局部干燥剂用于糖尿病足溃疡创面准备的早期临床经验。

IF 1.7 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2025-09-02 Epub Date: 2025-08-16 DOI:10.12968/jowc.2025.0240

Johannes P Snels, Alberto Cogo, Rachele Reitano, Chiara Grigolo, Bertus J Quint, Carlo A Bignozzi

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引用次数: 0

摘要

糖尿病足溃疡（DFUs）是糖尿病的主要并发症，通常需要有效的伤口床准备才能愈合。本回顾性病例系列评估了一种新型局部干燥剂（TDA）在机构伦理委员会批准的同情使用协议下使用。在2020年至2023年期间接受治疗的67例难以治愈（慢性）dfu患者被纳入研究。88.1%的患者实现了肉芽形成（平均时间：44.3天），85.1%的患者实现了完全的再上皮化。无不良事件报告。TDA耐受性良好，在高危患者群体中显示出良好的临床结果，支持在前瞻性研究中进一步评估。

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Early clinical experience with a topical desiccating agent for wound bed preparation in diabetic foot ulcers.

Diabetic foot ulcers (DFUs) are a major complication of diabetes, often requiring effective wound bed preparation for healing. This retrospective case series assessed a novel topical desiccating agent (TDA) used under a compassionate-use protocol approved by the institutional ethics board. A total of 67 patients with hard-to-heal (chronic) DFUs treated between 2020 and 2023 were included. Granulation was achieved in 88.1% of patients (mean time: 44.3 days), and 85.1% reached complete re-epithelialisation. No adverse events were reported. TDA was well tolerated and showed promising clinical outcomes in a high-risk patient population, supporting further evaluation in prospective studies.

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.