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Journal of veterinary pharmacology and therapeutics最新文献

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Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus) 鹅静脉和口服给药对罗贝那昔布的处置动力学(家鹅)。
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-13 DOI: 10.1111/jvp.13398
Charbel Fadel, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Seavchou Laut, Amnart Poapolathep, Mario Giorgi
{"title":"Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)","authors":"Charbel Fadel,&nbsp;Beata Łebkowska-Wieruszewska,&nbsp;Andrzej Lisowski,&nbsp;Seavchou Laut,&nbsp;Amnart Poapolathep,&nbsp;Mario Giorgi","doi":"10.1111/jvp.13398","DOIUrl":"10.1111/jvp.13398","url":null,"abstract":"<p>Robenacoxib (RX) is a veterinary cyclooxygenase-2 selective inhibitor drug. It has never been tested on birds and is only labelled for use in cats and dogs. The purpose of this study was to assess its pharmacokinetics in geese after single intravenous (IV) and oral (PO) administrations. Four-month healthy female geese (<i>n</i> = 8) were used. Geese were subjected to a two-phase, single-dose (2 mg/kg IV, 4 mg/kg PO), open, longitudinal study design with a four-month washout period between the IV and the PO phases. Blood was collected from the left wing vein to heparinized tubes at 0, 0.085 (for IV only), 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, and 24 h. Plasma RX concentrations were measured using HPLC coupled to an UV detector, and the data were pharmacokinetically analysed using ThothPro™ 4.3 software in a non-compartmental approach. Following IV administration, terminal elimination half-life, volume of distribution, and total clearance were 0.35 h, 0.34 L/kg, and 0.68 L/h/kg, respectively. For the PO route, the mean peak plasma concentration was 6.78 μg/mL at 0.50 h. The <i>t</i>1/2<i>λz</i> was very short and significantly different between the IV and PO administrations (0.35 h IV vs. 0.99 h PO), suggesting the occurrence of a flip-flop phenomenon. The Cl values corrected for the <i>F</i>% were significantly different between IV and PO administrations. It might have been a consequence of the longitudinal study design and the altered physiological and environmental conditions after a 4-month washout period. The absolute oral <i>F</i>% computed with the AUC method surpassed 150%, but after normalizing it to <i>t</i>1/2<i>λz</i>, it was 46%. In conclusion, the administration of RX might not be suitable for geese, due to its short <i>t</i>1/2<i>λz</i>.</p>","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 6","pages":"413-420"},"PeriodicalIF":1.3,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9982948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
P9 | Pharmacokinetics of lincomycin in laying hens and its residue profiles in egg and plasma 林可霉素在蛋鸡体内的药动学及其在蛋和血浆中的残留谱
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13288
{"title":"P9 | Pharmacokinetics of lincomycin in laying hens and its residue profiles in egg and plasma","authors":"","doi":"10.1111/jvp.13288","DOIUrl":"10.1111/jvp.13288","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"89"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42967064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O4 | Pharmacokinetics of bupivacaine after bilateral maxillary and inferior alveolar nerve blocks in adult cats O4|成年猫双侧上颌和下牙槽神经阻滞后布比卡因的药代动力学
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13170
{"title":"O4 | Pharmacokinetics of bupivacaine after bilateral maxillary and inferior alveolar nerve blocks in adult cats","authors":"","doi":"10.1111/jvp.13170","DOIUrl":"10.1111/jvp.13170","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"29"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45626995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O85 | Antibacterial activity of propyl gallate in combination with orbifloxacinagainst E. coli in an in vitro pharmacodynamic model 没食子酸丙酯联合奥比沙星对大肠杆菌的体外药效学研究
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13251
{"title":"O85 | Antibacterial activity of propyl gallate in combination with orbifloxacinagainst E. coli in an in vitro pharmacodynamic model","authors":"","doi":"10.1111/jvp.13251","DOIUrl":"10.1111/jvp.13251","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"70"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48516109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P67 | Determination of the PK/PD cut-off of oxytetracycline in cattle using the VetCAST method to support the establishment of a clinical breakpoint for antimicrobial susceptibility testing 利用VetCAST法测定牛体内土霉素的PK/PD切断值，以支持建立抗菌药敏试验的临床断点
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13346
{"title":"P67 | Determination of the PK/PD cut-off of oxytetracycline in cattle using the VetCAST method to support the establishment of a clinical breakpoint for antimicrobial susceptibility testing","authors":"","doi":"10.1111/jvp.13346","DOIUrl":"10.1111/jvp.13346","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"117-118"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43453119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P42 | Teat dip disinfectant formulation for dairy cows based on Melaleuca armillaris essential oil P42|以蜜环菌精油为基础的奶牛浸提消毒剂配方
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13321
{"title":"P42 | Teat dip disinfectant formulation for dairy cows based on Melaleuca armillaris essential oil","authors":"","doi":"10.1111/jvp.13321","DOIUrl":"10.1111/jvp.13321","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"105-106"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43541254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O73 | Determination of the pharmacokinetic parameters of 4 formulations of penicillin G in order to optimize the first-line antibiotic treatment in horses 4种青霉素G制剂的药动学参数测定，以优化马的一线抗生素治疗
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13239
{"title":"O73 | Determination of the pharmacokinetic parameters of 4 formulations of penicillin G in order to optimize the first-line antibiotic treatment in horses","authors":"","doi":"10.1111/jvp.13239","DOIUrl":"10.1111/jvp.13239","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"64"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48712270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O71 | Pharmacokinetics of macrocyclic lactones endectocide in indigenous zebu cattle and its insecticidal efficacy on Anopheles arabiensis O71|大环内酯类杀虫剂在当地泽布牛体内的药代动力学及其对阿拉伯按蚊的杀虫效果
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13237
{"title":"O71 | Pharmacokinetics of macrocyclic lactones endectocide in indigenous zebu cattle and its insecticidal efficacy on Anopheles arabiensis","authors":"","doi":"10.1111/jvp.13237","DOIUrl":"10.1111/jvp.13237","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"63"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46390931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O91 | Pharmacokinetics and therapeutic efficacy of liposomal cannabidiol (CBD) injection: A pilot clinical study in dogs with naturally-occurring osteoarthritis 脂质体大麻二酚(CBD)注射的药代动力学和治疗效果:一项自然发生的骨关节炎犬的初步临床研究
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13257
{"title":"O91 | Pharmacokinetics and therapeutic efficacy of liposomal cannabidiol (CBD) injection: A pilot clinical study in dogs with naturally-occurring osteoarthritis","authors":"","doi":"10.1111/jvp.13257","DOIUrl":"10.1111/jvp.13257","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"73"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47210592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O20 | The effect of ATR kinase inhibition on chlorambucil activity against canine lymphoma and leukemia cell lines ATR激酶抑制对氯霉素抗犬淋巴瘤和白血病细胞活性的影响
IF 1.3 4区 农林科学
Journal of veterinary pharmacology and therapeutics Pub Date : 2023-06-11 DOI: 10.1111/jvp.13186
{"title":"O20 | The effect of ATR kinase inhibition on chlorambucil activity against canine lymphoma and leukemia cell lines","authors":"","doi":"10.1111/jvp.13186","DOIUrl":"10.1111/jvp.13186","url":null,"abstract":"","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"46 S1","pages":"37-38"},"PeriodicalIF":1.3,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.13186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47323209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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