Kidney international最新文献

{"title":"Appendicitis associated with sevelamer use in a patient receiving peritoneal dialysis","authors":"Zan Shareef , Merry Spradling , Pamela Blair , Irmaris Quiñones-Vargas , Namita Singh , Darren Schmidt , Jain Zhou , Pablo Garcia","doi":"10.1016/j.kint.2024.04.023","DOIUrl":"10.1016/j.kint.2024.04.023","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 5","pages":"Page 1000"},"PeriodicalIF":14.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats.” Kidney International 2013;85:112–123","authors":"Hailin Zhao , Xianghong Luo , Zhaowei Zhou , Juying Liu , Catherine Tralau-Stewart , Andrew J.T. George , Daqing Ma","doi":"10.1016/j.kint.2024.07.017","DOIUrl":"10.1016/j.kint.2024.07.017","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 5","pages":"Page 1001"},"PeriodicalIF":14.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"journal club","authors":"","doi":"10.1016/j.kint.2024.09.004","DOIUrl":"10.1016/j.kint.2024.09.004","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 5","pages":"Pages 777-780"},"PeriodicalIF":14.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney failure and a reticulated dermatosis","authors":"Bastian Robinson Baarz , Julia Huynh , Felix Constantin Heuschert , Kai-Uwe Eckardt , Julia Bontscho","doi":"10.1016/j.kint.2024.05.012","DOIUrl":"10.1016/j.kint.2024.05.012","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 5","pages":"Page 998"},"PeriodicalIF":14.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with crush syndrome and kidney disease: lessons learned from the earthquake in Kahramanmaraş, Türkiye","authors":"Savas Ozturk ,&nbsp;Serhan Tuglular ,&nbsp;Refik Olmaz ,&nbsp;Ismail Kocyigit ,&nbsp;Muge Uzerk Kibar ,&nbsp;Kenan Turgutalp ,&nbsp;Dilek Torun ,&nbsp;Tuncay Sahutoglu ,&nbsp;Ozlem Usalan ,&nbsp;Ozkan Gungor ,&nbsp;Ramazan Danis ,&nbsp;Gursel Yildiz ,&nbsp;Ali Gurel ,&nbsp;Mehmet Horoz ,&nbsp;Mehmet Kucuksu ,&nbsp;Suleyman Karakose ,&nbsp;Tolga Yildirim ,&nbsp;Mehmet Riza Altiparmak ,&nbsp;Mehmet Deniz Ayli ,&nbsp;Murat Tugcu ,&nbsp;Mehmet Sukru Sever","doi":"10.1016/j.kint.2024.08.008","DOIUrl":"10.1016/j.kint.2024.08.008","url":null,"abstract":"<div><div>This study investigated in-hospital outcomes and related factors in patients diagnosed with postearthquake crush syndrome after the earthquakes in Kahramanmaraş, Türkiye. One thousand twenty-four adult patients diagnosed with crush syndrome were analyzed. Data on demographic characteristics, clinical presentation, laboratory values, treatments, and outcomes were collected. A total of 9.8% of patients died during their hospital stay. Nonsurvivors were generally older, more likely to have preexisting chronic kidney disease, and faced more severe injuries and complications, including hypotension-shock, arrhythmias, elevated markers of renal dysfunction, and higher rates of acute kidney injury (AKI) and compartment syndrome. In addition, intensive care unit needs were higher. Multivariate analysis confirmed that age, injury severity, shock, high potassium, uric acid, and lactate levels on admission, development of AKI, compartment syndrome, and intensive care unit admission were significant predictors of mortality. Better disaster preparedness and improved health care infrastructure could be potential explanations for improved in-hospital mortality in the current era, as compared to previous earthquakes.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 5","pages":"Pages 771-776"},"PeriodicalIF":14.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international, multi-center study evaluated rituximab therapy in childhood steroid-resistant nephrotic syndrome","authors":"Eugene Yu-hin Chan ,&nbsp;Aditi Sinha ,&nbsp;Ellen L.M. Yu ,&nbsp;Naureen Akhtar ,&nbsp;Andrea Angeletti ,&nbsp;Arvind Bagga ,&nbsp;Sushmita Banerjee ,&nbsp;Olivia Boyer ,&nbsp;Chang-Yien Chan ,&nbsp;Anna Francis ,&nbsp;Gian Marco Ghiggeri ,&nbsp;Riku Hamada ,&nbsp;Pankaj Hari ,&nbsp;Nakysa Hooman ,&nbsp;Luke Sydney Hopf ,&nbsp;Mohamad Ikram I ,&nbsp;Iftikhar Ijaz ,&nbsp;Dmytro D. Ivanov ,&nbsp;Suprita Kalra ,&nbsp;Hee Gyung Kang ,&nbsp;Kjell Tullus","doi":"10.1016/j.kint.2024.09.011","DOIUrl":"10.1016/j.kint.2024.09.011","url":null,"abstract":"<div><div>The efficacy and safety of rituximab in childhood steroid-resistant nephrotic syndrome (SRNS) remains unclear. Therefore, we conducted a retrospective cohort study at 28 pediatric nephrology centers from 19 countries in Asia, Europe, North America and Oceania to evaluate this. Children with SRNS treated with rituximab were analyzed according to the duration of calcineurin inhibitors (CNIs) treatment before rituximab [6 months or more (CNI-resistant) and under 6 months]. Primary outcome was complete/partial remission (CR/PR) as defined by IPNA/KDIGO guidelines. Secondary outcomes included kidney failure and adverse events. Two-hundred-forty-six children (mean age, 6.9 years; 136 boys; 57% focal segmental glomerulosclerosis, FSGS) were followed a median of 32.4 months after rituximab. All patients were in non-remission before rituximab. (146 and 100 children received CNIs for 6 month or more or under 6 months before rituximab, respectively). In patients with CNI-resistant SRNS, the remission rates (CR/PR) at 3-, 6-, 12- and 24-months were 26% (95% confidence interval 19.3-34.1), 35.6% (28.0-44.0), 35.1% (27.2-43.8) and 39.1% (29.2-49.9), respectively. Twenty-five patients were in PR at 12-months, of which 22 had over 50% reduction in proteinuria from baseline. The remission rates among children treated with CNIs under 6 months before rituximab were 42% (32.3-52.3), 52% (41.8-62.0), 54% (44.3-64.5) and 60% (47.6-71.3) at 3-, 6-, 12-, and 24-months. Upon Kaplan-Meier analysis, non-remission and PR at 12-months after rituximab, compared to CR, were associated with significantly worse kidney survival. Adverse events occurred in 30.5% and most were mild. Thus, rituximab enhances remission in a subset of children with SRNS, is generally safe and CR following rituximab is associated with favorable kidney outcome.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1146-1157"},"PeriodicalIF":14.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of aldehyde dehydrogenase 2 in kidney proximal tubules contributes to kidney fibrosis through Transforming Growth Factor-β signaling.","authors":"I-Jen Chiu, Amrendra K Ajay, Che-Hong Chen, Shreyas Jadhav, Li Zhao, Minghua Cao, Yan Ding, Kavya M Shah, Sujal I Shah, Li-Li Hsiao","doi":"10.1016/j.kint.2024.09.010","DOIUrl":"10.1016/j.kint.2024.09.010","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is an increasingly prevalent disorder that poses a significant global health and socioeconomic burden. East Asian countries such as China, Taiwan, Japan, and South Korea have a higher incidence and prevalence of kidney failure when compared to Western nations, and the reasons for this discrepancy remain unclear. Aldehyde dehydrogenase 2 (ALDH2) is an essential detoxifying enzyme for exogenous and endogenous aldehyde metabolism in mitochondria. Inactivating mutations at E504K and E487K are found in 35-45% of East Asian populations and has been linked to a higher risk of various disorders, including cardiovascular diseases and cancer. However, little is known about the role of ALDH2 in CKD. Here, we characterized the expression pattern of ALDH2 in normal and CKD human and mouse kidneys and demonstrated that ALDH2 expression was significantly reduced, and that the protein level was inversely correlated with the degree of CKD and fibrosis. Further, we treated ALDH2∗2 knock-in mice, a loss of ALDH2 function model, with aristolochic acid and found that these mice showed enhanced fibrosis. Moreover, ALDH2 deficiency was associated with kidney fibrosis involving epithelial cell differentiation process in vivo and in vitro. However, ALDH2 overexpression protected proximal tubule epithelial cells from transforming growth factor-β-induced dedifferentiation or partial epithelial-mesenchymal transdifferentiation in vitro. Thus, our findings yield important clinical information regarding the development and progression of CKD involving ALDH2, especially among East Asian populations.</p>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":" ","pages":""},"PeriodicalIF":14.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum","authors":"David Kavanagh ,&nbsp;Gianluigi Ardissino ,&nbsp;Vicky Brocklebank ,&nbsp;Romy N. Bouwmeester ,&nbsp;Arvind Bagga ,&nbsp;Rob ter Heine ,&nbsp;Sally Johnson ,&nbsp;Christoph Licht ,&nbsp;Alison L.T. Ma ,&nbsp;Marina Noris ,&nbsp;Manuel Praga ,&nbsp;Eric Rondeau ,&nbsp;Aditi Sinha ,&nbsp;Richard J.H. Smith ,&nbsp;Neil S. Sheerin ,&nbsp;H. Trimarchi ,&nbsp;Jack F.M. Wetzels ,&nbsp;Marina Vivarelli ,&nbsp;Nicole C.A.J. Van de Kar ,&nbsp;Larry A. Greenbaum ,&nbsp;Zoltán Prohászka","doi":"10.1016/j.kint.2024.09.012","DOIUrl":"10.1016/j.kint.2024.09.012","url":null,"abstract":"<div><div>Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1038-1050"},"PeriodicalIF":14.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removing interoceptive input from the kidney to the brain reduces salt appetite in DOCA hypertensive rats","authors":"Mariana R. Lauar ,&nbsp;Rawan N. Almutlaq ,&nbsp;Sridhatri Guntipally ,&nbsp;Babatunde S. Anidu ,&nbsp;Rachel Kram ,&nbsp;Jaryd Ross ,&nbsp;John W. Osborn ,&nbsp;Alex Dayton ,&nbsp;Louise C. Evans","doi":"10.1016/j.kint.2024.08.033","DOIUrl":"10.1016/j.kint.2024.08.033","url":null,"abstract":"","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1181-1185"},"PeriodicalIF":14.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary biomarkers for active Lupus Nephritis that have survived independent validation across cohorts","authors":"Sonja Vodehnal ,&nbsp;Chandra Mohan","doi":"10.1016/j.kint.2024.09.007","DOIUrl":"10.1016/j.kint.2024.09.007","url":null,"abstract":"<div><div>Most reported biomarkers for lupus nephritis (LN) have not been independently validated across cohorts. Moreover, many of the documented biomarker candidates have been reported to be elevated in LN compared to healthy controls. However, biomarkers that distinguish patients with active LN (ALN) from inactive systemic lupus erythematosus (iSLE) hold significant clinical utility. Hence, our review attempts to identify urine protein biomarkers for LN that have been independently validated across two or more cohorts and exhibit good diagnostic potential for distinguishing ALN from iSLE. PubMed and OVID were screened for studies assessing the diagnostic value of urinary biomarkers in patients with ALN compared to iSLE. Forty peer-reviewed articles were evaluated, encompassing urine biomarker data from 3,411 distinct patients. Of the 32 candidate biomarkers identified, fourteen were repeatedly reported/tested in four or more papers each, namely ALCAM, CCL2 (MCP1), CD163, HAVCR1 (KIM-1), HPGDS, ICAM-1 (CD54), ICAM-2 (CD102), IGFBP-2, LCN2, NCAM-1 (CD56), SELE (E-Selectin), SELL (L-Selectin), TNFSF12 (TWEAK), and VCAM-1, with most exhibiting C-statistics of 0.80 or more across multiple studies when discriminating patients with ALN from iSLE. The 32 reproducibly elevated biomarkers for active LN mapped to nine functional categories. The urinary proteins reported here promise to serve as a liquid biopsy for ALN. Besides representing potential candidates for diagnostic, monitoring, predictive, and prognostic biomarkers in LN, they also provide a window into potential molecular processes within the kidney that may be driving LN. Thus, ongoing advances in proteomics, which offer wider proteome coverage at increased sensitivity, are likely to further reshape our perspective of urinary biomarkers for LN.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1135-1145"},"PeriodicalIF":14.8,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}