonal gammopathy of undetermined significance occur frequently at older ages and because monoclonal gammopathy of renal significance is rare, it is difficult to select the right patient for a kidney biopsy. The “Mayo MGRS Prediction Tool” was developed to assist in decision making. Although there is some value in using the calculator, there are many caveats. Clinicians should be aware of the biases and limitations of the study before using the calculator in their routine practice.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 178-181"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}