Kidney international最新文献

{"title":"Glomerular filtration rate equations in kidney transplant recipients: the need for specificity","authors":"Marc Raynaud , Stephan J.L. Bakker , Andrew J. Bentall , Alexandre Loupy","doi":"10.1016/j.kint.2024.11.015","DOIUrl":"10.1016/j.kint.2024.11.015","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Page 568"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscription Information","authors":"","doi":"10.1016/S0085-2538(25)00020-1","DOIUrl":"10.1016/S0085-2538(25)00020-1","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Page A2"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combination of SGLT2 inhibitors and glucagon-like peptide 1 receptor agonists: are 2 drugs better than 1?","authors":"Talat Alp Ikizler","doi":"10.1016/j.kint.2024.11.032","DOIUrl":"10.1016/j.kint.2024.11.032","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 385-388"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney biopsy in acute kidney injury: increase insight or preserve the status quo?","authors":"Zoltán H. Endre","doi":"10.1016/j.kint.2024.09.022","DOIUrl":"10.1016/j.kint.2024.09.022","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 397-400"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial ROS connects P2X7-mediated Ca2+ influx with IL-1α release by monocytes upon chronic tissue damage","authors":"Verónica Miguel","doi":"10.1016/j.kint.2024.12.002","DOIUrl":"10.1016/j.kint.2024.12.002","url":null,"abstract":"<div><div>Whereas acute inflammation plays an important role in both tissue damage and repair, chronic inflammation favors tissue injury. Monocytes contribute to this deleterious effect by secreting proinflammatory cytokines. Amini <em>et al.</em> propose a novel mechanism involving adenosine triphosphate–induced purinergic P2X purinoceptor 7 receptor activation, which leads to calcium ion–dependent mitochondrial reactive oxygen species production, triggering interleukin-1α release by monocytes. This stimulates kidney immune cell infiltration and fibrosis in chronic kidney disease and promotes adverse cardiac remodeling following myocardial infarction.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 389-391"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we crystallize the role of urate-lowering treatment in chronic kidney disease?","authors":"Austin G. Stack","doi":"10.1016/j.kint.2024.11.025","DOIUrl":"10.1016/j.kint.2024.11.025","url":null,"abstract":"<div><div>The therapeutic value of serum urate lowering in chronic kidney disease is questionable given the lack of clinical benefit from randomized clinical trials. <em>Post hoc</em> analysis of the CARES (Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Gout and Cardiovascular Morbidities) trial suggests a protective effect of urate lowering in gout participants over 2.5 years of follow-up with the greatest benefit for those who maintained average urate levels of &lt;6 mg/dl. A shift in research focus from asymptomatic hyperuricemia to symptomatic hyperuricemia may yet yield dividends.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 394-396"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent AL amyloidosis and fibrillary glomerulonephritis","authors":"Sujal I. Shah ,&nbsp;Subhash Paudel ,&nbsp;Joanna C. Dalland ,&nbsp;Ellen M. McPhail ,&nbsp;Samih H. Nasr","doi":"10.1016/j.kint.2024.08.036","DOIUrl":"10.1016/j.kint.2024.08.036","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Page 579"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney biopsy in acute kidney injury: the Goldilocks principle","authors":"Nicholas M. Selby ,&nbsp;Maarten W. Taal","doi":"10.1016/j.kint.2024.09.021","DOIUrl":"10.1016/j.kint.2024.09.021","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 400-403"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble guanylate cyclase as a direct target for pharmacologic mitigation of chronic kidney disease","authors":"Mia Jensen ,&nbsp;Boye L. Jensen","doi":"10.1016/j.kint.2024.12.011","DOIUrl":"10.1016/j.kint.2024.12.011","url":null,"abstract":"<div><div>In a preclinical rat study, Lichtenberger <em>et al.</em> show that BAY-60-2770, a drug that activates soluble guanylyl cyclase, often rendered inactive by oxidative stress, mitigates kidney inflammation, injury, and fibrosis, likely by vascular effects after ischemia-reperfusion. Kidney perfusion, overall vascular reactivity, and medullary microvascular diameter are improved by the drug at doses that do not alter blood pressure. Soluble guanylyl cyclase is an attractive and potentially unexploited target to halt progression of chronic kidney disease.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 3","pages":"Pages 391-394"},"PeriodicalIF":14.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national registry study evaluated the landscape of kidney transplantation among presumed unauthorized immigrants in the United States.","authors":"Gayathri Menon, Garyn T Metoyer, Yiting Li, Yusi Chen, Sunjae Bae, Mario P DeMarco, Brian P Lee, Pablo C Loarte-Campos, Babak J Orandi, Dorry L Segev, Mara A McAdams-DeMarco","doi":"10.1016/j.kint.2025.01.025","DOIUrl":"10.1016/j.kint.2025.01.025","url":null,"abstract":"<p><p>Unauthorized immigrants and permanent residents may experience challenges in accessing kidney transplantation due to limited healthcare access, socioeconomic and cultural barriers. Understanding the United States (US) national landscape of kidney transplantation for non-citizens may inform policy changes. To evaluate this, we utilized two cohorts from the US national registry (2013-2023): 287,481 adult candidates for first transplant listing and 190,176 adult first transplant recipients. Citizenship was categorized as US citizen (reference), permanent resident, and presumed unauthorized immigrant. Negative binomial regression was used to quantify the incidence rate ratio over time by citizenship status. Cause-specific hazards models, with clustering at the state of listing/transplant, were used to calculate the adjusted hazard ratio of waitlist mortality, kidney transplant, and post-transplant outcomes (mortality/death-censored graft failure) by citizenship category. The crude proportion of presumed unauthorized immigrants listed increased over time (2013: 0.9%, 2023:1.9%). However, after accounting for case mix and waitlist size, there was no change in listing over time. Presumed unauthorized immigrants were less likely to experience waitlist mortality (adjusted Hazard Ratio 0.54, 95% Confidence Interval: 0.46-0.62), were more likely to obtain deceased donor kidney transplant (1.11: 1.05-1.18), but less likely to receive live donor (0.80: 0.71-0.90) or preemptive kidney transplant (0.52: 0.43-0.62). When stratified by insurance status, presumed unauthorized immigrants on Medicaid were less likely to receive deceased donor kidney transplants compared to their citizen counterparts; however, presumed unauthorized immigrants with private insurance or Medicare were more likely to receive deceased donor kidney transplants. Presumed unauthorized immigrants were less likely to experience post-transplant death (0.56: 0.43-0.69) and graft failure (0.69: 0.57-0.84). Residents had similar pre- and post-transplant outcomes. Despite the barriers to kidney transplantation faced by presumed unauthorized immigrants and residents in the US, better post-transplant outcomes for presumed unauthorized immigrants compared to citizens persisted, even after accounting for differences in patient characteristics.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}