Kidney international最新文献

{"title":"Phenotypic variability in phosphate transport disorders highlights need for individualized treatment strategies","authors":"Zewu Zhu ,&nbsp;Clemens Bergwitz","doi":"10.1016/j.kint.2024.10.020","DOIUrl":"10.1016/j.kint.2024.10.020","url":null,"abstract":"<div><div>Pathogenic variants in the <em>SLC34A1</em> and <em>SLC34A3</em> genes, encoding sodium-phosphate cotransporters 2a (NPT2a) and 2c (NPT2c), are linked to rare phosphate-wasting disorders. In this issue, Brunkhorst <em>et al.</em> explore the clinical presentations, biochemical profiles, and treatment outcomes associated with these genetic variants in 113 individuals. The study highlights distinct phenotypes, potential treatment challenges, and the need for further research to optimize therapeutic strategies and understand long-term outcomes for affected individuals.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 12-15"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential nuances in renoprotective properties of estrogen in females","authors":"Lanette M. Christensen ,&nbsp;Matthew H. Levine","doi":"10.1016/j.kint.2024.10.017","DOIUrl":"10.1016/j.kint.2024.10.017","url":null,"abstract":"<div><div>A current study by Kitai <em>et al.</em> found that ovariectomy before estrogen/female sex hormone sensitization at puberty provided protection against kidney ischemia reperfusion injury, challenging the general consensus within the field that estrogen provides renoprotective function. These results are intriguing and could have important clinical implications, while requiring some clarification and substantiation of the conclusions reported.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 10-12"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-acute kidney injury caused by postprocedure bladder perforation","authors":"Yusuke Nakamata ,&nbsp;Eiki Nagao ,&nbsp;Kiichiro Fujisaki","doi":"10.1016/j.kint.2024.08.007","DOIUrl":"10.1016/j.kint.2024.08.007","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Page 192"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Case | A patient with chronic kidney disease and new-onset heart failure","authors":"Shun Watanabe ,&nbsp;Naoki Sawa ,&nbsp;Rikako Hiramatsu ,&nbsp;Yuki Oba ,&nbsp;Hiroki Mizuno ,&nbsp;Shigekazu Kurihara ,&nbsp;Noriko Inoue ,&nbsp;Akinari Sekine ,&nbsp;Kiho Tanaka ,&nbsp;Masayuki Yamanouchi ,&nbsp;Eiko Hasegawa ,&nbsp;Tatsuya Suwabe ,&nbsp;Takehiko Wada ,&nbsp;Izumi Sugimoto ,&nbsp;Yoshifumi Ubara","doi":"10.1016/j.kint.2024.10.014","DOIUrl":"10.1016/j.kint.2024.10.014","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 195-196"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"journal club","authors":"","doi":"10.1016/j.kint.2024.11.002","DOIUrl":"10.1016/j.kint.2024.11.002","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 2-3"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission of tuberculosis via kidney allograft","authors":"Ludmila Beatriz Silva Santos ,&nbsp;Sérgio Pinto de Souza ,&nbsp;Julia Barros Cabral ,&nbsp;Rogério da Hora Passos ,&nbsp;Ricardo Santos Souza ,&nbsp;Ana Paula Maia Baptista","doi":"10.1016/j.kint.2024.08.011","DOIUrl":"10.1016/j.kint.2024.08.011","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Page 193"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the risk of cardiovascular events associated with different immunosuppression treatments for glomerular diseases","authors":"Mark Canney ,&nbsp;Mohammad Atiquzzaman ,&nbsp;Yuyan Zheng ,&nbsp;Dilshani Induruwage ,&nbsp;Yinshan Zhao ,&nbsp;Lee Er ,&nbsp;Christopher B. Fordyce ,&nbsp;Sean J. Barbour","doi":"10.1016/j.kint.2024.10.015","DOIUrl":"10.1016/j.kint.2024.10.015","url":null,"abstract":"<div><div>Patients with glomerular disease are at high risk of cardiovascular disease but the contribution of immunosuppression to this risk is unclear. In this retrospective cohort study of 1912 patients (comprised of 759 with IgA nephropathy, 540 with focal segmental glomerulosclerosis, 387 with membranous nephropathy and 226 with minimal change disease) from British Columbia, Canada, we evaluated the association between exposure to specific immunosuppressive medications and a composite outcome including coronary artery, cerebrovascular and peripheral arterial events. Survival models were adjusted for baseline cardiovascular risk factors, type of glomerular disease, estimated glomerular filtration rate (eGFR) and proteinuria over time. During a median follow-up of 6.8 years, 212 patients (11.1%) experienced the primary outcome. Corticosteroid exposure was not significantly associated with the primary outcome after adjusting for cardiovascular risk factors. In fully adjusted models, cumulative calcineurin inhibitor exposure at modest (150-300 defined daily doses [DDD]) and higher (300 or more DDD) doses were associated with a 2-fold higher risk of cardiovascular events (hazard ratio 2.98, 95% confidence interval 1.27-6.95) and (2.78, 1.32-5.84), respectively. A peak daily dose of antimetabolite (azathioprine, mycophenolate mofetil and mycophenolate sodium) of 0.5 or more DDD was associated with higher risk of cardiovascular events after adjustment for baseline risk factors and type of glomerular disease, but not after adjusting for time-varying eGFR and proteinuria (1.70, 0.91-3.20). Each 10 grams of cumulative cyclophosphamide exposure was associated with a 1.5-fold higher risk of cardiovascular events in a fully adjusted model (1.46, 1.22-1.75) Thus, our findings suggest that immunosuppressive therapies used in the treatment of glomerular disease may have different cardiovascular risk profiles, which should be considered when deciding on immunosuppression for individual patients and as a safety endpoint in future clinical trials.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 143-154"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher intraoperative blood pressure does not reduce acute kidney injury in noncardiac surgery: what do the results of the POISE-3 trial tell us?","authors":"Nicholas M. Selby ,&nbsp;Lui G. Forni","doi":"10.1016/j.kint.2024.10.011","DOIUrl":"10.1016/j.kint.2024.10.011","url":null,"abstract":"<div><div>Hypotension is a common cause of acute kidney injury (AKI), with strong associations between the duration and magnitude of hypotension seen across a range of situations including major surgery. However, it is less clear whether targeting higher intraoperative MAP results in lower rates of AKI. In a prespecified analysis of the Perioperative Ischemic Evaluation-3 (POISE-3) randomized controlled trial, this question is addressed for noncardiac major surgery. Despite an increase in cessation of antihypertensive medications and higher intraoperative mean arterial blood pressure in the intervention arm, no differences were seen in the rates of postoperative AKI. This commentary discusses the strengths and weaknesses of the trial, as well as providing some interpretation of results and their relevance to clinical practice.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 15-17"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amoxicillin crystalluria and amoxicillin-induced crystal nephropathy: a narrative review","authors":"Dominique Vodovar ,&nbsp;Cyril Mousseaux ,&nbsp;Michel Daudon ,&nbsp;Matthieu Jamme ,&nbsp;Emmanuel Letavernier","doi":"10.1016/j.kint.2024.09.019","DOIUrl":"10.1016/j.kint.2024.09.019","url":null,"abstract":"<div><div>Amoxicillin crystalluria (AC) refers to the precipitation of amoxicillin in the urine as amoxicillin trihydrate crystals. Amoxicillin-induced crystal nephropathy (AICN) refers to the obstruction of kidney tubules by amoxicillin trihydrate crystals, resulting in acute kidney injury. Usually considered rare and not serious, AC and AICN would be more frequent in patients receiving high-dose i.v. amoxicillin (≥150 mg/kg per day) than previously reported. AC prevalence ranges from 24% to 41%. AICN prevalence remains unclear. AC is generally asymptomatic, but sudden macroscopic hematuria with cloudy urine suggests the diagnosis. AC is diagnosed by detecting amoxicillin trihydrate crystals in urine. AC is a risk factor for acute kidney injury. Diagnosing AICN is more challenging in the absence of noninvasive diagnostic tools. It is suspected in high-dose i.v. amoxicillin–treated patients who develop acute kidney injury and AC, and after excluding other causes of acute kidney injury (mainly sepsis and acute interstitial nephritis). When testing for AC is unavailable, the presence of demonstrated (high blood amoxicillin levels and low urinary pH) or suspected (rapid i.v. amoxicillin administration and hypovolemia) risk factors for AC suggests its diagnosis. AICN management includes discontinuation/reduction of amoxicillin doses and volume resuscitation to improve tubular flow and urine output and decrease amoxicillin supersaturation. Patients generally recover normal kidney function rapidly after stopping amoxicillin, but renal replacement therapy is required in 10%-40% of patients. No deaths have been directly attributed to AICN. Future studies are needed to assess the exact prevalence of AC/AICN and to define optimal therapeutic options.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 33-43"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding arrythmias by personalizing the dialysate concentration: a case for precision medicine in patients on dialysis","authors":"T. Alp Ikizler ,&nbsp;Tilman B. Drueke ,&nbsp;Jürgen Floege ,&nbsp;Germaine Wong","doi":"10.1016/j.kint.2024.10.009","DOIUrl":"10.1016/j.kint.2024.10.009","url":null,"abstract":"<div><div>Cardiac arrythmias are common in patients undergoing maintenance hemodialysis. In this issue, Charytan <em>et al</em>. showed that in patients with hyperkalemia (serum potassium concentration 5.10–6.50 mmol/l [5.1–6.5 mEq/l]) on hemodialysis, a dialysate concentration of 3 mEq/l combined with sodium zirconium cyclosilicate on dialysis-free days is associated with a lower frequency of atrial fibrillation compared with a dialysate concentration of 2 mEq/l over 8 weeks. Despite the obvious limitations such as small sample size, short treatment period, and lack of information on longer-term impact on important patient outcomes such as sudden death, this well-conceived pilot study provided impetus for larger prospective trials to test whether this personalized approach reduces major cardiovascular events and mortality.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"107 1","pages":"Pages 18-20"},"PeriodicalIF":14.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}