Journal of veterinary pharmacology and therapeutics最新文献_第2页

Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Water Temperatures. 两种水温下单次口服恩诺沙星及其代谢物环丙沙星在黑岩鱼体内的药动学

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-08-13 DOI: 10.1111/jvp.70019

Jun Sung Bae, Chae Won Lee, Chan Young Yang, Eun Ha Jeong, Dong Hun Shin, Jeong Hwa So, Ji-Hoon Lee

{"title":"Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Water Temperatures.","authors":"Jun Sung Bae, Chae Won Lee, Chan Young Yang, Eun Ha Jeong, Dong Hun Shin, Jeong Hwa So, Ji-Hoon Lee","doi":"10.1111/jvp.70019","DOIUrl":"https://doi.org/10.1111/jvp.70019","url":null,"abstract":"This study investigated the pharmacokinetics of enrofloxacin (ENR) and its primary metabolite, ciprofloxacin (CIP), in black rockfish (Sebastes schlegelii) following a single oral administration of ENR (10 mg/kg) under two water temperature conditions (13°C and 22°C). Serum samples were collected up to 168 h post-dosing and analyzed using a validated HPLC-MS/MS method. Contrary to conventional expectations, ENR absorption was delayed and elimination was slower at 22°C compared to 13°C, while the plasma concentrations of CIP were higher at the elevated temperature. The elimination half-life of ENR increased from 27.38 h at 13°C to 42.01 h at 22°C, despite enhanced hepatic metabolism. These findings suggest that the primary route of ENR elimination may shift from passive diffusion via the gills at lower temperatures to hepatic metabolism at higher temperatures, likely due to functional impairment of the gill tissues under thermal stress. Notably, the AUC values of ENR remained comparable between the two groups, indicating consistent drug exposure despite differing pharmacokinetic dynamics. PK/PD analysis revealed that single-dose administration may not achieve optimal therapeutic indices (AUC0-24h/MIC ≥ 125, Cmax/MIC ≥ 10) against certain bacterial pathogens, underscoring the need for repeated dosing. Overall, this study provides novel insights into the temperature-modulated pharmacokinetics of ENR and highlights the importance of temperature-specific dosing strategies for effective antibiotic therapy in aquaculture species like black rockfish.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent Use of Tasipimidine Oral Solution and Clomipramine in Dogs. 他西咪定口服液与氯丙咪嗪在犬中的同时应用。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-08-07 DOI: 10.1111/jvp.70017

Jenni Maria Lindstedt, Merja H Kirjavainen, Jouko Levijoki, Jens Häggström, Mira Korpivaara

{"title":"Concurrent Use of Tasipimidine Oral Solution and Clomipramine in Dogs.","authors":"Jenni Maria Lindstedt, Merja H Kirjavainen, Jouko Levijoki, Jens Häggström, Mira Korpivaara","doi":"10.1111/jvp.70017","DOIUrl":"https://doi.org/10.1111/jvp.70017","url":null,"abstract":"The study evaluated pharmacokinetics, effects on functional alertness, and cardiovascular parameters of tasipimidine oral solution (Tessie, Orion Corporation) alone and in combination with oral clomipramine in six healthy laboratory dogs. Pharmacokinetics and functional alertness were studied after a single dose (Phase 1) and after 4 days of repeated twice daily dosing of tasipimidine 30 μg/kg and clomipramine at approximately 1 mg/kg, alone and in combination (Phase 2). Additionally, the combination was studied with a reduced dose of tasipimidine (20 μg/kg) as single and repeated dosing (Phase 3). Alertness was slightly reduced by the combination of tasipimidine 30 μg/kg with clomipramine. Decreasing tasipimidine dose to 20 μg/kg caused less reduction in alertness. Tasipimidine alone and in combination with clomipramine was well tolerated in respect to cardiovascular effects (BP, HR, and ECG). The exposure levels of tasipimidine were similar alone and in combination with clomipramine when administered as a single dose. After repeated dosing, tasipimidine exposure was higher when combined with clomipramine. Slightly slower absorption of clomipramine was observed when dosed concomitantly with tasipimidine, but there was no significant difference in plasma exposure. Effect on functional alertness supports the use of the lower dose of tasipimidine (20 μg/kg) when combined with clomipramine 1 mg/kg.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding “Recommendations for a Complete Reporting of Statistical Methods in Veterinary Pharmacology” 关于“兽医药理学统计方法完整报告的建议”的信。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-08-07 DOI: 10.1111/jvp.70018

Andrew P. Woodward, Jonathan P. Mochel

引用次数: 0

Response to the Letter to the Editor Regarding “Recommendations for a Complete Reporting of Statistical Methods in Veterinary Pharmacology” 对“关于兽医药理学统计方法完整报告的建议”致编辑的信的回复。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-08-07 DOI: 10.1111/jvp.70020

Nicolas F. Villarino

引用次数: 0

Pharmacokinetics of Intravenous and Transdermal Flunixin Meglumine in Wool and Hair Sheep (Ovis aries). 氟尼辛甲胺在毛羊体内的药动学研究。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-08-01 DOI: 10.1111/jvp.70015

Kaitlyn G Forrest, Jennifer L Halleran, Ronald E Baynes, Danielle A Mzyk

{"title":"Pharmacokinetics of Intravenous and Transdermal Flunixin Meglumine in Wool and Hair Sheep (Ovis aries).","authors":"Kaitlyn G Forrest, Jennifer L Halleran, Ronald E Baynes, Danielle A Mzyk","doi":"10.1111/jvp.70015","DOIUrl":"https://doi.org/10.1111/jvp.70015","url":null,"abstract":"The objective of the study was to evaluate the pharmacokinetics of flunixin meglumine of intravenous (IV) and transdermal (TD) flunixin meglumine administration on different coat types (wool vs. hair) in 12 healthy sheep. Polled dorset (wool) sheep (n = 6) and katahdin (hair) sheep (n = 6) received 2.2 mg/kg IV and 3.3 mg/kg TD with a 10-day washout period between treatments. Plasma samples were obtained for 96 h following both IV and TD administration, respectively. Flunixin concentrations were quantified by use of high-performance liquid chromatography with mass spectrometry, and PK parameters were derived using different modeling techniques. A population non-linear mixed effect model showed that coat type has a significant effect on the absorption rate following TD administration. The mean bioavailability of TD flunixin was not significantly different (48.76% ± 17.49% and 36.61% ± 4.33%; p = 0.093) in wool and hair sheep, respectively. Maximum plasma concentrations following TD administration were higher in wool sheep (1.57 μg/mL; range, 0.6-3.41 μg/mL) compared to hair sheep (0.57 μg/mL; range, 0.36-0.83 μg/mL). The PK results provide further support for clinical studies to examine the efficacy of TD flunixin in different breeds of sheep.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Pharmacokinetics of Meloxicam When Administered With a Needle-Free Injection Device Versus Needle-And-Syringe in Piglets. 美洛昔康在仔猪体内无针注射装置与针筒注射装置的药代动力学比较。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-07-29 DOI: 10.1111/jvp.70014

Minh Man Pham, Terri L O'Sullivan, Maria Del Rocio Amezcua, Saad Enouri, Yu Gu, Zvonimir Poljak, Jennifer M Reinhart, Ron Johnson

{"title":"Comparing Pharmacokinetics of Meloxicam When Administered With a Needle-Free Injection Device Versus Needle-And-Syringe in Piglets.","authors":"Minh Man Pham, Terri L O'Sullivan, Maria Del Rocio Amezcua, Saad Enouri, Yu Gu, Zvonimir Poljak, Jennifer M Reinhart, Ron Johnson","doi":"10.1111/jvp.70014","DOIUrl":"https://doi.org/10.1111/jvp.70014","url":null,"abstract":"Meloxicam is a common analgesic for castration in pigs. While needle-free technology is effective for swine vaccination, its implementation for administering meloxicam has not been fully explored. The objective of this study was to compare the pharmacokinetics (PK) of meloxicam administered via a commercial needle-free injection device (NFID) and intramuscularly via needle-and-syringe (NS) in nursing piglets. Twenty-six nursing piglets were randomly assigned to one of two treatment groups receiving the same approved label dosage of 0.4 mg/kg of meloxicam. Plasma meloxicam concentrations were measured using liquid chromatography-tandem mass spectrometry, and PK profiles were measured using non-compartmental analysis. The results indicated Cmax, AUC0-last, AUC0-∞, AUMC0-last, AUMC0-∞, and MRT in the NFID group were all significantly lower compared with those of the NS group (p < 0.05). No differences in Tmax, T1/2, and λz were found between the two groups (p > 0.05). The study concluded that further research is needed to determine the optimal NFID setting and the clinical efficacy when using NFID for injecting meloxicam in piglets.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pharmacokinetics and Pilot Efficacy of Levamisole Administered by Subcutaneous Injection of a Combination Product in Domestic Goats (Capra aegagrus hircus). 家山羊皮下注射左旋咪唑联合制剂的药代动力学及中试疗效。

IF 1.5 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-07-21 DOI: 10.1111/jvp.70013

Grace Malla, Joe Smith, Meggan Graves, Lisa Ebner, Ryan Branham, Jessica Lynch, Laura Gilliard, Julia Cutchin, Madeline Duncan, Rebecca Rahn, Michelle Buckley, Andrew Ursini, Cassandra Klostermann, Jessy Shanks, Sherry Cox

{"title":"The Pharmacokinetics and Pilot Efficacy of Levamisole Administered by Subcutaneous Injection of a Combination Product in Domestic Goats (Capra aegagrus hircus).","authors":"Grace Malla, Joe Smith, Meggan Graves, Lisa Ebner, Ryan Branham, Jessica Lynch, Laura Gilliard, Julia Cutchin, Madeline Duncan, Rebecca Rahn, Michelle Buckley, Andrew Ursini, Cassandra Klostermann, Jessy Shanks, Sherry Cox","doi":"10.1111/jvp.70013","DOIUrl":"https://doi.org/10.1111/jvp.70013","url":null,"abstract":"Anthelmintic resistance is a major welfare issue in goats, and the efficacy of anthelmintic drugs lies in judicious use. Recently, an injectable combination (levamisole-doramectin) product labeled for cattle became available. This study's goal was to compare the levamisole pharmacokinetic parameters of this new combination drug to a commercially available oral levamisole formulation in goats. Six adult goats received a 9 mg/kg dose subcutaneously of the combination product. Blood samples were collected at 14 time points over 48 h. After a 14-day washout period, the same goats were given 12 mg/kg of oral levamisole and sampled following the same time points. Levamisole concentrations were measured via liquid chromatography. A non-compartmental analysis was used to generate pharmacokinetic (PK) parameters for both formulations. After one subcutaneous (SC) injection, the maximum plasma concentration (Cmax), time to Cmax (Tmax), area under the curve (AUC), and elimination half-life (T1/2) were 468.57 ± 151.12 ng/mL, 2.24 ± 1.58 h, 3206.42 ± 1189.73 h ng/mL, and 2.36 ± 2.07 h, respectively. After a single oral administration, Cmax, Tmax, AUC, and T1/2 were 573.21 ± 149.01 ng/mL, 0.5 ± 0.41 h, 2995.47 ± 2203.93 h ng/mL, and 3.74 ± 2.19 h, respectively. Fecal samples taken before and after subcutaneous administration had an average egg count reduction of 61.97% (p = 0.0625). The relative bioavailability of the SC injection was 185%. Considering bioavailability and egg count reduction, the combination product may be considered for parasite management; however, a field trial is needed to determine its efficacy and other pharmacodynamic parameters.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics of Levamisole After a Single 20 mg/kg Intravenous, Intramuscular, or Subcutaneous Dose in Chukar Partridges (Alectoris chukar) 左旋咪唑单次静脉、肌肉或皮下给药20mg /kg楚卡鹧鸪（楚卡鹧鸪）药代动力学

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-07-15 DOI: 10.1111/jvp.70012

Ruhi Turkmen, Orhan Corum, Mario Gıorgı, Duygu Durna Corum, Orkun Atık, Erdinc Turk, Yavuz Osman Bırdane, Kamil Uney

{"title":"Pharmacokinetics of Levamisole After a Single 20 mg/kg Intravenous, Intramuscular, or Subcutaneous Dose in Chukar Partridges (Alectoris chukar)","authors":"Ruhi Turkmen, Orhan Corum, Mario Gıorgı, Duygu Durna Corum, Orkun Atık, Erdinc Turk, Yavuz Osman Bırdane, Kamil Uney","doi":"10.1111/jvp.70012","DOIUrl":"10.1111/jvp.70012","url":null,"abstract":"<div>\u0000 \u0000 The pharmacokinetic features of levamisole were assessed in chukar partridges (\u0000 Alectoris chukar\u0000 ) following intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations. The investigation included nine male partridges and a crossover pharmacokinetic design. Levamisole was administered to partridges at a dose of 20 mg/kg via IV, IM, and SC routes. Blood samples were collected at time points of 0, 0.25, 0.50, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 18, and 24 h after administrations. Plasma concentrations of levamisole were quantified by high-performance liquid chromatography (HPLC) and evaluated using a non-compartmental analysis. The elimination half-life was 1.92, 2.94, and 2.97 h for IV, IM, and SC administration, respectively. The IV injection for levamisole showed the volume of distribution at a steady state of 1.91 L/kg and total clearance of 0.73 L/h/kg. The peak plasma concentration (Cmax) for IM and SC routes of levamisole was 5.32 and 4.65 μg/mL at 0.25 h, respectively. The absolute bioavailability was 66.16% for the IM route and 58.48% for the SC route. The study findings reveal that levamisole administered via IM and SC routes exhibit comparable pharmacokinetic profiles, with both routes achieving bioavailability exceeding 50%. However, the significant adverse effects (muscle tremors, hyperexcitability, and increased respiratory rate) associated with IV administration underscore the need for caution and support the preference for IM and SC routes, which offer better safety profiles for bird anthelmintic treatments.\u0000 </div>","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"48 5","pages":"426-432"},"PeriodicalIF":1.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population Pharmacokinetics of Florfenicol in Crayfish (Procambarus clarkii) Based on the Sparse Sampling Method and a Nonlinear Mixed-Effect Model. 基于稀疏抽样和非线性混合效应模型的氟苯尼考在克氏原螯虾体内的种群药动学研究

IF 1.5 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-07-14 DOI: 10.1111/jvp.70011

Ning Xu, Juan Tian, Binbin Gong, Yongzhen Ding, Xiaohui Ai

{"title":"Population Pharmacokinetics of Florfenicol in Crayfish (Procambarus clarkii) Based on the Sparse Sampling Method and a Nonlinear Mixed-Effect Model.","authors":"Ning Xu, Juan Tian, Binbin Gong, Yongzhen Ding, Xiaohui Ai","doi":"10.1111/jvp.70011","DOIUrl":"https://doi.org/10.1111/jvp.70011","url":null,"abstract":"The present study was conducted to establish population pharmacokinetics (PPK) of florfenicol (FLO) in crayfish (Procambarus clarkii) after a single oral administration at a dose of 15 mg/kg at 25°C based on a nonlinear mixed effect model. The sparse sampling method was used to collect the blood samples. Thirty-two crayfish were divided into four groups, and one group included four male crayfish and four female crayfish. One animal undertook three sampling time points. All samples were quantified using high-performance liquid chromatography with an ultraviolet detector. The initial pharmacokinetic (PK) parameters were estimated by reference search and the calculation of a naïve pooled approach. The additive error model was selected using the tool of maximum likelihood model comparison. The covariate model included the two variations of body weight and sex. Through the addition and subtraction of parameters, weight and gender had no significant effect on the alterations of PK parameters. Afterward, the random effects were introduced in the model, which notably reduced the coefficient of variation. Finally, the calculated values of the absorption rate constant, apparent distribution volume, and total systemic clearance were estimated to be 1.93/h, 11.16 L/kg, and 2.35 L/h/kg, respectively. The secondary parameters of the elimination rate constant, elimination half-life, and area under the concentration-time curve were calculated to be 0.20/h, 3.47 h, and 6.38 h.mg/L, respectively. This study supported a concise method for conducting PK studies in crustacean animals that facilitated the development of PK methodology in aquaculture.","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Pharmacokinetics of Buprenorphine Following Intravenous and Buccal Administration in Cats, and Effects on Thermal Threshold” 更正“丁丙诺啡在猫静脉和口腔给药后的药代动力学以及对热阈值的影响”。

IF 1.7 4区农林科学

Journal of veterinary pharmacology and therapeutics Pub Date : 2025-06-27 DOI: 10.1111/jvp.70010

引用次数: 0