{"title":"The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes","authors":"Laith F. Al-Rabadi , Laurence H. Beck Jr.","doi":"10.1016/j.kint.2025.05.009","DOIUrl":"10.1016/j.kint.2025.05.009","url":null,"abstract":"<div><div>Proteases, such as A disintegrin and metalloproteinase 10, can cleave the extracellular domains of transmembrane proteins and trigger a subsequent regulated intramembrane proteolysis step that releases the cytosolic domain into the cell. In this issue, Rosenbaum <em>et al.</em> unraveled the role of A disintegrin and metalloproteinase 10 in the podocyte by showing that it can release the ectodomains of the membranous nephropathy target antigens phospholipase A2 receptor 1 and thrombospondin type 1 domain–containing 7A as well as the adhesion molecule β-dystroglycan.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 176-178"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the Mayo prediction tool for MGRS ready for prime time?","authors":"Jack F. Wetzels","doi":"10.1016/j.kint.2025.05.010","DOIUrl":"10.1016/j.kint.2025.05.010","url":null,"abstract":"<div><div>Kidney disorders caused by a monoclonal Ig (monoclonal gammopathy of renal significance) are now considered treatable kidney diseases. Because chronic kidney disease and monoclonal gammopathy of undetermined significance occur frequently at older ages and because monoclonal gammopathy of renal significance is rare, it is difficult to select the right patient for a kidney biopsy. The “Mayo MGRS Prediction Tool” was developed to assist in decision making. Although there is some value in using the calculator, there are many caveats. Clinicians should be aware of the biases and limitations of the study before using the calculator in their routine practice.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 178-181"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postpartum counseling and interventions to reduce the risk of chronic kidney disease: back to the future","authors":"Giorgina Barbara Piccoli , Alejandra Orozco , Rasha Shemies , Rossella Attini , Gianfranca Cabiddu , Massimo Toreggiani , Shilpanjali Jesudason , Vesna Garovic","doi":"10.1016/j.kint.2025.03.031","DOIUrl":"10.1016/j.kint.2025.03.031","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"108 2","pages":"Pages 160-166"},"PeriodicalIF":14.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}