Journal of wound care最新文献

{"title":"Efficacy and safety of a medical device based on hyaluronic acid and amino acids for the topical treatment of hard-to-heal skin ulcers: a pilot clinical trial.","authors":"Marco Romanelli, Alessandra Michelucci, Giorgio Reggiardo, Giorgio Saponati, Roberto Cassino","doi":"10.12968/jowc.2025.0005","DOIUrl":"10.12968/jowc.2025.0005","url":null,"abstract":"<p><strong>Objective: </strong>Wound healing is a complex process involving haemostasis, inflammation, proliferation and remodelling. Dysregulation in any phase impairs healing. Hyaluronic acid (HA) and amino acids are essential in promoting tissue repair. This study evaluated a topical medical device containing HA and amino acids for its safety and efficacy in treating hard-to-heal (chronic) wounds.</p><p><strong>Method: </strong>This four-week, one-arm, two-centre pilot clinical study included patients with hard-to-heal wounds of various aetiologies. Wounds were classified by exudate level and amount of necrosis. Treatment with different vehicles (cream, gel or powder) was tailored based on wound characteristics. Wound size was measured at baseline and final visit, while symptom severity was tracked using the total symptom score (TSS). Investigator assessment and safety monitoring were also conducted.</p><p><strong>Results: </strong>A total of 60 patients were included in the study. Wound size reduced significantly across all groups, with an average reduction of 54%, and 41% of patients achieving complete healing. Symptom severity, as measured by TSS, showed a consistent and significant reduction. Clinical improvement was observed in 95% of patients and no serious adverse events were reported. The product demonstrated good safety and tolerability.</p><p><strong>Conclusion: </strong>In this study, the HA and amino acids product effectively reduced ulcer size, improved symptoms and promoted healing, demonstrating its efficacy in hard-to-heal wound management. The findings are clinically significant but limited by the absence of a control group and a short observation period. Further randomised controlled trials are required to confirm these results and explore broader clinical applications.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"717-722"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of patient-centred skin care on barrier functions of skin in intensive care.","authors":"Tuğba Yeni, Nuray Enç, Peter R Worsley","doi":"10.12968/jowc.2025.0369","DOIUrl":"https://doi.org/10.12968/jowc.2025.0369","url":null,"abstract":"","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"689-690"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of care pathways in preventing and treating pressure ulcers never diminishes, even in times of technological expansion.","authors":"Andrea Pokorná, Tom O'Connor","doi":"10.12968/jowc.2025.0317","DOIUrl":"https://doi.org/10.12968/jowc.2025.0317","url":null,"abstract":"","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"653-654"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing pressure injury incidence rates through strategic focus on device-related injuries.","authors":"Mijin Kim, Youngsun Na, Juyoung Oh","doi":"10.12968/jowc.2025.0372","DOIUrl":"https://doi.org/10.12968/jowc.2025.0372","url":null,"abstract":"","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"688-689"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of nursing training on dependence-related skin lesions: a quasi-experimental study.","authors":"María Luisa Paniagua-Asensio, Lourdes Rubio-Rico, José Fernández-Sáez, Cinta Marsá-Fadurdo, Aurora Domínguez-Paniagua, Alba Roca-Biosca","doi":"10.12968/jowc.2021.0391","DOIUrl":"https://doi.org/10.12968/jowc.2021.0391","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of ad hoc designed, mixed methodology training on the prevention, classification and categorisation of dependence-related skin lesions (DRSL) among nursing professionals at a public general hospital in Spain.</p><p><strong>Method: </strong>A quasi-experimental study comprising a single group with 'pre-test' and 'post-test' measurements and measurements at 15 months involving nursing professionals from two hospitalisation units. The data were analysed considering the scores obtained in the measuring instrument, applied before, after and 15 months subsequent to a five-week blended training programme.</p><p><strong>Results: </strong>In the pre-test phase, 39 valid questionnaires were obtained, of which 23 were from nurses and the remainder from nurse aids. In 90% of the items assessing theoretical knowledge, there was an increase in correct answers in the post-test, with statistical significance in 30% of them. In the items assessing practical skills, there was an 83.3% increase in correct answers in the post-test and 80% of them were statistically significant. In the test conducted at 15 months, 60% of the items assessing theoretical knowledge and 83.3% of the items assessing practical skills underwent an increase in correct answers with respect to the pre-test. The comparison between professional groups and age groups does not reveal any statistically significant differences.</p><p><strong>Conclusion: </strong>Ad hoc blended training with theoretical and practical contents, as presented, can be considered a good instrument to improve knowledge and skills on the prevention, classification and categorisation of DRSL.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"754-762"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain perception and management during chemical debridement with a topical desiccating agent: a case-series analysis.","authors":"Polina Shabes, Waseem Garabet, Sven Tilhein, Hubert Schelzig, Julian-Dario Rembe","doi":"10.12968/jowc.2025.0136","DOIUrl":"https://doi.org/10.12968/jowc.2025.0136","url":null,"abstract":"<p><strong>Objective: </strong>A new topical desiccating agent (TDA; DEBRICHEM, DEBx Medical BV, the Netherlands) based on methanesulfonic acid (MSA) and dimethyl sulfoxide (DMSO) has proved to be an effective biofilm- and necrosis-removing chemical debridement option. However, its application can be temporarily accompanied by sharp pain perception, depending on the individual patient. This study aimed to assess application-associated pain and two strategies to manage this.</p><p><strong>Method: </strong>A single-centre, retrospective, case-series study design was used to assess pain associated with MSA/DMSO treatment. To lower pain sensation during the application, two different local anaesthetic procedures were applied using either an anaesthetic cream or a form of tumescent local anaesthesia (TLA). Pain was assessed using the visual analogue scale (VAS) before, during and at five minutes after treatment. Overall wound pain, pain during dressing change in general and during the last change, as well as during the last sharp debridement were assessed. Additionally, baseline pain medication, medication during treatment and local anaesthetic management before MSA/DMSO application were recorded. Patients with peripheral neuropathy were excluded from the analyses.</p><p><strong>Results: </strong>A total of 20 patients treated with TDA were identified. Application lasted 20 minutes before treatment. Chemical debridement was associated with individual pain during application (VAS range 0-10). However, using adequate management, pain could be effectively reduced with no significant difference between pain ratings for TDA and the usually applied sharp debridement.</p><p><strong>Conclusion: </strong>Accompanying pain during (chemical) TDA debridement was well managed using ready-to-use anaesthetic approaches. It demonstrated no increased overall pain perception compared with sharp debridement and, in some individual cases, even lower pain ratings.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"747-752"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TLC-NOSF dressings versus standard of care for the treatment of diabetic foot ulcers in Vietnam: an economic evaluation.","authors":"Thi Tuyet Mai Kieu, Cong Minh Nguyen, Hong Minh Le, Khac Quynh Truong, Isabelle Boucley, Serge Bohbot","doi":"10.12968/jowc.2025.0187","DOIUrl":"https://doi.org/10.12968/jowc.2025.0187","url":null,"abstract":"<p><strong>Objective: </strong>This economic evaluation compares two treatment strategies for patients with a diabetic foot ulcer (DFU): a lipido-colloid technology with nano-oligosaccharide factor (TLC-NOSF) dressing versus standard of care (SoC) over a one-year time horizon from the Vietnamese healthcare payer perspective.</p><p><strong>Method: </strong>A Markov microsimulation model was developed to simulate weekly progression of DFUs over one year, comparing two treatment strategies. Using a willingness-to-pay threshold of VND 305.7 million (equivalent to [Formula: see text]12,202 USD at the time of writing), the model included base-case, one-way, and probabilistic sensitivity analyses. Clinical inputs came from the Explorer trial and real-world data; cost data from Vietnamese studies and national sources. A budget impact analysis assessed the financial impact of UrgoStart (in either foam or contact forms, Laboratoires URGO, France) reimbursement on Vietnam Social Security (VSS).</p><p><strong>Results: </strong>Based on the base-case analysis, from the Vietnamese payer perspective, UrgoStart Foam and UrgoStart Contact each provided a gain of 0.0222 quality-adjusted life years, with cost savings of [Formula: see text]25.70 USD and [Formula: see text]163.60 USD per patient, respectively, indicating both were dominant over SoC. The results were underlined by both one-way sensitivity analysis and probabilistic sensitivity analysis, where all scenarios showed that TLC-NOSF dressings were cost-effective compared with SoC. Budget impact analysis showed that the reimbursement for the TLC-NOSF dressing was forecast to save the VSS budget approximately [Formula: see text]11,997,965 USD over five years (2024-2028).</p><p><strong>Conclusion: </strong>In this economic evaluation, TLC-NOSF dressings were cost-effective compared with SoC over a one-year time horizon from the Vietnamese healthcare payer perspective and could help save millions of dollars for the VSS budget. The finding supports the making of changes to the reimbursement policy to enable patients to access optimal therapy.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"692-703"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declaration by EPUAP at the 2025 Annual Meeting in Helsinki, Finland.","authors":"Andrea Pokorná, Tom O'Connor, Maarit Ahtiala","doi":"10.12968/jowc.2025.0383","DOIUrl":"https://doi.org/10.12968/jowc.2025.0383","url":null,"abstract":"<p><p>The prevention of pressure ulcers is a patient safety issue.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"656"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of EPUAP pressure ulcer e-Learning to improve knowledge in pressure ulcer/injury management.","authors":"Beáta Grešš Halász, Andrea Pokorná","doi":"10.12968/jowc.2025.0224","DOIUrl":"https://doi.org/10.12968/jowc.2025.0224","url":null,"abstract":"<p><p>Education for health professionals has changed significantly over the last decade due to technological advancements, the increased demand for remote education and computerisation, as well as due to the potential likelihood of remote teaching in the event of future major emergencies (e.g. a pandemic). The European Pressure Ulcer Advisory Panel (EPUAP) Education Committee, having recently issued the EPUAP Pressure Ulcer Curriculum, has decided to develop a living educational resource. This article presents the process of preparation and development of one of the EPUAP Pressure Ulcer Curriculum modules to facilitate the orientation and planning of the content and individual components of e-Learning. A module on the epidemiology of pressure ulcers/injuries has been piloted and provides materials in the context of what to teach as well as tailored guidelines on how to teach e-Learning. This paper demonstrates the capability of e-Learning in pressure ulcers/injuries management and education to improve performance and efficiency. Based on this work, the creation of e-Learning for all modules is the goal for further activities of the EPUAP Education Committee and its work group.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"666-671"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of temperature on vascular density at the sacrum and heel.","authors":"Ralph Jfh Gordon, Charlotte E Stevens, Peter R Worsley, Davide Filingeri","doi":"10.12968/jowc.2025.0368","DOIUrl":"https://doi.org/10.12968/jowc.2025.0368","url":null,"abstract":"","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 9","pages":"686-687"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}