Kidney international最新文献

{"title":"The importance of immunoglobulin replacement in plasma exchange to prevent infections","authors":"Marc Xipell , Beatriz Sánchez-Álamo , Elena Guillén , Paola Charry , Luis F. Quintana , Miquel Lozano","doi":"10.1016/j.kint.2025.04.019","DOIUrl":"10.1016/j.kint.2025.04.019","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Page 328"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum counseling and interventions to reduce the risk of chronic kidney disease: back to the future","authors":"Giorgina Barbara Piccoli , Alejandra Orozco , Rasha Shemies , Rossella Attini , Gianfranca Cabiddu , Massimo Toreggiani , Shilpanjali Jesudason , Vesna Garovic","doi":"10.1016/j.kint.2025.03.031","DOIUrl":"10.1016/j.kint.2025.03.031","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 160-166"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscription Information","authors":"","doi":"10.1016/S0085-2538(25)00440-5","DOIUrl":"10.1016/S0085-2538(25)00440-5","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Page A2"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The authors reply","authors":"Balazs Odler , Michael Walsh , Peter Merkel , David Jayne , Andreas Kronbichler , writing team","doi":"10.1016/j.kint.2025.04.022","DOIUrl":"10.1016/j.kint.2025.04.022","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 328-329"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is preeclampsia ever “mild?” Lessons on long-term consequences for offspring from a Danish registry–based study","authors":"Shilpanjali Jesudason ,&nbsp;Giorgina B. Piccoli","doi":"10.1016/j.kint.2025.05.011","DOIUrl":"10.1016/j.kint.2025.05.011","url":null,"abstract":"<div><div>Preeclampsia is now acknowledged as a systemic disorder with long-term implications for maternal and offspring health, reframing it as a sentinel event that reveals underlying vulnerabilities and signals future risk of cardiovascular, hypertensive, and kidney diseases in both mother and child. The “children of preeclampsia” should be on our radars as a population warranting early attention, shaping new standards of disease prevention.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 181-183"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stalled neutrophil traffic within the pulmonary vasculature: a novel discovery in systemic complications of acute kidney injury.","authors":"Isadore M Budnick,Sarah Faubel","doi":"10.1016/j.kint.2025.05.023","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.023","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"10 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triggering trouble: post-translational modifications may drive myeloperoxidase autoimmunity.","authors":"Peter Heeringa,Abraham Rutgers","doi":"10.1016/j.kint.2025.05.024","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.024","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"29 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes.","authors":"Toralf Melsom,Karl Marius Brobak,Jon Viljar Norvik,Inger Therese Enoksen,Ludvig Rinde,Trond G Jenssen,Bjørn O Eriksen","doi":"10.1016/j.kint.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.kint.2025.06.019","url":null,"abstract":"INTRODUCTIONPrediabetes, an intermediate state between normoglycemia and type 2 diabetes affecting 720 million individuals worldwide, is associated with hyperfiltration, an early stage of diabetic kidney disease. It remains unclear whether prediabetes is an independent risk factor for glomerular filtration rate (GFR) decline, potentially due to previously inaccurate GFR estimates.METHODSIn a prospective study of middle-aged Europeans without diabetes, cardiovascular disease, or kidney disease, we measured the GFR (mGFR) using iohexol clearance at baseline (1594 individuals), after a median of 5.2-6.0 years (1299 individuals), and 11.0 years (1151 individuals). A linear mixed model was used to estimate the mGFR slope. Accelerated mGFR decline was defined as the participants with the 10% steepest mGFR decline. We also estimated GFR (eGFR) from creatinine (eGFRcrea) and cystatin C (eGFRcys). Prediabetes was defined as fasting glucose of 6.1-6.9 mmol/l (prediabetes World Health Organization (WHO)) or 5.6- 6.9 mmol/l and/or HbA1c 5.7-6.4% (39 - 46 mmol/mol) (prediabetes American Diabetes Association (ADA)).RESULTSIn adjusted linear mixed models, those with prediabetesWHO and those with prediabetesADA had steeper mean mGFR decline rates of 0.30 (95% confidence interval: 0.04 to 0.57) and (0.14 to 0.28) mL/min per year, respectively. The odds ratios of accelerated GFR decline were 2.6 (2.0-5.1) for prediabetesWHO and 2.0 (1.3-3.0) for prediabetesADA. Significantly, prediabetes was not associated with eGFRcrea or eGFRcys decline.CONCLUSIONSIn a representative sample of Caucasians without diabetes, prediabetes was associated with an accelerated mGFR decline but not with eGFR decline. Prediabetes represents a window of opportunity to prevent hyperfiltration and early mGFR loss before diabetic kidney disease.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"23 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression.","authors":"Delal Dalga,Anna Rinaldi,Xiaorong Fu,Lucie Chanvillard,Aurelie Huber,Anna Faivre,David Jaques,Lena Berchtold,Julien Boccard,Gregoire Arnoux,Arnaud Lyon,Joseph M Rutkowski,Quentin Gex,Deborah Paolucci,Mario Kreuzfeld,Thomas Cagarelli,Lea Lutz,Alban Longchamp,Solange Moll,Nicolas Hulo,Belen Ponte,Shawn C Burgess,Pietro E Cippà,Thomas Verissimo,Sophie de Seigneux","doi":"10.1016/j.kint.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.kint.2025.06.018","url":null,"abstract":"INTRODUCTIONMetabolic alterations are recognized as key features of kidney injury, but their causal role in kidney repair remains debatable. Here, we investigate the role of phosphoenolpyruvate carboxykinase 1 (PCK1), an enzyme involved in gluconeogenesis and cataplerosis (removal of tricarboxylic acid (TCA) cycle intermediates from the mitochondrial matrix) in kidney disease progression.METHODSWe used mice with kidney tubular cell-specific deletion or overexpression of the PCK1 enzyme, and different models of kidney injury such as ischemia-reperfusion injury or cis-platin-induced nephropathy. Furthermore, we measured metabolites in kidney biopsy tissue from patients with stage 3b/4 chronic kidney disease (CKD).RESULTSUsing flux analysis, we confirm that cataplerosis and the TCA cycle are blocked by PCK1 deficiency. This results in injured mitochondria leading to inflammation, tubular injury and impaired tubular cell repair. Inversely, maintaining PCK1 function in different models of kidney injury preserves kidney structure, improves TCA cycle metabolite clearance and increase ATP production. In kidney biopsies from different patient cohorts, we confirm the correlation between PCK1 loss, mitochondrial injury and a failed tubular cell repair phenotype. Furthermore, in CKD, accumulation of TCA cycle metabolites is consistent with disrupted cataplerosis.CONCLUSIONSOverall, we demonstrate that PCK1 loss in kidney tubular cells leads to decreased respiration and the accumulation of TCA cycle metabolites. Maintenance of cataplerosis is an important factor of tubular physiology and repair, with PCK1 serving as a causal and potential therapeutic target in this process. PCK1 restoration enhances mitochondrial health, limiting progression to inflammation and fibrosis.","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"29 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of ceramides in the pathogenesis of atherosclerosis.","authors":"Tilman B Drueke,Ziad A Massy","doi":"10.1016/j.kint.2025.05.020","DOIUrl":"https://doi.org/10.1016/j.kint.2025.05.020","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"7 10 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}