Journal of wound care最新文献_第3页

Autologous adipose-derived tissue stromal vascular fraction and intralesional epidermal growth factor combined application in patients with diabetic foot. 自体脂肪源性组织间质血管组分与病灶内表皮生长因子联合应用于糖尿病足患者。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-03-01 DOI: 10.12968/jowc.2024.0107

Mustafa Aydın, Simay Akyüz, Hamdullah Yanik, Eda Yildirim, Ali Murat Başak, Hikmet Erhan Güven, Yasin Gülap, Kerim Bora Yilmaz

{"title":"Autologous adipose-derived tissue stromal vascular fraction and intralesional epidermal growth factor combined application in patients with diabetic foot.","authors":"Mustafa Aydın, Simay Akyüz, Hamdullah Yanik, Eda Yildirim, Ali Murat Başak, Hikmet Erhan Güven, Yasin Gülap, Kerim Bora Yilmaz","doi":"10.12968/jowc.2024.0107","DOIUrl":"10.12968/jowc.2024.0107","url":null,"abstract":"Objective: The aim of this study was to evaluate the effect on wound healing of intralesional epidermal growth factor (iEGF) (Heberprot-p; Hasbiotech, Cuba) and autologous adipose-derived tissue stromal vascular fraction (AD-tSVF) applied in the closure of tissue defects.Method: The patients included in the study were separated into three approximately equal groups: Group 1 with iEGF+AD-tSVF applied; Group 2 with iEGF only applied; and Group 3 with conventional wound care products applied. Granulation tissue was taken from the wound bed before the application of iEGF and AD-tSVF and at intervals thereafter for flow cytometry analysis.Results: Group 1 included 11 patients; Group 2 included 10 patients; and Group 3 included 10 patients. The time to re-epithelialisation was determined as 187.60±68.78 days in Group 3 patients compared with Group 1 (72.27±10.33 days) and Group 2 (70.50±18.02 days) (p<0.001). Following the application of iEGF to the wound bed, an increase was observed in M2 macrophage (CD209+), and M1 macrophage (CD38+) levels. The (CD34+) stem cells obtained from the granulation tissue after the application of AD-tSVF were determined to still be statistically significantly increased in the wound bed on the 21st day.Conclusion: The results of this study demonstrated that the application of iEGF and iEGF+ AD-tSVF significantly shortened the wound healing period compared with conventional methods. AD-tSVF stands as an effective option, especially in the patient group with halted or delayed wound healing despite the application of iEGF. Moreover, the significant increase (p<0.001) in the level of M2 macrophages (CD209+), M1 macrophages (CD38+) and stem cells (CD34+) provided by this treatment modality showed that it contributed to wound healing at the cellular level.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 Sup3","pages":"xxx-xxxviii"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vacuum-assisted closure in secondary wound healing after pilonidal sinus surgery. 真空辅助封闭在毛窦手术后继发伤口愈合中的应用。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-03-01 DOI: 10.12968/jowc.2021.0250

Akyol Hüseyin, Erok Berrin

{"title":"Vacuum-assisted closure in secondary wound healing after pilonidal sinus surgery.","authors":"Akyol Hüseyin, Erok Berrin","doi":"10.12968/jowc.2021.0250","DOIUrl":"10.12968/jowc.2021.0250","url":null,"abstract":"Objective: This study evaluated the utility of vacuum-assisted closure (VAC) in comparison to standard open wound care in patients operated for pilonidal sinus disease (PSD).Method: Patients with PSD who underwent standard pilonidal sinus excision-lay open technique/surgery in the Altınbas University School of Medicine Bahcelievler Medical Park Hospital, Istanbul, Turkey, between May 2015 and May 2018, were included in this study. A retrospective analysis of prospectively collected data was performed. The patients were divided into two groups according to the type of wound care, including the vacuum-assisted closure group (n=30, postoperative vacuum-assisted closure application) and the control group (n=30, standard open wound care). Wound size, postoperative infection rates and wound healing times were compared between study groups.Results: The experimental cohort included 60 patients. There was no statistically significant difference between vacuum-assisted closure and the control groups in terms of preoperative and postoperative infection rates (p>0.05). The total recovery time (time to complete wound healing) was significantly shorter in the vacuum-assisted closure group compared with the control group (21.47±4.38 days versus 67.60±7.83 days, p=0.001).Conclusion: The findings of this study emphasise that the use of vacuum-assisted closure in PSD patients treated with the lay-open technique seems notable in terms of its potential to shorten the otherwise longer secondary recovery time and thus enables the consideration of the lay-open technique once again among the most preferable methods. However, there is a need for larger scale prospective studies addressing the utility of vacuum-assisted closure in patients with PSD to validate these findings.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 Sup3","pages":"xxxix-xliii"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The inducing effect of epidermal growth factor on acellular dermal matrix in a rat model of skin regeneration. 表皮生长因子对大鼠皮肤再生模型脱细胞真皮基质的诱导作用。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0286

Seyedeh-Sara Hashemi, Parisa Sanati, AliReza Rafati

{"title":"The inducing effect of epidermal growth factor on acellular dermal matrix in a rat model of skin regeneration.","authors":"Seyedeh-Sara Hashemi, Parisa Sanati, AliReza Rafati","doi":"10.12968/jowc.2021.0286","DOIUrl":"https://doi.org/10.12968/jowc.2021.0286","url":null,"abstract":"Objective: Tissue engineering, a novel approach in dermatology, has resulted in the development of scaffolds as skin substitutes that have accelerated wound healing. The aim of the present study was to synthesise acellular dermal matrix (ADM) as a dermal alternative and assess the effect of human epidermal growth factor (EGF) on the proliferation and migration of seeded fibroblast cells.Method: ADM from fresh, full-thickness human skin was developed and characterised. Next, foreskin fibroblast cells were isolated, cultured and characterised. The fibroblast cells were sown into the ADM in two groups: one with EGF and one without EGF. We assessed the adhesion and proliferation of the cells on the scaffold by scanning electron microscopy, and thiazolyl blue tetrazolium bromide and 4',6-diamidino-2-phenylindole staining. For the animal study, 30 rats were divided into two equal groups at random (ADM, ADM+EGF). Wound healing was assessed macroscopically, histologically and by real-time polymerase chain reaction for Bax and Bcl-2 gene expression.Results: The ADM characterisation results showed that the scaffold was dense and integral with good stretching. The morphology and phenotype of the isolated fibroblast cells confirmed their identity. The fibroblast cells cultured on the ADM showed proliferation, which improved with the addition of EGF. In the animal model, EGF addition caused significantly (p<0.05) improved wound healing compared with isolated ADM; it also resulted in increased Bcl-2 and reduced Bax expressions.Conclusion: A combination of ADM, fibroblast cells and EGFs could serve as skin substitutes and represent a novel therapeutic methodology for treating burns and hard-to-heal wounds.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"137-145"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of acids as topical antimicrobial agents: a review. 酸类外用抗菌药物的有效性和安全性综述。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2023.0176

Basavraj S Nagoba, Abhijit S Rayate, Ajay M Gavkare, Arunkumar Rao

{"title":"The efficacy and safety of acids as topical antimicrobial agents: a review.","authors":"Basavraj S Nagoba, Abhijit S Rayate, Ajay M Gavkare, Arunkumar Rao","doi":"10.12968/jowc.2023.0176","DOIUrl":"https://doi.org/10.12968/jowc.2023.0176","url":null,"abstract":"Objective: Infected wounds, refractory to conventional therapy, are a major burden on the healthcare system. Available data show that many commonly used antiseptic agents may be toxic to the cells involved in the healing process and may affect the normal tissue repair. The topical use of different acids to control wound infections effectively and promote healing is well known. The present review aims to summarise the safety and efficacy of various acids as topical agents for treating wound infections.Method: A literature search was performed in PubMed and manually from other sources (cross references and journal sites).Results: We reviewed 116 articles, from which data from 86 relevant articles were analysed. The studies showed that various organic acids were clinically effective in treating wound infections.Conclusion: This study found that various organic acids can act as a substitute for antiseptics to control wound infections refractory to conventional antibiotic therapy and local wound care. Various organic acids differ in efficacy, safety and limitations as topical agents to control wound infections and promote healing. Some acids deliver better results than others, particularly in those cases in which antibiotics and routine antiseptic agents yield little lasting success, especially in controlling hospital strains with multiple antibiotic resistance. Among topically used acids, citric acid and acetic acid are associated with better results.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"119-127"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Errata. 勘误表。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2025.34.2.163

引用次数: 0

Usefulness of a negative pressure wound therapy system for stoma closure. 负压伤口治疗系统在造口术中的应用。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2023.0320

Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi

{"title":"Usefulness of a negative pressure wound therapy system for stoma closure.","authors":"Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi","doi":"10.12968/jowc.2023.0320","DOIUrl":"https://doi.org/10.12968/jowc.2023.0320","url":null,"abstract":"Objective: Although wound infection rates after stoma closure have decreased, they remain high. Negative pressure wound therapy (NPWT) for stoma closure wounds can shorten healing time for many wound types. The PICO (Smith+Nephew, UK) wound dressing, a single-use NPWT system that can be used for outpatients, was introduced at the Japan Community Health Care Organization Hokkaido Hospital, Japan in November 2017. We evaluated the effectiveness of this dressing in stoma closure wounds.Method: We retrospectively evaluated patients who underwent stoma closure between March 2012 and July 2021. We compared postoperative short-term outcomes (surgical site infection (SSI), number of pain medications, and postoperative hospital stay) by allocating the patients to one of two groups: purse-string closure or purse-string closure with PICO. The purse-string closure group (PC) underwent purse-string closure alone, while the other group underwent purse-string closure and PICO (PCP).Results: A total of 35 patients were evaluated; 20 in the PC group and 15 in the PCP group. No significant differences in characteristics were noted between the groups. Comparisons between stoma closure techniques revealed that the PCP group had shorter hospital stays (p=0.04), lower SSI rates (p=0.04), and less pain medication (p<0.01) than the PC group. Comparisons between SSI occurrence revealed that the group of patients with an SSI had a higher number of colostomies compared with ileostomies (37.5% versus 0%, p<0.01, respectively), used more pain medication (p<0.01), and had longer hospital stays (p=0.04) than patients who did not have an SSI.Conclusion: After stoma closure, combining PICO with purse-string closure may be effective in preventing SSI and controlling postoperative pain.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"106-110"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study. 新一代多层泡沫敷料在难愈合伤口中的应用：一项前瞻性、多中心研究。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 Epub Date: 2025-01-27 DOI: 10.12968/jowc.2024.0416

Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo

{"title":"Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study.","authors":"Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo","doi":"10.12968/jowc.2024.0416","DOIUrl":"https://doi.org/10.12968/jowc.2024.0416","url":null,"abstract":"Objective: Hard-to-heal wounds present a significant healthcare challenge due to their complex aetiology, impact on quality of life (QoL) and consequent economic burden. The aim of this study was to assess the usability, safety and performance of a next-generation, multilayered foam dressing, ConvaFoam (Convatec Ltd., UK), in the management of indicated hard-to-heal wounds.Method: In this prospective, multicentre, interventional, non-comparator, open-label study, wounds included venous leg ulcers, arterial leg ulcers, diabetic foot ulcers and pressure injuries. The primary endpoint was percentage change in wound area at four weeks. Additional endpoints included percentage change in wound area at 12 weeks, satisfactory clinical progress (defined as ≥40% reduction in study wound area at four weeks), complete wound closure, adverse events, pain, QoL and health professional usability outcomes.Results: A total of 90 patients (109 wounds) were included in the full analysis set. The median percentage reduction in wound area from baseline was 47.88% (p<0.0001) at week 4 and 93.75% (p<0.0001) at week 12. Satisfactory clinical progress at four weeks was reported for 61 (55.96%) wounds. Complete wound closure by week 12 was observed in 43 (39.45%) wounds (p<0.0001). The median Wound Quality of Life-14 score improved from 55.36 at baseline, to 80.36 at week 12. Of the 2935 dressing applications, there were only two adverse events which were reported to be related to the study dressings. The majority of health professionals rated ease of application, exudate management, ease of removal and conformity as excellent.Conclusion: The ConvaFoam dressings were shown to be effective at reducing wound size and promoting healing in indicated hard-to-heal wounds, particularly diabetic foot and venous ulcers.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"154-162"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications. 汗腺炎手术期间阿达木单抗的中断与继续：继发性伤口愈合和术后并发症。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0365

Pelin Esme, Aysenur Botsali, Ercan Caliskan

{"title":"Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications.","authors":"Pelin Esme, Aysenur Botsali, Ercan Caliskan","doi":"10.12968/jowc.2021.0365","DOIUrl":"https://doi.org/10.12968/jowc.2021.0365","url":null,"abstract":"Objective: The combination of adalimumab and surgical interventions plays a crucial role in managing severe hidradenitis suppurativa (HS). However, there is still limited scientific evidence regarding administering adalimumab during the perioperative period. This study aimed to evaluate whether adalimumab could adversely affect postoperative complications and the total time of wound closure (TTWC) in patients undergoing cutaneous surgery for HS.Method: In this single-centre cohort study, patients with HS were allocated to two groups. Group 1 (biological cohort) consisted of patients with HS who had continuously received adalimumab for at least three months before the procedure. Group 2 (non-biological cohort) patients underwent cutaneous surgery after only four weeks of anti-inflammatory medication. All patients were left to secondary wound healing.Results: A total of 30 surgical sites in 20 patients were included in the study (Group 1: 15 surgical sites/nine patients; Group 2: 15 surgical sites/11 patients). Disease severity and excised skin areas were significantly higher in Group 1 (p<0.001 and p=0.042, respectively) than in Group 2. While the median TTWC was longer in Group 1 than in Group 2 (p=0.004), multivariate regression analysis showed that TTWC was associated with the excised skin area (p=0.016) and Hurley stage (p=0.032), but was not affected by the use of adalimumab (p=0.076).Conclusion: In this study, the use of adalimumab around surgery was not associated with an increased risk of postoperative complications or a prolonged course of wound closure. The results in this patient cohort suggest that adalimumab should not be discontinued during the perioperative period of HS surgery.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"112-118"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study. 静脉性腿部溃疡患者的护理人员在预防复发中的作用：一个案例研究。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2022.0128

Anna Karafová, Agnieszka Siemieniecka, Marian Karafa

{"title":"The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study.","authors":"Anna Karafová, Agnieszka Siemieniecka, Marian Karafa","doi":"10.12968/jowc.2022.0128","DOIUrl":"https://doi.org/10.12968/jowc.2022.0128","url":null,"abstract":"Objective: Venous leg ulcer (VLU) is a common complication which significantly reduces the patient's quality of life. Despite many effective treatment methods, such as compression therapy, which allow the wound to heal in a short time, it is important to maintain the long-term effects of the therapy. We present the case of a 67-year-old male patient with a trophic ulcer of his left leg.Method: The patient was treated with inelastic multicomponent compression bandages applied every day under Kikuhime pressure-measuring device (HPM-KH-01; TT Meditrade, Denmark) control and advised to wear a compression stocking.Results: The patient's wound closed within eight weeks. After five months, the patient returned to our clinic with a one-month-old wound due to non-adherence with medical recommendations.Conclusion: Key roles in recurrence prevention seem to be played not only by the patient's motivation and perseverance, but, more importantly, by the approach of the therapist. Health professionals should focus not only on one-time closure of the patient's wound, but on cooperation with the patient's family and caregivers, and instructing them on how to look after the patient on a daily basis, including with help to put on compression garments and with motivation to move and exercise. In many cases, with unaccompanied patients, rapid VLU recurrence is observed.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"128-132"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appreciating the past but focusing on the future: specialist nurses in wound care in Europe. 欣赏过去，关注未来：欧洲伤口护理专业护士。

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2025.0008

Corinne Scicluna Ward

引用次数: 0