Pharmacokinetic report: Pharmacokinetics of a single oral dose of gabapentin in goats (Capra hircus)

IF 1.5 4区农林科学 Q3 PHARMACOLOGY & PHARMACY

Journal of veterinary pharmacology and therapeutics Pub Date : 2024-03-01 DOI:10.1111/jvp.13436

Michael D. Kleinhenz, Darian Davis, Mikaela M. Weeder, Alyssa Leslie, Emily J. Reppert, Kushan Kompalage, Ryan Tucker, Johann F. Coetzee

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Abstract

Gabapentin is used in goats to treat chronic pain associated with lameness. However, pharmacokinetic data and clinical effectiveness trials are lacking. The objective of the study was to describe the pharmacokinetics of gabapentin in goats following a single oral dose. Six Spanish-crossbred goats were enrolled. Each goat was administered gabapentin at a target dose of 15 mg/kg per os. Serial blood samples were collected out to 60 h post-gabapentin administration for plasma gabapentin concentration determination. Plasma samples were analyzed for gabapentin concentration using ultra-high-pressure liquid chromatography coupled with mass spectroscopy. Individual animal pharmacokinetic outcomes were determined using non-compartmental analysis. Gabapentin was detectable in the plasma of all goats at 60 h post-administration. The mean (±SD) C_max was 2.01 ± 0.62 μg/mL which occurred at 8.47 ± 1.9 h. The mean terminal half-life (T¹/₂) and mean resident time were determined to be 8.52 ± 1.8 and 18.7 ± 4.0 h, respectively. This study indicates gabapentin is absorbed from the gastrointestinal tract of goats. Further research is needed to determine an optimal dose for clinical efficacy in goats.

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药代动力学报告：山羊（Capra hircus）单次口服加巴喷丁的药代动力学。

加巴喷丁用于治疗山羊跛足引起的慢性疼痛。然而，目前尚缺乏药代动力学数据和临床有效性试验。本研究旨在描述山羊单次口服加巴喷丁后的药代动力学。研究共招募了六只西班牙杂交山羊。每只山羊每次口服加巴喷丁的目标剂量为 15 毫克/千克。在服用加巴喷丁后 60 小时内采集连续血样，测定血浆中的加巴喷丁浓度。使用超高压液相色谱法和质谱法分析血浆样本中的加巴喷丁浓度。采用非室分析法确定动物个体的药代动力学结果。给药后 60 小时，所有山羊的血浆中均可检测到加巴喷丁。平均（±SD）Cmax 为 2.01 ± 0.62 μg/mL，出现在 8.47 ± 1.9 h。平均终末半衰期（T1 /2 ）和平均驻留时间分别为 8.52 ± 1.8 h 和 18.7 ± 4.0 h。这项研究表明，加巴喷丁可从山羊的胃肠道吸收。要确定对山羊具有临床疗效的最佳剂量，还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary pharmacology and therapeutics 农林科学-兽医学

CiteScore

3.10

自引率

15.40%

发文量

审稿时长

8-16 weeks

期刊介绍： The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.