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IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/S0085-2538(24)00485-X
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引用次数: 0
Chemical chaperones to the rescue of Alport syndrome? 化学伴侣拯救阿尔波特综合征？
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.07.006
{"title":"Chemical chaperones to the rescue of Alport syndrome?","authors":"","doi":"10.1016/j.kint.2024.07.006","DOIUrl":"10.1016/j.kint.2024.07.006","url":null,"abstract":"<div><p>Alport syndrome is a hereditary kidney disease caused by collagen IV mutations that interfere with the formation and deposition of the α3α4α5 protomer into the glomerular basement membrane. In this issue, Yu <em>et al.</em> show that the chemical chaperone tauroursodeoxycholic acid prevented kidney structural changes and function decline in mice with a pathogenic missense <em>Col4a3</em> mutation by increasing mutant α3α4α5 protomer glomerular basement membrane deposition and preventing podocyte apoptosis induced by endoplasmic reticulum stress.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney-limited TMA is common in patients with complement dysregulation 肾脏局限性 TMA 常见于补体失调患者
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.06.009
{"title":"Kidney-limited TMA is common in patients with complement dysregulation","authors":"","doi":"10.1016/j.kint.2024.06.009","DOIUrl":"10.1016/j.kint.2024.06.009","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aging kidneys reveal underlying mechanisms of endothelial dysfunction 衰老的肾脏揭示了内皮功能障碍的内在机制
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.06.020
{"title":"Aging kidneys reveal underlying mechanisms of endothelial dysfunction","authors":"","doi":"10.1016/j.kint.2024.06.020","DOIUrl":"10.1016/j.kint.2024.06.020","url":null,"abstract":"<div><p>Jiang <em>et al.</em> show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The significance of subclassifying focal segmental glomerulosclerosis lesions (S1) in IgA nephropathy 对 IgA 肾病中局灶节段性肾小球硬化病变（S1）进行亚分类的意义
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.06.016
{"title":"The significance of subclassifying focal segmental glomerulosclerosis lesions (S1) in IgA nephropathy","authors":"","doi":"10.1016/j.kint.2024.06.016","DOIUrl":"10.1016/j.kint.2024.06.016","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unfairness of fairness creams: unveiling the toxic impact on kidneys of mercury in beauty products 美白霜的不公平：揭示美容产品中的汞对肾脏的毒性影响
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.06.014
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引用次数: 0
Unfair enough: the cosmetic-TIM-kidney syndromes 不够公平：美容-TIM-肾综合症
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.04.012
{"title":"Unfair enough: the cosmetic-TIM-kidney syndromes","authors":"","doi":"10.1016/j.kint.2024.04.012","DOIUrl":"10.1016/j.kint.2024.04.012","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular disease as a risk factor for frailty in dialysis patients 心血管疾病是导致透析患者虚弱的风险因素之一
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.06.008
{"title":"Cardiovascular disease as a risk factor for frailty in dialysis patients","authors":"","doi":"10.1016/j.kint.2024.06.008","DOIUrl":"10.1016/j.kint.2024.06.008","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An expert discussion on the atypical hemolytic uremic syndrome nomenclature—identifying a road map to precision: a report of a National Kidney Foundation Working Group 关于非典型溶血性尿毒症命名法的专家讨论--确定精确化路线图：全美肾脏基金会工作组报告
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.05.021
{"title":"An expert discussion on the atypical hemolytic uremic syndrome nomenclature—identifying a road map to precision: a report of a National Kidney Foundation Working Group","authors":"","doi":"10.1016/j.kint.2024.05.021","DOIUrl":"10.1016/j.kint.2024.05.021","url":null,"abstract":"<div><p>The term <em>atypical hemolytic uremic syndrome</em> has been in use since the mid-1970s. It was initially used to describe the familial or sporadic form of hemolytic uremic syndrome as opposed to the epidemic, <em>typical</em> form of the disease. Over time, the atypical hemolytic uremic syndrome term has evolved into being used to refer to anything that is <em>not</em> Shiga toxin–associated hemolytic uremic syndrome. The term describes a heterogeneous group of diseases of disparate causes, a circumstance that makes defining disease-specific natural history and/or targeted treatment approaches challenging. A working group of specialty-specific experts in the thrombotic microangiopathies was convened to review the validity of this broad term in an era of swiftly advancing science and targeted therapeutics. A Delphi approach was used to define and interrogate some of the key issues related to the atypical hemolytic uremic syndrome nomenclature.</p></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0085253824004022/pdfft?md5=2b97809560922b12e6443760e75e23a2&pid=1-s2.0-S0085253824004022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal Club 期刊俱乐部
IF 14.8 1区 医学
Kidney international Pub Date : 2024-08-20 DOI: 10.1016/j.kint.2024.07.007
{"title":"Journal Club","authors":"","doi":"10.1016/j.kint.2024.07.007","DOIUrl":"10.1016/j.kint.2024.07.007","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":null,"pages":null},"PeriodicalIF":14.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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