Xiao Chang, Michael D. Kim, A. Chiba, G. Tsechpenakis
{"title":"Motor neuron recognition in the Drosophila ventral nerve cord","authors":"Xiao Chang, Michael D. Kim, A. Chiba, G. Tsechpenakis","doi":"10.1109/ISBI.2013.6556816","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556816","url":null,"abstract":"We exploit the morphological stereotypy and relative simplicity of the Drosophila nervous system to model the diverse neuronal morphologies of individual motor neurons and understand underlying principles of synaptic connectivity in a motor circuit. In our analysis, we use images depicting single neurons labeled with green fluorescent protein (GFP) and serially imaged with laser scanning confocal microscopy. We model morphology with a novel formulation of Conditional Random Fields, a hierarchical latent-state CRF, to capture the highly varying compartment-based structure of the neurons (soma-axon-dendrites). In the training phase, we follow two approaches: (i) hierarchical learning, were compartment labels are given, and (ii) latent-state learning, where compartment labels are not given in the training samples. We demonstrate the accuracy of our approach using wild-type MNs in the larval ventral nerve cord. However, our method can also be used for the identification of MN mutations, as well as the automated annotation of the motor circuitry in wild type and mutant animals.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116928260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accelerated noncartesian sense reconstruction using a majorize-minimize algorithm combining variable-splitting","authors":"S. Ramani, J. Fessler","doi":"10.1109/ISBI.2013.6556572","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556572","url":null,"abstract":"Magnetic resonance imaging (MRI) provides great flexibility in the choice of k-space sampling trajectories. NonCartesian trajectories exhibit several advantages over Cartesian ones but are less amenable to FFT-based manipulation of k-space data. Thus, existing iterative reconstruction methods for nonCartesian trajectories require relatively more computation (interpolation/gridding in addition to FFTs) and can be slow, especially for (undersampled) parallel MRI. In this work, we focus on SENSE-based regularized image reconstruction for nonCartesian trajectories and propose a majorize-minimize approach where we first majorize the SENSE data-fidelity term with a quadratic form involving a symmetric positive definite circulant matrix. For the minimization step, we apply a suitable variable splitting (VS) strategy combined with the augmented Lagrangian framework and alternating minimization that together decouple the circulant matrix from coil sensitivities and the regularizer. The resulting iterative algorithm admits simple update steps, is amenable to FFT-based matrix inversions due in part to the circulant matrix in the majorizer and provides a natural framework for incorporating a two-step procedure for acceleration. Simulations indicate that the proposed algorithm converges faster than some state-of-the-art VSbased iterative image reconstruction methods for the same problem.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117133102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D cardiac cine reconstruction from free-breathing 2D real-time image acquisitions using iterative motion correction","authors":"Martin Jantsch, D. Rueckert, A. Price, J. Hajnal","doi":"10.1109/ISBI.2013.6556599","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556599","url":null,"abstract":"MR imaging is well suited for diagnosis, treatment and study of various cardiac diseases affecting the functionality and morphology of the heart. MR imaging provides good tissue contrast and can achieve high spatial and temporal resolution. Most current MR acquisition methods require breath-holds during the acquisition or employ respiratory gating to avoid image corruption caused by respiratory motion. Also cardiac gating is applied to achieve time resolved sampling for functional analysis. Breath-holds can be difficult for patients and gating methods can be undermined by irregular motion patterns. Real-time imaging offers a potential solution to both these issues, but poses its own challenges. We present initial results for a reconstruction pipeline that takes multiple stacks of 2D real-time, short-axis images acquired during free-breathing and computes the respiratory deformations to reconstruct a coherent 3D+t volume of the beating heart.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117154259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Yaroshenko, F. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, Mark Müller, S. Auweter, A. Bohla, A. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. Reiser, F. Pfeiffer
{"title":"Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation","authors":"A. Yaroshenko, F. Meinel, M. Bech, A. Tapfer, A. Velroyen, S. Schleede, Mark Müller, S. Auweter, A. Bohla, A. Yildirim, K. Nikolaou, F. Bamberg, O. Eickelberg, M. Reiser, F. Pfeiffer","doi":"10.1109/ISBI.2013.6556489","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556489","url":null,"abstract":"Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an X-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and darkfield signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and darkfield signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121098845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuo Zhang, Dajiang Zhu, Xi Jiang, Lei Guo, Tianming Liu
{"title":"Predicting functional cortical ROIs via joint modeling of anatomical and connectional profiles","authors":"Tuo Zhang, Dajiang Zhu, Xi Jiang, Lei Guo, Tianming Liu","doi":"10.1109/ISBI.2013.6556525","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556525","url":null,"abstract":"Localization of functional cortical ROIs (regions of interests) in structural data such as DTI and T1-weighted MRI has significant importance in basic and clinical neuroscience. However, this problem is challenging due to the lack of quantitative mapping between brain structure and function, which relies on both the availability of benchmark training data such as task-based fMRI and effective machine learning algorithms. By using task-based fMRI derived ROIs as benchmarks, this paper presents a novel approach that develops predictive models of those ROIs based on concurrent DTI and T1-weighted MRI datasets within a machine learning paradigm. Particularly, in application stage, the predictive models are only applied on the structural datasets to predict functional ROI locations, which are evaluated by cross-validation studies, independent tests and reproducibility studies. We envision that these predictive models can be widely applied in scenarios that have only DTI and/or MRI data, but without task-based fMRI data.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121369631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chenhui Hu, Lin Cheng, J. Sepulcre, G. Fakhri, Yue M. Lu, Quanzheng Li
{"title":"A graph theoretical regression model for brain connectivity learning of Alzheimer'S disease","authors":"Chenhui Hu, Lin Cheng, J. Sepulcre, G. Fakhri, Yue M. Lu, Quanzheng Li","doi":"10.1109/ISBI.2013.6556550","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556550","url":null,"abstract":"Learning functional brain connectivity is essential to the understanding of neurodegenerative diseases. In this paper, we introduce a novel graph regression model (GRM) which regards the imaging data as signals defined on a graph and optimizes the fitness between the graph and the data, with a sparsity level regularization. The proposed framework features a nice interpretation in terms of low-pass signals on graphs, and is more generic compared with the previous statistical models. Results based on the simulated data illustrates that our approach can obtain a very close reconstruction of the true network. We then apply the GRM to learn the brain connectivity of Alzheimer's disease (AD). Evaluations performed upon PET imaging data of 30 AD patients demonstrate that the connectivity patterns discovered are easy to interpret and consistent with known pathology.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127084308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Lee, R. Sparks, Sahirzeeshan Ali, A. Madabhushi, M. Feldman, S. Master, N. Shih, J. Tomaszeweski
{"title":"Co-occurring gland tensors in localized cluster graphs: Quantitative histomorphometry for predicting biochemical recurrence for intermediate grade prostate cancer","authors":"George Lee, R. Sparks, Sahirzeeshan Ali, A. Madabhushi, M. Feldman, S. Master, N. Shih, J. Tomaszeweski","doi":"10.1109/ISBI.2013.6556425","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556425","url":null,"abstract":"Quantitative histomorphometry (QH), computational tools to analyze digitized tissue histology, has become increasingly important for aiding pathologists in assessing cancer severity. In this study, we introduce a novel set of QH features utilizing co-occurring gland tensors (CGT) in localized cluster graphs to quantitatively evaluate prostate cancer (CaP) histology. CGTs offer three main advantages over previous QH features: 1) gland tensors represent a novel measurement that has been anecdotally described as one of interest, but never quantitatively modeled, 2) CGTs extract measurements based on local rather than global glandular networks, constructed using cluster graphs, and 3) second order statistical features (energy, homogeneity, energy, and correlation) obtained from a co-occurrence matrix capture the spatial interactions of gland tensors in the image. We extract 4 CGT features from 56 regions across 40 intermediate grade CaP patients and evaluated the ability of CGT features to predict biochemical recurrence (BCR) within 5 years of radical prostatectomy. Intermediate Gleason score 7 cancers represent the predictive borderline for BCR cases, where 50% of cases develop BCR. We found that CGT features outperformed 5 different sets of QH features, previously shown to be effective in CaP grading, when evaluated via a Random Forest classifier (66% accuracy for CGT features versus 55% for the next closest QH feature set), all comparisons being statistically significant.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127447313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hippocampus segmentation through gradient based reliability maps for local blending of ACM energy terms","authors":"D. Zarpalas, P. Gkontra, P. Daras, N. Maglaveras","doi":"10.1109/ISBI.2013.6556410","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556410","url":null,"abstract":"This paper presents a novel 3D segmentation framework for structures with spatially varying boundary properties, such as the hippocampus (HC). The proposed method is based on Active Contour Models (ACMs) built on top of the multi-atlas concept. We propose the incorporation of an Adaptive Gradient Distribution on the Boundary map (AGDB) into the ACM framework. AGDB, by being adapted to the evolving contour, constantly redefines, at a voxel level and at each contour evolution, the degree of contribution of the image information and the prior information to the energy minimization. The proposed segmentation scheme was tested for HC segmentation using the publicly available IBSR database.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126125618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Q. Tao, M. V. D. Giessen, Sebastiaan R. Piers, K. Zeppenfeld, R. Geest
{"title":"Combining magnetic resonance late gadolinium enhanced and Look-Locker sequences for myocardial scar characterization","authors":"Q. Tao, M. V. D. Giessen, Sebastiaan R. Piers, K. Zeppenfeld, R. Geest","doi":"10.1109/ISBI.2013.6556479","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556479","url":null,"abstract":"Characterization of myocardial scar has important diagnostic and prognostic value for treatment of post-infarction patients. Late gadolinium enhanced (LGE) MR visualizes myocardial scar as regions of hyper-enhanced signal intensity, however, the accuracy and reproducibility of scar characterization is impaired by the lack of an absolute measure in this imaging modality. We propose a new method to calibrate the signal intensity of LGE MR using the accompanying Look-Locker (LL) MR sequence which measures the absolute tissue T1 relaxation properties. The calibrated LGE MR results in accurate scar characterization, as demonstrated by comparison with high-density electroanatomic voltage mapping (EAVM) data acquired during a ventricular tachycardia (VT) ablation procedure in a group of 15 post-infarction patients.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123555328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenqi Li, Jianguo Zhang, S. McKenna, M. Coats, F. Carey
{"title":"Classification of colorectal polyp regions in optical projection tomography","authors":"Wenqi Li, Jianguo Zhang, S. McKenna, M. Coats, F. Carey","doi":"10.1109/ISBI.2013.6556580","DOIUrl":"https://doi.org/10.1109/ISBI.2013.6556580","url":null,"abstract":"The potential of optical projection tomography (OPT) to enhance colorectal polyp diagnosis is beginning to be explored. This paper presents, to the best of our knowledge, the first study on automatic image analysis of OPT images of colorectal polyps. 3D regions are classified using the bag of visual words framework and support vector machines. Independent subspace analysis is used to learn a domain-specific feature dictionary. This is compared to the use of raw patches (after random projection) and local binary patterns. Classification experiments (across patients) at the patch level and at the region level are presented using a set of 30 expert-annotated OPT images. Results show that accurate classification of 3D OPT image regions is feasible using this approach; regions of low-grade dysplasia and invasive cancer were discriminated with approximately 90% accuracy.","PeriodicalId":178011,"journal":{"name":"2013 IEEE 10th International Symposium on Biomedical Imaging","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128443422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}