Journal of wound care最新文献

The inducing effect of epidermal growth factor on acellular dermal matrix in a rat model of skin regeneration.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0286

Seyedeh-Sara Hashemi, Parisa Sanati, AliReza Rafati

{"title":"The inducing effect of epidermal growth factor on acellular dermal matrix in a rat model of skin regeneration.","authors":"Seyedeh-Sara Hashemi, Parisa Sanati, AliReza Rafati","doi":"10.12968/jowc.2021.0286","DOIUrl":"https://doi.org/10.12968/jowc.2021.0286","url":null,"abstract":"Objective: Tissue engineering, a novel approach in dermatology, has resulted in the development of scaffolds as skin substitutes that have accelerated wound healing. The aim of the present study was to synthesise acellular dermal matrix (ADM) as a dermal alternative and assess the effect of human epidermal growth factor (EGF) on the proliferation and migration of seeded fibroblast cells.Method: ADM from fresh, full-thickness human skin was developed and characterised. Next, foreskin fibroblast cells were isolated, cultured and characterised. The fibroblast cells were sown into the ADM in two groups: one with EGF and one without EGF. We assessed the adhesion and proliferation of the cells on the scaffold by scanning electron microscopy, and thiazolyl blue tetrazolium bromide and 4',6-diamidino-2-phenylindole staining. For the animal study, 30 rats were divided into two equal groups at random (ADM, ADM+EGF). Wound healing was assessed macroscopically, histologically and by real-time polymerase chain reaction for Bax and Bcl-2 gene expression.Results: The ADM characterisation results showed that the scaffold was dense and integral with good stretching. The morphology and phenotype of the isolated fibroblast cells confirmed their identity. The fibroblast cells cultured on the ADM showed proliferation, which improved with the addition of EGF. In the animal model, EGF addition caused significantly (p<0.05) improved wound healing compared with isolated ADM; it also resulted in increased Bcl-2 and reduced Bax expressions.Conclusion: A combination of ADM, fibroblast cells and EGFs could serve as skin substitutes and represent a novel therapeutic methodology for treating burns and hard-to-heal wounds.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"137-145"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of acids as topical antimicrobial agents: a review.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2023.0176

Basavraj S Nagoba, Abhijit S Rayate, Ajay M Gavkare, Arunkumar Rao

{"title":"The efficacy and safety of acids as topical antimicrobial agents: a review.","authors":"Basavraj S Nagoba, Abhijit S Rayate, Ajay M Gavkare, Arunkumar Rao","doi":"10.12968/jowc.2023.0176","DOIUrl":"https://doi.org/10.12968/jowc.2023.0176","url":null,"abstract":"Objective: Infected wounds, refractory to conventional therapy, are a major burden on the healthcare system. Available data show that many commonly used antiseptic agents may be toxic to the cells involved in the healing process and may affect the normal tissue repair. The topical use of different acids to control wound infections effectively and promote healing is well known. The present review aims to summarise the safety and efficacy of various acids as topical agents for treating wound infections.Method: A literature search was performed in PubMed and manually from other sources (cross references and journal sites).Results: We reviewed 116 articles, from which data from 86 relevant articles were analysed. The studies showed that various organic acids were clinically effective in treating wound infections.Conclusion: This study found that various organic acids can act as a substitute for antiseptics to control wound infections refractory to conventional antibiotic therapy and local wound care. Various organic acids differ in efficacy, safety and limitations as topical agents to control wound infections and promote healing. Some acids deliver better results than others, particularly in those cases in which antibiotics and routine antiseptic agents yield little lasting success, especially in controlling hospital strains with multiple antibiotic resistance. Among topically used acids, citric acid and acetic acid are associated with better results.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"119-127"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Errata.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2025.34.2.163

引用次数: 0

Usefulness of a negative pressure wound therapy system for stoma closure.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2023.0320

Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi

{"title":"Usefulness of a negative pressure wound therapy system for stoma closure.","authors":"Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi","doi":"10.12968/jowc.2023.0320","DOIUrl":"https://doi.org/10.12968/jowc.2023.0320","url":null,"abstract":"Objective: Although wound infection rates after stoma closure have decreased, they remain high. Negative pressure wound therapy (NPWT) for stoma closure wounds can shorten healing time for many wound types. The PICO (Smith+Nephew, UK) wound dressing, a single-use NPWT system that can be used for outpatients, was introduced at the Japan Community Health Care Organization Hokkaido Hospital, Japan in November 2017. We evaluated the effectiveness of this dressing in stoma closure wounds.Method: We retrospectively evaluated patients who underwent stoma closure between March 2012 and July 2021. We compared postoperative short-term outcomes (surgical site infection (SSI), number of pain medications, and postoperative hospital stay) by allocating the patients to one of two groups: purse-string closure or purse-string closure with PICO. The purse-string closure group (PC) underwent purse-string closure alone, while the other group underwent purse-string closure and PICO (PCP).Results: A total of 35 patients were evaluated; 20 in the PC group and 15 in the PCP group. No significant differences in characteristics were noted between the groups. Comparisons between stoma closure techniques revealed that the PCP group had shorter hospital stays (p=0.04), lower SSI rates (p=0.04), and less pain medication (p<0.01) than the PC group. Comparisons between SSI occurrence revealed that the group of patients with an SSI had a higher number of colostomies compared with ileostomies (37.5% versus 0%, p<0.01, respectively), used more pain medication (p<0.01), and had longer hospital stays (p=0.04) than patients who did not have an SSI.Conclusion: After stoma closure, combining PICO with purse-string closure may be effective in preventing SSI and controlling postoperative pain.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"106-110"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0365

Pelin Esme, Aysenur Botsali, Ercan Caliskan

{"title":"Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications.","authors":"Pelin Esme, Aysenur Botsali, Ercan Caliskan","doi":"10.12968/jowc.2021.0365","DOIUrl":"https://doi.org/10.12968/jowc.2021.0365","url":null,"abstract":"Objective: The combination of adalimumab and surgical interventions plays a crucial role in managing severe hidradenitis suppurativa (HS). However, there is still limited scientific evidence regarding administering adalimumab during the perioperative period. This study aimed to evaluate whether adalimumab could adversely affect postoperative complications and the total time of wound closure (TTWC) in patients undergoing cutaneous surgery for HS.Method: In this single-centre cohort study, patients with HS were allocated to two groups. Group 1 (biological cohort) consisted of patients with HS who had continuously received adalimumab for at least three months before the procedure. Group 2 (non-biological cohort) patients underwent cutaneous surgery after only four weeks of anti-inflammatory medication. All patients were left to secondary wound healing.Results: A total of 30 surgical sites in 20 patients were included in the study (Group 1: 15 surgical sites/nine patients; Group 2: 15 surgical sites/11 patients). Disease severity and excised skin areas were significantly higher in Group 1 (p<0.001 and p=0.042, respectively) than in Group 2. While the median TTWC was longer in Group 1 than in Group 2 (p=0.004), multivariate regression analysis showed that TTWC was associated with the excised skin area (p=0.016) and Hurley stage (p=0.032), but was not affected by the use of adalimumab (p=0.076).Conclusion: In this study, the use of adalimumab around surgery was not associated with an increased risk of postoperative complications or a prolonged course of wound closure. The results in this patient cohort suggest that adalimumab should not be discontinued during the perioperative period of HS surgery.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"112-118"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 Epub Date: 2025-01-27 DOI: 10.12968/jowc.2024.0416

Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo

{"title":"Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study.","authors":"Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo","doi":"10.12968/jowc.2024.0416","DOIUrl":"https://doi.org/10.12968/jowc.2024.0416","url":null,"abstract":"Objective: Hard-to-heal wounds present a significant healthcare challenge due to their complex aetiology, impact on quality of life (QoL) and consequent economic burden. The aim of this study was to assess the usability, safety and performance of a next-generation, multilayered foam dressing, ConvaFoam (Convatec Ltd., UK), in the management of indicated hard-to-heal wounds.Method: In this prospective, multicentre, interventional, non-comparator, open-label study, wounds included venous leg ulcers, arterial leg ulcers, diabetic foot ulcers and pressure injuries. The primary endpoint was percentage change in wound area at four weeks. Additional endpoints included percentage change in wound area at 12 weeks, satisfactory clinical progress (defined as ≥40% reduction in study wound area at four weeks), complete wound closure, adverse events, pain, QoL and health professional usability outcomes.Results: A total of 90 patients (109 wounds) were included in the full analysis set. The median percentage reduction in wound area from baseline was 47.88% (p<0.0001) at week 4 and 93.75% (p<0.0001) at week 12. Satisfactory clinical progress at four weeks was reported for 61 (55.96%) wounds. Complete wound closure by week 12 was observed in 43 (39.45%) wounds (p<0.0001). The median Wound Quality of Life-14 score improved from 55.36 at baseline, to 80.36 at week 12. Of the 2935 dressing applications, there were only two adverse events which were reported to be related to the study dressings. The majority of health professionals rated ease of application, exudate management, ease of removal and conformity as excellent.Conclusion: The ConvaFoam dressings were shown to be effective at reducing wound size and promoting healing in indicated hard-to-heal wounds, particularly diabetic foot and venous ulcers.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"154-162"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2022.0128

Anna Karafová, Agnieszka Siemieniecka, Marian Karafa

{"title":"The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study.","authors":"Anna Karafová, Agnieszka Siemieniecka, Marian Karafa","doi":"10.12968/jowc.2022.0128","DOIUrl":"https://doi.org/10.12968/jowc.2022.0128","url":null,"abstract":"Objective: Venous leg ulcer (VLU) is a common complication which significantly reduces the patient's quality of life. Despite many effective treatment methods, such as compression therapy, which allow the wound to heal in a short time, it is important to maintain the long-term effects of the therapy. We present the case of a 67-year-old male patient with a trophic ulcer of his left leg.Method: The patient was treated with inelastic multicomponent compression bandages applied every day under Kikuhime pressure-measuring device (HPM-KH-01; TT Meditrade, Denmark) control and advised to wear a compression stocking.Results: The patient's wound closed within eight weeks. After five months, the patient returned to our clinic with a one-month-old wound due to non-adherence with medical recommendations.Conclusion: Key roles in recurrence prevention seem to be played not only by the patient's motivation and perseverance, but, more importantly, by the approach of the therapist. Health professionals should focus not only on one-time closure of the patient's wound, but on cooperation with the patient's family and caregivers, and instructing them on how to look after the patient on a daily basis, including with help to put on compression garments and with motivation to move and exercise. In many cases, with unaccompanied patients, rapid VLU recurrence is observed.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"128-132"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appreciating the past but focusing on the future: specialist nurses in wound care in Europe.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2025.0008

Corinne Scicluna Ward

引用次数: 0

Hippophae rhamnoides L. leaf extract augments dermal wound healing in streptozocin-induced diabetic rats.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0309

Nitin K Upadhyay, Gaurav K Keshri, Asheesh Gupta

{"title":"Hippophae rhamnoides L. leaf extract augments dermal wound healing in streptozocin-induced diabetic rats.","authors":"Nitin K Upadhyay, Gaurav K Keshri, Asheesh Gupta","doi":"10.12968/jowc.2021.0309","DOIUrl":"https://doi.org/10.12968/jowc.2021.0309","url":null,"abstract":"Objective: The present investigation was undertaken to determine the healing efficacy of Hippophae rhamnoides L. (sea buckthorn (SBT)) leaf aqueous lyophilised extract (SBTL-ALE) on a diabetic wound model in rats. The effect of SBTL-ALE was also evaluated on human epithelial cell lines (A431) by using in vitro wound closure and transwell migration assays.Method: A total of four full-thickness excision-type wounds were created on the dorsal surface of streptozocin-induced diabetic rats. The animals were divided into two groups: control rats treated with soft white petroleum jelly and experimental rats treated with SBTL-ALE (5.0%, weight/weight) ointment applied topically, twice daily for seven days.Results: SBTL-ALE significantly (p<0.05) accelerated the migration of epithelial cells in in vitro wound closure and transwell migration assays. Further, SBTL-ALE augmented the healing process by significantly (p<0.05) enhanced wound area contraction, faster complete epithelial closure, increased hydroxyproline (collagen) and hexosamine levels in diabetic rats. Histopathological findings confirmed the healing potential of SBTL-ALE. Immunohistochemical analyses showed increased expression of transforming growth factor (TGF)-β and α-smooth muscle actin in SBTL-ALE-treated wounds of diabetic rats. Superoxide dismutase, catalase and reduced glutathione levels increased, whereas reactive oxygen levels were decreased significantly (p<0.05) in SBTL-ALE-treated wounds compared to diabetic controls, which conferred redox homeostasis.Conclusion: Our results suggest that SBTL-ALE accelerated transdermal wound healing in diabetic rats by increasing the rate of wound contraction, enhancing levels of collagen, hexosamine and endogenous antioxidants, and reducing oxidative stress.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"146-153"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ulcerated tophaceous gout of the foot: a case report and retrospective chart review.

IF 1.5 4区医学

Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2022.0166

Laura Iglesias-Girard, Justine Lafleur-Careau, Jérôme Patry

引用次数: 0