Kidney international最新文献

{"title":"Life-supporting functional kidney replacement by integration of embryonic metanephros-bladder composite tissue transplants","authors":"Yoshitaka Kinoshita ,&nbsp;Eiji Kobayashi ,&nbsp;Kenji Matsui ,&nbsp;Yuka Inage ,&nbsp;Keita Morimoto ,&nbsp;Shutaro Yamamoto ,&nbsp;Satomi Iwai ,&nbsp;Kento Kitada ,&nbsp;Kentaro Iwasawa ,&nbsp;Yatsumu Saito ,&nbsp;Toshinari Fujimoto ,&nbsp;Kei Matsumoto ,&nbsp;Shushi Nagamori ,&nbsp;Akira Nishiyama ,&nbsp;Haruki Kume ,&nbsp;Takanori Takebe ,&nbsp;Takashi Yokoo ,&nbsp;Shuichiro Yamanaka","doi":"10.1016/j.kint.2025.02.024","DOIUrl":"10.1016/j.kint.2025.02.024","url":null,"abstract":"<div><div>Novel transplantable organs need to be developed to address the global organ shortage. Transplantation of embryonic kidney tissue, or metanephros, facilitates glomerular and tubular maturation and offers partial organ functional support. However, adult environments do not permit exponential growth in size, limiting the life-supporting functionality and organ replacement effect of this approach. Here, we developed a novel strategy that combines the fusion of embryonic bladders with multiple anastomoses to the host ureter, enabling a significant increase in metanephros transplantation and urinary tract integration. By surgically anastomosing divided bladder segments, we reconstructed the excretory pathways by merging four metanephroi into each bladder and integrating them with the host ureter. Following the transplantation and integration of 20 metanephroi at the para-aortic region, anephric rats survived for over a month and generated approximately 50,000 nephrons <em>in vivo</em>. Ultrastructural and single-cell–transcriptomic analyses revealed that the maturity of the transplanted metanephroi was comparable to that of adult kidneys, although their small size likely contributed to their decreased urine concentration ability. Postoperative support helped normalize physiological homeostasis, including solute clearance, acid–base balance, electrolyte levels, and kidney hormone levels, within vital ranges. Our findings underscore the functional maturation capacity and dose-dependent therapeutic efficacy of embryonic kidney tissue, suggesting its potential as a transplantable organ system.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 1051-1063"},"PeriodicalIF":14.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from ADPedKD, ERKReg and RaDaR registries provide a multi-national perspective on the presentation of childhood autosomal dominant polycystic kidney disease in high- and middle-income countries.","authors":"Charlotte Gimpel, Steffen Fieuws, Jonas Hofstetter, David Pitcher, Lotte Vanmeerbeek, Stefanie Haeberle, Angélique Dachy, Laura Massella, Tomas Seeman, Bruno Ranchin, Lise Allard, Justine Bacchetta, Umut S Bayrakci, Francesca Becherucci, Victor Perez-Beltran, Martine Besouw, Hanna Bialkevich, Olivia Boyer, Nur Canpolat, Dominique Chauveau, Neslihan Çiçek, Peter J Conlon, Olivier Devuyst, Claire Dossier, Marc Fila, Hana Flögelová, Astrid Godron-Dubrasquet, Ibrahim Gokce, Elsa Gonzalez Nguyen-Tang, Juan David González-Rodríguez, Anne Guffens, Giuseppe Grandaliano, Laurence Heidet, Augustina Jankauskiene, Tanja Kersnik Levart, Bertrand Knebelmann, Jens Christian König, Claudio La Scola, Valentina Fanny Leone, Valérie Leroy, Mieczyslaw Litwin, Laura Lucchetti, Adrian C Lungu, Pierluigi Marzuillo, Antonio Mastrangelo, Monika Miklaszewska, Giovanni Montini, François Nobili, Lukasz Obrycki, Svetlana Papizh, Aleksandra Paripović, Dušan Paripović, Licia Peruzzi, Ann Raes, Seha Saygili, Brankica Spasojević, Thomas Simon, Maria Szczepańska, Francesco Trepiccione, Nataša Marčun Varda, Rik Westland, Selcuk Yüksel, Iga Zaluska-Lesniewska, Julie Tenebaum, Reem Mustafa, Andrew J Mallett, Lisa M Guay-Woodford, Daniel P Gale, Detlef Böckenhauer, Max C Liebau, Franz Schaefer, Djalila Mekahli","doi":"10.1016/j.kint.2025.02.026","DOIUrl":"10.1016/j.kint.2025.02.026","url":null,"abstract":"<p><p>Data on the presentation of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in children have been based on small/regional cohorts and practices regarding both asymptomatic screening in minors and genetic testing differ greatly between countries. To provide a global perspective, we analyzed over 2100 children and adolescents with ADPKD from 32 countries in six World Health Organization regions: 1060 children from the multi-national ADPedKD registry were compared to 269 pediatric patients from the United Kingdom (RaDaR) and 825 from the European Rare Kidney Disease Registry (ERKReg). Asymptomatic family screening was a common mode of presentation (48% in ADPedKD, 62% in ERKReg) with broad international variability (19%-75%), but fairly stable temporal trends in both registries with no correlation to genetic testing. The national rates of genetic testing varied and correlated significantly with healthcare expenditure (odds ratio 1.030 per 100 United States Dollars/capita/year, in the ERKReg cohort), with little variation over time. Diagnosis due to prenatal abnormalities was more common than anticipated at 14% increasing steadily from 2000 onward in both registries. Realistically, a high proportion of children were diagnosed with ADPKD by active screening, underlining that families affected by ADPKD have a high need for counselling on the complex issues around presymptomatic diagnosis. Regional variations in rate of genetic testing appeared to be driven by economic factors. However, large differences in rate of active screening were not correlated to healthcare spending and probably reflect the influence of different of cultural, legal and ethical frameworks on families and clinicians in different healthcare systems.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscription Information","authors":"","doi":"10.1016/S0085-2538(25)00100-0","DOIUrl":"10.1016/S0085-2538(25)00100-0","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Page A2"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nephrology consult for a child with three kidneys!","authors":"Vivek Sharma ,&nbsp;Sidharth Kumar Sethi ,&nbsp;Shyam Bihari Bansal ,&nbsp;Rupesh Raina","doi":"10.1016/j.kint.2024.10.030","DOIUrl":"10.1016/j.kint.2024.10.030","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Page 761"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Case | Recurring acute kidney injury following iliac arteriovenous fistula","authors":"Hiroki Ito ,&nbsp;Katsuya Ishiyama ,&nbsp;Fumiya Sato ,&nbsp;Risa Ishikawa ,&nbsp;Akari Endo ,&nbsp;Shigemitsu Sato ,&nbsp;Go Anan ,&nbsp;Takuo Hirose ,&nbsp;Ikuko Oba-Yabana ,&nbsp;Tomoyoshi Kimura ,&nbsp;Takuya Shimizu ,&nbsp;Takefumi Mori","doi":"10.1016/j.kint.2025.01.004","DOIUrl":"10.1016/j.kint.2025.01.004","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Pages 763-764"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is online hemodiafiltration a cost-effective alternative to conventional hemodialysis?","authors":"Kevin F. Erickson ,&nbsp;James Fotheringham","doi":"10.1016/j.kint.2025.01.012","DOIUrl":"10.1016/j.kint.2025.01.012","url":null,"abstract":"<div><div>In this issue, Schouten <em>et al.</em> report findings from a cost-effectiveness analysis of hemodiafiltration versu<em>s</em> conventional high-flux hemodialysis using data from the Comparison of High-Dose Hemodiafiltration with High-Flux Hemodialysis (CONVINCE) trial. They found that the overall cost-effectiveness of hemodiafiltration is within the range of accepted willingness-to-pay thresholds in some countries, while near (but outside) the lower-bound thresholds of other countries. How decision-makers value treatment costs for additional years on dialysis and country-specific costs and willingness-to-pay thresholds influence the cost-effectiveness of hemodiafiltration.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Pages 602-605"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney supportive care: every nephrologist’s business","authors":"Mark A. Brown ,&nbsp;Barnaby D. Hole ,&nbsp;Frank Brennan ,&nbsp;Nandini Vallath ,&nbsp;Sara N. Davison","doi":"10.1016/j.kint.2025.01.010","DOIUrl":"10.1016/j.kint.2025.01.010","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Pages 582-586"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphate transporters and avoiding the prosecutor’s fallacy","authors":"Detlef Bockenhauer ,&nbsp;Omid Sadeghi-Alavijeh ,&nbsp;Daniel P. Gale","doi":"10.1016/j.kint.2025.01.001","DOIUrl":"10.1016/j.kint.2025.01.001","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Page 757"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reevaluating anti-nephrin autoantibodies by ELISA using human embryonic kidney–derived recombinant extracellular domain of human nephrin","authors":"Yoko Shirai ,&nbsp;Kenichiro Miura ,&nbsp;Keita Morimoto ,&nbsp;Takashi Yokoo ,&nbsp;Motoshi Hattori","doi":"10.1016/j.kint.2025.01.003","DOIUrl":"10.1016/j.kint.2025.01.003","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Pages 757-759"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RASSF1A loss in ccRCC: genomic instability and the role of chromosome 3p","authors":"Joseph Walton ,&nbsp;Laurie Ailles","doi":"10.1016/j.kint.2025.01.016","DOIUrl":"10.1016/j.kint.2025.01.016","url":null,"abstract":"<div><div>Clear cell renal cell carcinoma is characterized by the loss of chromosome 3p, which includes several tumor suppressor genes (e.g., <em>VHL</em>, <em>PBRM1</em>, <em>SETD2</em>, and <em>BAP1</em>) as well as <em>RASSF1a,</em> a frequently inactivated gene in many cancers. This commentary highlights work by Catalano <em>et al.</em>, which explores the functional consequences of Ras association domain family 1, isoform A (RASSF1A) loss in kidney epithelial cells and calls for further research to investigate the impacts of 3p loss to uncover new therapeutic targets for clear cell renal cell carcinoma.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 4","pages":"Pages 599-602"},"PeriodicalIF":14.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}