维生素D过多与伤口难愈合1例。

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2025-05-02 DOI:10.12968/jowc.2023.0177

Thomas Steve Jessop, Nicolas Kairinos

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引用次数: 0

摘要

维生素D被认为是安全的，因为它具有广泛的治疗指数，而且血液中的浓度很少上升到有毒水平。然而，过量补充维生素D会导致维生素D过多症，引起高钙血症和高磷血症。由于其脂溶性，维生素D可以储存在脂肪组织中，导致持续的高钙血症，即使在停止补充后也是如此。本病例报告一位81岁女性患者，在服用过量维生素D补充剂30年后发生维生素D过多症。患者表现为复杂的双侧腿部伤口和组织钙化。本病例强调了监测维生素D补充的重要性以及与维生素D过多症相关的风险，包括软组织钙化。

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Hypervitaminosis D and hard-to-heal wounds: a case report.

Vitamin D is thought to be safe due to its wide therapeutic index and concentrations are rarely raised to toxic levels in the blood. However, excessive vitamin D supplementation can lead to hypervitaminosis D, causing hypercalcaemia and hyperphosphataemia. Due to its lipid solubility, vitamin D can be stored in adipose tissue, leading to persistent hypercalcaemia, even after supplementation has been discontinued. This case reports an 81-year-old female patient who developed hypervitaminosis D after taking excessive vitamin D supplementation for 30 years. The patient presented with complex bilateral leg wounds and tissue calcification. This case highlights the importance of monitoring vitamin D supplementation and the risks associated with hypervitaminosis D, including soft tissue calcification.

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.