绿海龟(Chelonia mydas)和玳瑁(Eretmochelys imbricata)肌肉注射氟苯尼考的药代动力学特征。

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Pandaree Sitthiangkool, Amnart Poapolathep, Thanaphan Chomcheun, Oranee Jongkolpath, Kraisiri Khidkhan, Narumol Klangkaew, Napasorn Phaochoosak, Mario Giorgi, Saranya Poapolathep
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引用次数: 0

摘要

本研究评估了绿海龟和玳瑁在肌肉注射 20 或 30 毫克/千克体重(b.w.)两种不同剂量的氟苯尼考(FFC)后的药代动力学。这项研究(纵向设计)使用了 5 只绿海龟和 5 只玳瑁海龟,分别服用两种剂量。在指定时间至 168 小时内采集血样。使用配备二极管阵列检测器的高效液相色谱法对 FFC 血浆样本进行分析。药代动力学分析采用非隔室方法进行。FFC 的血浆浓度随着剂量的增加而增加。各治疗组的消除半衰期(19-25 h)和血浆蛋白结合率(18.59%-20.65%)相似。根据代用 PK/PD 参数(T > MIC,2 μg/mL),20 毫克/千克和 30 毫克/千克的剂量应是绿海龟和玳瑁易感细菌感染的有效剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacokinetic characteristics of florfenicol in green sea turtles (Chelonia mydas) and hawksbill sea turtles (Eretmochelys imbricata) after intramuscular administration

The pharmacokinetics of florfenicol (FFC) in green sea and hawksbill sea turtles were evaluated following intramuscular (i.m.) administration at two different dosages of 20 or 30 mg/kg body weight (b.w.). This study (longitudinal design) used 5 green sea and 5 hawksbill sea turtles for the two dosages. Blood samples were collected at assigned times up to 168 h. FFC plasma samples were analyzed using validated high-performance liquid chromatography equipped with diode array detection. The pharmacokinetic analysis was performed using a non-compartment approach. The FFC plasma concentrations increased with the dosage. The elimination half-life was similar between the treatment groups (range 19–25 h), as well as the plasma protein binding (range 18.59%–20.65%). According to the surrogate PK/PD parameter (T > MIC, 2 μg/mL), the 20 and 30 mg/kg dosing rates should be effective doses for susceptible bacterial infections in green sea and hawksbill sea turtles.

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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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