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IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.07.005
Rodrigo Bueno de Oliveira , Lauter E. Pelepenko , Mariana Cassani de Oliveira , Saïd Kamel , Loïc Louvet , Talita Mazon
{"title":"The authors reply","authors":"Rodrigo Bueno de Oliveira , Lauter E. Pelepenko , Mariana Cassani de Oliveira , Saïd Kamel , Loïc Louvet , Talita Mazon","doi":"10.1016/j.kint.2024.07.005","DOIUrl":"10.1016/j.kint.2024.07.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 757-758"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal monocytosis of renal significance 具有肾脏意义的克隆性单核细胞增多症
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.07.036
Anuya A. Natu , Ishan Gupta , Nelson Leung , Mariam P. Alexander , Mrinal M. Patnaik
{"title":"Clonal monocytosis of renal significance","authors":"Anuya A. Natu ,&nbsp;Ishan Gupta ,&nbsp;Nelson Leung ,&nbsp;Mariam P. Alexander ,&nbsp;Mrinal M. Patnaik","doi":"10.1016/j.kint.2024.07.036","DOIUrl":"10.1016/j.kint.2024.07.036","url":null,"abstract":"<div><div>Clonal monocytosis reflects a preneoplastic or neoplastic sustained increase in the absolute monocyte count in the absence of reactive causes. Causes of clonal monocytosis include clonal cytopenias with monocytosis and acute and chronic myeloid neoplasms. Chronic myelomonocytic leukemia is a prototypical myelodysplastic/myeloproliferative overlap neoplasm in adults, characterized by sustained peripheral blood monocytosis. Kidney abnormalities, including acute kidney injury and chronic kidney disease, are frequent in patients with chronic myelomonocytic leukemia and are predictors of worse outcomes. In addition, acute kidney injury/chronic kidney disease often limits eligibility for allogeneic stem cell transplantation or enrollment in clinical trials. In this review, we highlight clonal monocytosis–related etiologies that give rise to acute kidney injury and chronic kidney disease, with special emphasis on chronic myelomonocytic leukemia and lysozyme-induced nephropathy. Monocytes produce lysozyme, which, in excess, can accumulate in and damage the proximal renal tubular epithelium. Early identification of this etiology and a timely reduction in monocyte counts can salvage kidney function. Other etiologies of kidney injury associated with clonal monocytosis include direct renal infiltration by monocytes, renal extramedullary hematopoiesis, myeloproliferative neoplasm–associated glomerulopathy, autoimmune (membranous nephropathy, minimal change disease) and paraneoplastic manifestations, thrombotic microangiopathy, obstructive nephropathy due to myeloproliferation, and urate nephropathy due to tumor lysis syndrome. We propose to group these mechanistic etiologies of kidney injury as clonal monocytosis of renal significance and provide guidance on their diagnosis and management.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1062-1071"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAVKIDS2: a lesson in matching outcome measures to interventions NAVKIDS2：将成果措施与干预措施相匹配的一课
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.07.018
Rachel Willard-Grace , Delphine S. Tuot
{"title":"NAVKIDS2: a lesson in matching outcome measures to interventions","authors":"Rachel Willard-Grace ,&nbsp;Delphine S. Tuot","doi":"10.1016/j.kint.2024.07.018","DOIUrl":"10.1016/j.kint.2024.07.018","url":null,"abstract":"<div><p>Patient navigator programs may improve outcomes among individuals with chronic kidney disease by reducing barriers to evidence-based care. The NAVKIDS<sup>2</sup> trial evaluated a patient navigation program among 162 children with chronic kidney disease from marginalized populations. The intervention was not associated with quantitative changes in self-reported health, but qualitative data indicated substantial benefit in alleviating caregiver strain and facilitating care coordination. Future studies should identify quantitative measures that capture the benefits experienced by patients in care coordination, empowerment, and self-management.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 568-570"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0085253824005404/pdfft?md5=ccb1fed914bcfacbe1cd9e4a64ef748e&pid=1-s2.0-S0085253824005404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nephronophthisis-associated ciliopathy with brachydactyly, medullary cysts, and chronic kidney disease 肾炎相关性纤毛病伴有手足畸形、髓质囊肿和慢性肾病
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.04.022
Way Loon Jonathan Chen , Kin Fen Kevin Fung , Eugene Yu-hin Chan
{"title":"Nephronophthisis-associated ciliopathy with brachydactyly, medullary cysts, and chronic kidney disease","authors":"Way Loon Jonathan Chen ,&nbsp;Kin Fen Kevin Fung ,&nbsp;Eugene Yu-hin Chan","doi":"10.1016/j.kint.2024.04.022","DOIUrl":"10.1016/j.kint.2024.04.022","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Page 759"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new mechanism in adrenal control of aldosterone secretion involving the macrophage and VEGF 肾上腺控制醛固酮分泌的新机制涉及巨噬细胞和血管内皮生长因子。
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.08.030
Tilman B. Drüeke , François Alhenc-Gelas
{"title":"A new mechanism in adrenal control of aldosterone secretion involving the macrophage and VEGF","authors":"Tilman B. Drüeke ,&nbsp;François Alhenc-Gelas","doi":"10.1016/j.kint.2024.08.030","DOIUrl":"10.1016/j.kint.2024.08.030","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1011-1014"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The renal function trajectory in clinical trial design: challenges and opportunities 临床试验设计中的肾功能轨迹：挑战与机遇
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.07.023
Steven Rosansky , Richard Glassock
{"title":"The renal function trajectory in clinical trial design: challenges and opportunities","authors":"Steven Rosansky ,&nbsp;Richard Glassock","doi":"10.1016/j.kint.2024.07.023","DOIUrl":"10.1016/j.kint.2024.07.023","url":null,"abstract":"<div><p>The changes in renal function over time as surrogate endpoints for new drug trials are complicated by many factors, including the often-expected initial decrease in estimated glomerular filtration rate when a new drug is started. Two articles in the journal address this challenge, but multiple other challenges are explored in this commentary. To maximize the benefits of expensive new drugs that may slow decline in renal function, these drugs should be reserved for those patients who have a high probability of rapid loss of kidney function.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 565-568"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0085253824005507/pdfft?md5=f6e4206dabb00871bb1bebd4015d4cd4&pid=1-s2.0-S0085253824005507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the role of clonal hematopoiesis in acute kidney injury 阐明克隆造血在急性肾损伤中的作用
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.06.017
Yang Pan , Xiao Sun , Tanika N. Kelly
{"title":"Elucidating the role of clonal hematopoiesis in acute kidney injury","authors":"Yang Pan ,&nbsp;Xiao Sun ,&nbsp;Tanika N. Kelly","doi":"10.1016/j.kint.2024.06.017","DOIUrl":"10.1016/j.kint.2024.06.017","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 554-556"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unpicking the multi-omic response to endurance training: relevance for exercise benefits in chronic kidney disease. 解读耐力训练的多基因组反应：运动对慢性肾脏病的益处。
IF 19.6 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.09.005
Nicolette C Bishop
{"title":"Unpicking the multi-omic response to endurance training: relevance for exercise benefits in chronic kidney disease.","authors":"Nicolette C Bishop","doi":"10.1016/j.kint.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.kint.2024.09.005","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"23 1","pages":""},"PeriodicalIF":19.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR 瑞马吡嗪，一种新的外源性滤过标志物，以及更广泛地使用测量的 GFR
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.07.019
Marcelle Tuttle , Andrew S. Levey
{"title":"Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR","authors":"Marcelle Tuttle ,&nbsp;Andrew S. Levey","doi":"10.1016/j.kint.2024.07.019","DOIUrl":"10.1016/j.kint.2024.07.019","url":null,"abstract":"<div><p>Plasma or urinary clearance of exogenous filtration markers is required for assessment of measured glomerular filtration rate. Although multiple methods are available, none is widely used because of their complexity, each has measurement error, and standardization is limited. Recently, a study validated the plasma clearance of a new exogenous filtration marker, relmapirazin, which can be detected by its transdermal fluorescence, potentially simplifying the procedure and increasing access to measured glomerular filtration rate.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 562-565"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0085253824005416/pdfft?md5=e1b2629eafc80d55260a35b7fed83894&pid=1-s2.0-S0085253824005416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Case | Dark dialysate after colonoscopy 结肠镜检查后的深色透析液案例
IF 14.8 1区 医学
Kidney international Pub Date : 2024-09-18 DOI: 10.1016/j.kint.2024.06.006
Arrsh Bajaj , Monica Arora , Udayan Bhatt
{"title":"The Case | Dark dialysate after colonoscopy","authors":"Arrsh Bajaj ,&nbsp;Monica Arora ,&nbsp;Udayan Bhatt","doi":"10.1016/j.kint.2024.06.006","DOIUrl":"10.1016/j.kint.2024.06.006","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 4","pages":"Pages 761-762"},"PeriodicalIF":14.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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