Kidney international最新文献

{"title":"Does the kidney influence the hunger for salt?","authors":"Matthew A. Bailey","doi":"10.1016/j.kint.2024.09.009","DOIUrl":"10.1016/j.kint.2024.09.009","url":null,"abstract":"<div><div>Sympathetic overactivation contributes to hypertension. Renal denervation can reduce blood pressure. In the deoxycorticosterone acetate (DOCA)–salt model of hypertension, salt consumption contributes to high blood pressure. A report in <em>Kidney International</em> finds selective ablation of renal sensory afferent nerves diminishes self-directed saline intake in the DOCA-salt rat. This suggests that these sensory nerves input to centers in the brain, amplifying salt intake. If translatable, renal denervation may have an unanticipated benefit of reducing the drive to consume salty foods in patients with poorly controlled hypertension.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1025-1028"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxalate nephropathy associated with glyoxylate-containing hair-straightening products: a call for caution","authors":"Naim M. Maalouf ,&nbsp;Jonathan M. Whittamore","doi":"10.1016/j.kint.2024.09.015","DOIUrl":"10.1016/j.kint.2024.09.015","url":null,"abstract":"<div><div>Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert <em>et al.</em> help elucidate the underlying mechanisms in a murine model that replicates the human pathology. Cutaneous absorption of glyoxylic acid from hair-straightening products and its subsequent conversion to oxalate are identified as crucial steps in the development of oxalate nephropathy. This newly described “skin-kidney” axis expands our understanding of oxalate metabolism, calls for additional studies to explore susceptibility to acute kidney injury following cutaneous glyoxylate exposure, and warrants vigilance around the use of these products.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1023-1025"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ molecular profiles of glomerular cells by integrated imaging mass spectrometry and multiplexed immunofluorescence microscopy.","authors":"Allison B Esselman, Felipe A Moser, Léonore E M Tideman, Lukasz G Migas, Katerina V Djambazova, Madeline E Colley, Ellie L Pingry, Nathan Heath Patterson, Melissa A Farrow, Haichun Yang, Agnes B Fogo, Mark de Caestecker, Raf Van de Plas, Jeffrey M Spraggins","doi":"10.1016/j.kint.2024.11.008","DOIUrl":"10.1016/j.kint.2024.11.008","url":null,"abstract":"<p><p>Glomeruli filter blood through the coordination of podocytes, mesangial cells, fenestrated endothelial cells, and the glomerular basement membrane. Cellular changes, such as podocyte loss, are associated with pathologies like diabetic kidney disease. However, little is known regarding the in situ molecular profiles of specific cell types and how these profiles change with disease. Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is well-suited for untargeted tissue mapping of a wide range of molecular classes. Importantly, additional imaging modalities can be integrated with MALDI IMS to associate these biomolecular distributions to specific cell types. Here, we integrated workflow combining MALDI IMS and multiplexed immunofluorescence (MxIF) microscopy. High spatial resolution MALDI IMS (5 μm) was used to determine lipid distributions within human glomeruli from a normal portion of fresh-frozen kidney cancer nephrectomy tissue revealing intra-glomerular lipid heterogeneity. Mass spectrometric data were linked to specific glomerular cell types and substructures through new methods that enable MxIF microscopy to be performed on the same tissue section following MALDI IMS, without sacrificing signal quality from either modality. Machine learning approaches were combined enabling cell type segmentation and identification based on MxIF data. This was followed by mining of cell type or cluster-associated MALDI IMS signatures using classification and interpretable machine learning. This allowed automated discovery of spatially specific molecular markers for glomerular cell types and substructures as well as lipids correlated to deep and superficial glomeruli. Overall, our work establishes a toolbox for probing molecular signatures of glomerular cell types and substructures within tissue microenvironments providing a framework applicable to other kidney tissue features and organ systems.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsy before transplant: optimizing allocation or fueling discard?","authors":"Griffith B. Perkins","doi":"10.1016/j.kint.2024.10.005","DOIUrl":"10.1016/j.kint.2024.10.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1036-1037"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing kidney organoid maturity with inducible vascularization: another step forward for in vitro modeling","authors":"Lori L. O’Brien","doi":"10.1016/j.kint.2024.09.013","DOIUrl":"10.1016/j.kint.2024.09.013","url":null,"abstract":"<div><div>Kidney organoids represent a tangible <em>in vitro</em> system in which to model disease, identify novel therapeutics, and investigate cellular and physiological mechanisms. However, their relative immaturity and insufficient endowment of critical cell types limits their translational efficacy. Addressing a number of these shortcomings, Maggiore <em>et al.</em> present a novel genetically inducible vascularized kidney organoid model. Organoids develop a robust endothelial network with kidney-specific features that enhances podocyte maturity and supports the generation of functional renin+ cells.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1017-1020"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular large B-cell-lymphoma: a rare post-transplant lymphoproliferative disease","authors":"Ole Hudowenz ,&nbsp;Niklas Gebauer","doi":"10.1016/j.kint.2024.08.010","DOIUrl":"10.1016/j.kint.2024.08.010","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Page 1189"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretransplant biopsies for kidney allocation and discard: more questions than answers","authors":"Karolien Wellekens ,&nbsp;Maarten Naesens","doi":"10.1016/j.kint.2024.09.016","DOIUrl":"10.1016/j.kint.2024.09.016","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1032-1036"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubular glycogen nuclei in a patient with glycogen storage disease type Ia","authors":"Dandan Liang ,&nbsp;Jing Liu ,&nbsp;Ke Zuo ,&nbsp;Erzhi Gao ,&nbsp;Shaoshan Liang ,&nbsp;Feng Xu ,&nbsp;Caihong Zeng","doi":"10.1016/j.kint.2024.08.013","DOIUrl":"10.1016/j.kint.2024.08.013","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Page 1188"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.” Kidney International 2023;103:304–319","authors":"Shruthi Krishnan ,&nbsp;Jayakumar Manoharan ,&nbsp;Hongjie Wang ,&nbsp;Dheerendra Gupta ,&nbsp;Sameen Fatima ,&nbsp;Yanfei Yu ,&nbsp;Akash Mathew ,&nbsp;Zhen Li ,&nbsp;Shrey Kohli ,&nbsp;Constantin Schwab ,&nbsp;Antje Körner ,&nbsp;Peter R. Mertens ,&nbsp;Peter Nawroth ,&nbsp;Khurrum Shahzad ,&nbsp;Michael Naumann ,&nbsp;Berend Isermann ,&nbsp;Ronald Biemann","doi":"10.1016/j.kint.2024.10.003","DOIUrl":"10.1016/j.kint.2024.10.003","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1193-1196"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chylothorax and chylopericardium in a dialysis patient","authors":"Mohamad Hanouneh ,&nbsp;Shelby Stewart ,&nbsp;Recai Aktay ,&nbsp;Adam S. Fang ,&nbsp;C. Elena Cervantes","doi":"10.1016/j.kint.2024.06.005","DOIUrl":"10.1016/j.kint.2024.06.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Page 1190"},"PeriodicalIF":14.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}