足细胞得到一个足疗：小指甲钳足细胞足突

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2025-07-18 DOI:10.1016/j.kint.2025.05.009

Laith F. Al-Rabadi , Laurence H. Beck Jr.

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引用次数: 0

摘要

蛋白酶，如A崩解素和金属蛋白酶10，可以切割跨膜蛋白的胞外结构域，并触发随后受调节的膜内蛋白水解步骤，将胞质结构域释放到细胞中。在这一期中，Rosenbaum等人揭示了A崩解素和金属蛋白酶10在足细胞中的作用，表明它可以释放膜性肾病靶抗原磷脂酶A2受体1和含7A的血栓反应蛋白1型结构域的外畴以及粘附分子β-糖代谢障碍。

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The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes

Proteases, such as A disintegrin and metalloproteinase 10, can cleave the extracellular domains of transmembrane proteins and trigger a subsequent regulated intramembrane proteolysis step that releases the cytosolic domain into the cell. In this issue, Rosenbaum et al. unraveled the role of A disintegrin and metalloproteinase 10 in the podocyte by showing that it can release the ectodomains of the membranous nephropathy target antigens phospholipase A2 receptor 1 and thrombospondin type 1 domain–containing 7A as well as the adhesion molecule β-dystroglycan.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.