Kidney international最新文献

{"title":"The Standardized Outcomes in Nephrology (SONG) initiative: a decade of harmonizing patient voices and research in kidney disease","authors":"Colm O’Reilly , Jonathan C. Craig , Younghee Cho , Sally Crowe , John S. Gill , Brenda Hemmelgarn , Martin Howell , Anastasia Hughes , Angela Ju , Karine Manera , Braden Manns , Roberto Pecoits-Filho , Benedicte Sautenet , Nicole Scholes-Robertson , Armando Teixeira-Pinto , Peter Tugwell , Wim Van Biesen , Andrea K. Viecelli , Angela Yee-Moon Wang , Wolfgang C. Winkelmayer , Allison Jaure","doi":"10.1016/j.kint.2025.02.016","DOIUrl":"10.1016/j.kint.2025.02.016","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 955-958"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How frequent is frequent? Rethinking monitoring intervals in glomerular disease","authors":"Mohamed E. Elrggal","doi":"10.1016/j.kint.2025.02.007","DOIUrl":"10.1016/j.kint.2025.02.007","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 1111-1112"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mayo MGRS Prediction Tool calculates the risk of finding monoclonal gammopathy of renal significance in a kidney biopsy in patients with monoclonal gammopathy","authors":"Nattawat Klomjit ,&nbsp;Michael D. Evans ,&nbsp;Maria Vargas ,&nbsp;Nicholas Marka ,&nbsp;Fernando C. Fervenza ,&nbsp;Sanjeev Sethi ,&nbsp;Ladan Zand","doi":"10.1016/j.kint.2025.04.018","DOIUrl":"10.1016/j.kint.2025.04.018","url":null,"abstract":"<div><h3>Introduction</h3><div>Monoclonal gammopathy of renal significance (MGRS) is increasingly recognized as an important cause of kidney failure. A kidney biopsy remains an important diagnostic measure. However, a kidney biopsy is not without risks. Here, we devised the Mayo MGRS Prediction Tool to assess the probability of finding MGRS in patients with chronic kidney disease with monoclonal gammopathy (MG).</div></div><div><h3>Methods</h3><div>We included patients from 2013 to October 2023 who underwent a kidney biopsy at the Mayo Clinic excluding those whose hematological condition required specific treatment due to tumor burden such as multiple myeloma.</div></div><div><h3>Results</h3><div>Of 280 patients, 92 (32.9%) had MGRS lesions with amyloid light chain or primary amyloidosis being the most common lesion in 38 patients (41.3%). We performed multivariable logistic regression with forward variable selection to fit the model. The final model included eight predictors: diabetes, affected/unaffected free light chain ratio, urinary protein (g/24 hours), positive urine protein electrophoresis or immunofixation electrophoresis, serum creatinine, C3 level (mg/dL), hematuria, and systolic blood pressure. The calculated and optimism-corrected area under the curve was 0.896 and 0.836, respectively. The decision curve analysis showed that the model provided net benefit across all thresholds. A threshold probability of 0.10 was 98.9% sensitive and 50.5% specific, and a threshold probability of 0.25 was 88.0% sensitive and 70.2% specific. The model was validated using an external cohort of 109 patients from the University of Minnesota with good performance.</div></div><div><h3>Conclusions</h3><div>Our Mayo MGRS Prediction Tool is useful in assisting clinicians in predicting the probability of finding an MGRS lesion in a kidney biopsy.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 271-282"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The authors reply","authors":"Smeeta Sinha ,&nbsp;Rachel M. Holden ,&nbsp;Rosa M.A. Moysés ,&nbsp;Markus Ketteler ,&nbsp;coauthors","doi":"10.1016/j.kint.2025.03.005","DOIUrl":"10.1016/j.kint.2025.03.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Pages 1113-1114"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osmotic nephropathy induced by SGLT2 inhibitor overdose","authors":"Yoshihiro Kawata ,&nbsp;Makoto Araki ,&nbsp;Yasuhiro Onodera ,&nbsp;Yayoi Ogawa ,&nbsp;Mitsuru Yanai","doi":"10.1016/j.kint.2024.10.035","DOIUrl":"10.1016/j.kint.2024.10.035","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 6","pages":"Page 1116"},"PeriodicalIF":14.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the use of anti-CD20 in childhood idiopathic nephrotic syndrome: an intersection of art and science.","authors":"Eugene Yu-Hin Chan, Brad Rovin","doi":"10.1016/j.kint.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.kint.2025.03.026","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway","authors":"Mingwei Fu ,&nbsp;Zirong Lan ,&nbsp;Yuanzhi Ye ,&nbsp;Yuan Gong ,&nbsp;Qingchun Liang ,&nbsp;Mingxi Li ,&nbsp;Liyun Feng ,&nbsp;An Chen ,&nbsp;Qianqian Dong ,&nbsp;Yining Li ,&nbsp;Siyi Wang ,&nbsp;Xiaoyu Liu ,&nbsp;Xiuli Zhang ,&nbsp;Jing-Song Ou ,&nbsp;Lihe Lu ,&nbsp;Jianyun Yan","doi":"10.1016/j.kint.2025.04.016","DOIUrl":"10.1016/j.kint.2025.04.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Vascular calcification is prevalent in chronic kidney disease (CKD), but existing medical treatments fail to achieve satisfactory therapeutic effects. Vascular calcification is now recognized as an active multifactorial process involving diverse mechanisms. Alpha-ketoglutarate (AKG), an intermediate in tricarboxylic acid cycle, has been demonstrated to extend lifespan and ameliorate age-related osteoporosis. However, whether AKG inhibits vascular calcification remains unknown.</div></div><div><h3>Methods</h3><div>Here, mineral deposition was studied with AKG treatment in rodent and human vascular smooth muscle cells (VSMCs) under osteogenic conditions <em>in vivo</em> and <em>in vitro</em>.</div></div><div><h3>Results</h3><div>AKG treatment remarkably ameliorated calcification of rat and human arterial rings <em>ex vivo</em> and aortic calcification in CKD rats and mice. Mechanistically, AKG treatment upregulated DNA demethylase ten-eleven translocation 2 (TET2) expression during vascular calcification. Knockdown of TET2 by siRNA and pharmacological inhibition of TET2 by Bobcat339 promoted vascular calcification in rat VSMCs. Bobcat339 also enhanced rat aortic ring calcification. Conversely, TET2 overexpression ameliorated vascular calcification in rat VSMCs, rat aortic rings and CKD rats. Furthermore, VSMC-specific TET2 deficiency promoted aortic calcification in CKD mice. Both TET2 siRNA and Bobcat339 independently counteracted the inhibitory effect of AKG on vascular calcification of rat VSMCs. Inhibitory effect of AKG administration on vascular calcification was reduced in TET2 knockout mice. TET2 overexpression reduced the levels of the NLRP3 inflammasome pathway, cleaved Caspase-1 and IL-1β protein expression in VSMCs and NLRP3 agonist Nigericin-induced cell calcification.</div></div><div><h3>Conclusions</h3><div>Our study demonstrate that AKG attenuates vascular calcification partially via upregulation of TET2 and inhibition of NLRP3 inflammasome, indicating the critical role of epigenetic modifier in vascular calcification. Modulation of TET2 may become a promising strategy for the treatment of vascular calcification.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 233-252"},"PeriodicalIF":14.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy","authors":"Zhuo-ran Song ,&nbsp;Zhi-ying Liu ,&nbsp;Meng-shi Li ,&nbsp;Yang Li ,&nbsp;Jing-yi Li ,&nbsp;Ji-Cheng Lv ,&nbsp;Hong Zhang ,&nbsp;Xu-jie Zhou","doi":"10.1016/j.kint.2025.04.014","DOIUrl":"10.1016/j.kint.2025.04.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Thrombotic microangiopathy (TMA) is a complex condition involving endothelial damage and microvascular thrombi. The International Society of Nephrology’s aHUS International Forum identified genetic variants as crucial for tailored therapies like plasma exchange and anti-complement therapy. Recent studies suggested that new pathogenic genes beyond complement and coagulation pathways contribute to TMA including <em>TREX1</em> variants. The protein TREX1, a DNA-specific exonuclease, maintains genome integrity and regulates immune responses by degrading damaged cytosolic DNA. Variants disrupting <em>TREX1</em>’s endoplasmic reticulum anchoring can lead to vasculopathy.</div></div><div><h3>Methods</h3><div>We conducted retrospective in silico studies involving 53 patients with TMA, 94 with IgA nephropathy with microangiopathic lesions, 25 with C3G glomerulopathy and 20 with ANCA-associated vasculitis.</div></div><div><h3>Results</h3><div>Pathogenic variants of <em>TREX1</em> were found in 5.7% of patients with TMA and 3.2% of patients with IgA nephropathy with microangiopathic lesions, but none in C3 glomerulopathy or ANCA-associated vasculitis.</div></div><div><h3>Conclusions</h3><div>Our study highlights the importance of <em>TREX1</em> variants in microvascular diseases, particularly in thrombotic microangiopathy and IgA nephropathy. <em>TREX1</em>’s critical role in genome integrity and immune regulation may offer new therapeutic avenues for treatment.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 317-320"},"PeriodicalIF":14.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-nephrin antibodies guide living donor kidney transplantation in a pediatric patient with primary focal segmental glomerular sclerosis","authors":"Sandra Habbig ,&nbsp;Hanna Debiec ,&nbsp;Malha Chedik ,&nbsp;Dirk L. Stippel ,&nbsp;Florian Erger ,&nbsp;Alexia Lourenço ,&nbsp;Max C. Liebau ,&nbsp;Pierre Ronco","doi":"10.1016/j.kint.2025.04.015","DOIUrl":"10.1016/j.kint.2025.04.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Disease recurrence after kidney transplantation (KTx) remains a major challenge in patients with primary focal segmental glomerulosclerosis (pFSGS). Antibodies targeting the slit diaphragm protein nephrin have been identified in patients with early disease recurrence. Here, we describe monitoring and effective pre-transplant elimination of anti-nephrin antibodies in an adolescent with pFSGS prior to living-donor KTx.</div></div><div><h3>Methods</h3><div>Anti-nephrin antibodies were assessed in pre- and post-transplant serum samples by ELISA, Western blot and immunoprecipitation using three different nephrin proteins.</div></div><div><h3>Results</h3><div>Pre-transplant treatment including rituximab and repetitive therapeutic plasma exchanges resulted in effective and sustainable reduction of anti-nephrin antibodies. Allograft function has remained excellent without albuminuria over a follow-up of more than one year. Further analysis showed that the antibodies were cross-reactive with NEPH3 (filtrin), another key slit diaphragm protein.</div></div><div><h3>Conclusions</h3><div>Monitoring and pre-transplant elimination of anti–slit diaphragm antibodies may become a standard, personalized approach in patients with pFSGS requiring KTx.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 321-327"},"PeriodicalIF":14.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nationwide register-based cohort study examined the association between preeclampsia in mothers and the risk of kidney disease in their offspring","authors":"Ida Lihme ,&nbsp;Saima Basit ,&nbsp;Frederikke Lihme ,&nbsp;Mette B. Damholt ,&nbsp;Sarah Hjorth ,&nbsp;Ellen A. Nohr ,&nbsp;Heather A. Boyd","doi":"10.1016/j.kint.2025.04.017","DOIUrl":"10.1016/j.kint.2025.04.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Women with preeclampsia often deliver preterm (under 37 weeks of gestation). Preterm birth is associated with an increased risk of offspring kidney disease, but whether preeclampsia is independently associated with kidney disease risk is unknown. Here, we conducted a register-based cohort study to explore associations between maternal preeclampsia and offspring kidney disease after accounting for preterm birth.</div></div><div><h3>Methods</h3><div>Using Cox regression, we estimated hazard ratios (HRs) comparing kidney disease rates, overall and by subtype, in offspring with and without exposure to maternal preeclampsia.</div></div><div><h3>Results</h3><div>The study included 2,288,589 persons born in Denmark 1978-2017 of whom 63,191 were exposed to preeclampsia; 37,782 individuals developed kidney disease during 43,137,193 person-years of follow-up. Offspring exposed to preeclampsia and born at term (37 or more weeks’ gestation) were 26% more likely than offspring born at term but not exposed to preeclampsia to develop kidney disease in infancy (HR 1.26, 95% confidence interval [1.09-1.46]), and had increased rates of all kidney disease subtypes except acute kidney disease after one year of age (HR range 1.11 to 1.88). Associations between term preeclampsia and offspring chronic, unspecified, and diabetic kidney disease were strongest after 25 years of age (HRs 1.36, 1.70 and 2.85, respectively). Conversely, there was little evidence that exposure to preeclampsia with preterm delivery was associated with increased rates of offspring kidney disease beyond the first year of life (under 1 year: 1.41, [1.05-1.90]; one year or more: 0.94, [ 0.79- 1.11]).</div></div><div><h3>Conclusions</h3><div>Associations of maternal term preeclampsia with offspring kidney disease hint at underlying mechanisms different from those potentially explaining established associations with preterm birth.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 283-292"},"PeriodicalIF":14.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}