Jurnal e-Biomedik最新文献

{"title":"Pengaruh Obat Antihipertensi terhadap Disfungsi Ereksi","authors":"Stela G. Amrin, Lydia E. N. Tendean, Grace L. A. Turalaki","doi":"10.35790/ebm.v9i1.31766","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31766","url":null,"abstract":"Abstract: Erectile dysfunction (ED) is a condition where intercourse is not interrupted due to the inability of the penis to achieve a penile erection. Drugs that can affect erectile dysfunction are drugs for hypertension therapy, namely diuretics and β-blockers, except for nebivolol and clonidine. The purpose of this study was to determine the effect of antihypertensive drugs on erectile dysfunction. This study was in the form of a literature review by searching data using three databases namely ScienceDirect, Pubmed and Google Scholar. The keywords used were antihypertensive drugs AND erectile dysfunction. After being selected based on inclusion and exclusion criteria, there were 12 literature consisting of 4 randomized controlled trials, 3 cross-sectional studies, 2 cohort studies and 1 case control study. The research shows that 3 out of 5 literature states that there is an effect of diuretic antihypertensive drugs on the occurrence of erectile dysfunction, while 6 out of 9 literature states that there is no effect of β-blocker antihypertensive drugs on the occurrence of erectile dysfunction. In conclusion, diuretic and β-blocker as antihypertensive drugs have an effect on erectile dysfunction. Diuretic antihypertensive drugs have more impact on erectile dysfunction compared to β-blocker antihypertensive drugs.Keywords: Antihypertensive drugs, erectile dysfunction  Abstrak: Disfungsi ereksi (DE) adalah keadaan dimana hubungan seksual terganggu akibat ketidakmampuan penis dalam mencapai ereksi penis. Obat yang dapat mempengaruhi disfungsi ereksi yaitu obat untuk terapi hipertensi yaitu golongan diuretik dan golongan β-blocker kecuali nebivolol dan klonidin. Tujuan penelitian ini adalah untuk mengetahui pengaruh obat antihipertensi terhadap disfungsi ereksi. Penelitian ini dalam bentuk literature review dengan pencarian data menggunakan tiga database yaitu ScienceDirect, Pubmed dan Google Cendekia. Kata kunci yang digunakan yaitu obat antihipertensi DAN disfungsi ereksi. Setelah diseleksi berdasarkan kriteria inklusi dan eksklusi didapatkan 12 literatur yang terdiri dari 4 randomized controlled trial, 3 cross-sectional study, 2 cohort study dan 1 case control study. Dari penelitian menunjukan bahwa 3 dari 5 literatur menyebutkan terdapat pengaruh obat antihipertensi golongan diuretik terhadap terjadinya disfungsi ereksi, sedangkan 6 dari 9 literatur menyebutkan tidak terdapat pengaruh obat antihipertensi golongan β-blocker terhadap terjadinya disfungsi ereksi. Sebagai simpulan, obat antihipertensi golongan diuretik dan β-blocker memiliki pengaruh terhadap disfungsi ereksi. Obat antihipertensi golongan diuretik lebih berpengaruh terhadap disfungsi ereksi dibandingkan dengan obat antihipertensi golongan β-blocker.Kata Kunci: Obat antihipertensi, disfungsi ereksi","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76022805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostik Coronavirus Disease 2019 (COVID-19) dengan Pemeriksaan Laboratorium Mikrobiologi Klinik","authors":"Natasya Y. Damo, J. Porotu’o, Glady I. Rambert, Fredine E. S. Rares","doi":"10.35790/ebm.v9i1.31899","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31899","url":null,"abstract":"Abstract: The world is in fear of the pandemic Coronavirus Disease (COVID-19) which is so deadly, the World Health Organization (WHO) declared the world a global health emergency. The number of confirmed cases is still very high until now, even in Indonesia this pandemic is still not over. The transmission is so fast and wide, plus the current clinical manifestations of COVID-19 have varied, ranging from asymptomatic to severe. This literature review aims to determine the Diagnostic of COVID-19 with the most appropriate Clinical Microbiology Laboratory Examination and to find out the importance of Clinical Microbiology Laboratory examinations in COVID-19 Diagnostics. The method used is in the form of literature studies from several scientific sources that are accurate and valid regarding the Diagnostic of COVID-19 with Clinical Microbiology Laboratory Examination. The results showed that Polymerase Chain Reaction (PCR) is the gold standard in detecting COVID-19 although there are several factors that can affect the results of the PCR examination which then cause false negatives / positives. Conclusion Clinical Microbiology Laboratory Examination is very important and very helpful. Diagnostic COVID-19 in the Microbiology Laboratory can be done by using Rapid Diagnostic Test (RDT) Antigen, RDT Antibody, PCR, and Virus Culture. Diagnostic COVID-19 with the recommended Clinical Microbiology Laboratory Examination and the gold standard is PCR examination. However, there are also several factors that can affect the results of the PCR examination.Keywords: diagnostic, COVID-19, Clinical Microbiology Laboratory  Abstrak: Dunia sedang dalam ketakutan dengan pandemi Coronavirus Disease (COVID-19) yang begitu mematikan, Organisasi Kesehatan Dunia (WHO) menyatakan dunia sebagai darurat kesehatan global. Jumlah kasus yang terkonfirmasi masih sangat tinggi hingga saat ini, bahkan di Indonesia pandemi ini masih belum berakhir. Penularannya begitu cepat dan luas, sertta manifestasi klinis COVID-19 yang bervariasi, mulai dari asimtomatik hingga parah. Tinjauan pustaka ini bertujuan untuk mengetahui Diagnostik COVID-19 dengan Pemeriksaan Laboratorium Mikrobiologi Klinik yang paling sesuai dan untuk mengetahui pentingnya pemeriksaan Laboratorium Mikrobiologi Klinik dalam Diagnostik COVID-19. Metode yang digunakan berupa studi pustaka dari beberapa sumber ilmiah yang akurat dan valid mengenai Diagnostik COVID-19 dengan Pemeriksaan Laboratorium Mikrobiologi Klinik. Hasil penelitian menunjukkan bahwa Polymerase Chain Reaction (PCR) merupakan gold standard dalam mendeteksi COVID-19 meskipun terdapat beberapa faktor yang dapat mempengaruhi hasil pemeriksaan PCR yang kemudian menimbulkan false negatif/positif. Kesimpulan Pemeriksaan Laboratorium Mikrobiologi Klinik sangat penting dan sangat membantu. Diagnostik COVID-19 di Laboratorium Mikrobiologi dapat dilakukan dengan menggunakan Antigen Rapid Diagnostic Test (RDT), Antibodi RDT, PCR, dan Kultur Virus. Diagnostik COVI","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90912972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Kopi Terhadap Kekuatan Otot","authors":"Gabriella Kakauhe, Djon Wongkar, Elvin C. Angmalisang","doi":"10.35790/ebm.v9i1.32298","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.32298","url":null,"abstract":"Abstract: Coffee is one of the favorite drinks in the world today, with a consumption of 75% of the total consumption of soft drinks worldwide. Coffee consumption is believed to have an impact on health and muscle strength. Muscle strength itself is a component of fitness that has many aspects and is related to performances, which is supported by muscle, nerves, and mechanics factors. This study reviews the literature on the topic of the effect of coffee on muscle strength in order to determine the effects of coffee on muscle strength. This research is a literature review. Data searching was performed using 1 database, namely PubMed, using the keyword coffee AND muscle strength. The final result is (n=13). This study shows that coffee has a significant effect in increasing muscle strength. In conclusion, coffee has a significant effect on muscle strength.Keywords: coffee, muscle strength Abstrak: Kopi merupakan salah satu minuman terfavorit di dunia saat ini, dengan jumlah konsumsi 75% dari angka keseluruhan konsumsi minuman ringan di seluruh dunia. Konsumsi kopi sendiri dipercaya memiliki pengaruh terhadap kesehatan tubuh dan kekuatan otot. Kekuatan otot merupakan komponen kebugaran yang memiliki banyak aspek dan terkait dengan kinerja yang didukung oleh faktor otot, saraf, dan mekanis. Penelitian ini mengulas literatur dengan topik terkait pengaruh kopi terhadap kekuatan otot untuk mengetahui pengaruh kopi terhadap kekuatan otot. Penelitian ini merupakan penelitian yang sifatnya literature review. Pencarian data menggunakan 1 database yaitu PubMed menggunakan kata kunci coffee AND muscle strength. Didapatkan hasil akhir (n=13). Penelitian ini menunjukkan bahwa kopi memiliki pengaruh yang signifikan dalam meningkatkan kekuatan otot. Sebagai simpulan, kopi memiliki pengaruh yang signifikan terhadap kekuatan otot.Kata kunci: kopi, kekuatan otot","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87108144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakteristik Gambaran Histologis Paru-Paru Pasien COVID-19","authors":"Andre M. Gaghaube, Martha M. Kaseke, Sonny J. R. Kalangi","doi":"10.35790/ebm.v9i1.31896","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31896","url":null,"abstract":"Abstract: Severe acute respiratory syndrome coronavirus (SARS-COV-2) is an infectious disease caused by coronavirus. Coronavirus (COVID-19) first attacks the upper respiratory system such as the nose, mouth, throat even the lungs and can trigger symptoms of fever and cough (pneumonia) resulting in changes in lung organ tissue during histological examination. This study aimed to determine the characteristics of the histological picture of the lungs of COVID-19 patients. This research uses a literature review research method. Based on 12 research reports analyzed in this research, the most common characteristic of histological features found in 12 research report journals is the finding of a diffuse alveolar damage pattern. Diffuse alveolar damage is a condition of acute lung injury which is accompanied by an acute phase with edema, a hyaline membrane, and inflammation followed by an organizing phase, where there is hyperplasia of type II pneumocytes, there is also fibrin or intra-alveolar protein. In conclusion, the characteristics of the histological features of the lungs most commonly found in COVID-19 patients are the findings of a diffuse alveolar damage pattern, which is a condition of acute lung injury and an acute phase with edema, hyaline membrane, and inflammation followed by an organizing phase, namely there is hyperplasia of type II pneumocytes, there is also fibrin or intra-alveolar proteinKeywords: lung histology, COVID-19.  Abstrak: Severe acute respiratory syndrome coronavirus (SARS-COV-2) adalah sebuah penyakit menular yang disebabkan oleh coronavirus. Coronavirus (COVID-19) pertama kali menyerang sistem pernapasan bagian atas seperti hidung, mulut, tenggorokan bahkan sampai ke paru – paru dan dapat memicu gejala demam dan batuk (pneumonia) sehingga terjadi perubahan jaringan organ paru – paru  pada saat dilakukan pemeriksaan histologi. Penelitian bertujuan untuk mengetahui karakteristik gambaran histologis paru – paru pasien COVID-19. Penelitian ini menggunakan metode penelitian literature review. Berdasarkan 12 laporan penelitian yang di analisis pada penelitian ini, karakteristik gambaran histologis yang paling umum ditemukan pada 12 jurnal laporan penelitian yaitu terdapat temuan pola diffuse alveolar damage. Diffuse alveolar damage merupakan kondisi cedera paru akut atau acute lung injury yang disertai dengan fase akut dengan adanya edema, terdapat membran hialin, dan inflamasi di ikuti dengan fase pengorganisasian yaitu terdapat hiperplasia pneumosit tipe II, juga terdapat fibrin atau protein intra-alveolar. Sebagai simpulan, karakteristik gambaran histologis paru – paru yang paling umum ditemukan pada pasien COVID-19 adalah temuan pola diffuse alveolar damage yang merupakan kondisi cedera paru akut atau acute lung injury serta fase akut dengan adanya edema, terdapat membran hialin, dan inflamasi di ikuti dengan fase pengorganisasian yaitu terdapat hiperplasia pneumosit tipe II, juga terdapat fibrin atau protein intra-alveola","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81507171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nervus Olfaktorius: Dasar, Klinis Medis, dan Psikologis","authors":"Pingkan M. Ruru, T. Pasiak, M. M. Kaseke","doi":"10.35790/ebm.v9i1.31895","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31895","url":null,"abstract":"Abstract: The olfactory nerve is the first cranial nerve. Olfactory disorders can have a negative impact on health and quality of life and affect human psychology. The aim of this study is to determine the basic anatomical, clinical medical and psychological picture of the olfactory nerve. This study was in the form of a literature review. Literature is taken from one database, namely PubMed. The keywords used were olfactory nerve anatomy AND clinical AND psychology. After being selected with inclusion and exclusion criteria, 11 literature will be reviewed. Research from 11 literature reviewed found the basic anatomy of the olfactory nerve. Clinical disorders such as anosmia, hyposmia, phantosmia can occur in several non-neurodegenerative and neurodegenerative events or diseases, namely head injury trauma, Alzheimer's, Parkinson's and COVID-19. Psychological issues related to emotional and psychiatric disorders are also related to smell. In conclusion, the first cranial nerve is the olfactory nerve or the olfactory nerve, which clinically can occur in neurogenerative and non-neurodegenerative diseases. Smell and its disturbances can have a psychological impact.Keywords: olfactory nerve, anatomy, clinical, psychology.  Abstrak: Nervus olfaktorius merupakan saraf kranial pertama. Gangguan olfaktorius dapat berdampak buruk pada kesehatan dan kualitas hidup serta memengaruhi psikologis manusia. Tujuan penelitian untuk mengetahui gambaran dasar anatomi, klinis medis dan psikologis dari nervus olfaktorius. Penelitian ini dalam bentuk literature review. Literatur diambil dari  satu database yaitu PubMed. Kata kunci yang digunakan yaitu olfactory nerve anatomy AND clinical AND psychology. Setelah diseleksi dengan kriteria inklusi dan eksklusi didapatkan 11 literatur yang akan di review. Hasil penelitian dari 11 literatur yang di review didapatkan anatomi dasar nervus olfaktorius. Gangguan klinis seperti anosmia, hiposmia, phantosmia dapat terjadi pada beberapa kejadian atau penyakit non-neurodegeneratif dan neurodegeneratif yaitu Trauma cedera kepala, Alzheimer, Parkinson dan COVID-19. Psikologis yang berkaitan dengan emosional dan gangguan psikiatri juga berhubungan dengan penciuman. Sebagai simpulan, saraf kranial pertama adalah nervus olfaktorius atau disebut saraf penciuman, secara klinis bisa terjadi pada penyakit neurogeneratif dan non-neurodegeneratif. Penciuman dan gangguannya dapat memengaruhi psikologis.Kata kunci: Saraf olfaktori, anatomi, klinis, psikologi.","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85237546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gambaran Hematologi pada Wanita Hamil Trimester 3 yang Terkonfirmasi Positif SARS-CoV-2 di RSUP Prof. Dr. R.D. Kandou Periode Juli-September 2020","authors":"Tri M. Ibrahim, Glady I. Rambert, Siemona L. E. Berhimpon","doi":"10.35790/ebm.v9i1.31850","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31850","url":null,"abstract":"Abstract: Pregnancy is a condition of physiological and mechanical changes in the body that can reduce the ability of the immune system. During pregnancy, the normal changes that occur can be observed on the hematological index. There are studies that have found decreased levels of lymphocytes and monocytes, total leukocytes, increased platelet counts, and increased Hb in pregnant women infected with SARS-CoV-2. This study aimed to determine an overview of leucocytes, differential counting and platelets in 3rd trimester pregnant women. This research is a descriptive type of retrospective study, by collecting secondary data from medical record status. There were 26 samples of pregnant women in trimester 3 who were confirmed positive for SARS-CoV-2, 17 patients (65%) had an increase in the number of leukocytes. Differential counting was decreased stem neutrophils in 13 patients (50%), normal segment neutrophils in 16 patients (62%), decreased lymphocytes in 13 patients (50%), decreased eosinophils in 14 patients (54%), monocytes increased only in 2 patients (8%) and basophils were normal in all patients. 100% normal platelet count in all samples. In conclusion, the hematological features obtained are leukocytosis, decreased stem neutrophils, 62% normal segment neutrophils, lymphopenia, eosinopenia. normal 92% monocytes are normal, basophils and platelets within normal limits.Keywords: SARS-CoV-2, pregnant women, leukocytes, differential counting, thrombocyte  Abstrak: Kehamilan merupakan suatu kondisi perubahan fisiologis dan mekanis tubuh yang dapat berdampak pada penurunan kemampuan sistem kekebalan tubuh. Selama kehamilan, perubahan normal yang terjadi dapat diamati pada indeks hematologi. Terdapat penelitian yang menemukan penurunan kadar limfosit dan monosit, total leukosit, peningkatan jumlah trombosit, dan peningkatan Hb pada wanita hamil yang terinfeksi SARS-CoV-2. Tujuan penelitian ini untuk mengetahui gambaran leukosit, differential counting dan trombosit pada wanita hamil trimester 3. Penelitian ini merupakan jenis penelitian deskriptif dengan studi retrospektif, yaitu dengan mengumpulkan data sekunder berupa data dari status rekam medik. Terdapat 26 sampel wanita hamil trimester 3 yang terkonfirmasi positif SARS-CoV-2, 17 pasien (65%) mengalami peningkatan jumlah leukosit. Differential counting yaitu neutrofil batang menurun pada 13 pasien (50%), neutrofil segmen normal pada 16 pasien (62%), limfosit menurun pada 13 pasien (50%), eosinofil menurun pada 14 pasien (54%), monosit meningkat hanya pada 2 pasien (8%) dan basofil dalam jumlah normal pada semua pasien. Jumlah trombosit 100% normal pada semua sampel. Sebagai simpulan, gambaran hematologi yang didapatkan yaitu leukositosis, penurunan neutrofil batang, neutrofil segmen 62% normal, limfopenia, eosinopenia. monosit 92% normal, basofil dan trombosit dalam batas normal.Kata kunci : SARS-CoV-2, wanita hamil, leukosit, differential counting, trombosit ","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84888005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Ekstrak Biji Pepaya (Carica papaya L.) terhadap Kualitas Sperma","authors":"Muhammad I. Syamsuddin, Grace L. A. Turalaki, Lydia E. N. Tendean","doi":"10.35790/ebm.v9i1.31755","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31755","url":null,"abstract":"Abstract: Spermatozoa is a form of mature cells from cells germinal contained in the seminiferous tubules. The quality of spermatozoa can be seen from several parameters such as concentration, motility and morphology of spermatozoa. One of the plants that have the ability to affect the quality of spermatozoa is the seeds of the pepaya plant (Carica papaya L.). The purpose of this study was to determine the effect seed extract of papaya (Carica papaya L.) on the quality of spermatozoa, especially the concentration, motility and morphology of spermatozoa. This research is a literature review conducted by identifying and interpreting all the results of certain studies. Literature was obtained from the databases Pubmed, Sciencedirect, and Google Scholar. Based on the inclusion and exclusion criteria, 14 literatures were obtained. All selected literature are experimental form research. This study shows that 14 selected literatures, 8 literatures which the research result data gives a significant response in the form of a decrease in spermatozoa concentration, 13 literatures which the research result data gives a significant response in the form of decreased spermatozoa motility and 12 literatures which the research result data gives a significant response in the form of decreased normal morphology of spermatozoa. Conclusion: Seed extract of pepaya (Carica papaya L.) affects the quality of spermatozoa by reducing the concentration, motility and morphology of spermatozoa.  Abstrak: Spermatozoa merupakan bentuk sel matur dari sel germinal yang terdapat dalam tubulus seminiferus. Kualitas spermatozoa dapat dilihat dari beberapa parameter seperti konsentrasi, motilitas dan morfologi spermatozoa. Salah satu tanaman yang mempunyai kemampuan untuk memengaruhi kualitas spermatozoa adalah biji tanaman pepaya (Carica papaya L.). Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak biji pepaya (Carica papaya L.) terhadap kualitas spermatozoa terutama konsentrasi, motilitas dan morfologi spermatozoa. Penelitian ini merupakan penelitian yang bersifat studi pustaka (literature review) yang dilakukan dengan cara identifikasi dan interpretasi terhadap semua hasil penelitian tertentu. Literatur diperoleh dari database Pubmed, Sciencedirect, dan Google Scholar. Berdasarkan kriteria inklusi dan eksklusi didapatkan 14 literatur. Semua literatur yang terpilih adalah penelitian bentuk eksperimental. Penelitian ini menunjukkan bahwa dari 14 literatur yang terpilih, 8 literatur yang data hasil penelitiannya memberikan respon bermakna berupa penurunan konsentrasi spermatozoa, 13 literatur yang data hasil penelitiannya memberikan respon bermakna berupa penurunan motilitas spermatozoa dan 12 literatur yang data hasil penelitiannya memberikan respon bermakna berupa penurunan morfologi normal spermatozoa. Simpulan: Ekstrak biji pepaya (Carica papaya L.) memengaruhi kualitas spermatozoa yaitu menurunkan konsentrasi, motilitas dan morfologi spermatozoa.Kata kunci","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84486082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molekuler Docking tehadap Senyawa Eugenol dan Myricetin pada Tanaman Cengkeh (Syzygium aromaticum) sebagai Penghambat Pertumbuhan SARS-CoV-2","authors":"Yizreel Y. Gerungan, B. Kepel, .. Fatimawali, A. Manampiring, Fona Budiarso, Widdhi Bodhi","doi":"10.35790/ebm.v9i1.31748","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31748","url":null,"abstract":"Abstract: Cloves contain many chemical compounds that can be used for health. COVID-19 is a disease that is shaking the world today. Many people feel the impact of this disease. Until now, there is no definite cure and vaccine for the handling of COVID-19.  Objective to determine the interaction between compounds in cloves (eugenol and myricetin) and the main protease COVID-19 (6LU7). This study use a molecular docking, method using 4 main applications: autodock tools, autodock vina, biovia discovery studio and open babel. This study showed that almost all amino acid residues in the eugenol and myricetin compounds worked on the 6LU7 active site. The binding affinity of eugenol compounds in clove plants does not exceed the binding affinity of remdesivir, a drug studied as a drug for handling COVID-19, while the binding affinity of myricetin compounds in cloves plant exceeds the binding affinity of remdesivir. In conclusion, myricetin compounds have better results for use as a growth inhibitor for COVID-19 than eugenol.Key words: Cloves, COVID-19, molecular docking.  Abstrak: Cengkeh memiliki banyak kandungan senyawa kimia yang dapat dimanfaatkan bagi kesehatan. COVID-19 merupakan penyakit yang mengguncang dunia saat ini. Banyak masyarakat yang merasakan dampak dari penyakit ini. Hingga saat ini belum ada obat dan vaksin yang pasti untuk penanganan COVID-19. Penelitian ini bertujuan untuk mengetahui interaksi antara senyawa pada cengkeh (eugenol dan myricetin) dengan main protease COVID-19 (6LU7). Jenis penelitian ini menggunakan metode molekuler docking dengan menggunakan 4 aplikasi utama: autodock tools, autodock vina, biovia discovery studio dan open babel. Hasil penelitian ini menunjukkan bahwa hampir semua residu asam amino pada senyawa eugenol dan myricetin bekerja pada sisi aktif 6LU7. Hasil binding affinity senyawa eugenol pada tumbuhan cengkeh tidak melebihi binding affinity dari remdesivir, obat yang diteliti sebagai obat penanganan COVID-19, sedangkan hasil binding affinity senyawa myricetin pada tumbuhan cengkeh melebihi binding affinity dari remdesivir. Simpulan penelitian ini ialah senyawa myricetin memiliki hasil yang lebih baik untuk digunakan sebagai penghambat pertumbuhan COVID-19 dari pada eugenol.Kata kunci: Cengkeh, COVID-19, molekuler docking.","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"81 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87999080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Efikasi Ekstrak Tanaman Serai (Cymbopogon citratus) terhadap Tingkat Mortalitas Larva Nyamuk Aedes sp.","authors":"Sonnia J. Giroth, Janno B. B. Bernadus, Angle M. H. Sorisi","doi":"10.35790/ebm.v9i1.31716","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31716","url":null,"abstract":"Abstract: Aedes aegypti and Aedes albopictus are known as the two main vectors of DHF disease. One way to control DHF is by breaking the chain of spread in the larval phase with larvicides. The use of organic larvicides derived from plants is in great demand, one of which is extracts of lemongrass (Cymbopogon citratus). This study aims to determine the level of efficacy or the effect of concentration of lemongrass extract solution on mortality rates of Aedes sp. larvae. This is an experimental study using 40 instar larvae III / IV of Aedes sp. which were given the intervention of lemongrass plant extracts with a concentration of 5%, 10%, 15%, and 20%. This experiment was carried out twice. Four observations were made every 6 hours. Probit analysis was performed to determine Lethal Concentration (LC50 and LC90) and Lethal Time (LT50 and LT90). The analysis showed that the lemongrass plant extract at a concentration of 20% had a significant difference with the concentration of 5%, 10%, 15%, and the control group (p <0.05). In conclusion, extract of lemongrass (Cymbopogon citratus) with a concentration of 20% is effective for killing larvae of Aedes sp.Keywords: Aedes sp., Cymbopogon citratus, larval mortality  Abstrak: Nyamuk Aedes aegypti dan Aedes albopictus diketahui sebagai dua vektor utama dari penyakit DBD. Salah satu cara pengendalian DBD adalah dengan memutus rantai penyebaran pada fase larva dengan larvasida. Pemanfaatan larvasida organik atau alami yang berasal dari tumbuh-tumbuhan banyak diminati, salah satunya adalah ekstrak tanaman serai (Cymbopogon citratus). Penelitian ini bertujuan mengetahui tingkat keampuhan atau pengaruh konsentrasi larutan ekstrak tanaman serai terhadap tingkat mortalitas larva nyamuk Aedessp. Penelitian ini bersifat eksperimental sederhana menggunakan 40 ekor larva instar III/IV nyamuk Aedes sp. yang diberikan intervensi ekstrak tanaman serai dengan konsentrasi 5%, 10%, 15%, dan 20%. Pengamatan dilakukan setiap 6 jam sebanyak 4 kali, dengan 2 kali percobaan. Analisis probit dilakukan untuk mengetahui Lethal Concentration (LC50 dan LC90) dan Lethal Time (LT50dan LT90). Hasil analisis menunjukkan bahwa ekstrak tanaman serai pada konsentrasi 20% memiliki perbedaan signifikan dengan konsentrasi 5%, 10%, 15%, dan kelompok kontrol (p < 0,05). Simpulan penelitian ialah ekstrak tanaman serai dengan konsentrasi 20% efektif untuk mematikan larva Aedes sp.Kata Kunci: Aedes sp., Cymbopogon citratus, mortalitas larva","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89856576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Potensi Ekstrak Daun Pepaya (Carica papaya linn) sebagai Larvasida terhadap Larva Aedes sp. Di Manado","authors":"Nazzirah A. Ammari, G. Wahongan, Janno B. B. Bernadus","doi":"10.35790/ebm.v9i1.31733","DOIUrl":"https://doi.org/10.35790/ebm.v9i1.31733","url":null,"abstract":"Abstract: Papaya leaf extract as a natural larvicide can be used as an alternative to control resistant Aedes aegypti populations. The benefits of controlling the dengue hemorrhagic fever (DHF) vektor are reducing the level of morbidity, mortality and suffering of individuals and their families. This research was conducted with a simple laboratory experimental method. Used papaya leaves extract and larvae of Aedes sp. instar III and IV taken in water float. This study used 100 larvae divided into 2 groups with positive groups, namely the concentration of 5gr, 10 gr, 15 gr and 20 gr and a control group that only used aquadesh which was repeated twice. This study aimed to determine the potential of papaya leaf extract (Carica Papaya Linn) as a larvicide against larvae of Aedes sp. in Manado. In conclusion, papaya leaf extract (Carica Papaya Linn) has potential as a larvicide against Aedes sp. Larvae. where the higher the extract concentration given, so the mortality rate of Aedes sp. larvae higher.Keyword :  Papaya Leaves (Carica Papaya Linn), Larvacides, Larvae Aedes sp.  Abstrak: Ekstrak daun pepaya sebagai larvasida alami dapat digunakan sebagai salah satu alternatif untuk mengendalikan populasi Aedes aegypti yang telah resisten. Manfaat dari pengendalian vektor penyakit demam berdarah dengue (DBD) adalah mengurangi tingkat kesakitan, kematian, dan penderitaan individu beserta keluarganya. Tujuan penelitian ini untuk mengetahui potensi ekstrak daun papaya (Carica Papaya Linn) sebagai larvasida terhadap larva Aedes sp. di Manado. Penelitian ini dilakukan dengan  metode eksperimental laboratoris sederhana.  Menggunakan ekstrak daun pepaya dan larva Aedes sp. instar III dan IV yang di ambil di penampungan air. Penelitian ini menggunakan 100 ekor larva yang terbagi atas 2 kelompok dengan kelompok uji yaitu konsentrasi 5gr, 10 gr, 15 gr dan 20 gr serta kelompok control yang hanya menggunakan aquadesh  yang diulangi sebanyak dua kali percobaan. Hasil nilai p yang didapat dari uji Kruskall Wallis memiliki nilai p < 0.05, hal ini menunjukkan bahwa terdapat perbedaan tingkat kematian larva Aedes sp. setelah 6 jam, 12 jam, 18 jam dan 24 jam pada berbagai konsentrasi perlakuan. Sebagai simpulan, ekstrak daun papaya (Carica Papaya Linn) memiliki potensi sebagai  larvasida terhadap larva Aedes sp. dimana semakin tinggi konsentrasi ekstrak yang diberikan maka semakin tinggi pula tingkat kematian larva Aedes sp. Kata Kunci : Daun Pepaya (Carica Papaya Linn), Larvasida, Larva Aedes sp.","PeriodicalId":17693,"journal":{"name":"Jurnal e-Biomedik","volume":"243 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73587185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}