Journal of wound care最新文献

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Usefulness of a negative pressure wound therapy system for stoma closure. 负压伤口治疗系统在造口术中的应用。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2023.0320
Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi
{"title":"Usefulness of a negative pressure wound therapy system for stoma closure.","authors":"Chisato Shirakawa, Yuzuru Sakamoto, Shinya Ueki, Hiroki Shomura, Keizo Kazui, Akinobu Taketomi","doi":"10.12968/jowc.2023.0320","DOIUrl":"10.12968/jowc.2023.0320","url":null,"abstract":"<p><strong>Objective: </strong>Although wound infection rates after stoma closure have decreased, they remain high. Negative pressure wound therapy (NPWT) for stoma closure wounds can shorten healing time for many wound types. The PICO (Smith+Nephew, UK) wound dressing, a single-use NPWT system that can be used for outpatients, was introduced at the Japan Community Health Care Organization Hokkaido Hospital, Japan in November 2017. We evaluated the effectiveness of this dressing in stoma closure wounds.</p><p><strong>Method: </strong>We retrospectively evaluated patients who underwent stoma closure between March 2012 and July 2021. We compared postoperative short-term outcomes (surgical site infection (SSI), number of pain medications, and postoperative hospital stay) by allocating the patients to one of two groups: purse-string closure or purse-string closure with PICO. The purse-string closure group (PC) underwent purse-string closure alone, while the other group underwent purse-string closure and PICO (PCP).</p><p><strong>Results: </strong>A total of 35 patients were evaluated; 20 in the PC group and 15 in the PCP group. No significant differences in characteristics were noted between the groups. Comparisons between stoma closure techniques revealed that the PCP group had shorter hospital stays (p=0.04), lower SSI rates (p=0.04), and less pain medication (p<0.01) than the PC group. Comparisons between SSI occurrence revealed that the group of patients with an SSI had a higher number of colostomies compared with ileostomies (37.5% versus 0%, p<0.01, respectively), used more pain medication (p<0.01), and had longer hospital stays (p=0.04) than patients who did not have an SSI.</p><p><strong>Conclusion: </strong>After stoma closure, combining PICO with purse-string closure may be effective in preventing SSI and controlling postoperative pain.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"106-110"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study. 新一代多层泡沫敷料在难愈合伤口中的应用:一项前瞻性、多中心研究。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 Epub Date: 2025-01-27 DOI: 10.12968/jowc.2024.0416
Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo
{"title":"Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study.","authors":"Marisa Ranire-Maguire, Russell Caprioli, Cristin Taylor, Rebecca Rodger, Andrew Thomas, Alisha Oropallo","doi":"10.12968/jowc.2024.0416","DOIUrl":"10.12968/jowc.2024.0416","url":null,"abstract":"<p><strong>Objective: </strong>Hard-to-heal wounds present a significant healthcare challenge due to their complex aetiology, impact on quality of life (QoL) and consequent economic burden. The aim of this study was to assess the usability, safety and performance of a next-generation, multilayered foam dressing, ConvaFoam (Convatec Ltd., UK), in the management of indicated hard-to-heal wounds.</p><p><strong>Method: </strong>In this prospective, multicentre, interventional, non-comparator, open-label study, wounds included venous leg ulcers, arterial leg ulcers, diabetic foot ulcers and pressure injuries. The primary endpoint was percentage change in wound area at four weeks. Additional endpoints included percentage change in wound area at 12 weeks, satisfactory clinical progress (defined as ≥40% reduction in study wound area at four weeks), complete wound closure, adverse events, pain, QoL and health professional usability outcomes.</p><p><strong>Results: </strong>A total of 90 patients (109 wounds) were included in the full analysis set. The median percentage reduction in wound area from baseline was 47.88% (p<0.0001) at week 4 and 93.75% (p<0.0001) at week 12. Satisfactory clinical progress at four weeks was reported for 61 (55.96%) wounds. Complete wound closure by week 12 was observed in 43 (39.45%) wounds (p<0.0001). The median Wound Quality of Life-14 score improved from 55.36 at baseline, to 80.36 at week 12. Of the 2935 dressing applications, there were only two adverse events which were reported to be related to the study dressings. The majority of health professionals rated ease of application, exudate management, ease of removal and conformity as excellent.</p><p><strong>Conclusion: </strong>The ConvaFoam dressings were shown to be effective at reducing wound size and promoting healing in indicated hard-to-heal wounds, particularly diabetic foot and venous ulcers.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"154-162"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications. 汗腺炎手术期间阿达木单抗的中断与继续:继发性伤口愈合和术后并发症。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0365
Pelin Esme, Aysenur Botsali, Ercan Caliskan
{"title":"Interruption versus continuation of adalimumab during hidradenitis surgery: secondary wound healing and postoperative complications.","authors":"Pelin Esme, Aysenur Botsali, Ercan Caliskan","doi":"10.12968/jowc.2021.0365","DOIUrl":"10.12968/jowc.2021.0365","url":null,"abstract":"<p><strong>Objective: </strong>The combination of adalimumab and surgical interventions plays a crucial role in managing severe hidradenitis suppurativa (HS). However, there is still limited scientific evidence regarding administering adalimumab during the perioperative period. This study aimed to evaluate whether adalimumab could adversely affect postoperative complications and the total time of wound closure (TTWC) in patients undergoing cutaneous surgery for HS.</p><p><strong>Method: </strong>In this single-centre cohort study, patients with HS were allocated to two groups. Group 1 (biological cohort) consisted of patients with HS who had continuously received adalimumab for at least three months before the procedure. Group 2 (non-biological cohort) patients underwent cutaneous surgery after only four weeks of anti-inflammatory medication. All patients were left to secondary wound healing.</p><p><strong>Results: </strong>A total of 30 surgical sites in 20 patients were included in the study (Group 1: 15 surgical sites/nine patients; Group 2: 15 surgical sites/11 patients). Disease severity and excised skin areas were significantly higher in Group 1 (p<0.001 and p=0.042, respectively) than in Group 2. While the median TTWC was longer in Group 1 than in Group 2 (p=0.004), multivariate regression analysis showed that TTWC was associated with the excised skin area (p=0.016) and Hurley stage (p=0.032), but was not affected by the use of adalimumab (p=0.076).</p><p><strong>Conclusion: </strong>In this study, the use of adalimumab around surgery was not associated with an increased risk of postoperative complications or a prolonged course of wound closure. The results in this patient cohort suggest that adalimumab should not be discontinued during the perioperative period of HS surgery.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"112-118"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study. 静脉性腿部溃疡患者的护理人员在预防复发中的作用:一个案例研究。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2022.0128
Anna Karafová, Agnieszka Siemieniecka, Marian Karafa
{"title":"The role of a caregiver of a patient with venous leg ulcers in recurrence prevention: a case study.","authors":"Anna Karafová, Agnieszka Siemieniecka, Marian Karafa","doi":"10.12968/jowc.2022.0128","DOIUrl":"10.12968/jowc.2022.0128","url":null,"abstract":"<p><strong>Objective: </strong>Venous leg ulcer (VLU) is a common complication which significantly reduces the patient's quality of life. Despite many effective treatment methods, such as compression therapy, which allow the wound to heal in a short time, it is important to maintain the long-term effects of the therapy. We present the case of a 67-year-old male patient with a trophic ulcer of his left leg.</p><p><strong>Method: </strong>The patient was treated with inelastic multicomponent compression bandages applied every day under Kikuhime pressure-measuring device (HPM-KH-01; TT Meditrade, Denmark) control and advised to wear a compression stocking.</p><p><strong>Results: </strong>The patient's wound closed within eight weeks. After five months, the patient returned to our clinic with a one-month-old wound due to non-adherence with medical recommendations.</p><p><strong>Conclusion: </strong>Key roles in recurrence prevention seem to be played not only by the patient's motivation and perseverance, but, more importantly, by the approach of the therapist. Health professionals should focus not only on one-time closure of the patient's wound, but on cooperation with the patient's family and caregivers, and instructing them on how to look after the patient on a daily basis, including with help to put on compression garments and with motivation to move and exercise. In many cases, with unaccompanied patients, rapid VLU recurrence is observed.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"128-132"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appreciating the past but focusing on the future: specialist nurses in wound care in Europe. 欣赏过去,关注未来:欧洲伤口护理专业护士。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2025.0008
Corinne Scicluna Ward
{"title":"Appreciating the past but focusing on the future: specialist nurses in wound care in Europe.","authors":"Corinne Scicluna Ward","doi":"10.12968/jowc.2025.0008","DOIUrl":"https://doi.org/10.12968/jowc.2025.0008","url":null,"abstract":"","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"103-104"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hippophae rhamnoides L. leaf extract augments dermal wound healing in streptozocin-induced diabetic rats. 沙棘叶提取物促进链脲佐菌素诱导的糖尿病大鼠皮肤创面愈合。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2021.0309
Nitin K Upadhyay, Gaurav K Keshri, Asheesh Gupta
{"title":"<i>Hippophae rhamnoides</i> L. leaf extract augments dermal wound healing in streptozocin-induced diabetic rats.","authors":"Nitin K Upadhyay, Gaurav K Keshri, Asheesh Gupta","doi":"10.12968/jowc.2021.0309","DOIUrl":"10.12968/jowc.2021.0309","url":null,"abstract":"<p><strong>Objective: </strong>The present investigation was undertaken to determine the healing efficacy of <i>Hippophae rhamnoides</i> L. (sea buckthorn (SBT)) leaf aqueous lyophilised extract (SBTL-ALE) on a diabetic wound model in rats. The effect of SBTL-ALE was also evaluated on human epithelial cell lines (A431) by using in vitro wound closure and transwell migration assays.</p><p><strong>Method: </strong>A total of four full-thickness excision-type wounds were created on the dorsal surface of streptozocin-induced diabetic rats. The animals were divided into two groups: control rats treated with soft white petroleum jelly and experimental rats treated with SBTL-ALE (5.0%, weight/weight) ointment applied topically, twice daily for seven days.</p><p><strong>Results: </strong>SBTL-ALE significantly (p<0.05) accelerated the migration of epithelial cells in in vitro wound closure and transwell migration assays. Further, SBTL-ALE augmented the healing process by significantly (p<0.05) enhanced wound area contraction, faster complete epithelial closure, increased hydroxyproline (collagen) and hexosamine levels in diabetic rats. Histopathological findings confirmed the healing potential of SBTL-ALE. Immunohistochemical analyses showed increased expression of transforming growth factor (TGF)-β and α-smooth muscle actin in SBTL-ALE-treated wounds of diabetic rats. Superoxide dismutase, catalase and reduced glutathione levels increased, whereas reactive oxygen levels were decreased significantly (p<0.05) in SBTL-ALE-treated wounds compared to diabetic controls, which conferred redox homeostasis.</p><p><strong>Conclusion: </strong>Our results suggest that SBTL-ALE accelerated transdermal wound healing in diabetic rats by increasing the rate of wound contraction, enhancing levels of collagen, hexosamine and endogenous antioxidants, and reducing oxidative stress.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"146-153"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ulcerated tophaceous gout of the foot: a case report and retrospective chart review. 溃疡性痛风的足:一个病例报告和回顾性图表回顾。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-02 DOI: 10.12968/jowc.2022.0166
Laura Iglesias-Girard, Justine Lafleur-Careau, Jérôme Patry
{"title":"Ulcerated tophaceous gout of the foot: a case report and retrospective chart review.","authors":"Laura Iglesias-Girard, Justine Lafleur-Careau, Jérôme Patry","doi":"10.12968/jowc.2022.0166","DOIUrl":"10.12968/jowc.2022.0166","url":null,"abstract":"<p><p>Ulcerated tophaceous gout is an uncommon presentation of the lower limbs. Treatment of these wounds can be a challenge, as their optimal management remains to be determined. Therefore, a retrospective analysis of medical charts between 2015 and 2021 was conducted at a wound clinic of a university-affiliated hospital to determine the characteristics of patients treated for tophaceous wounds, their evolution and treatment. We report a total of five patients with ulcerated tophaceous gout of the foot who initially presented predominantly with soft tissue infection or osteomyelitis. All progressed well with local wound care, including conservative sharp debridement of the tophi and rapid initiation of urate-lowering therapy. Therefore, a diagnosis of tophi should be considered in an ulceration of the first metatarsophalangeal joint or other toes when whitish-chalky material is present, even if the patient was not previously known to have gout. Tophi ulceration is a rare complication; however, prompt diagnosis and management are important to avoid destruction of the underlying bone structures.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 2","pages":"133-136"},"PeriodicalIF":1.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure injury detection using alternate light: a proof-of-concept study. 使用交替光进行压力损伤检测:概念验证研究。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-01 DOI: 10.12968/jowc.2023.0304
Katherine N Scafide, Linda Arundel, Ghadeer Assas, Erica L King
{"title":"Pressure injury detection using alternate light: a proof-of-concept study.","authors":"Katherine N Scafide, Linda Arundel, Ghadeer Assas, Erica L King","doi":"10.12968/jowc.2023.0304","DOIUrl":"10.12968/jowc.2023.0304","url":null,"abstract":"<p><strong>Objective: </strong>Identification of early-stage pressure injuries (PIs) during visual skin assessment may be subjective and unreliable. An alternate light source (ALS) has been shown to increase the probability of detecting evidence of bruises on individuals with darker skin tones. Bruises and early-stage PIs are often difficult to identify, especially in those with darker skin tones, where melanin concentration is high. Given the effect skin pigmentation has on detecting both types of cutaneous injuries, this proof-of-concept study aimed to describe the characteristics of Stage 1 PIs and deep tissue PIs as viewed under an ALS.</p><p><strong>Method: </strong>Eligible participants were first examined by a certified wound ostomy continence nurse using environmentally available white light. A blinded second examiner then evaluated the size of the potential tissue impairment using violet (406nm) and blue (448nm) ALS viewed through yellow and orange goggles, respectively. Portable ultrasound was used to confirm tissue involvement. Data were summarised using descriptive statistics.</p><p><strong>Results: </strong>The study included 10 participants (40% of whom were from minority racial/ethnic groups) with a mean Braden Scale score of 11.1. The majority of PIs (80%) involved deep tissue and were located on lower extremities (60%). The median PI size was larger by 17.5cm<sup>2</sup> and 13.7cm<sup>2</sup>, respectively, using ALS compared with white light when viewed under violet and blue wavelengths. Ultrasound data were limited to non-extremity regions (n=3 participants) with hypoechoic areas noted as being 10-13mm in thickness and up to 16.7mm deep.</p><p><strong>Conclusion: </strong>Evidence of tissue damage that extended beyond that visualised under white light was noted with ALS. Usefulness of ultrasound was limited over bony prominences where there was too little subcutaneous tissue. Further research is warranted to investigate the potential application of ALS for the early detection of PIs.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 Sup2","pages":"S17-S23"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive bacterial synergistic gangrene (Meleney's gangrene): a rare case. 进行性细菌增效坏疽(Meleney坏疽):一例罕见病例。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-01 DOI: 10.12968/jowc.2020.0119
Fatma Bilgen, Alper Ural, Mehmet Bekerecioglu
{"title":"Progressive bacterial synergistic gangrene (Meleney's gangrene): a rare case.","authors":"Fatma Bilgen, Alper Ural, Mehmet Bekerecioglu","doi":"10.12968/jowc.2020.0119","DOIUrl":"10.12968/jowc.2020.0119","url":null,"abstract":"<p><p>Meleney's gangrene, also known as progressive bacterial synergistic gangrene, is a type of necrotising fasciitis. It is believed that it arises from synergistic effects of multiple bacterial agents, hence its name. In this case report, we present a non-surgical treatment approach of lower extremity Meleney's gangrene. A 32-year-old female patient was found to have a necrotic wound measuring 10×2cm on the inferior-lateral aspect of the thigh. A pouch of approximately 30×30cm was found on the subcutaneous deep muscle layer, extending to both anterior and posterior thigh. Effective treatment modalities can be implemented only if early diagnosis of this unique type of gangrene is possible. Therefore, Meleney's gangrene should be kept in mind in the differential diagnosis of subcutaneous soft tissue infections.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 Sup2a","pages":"xix-xxi"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds. 开放性创面患者阿片类药物耐受性与创面因素及创面微环境的关系。
IF 1.5 4区 医学
Journal of wound care Pub Date : 2025-02-01 DOI: 10.12968/jowc.2023.0215
Jaewon Bae, Amy Campbell, Maria Hein, Stephen L Hillis, Elizabeth Grice, Barbara A Rakel, Sue E Gardner
{"title":"Relationship of opioid tolerance to patient and wound factors, and wound micro-environment in patients with open wounds.","authors":"Jaewon Bae, Amy Campbell, Maria Hein, Stephen L Hillis, Elizabeth Grice, Barbara A Rakel, Sue E Gardner","doi":"10.12968/jowc.2023.0215","DOIUrl":"10.12968/jowc.2023.0215","url":null,"abstract":"<p><strong>Objective: </strong>Opioid tolerance is a criterion for opioid use disorder, which is currently an epidemic in the US. Individuals with open wounds are frequently administered opioids; however, the phenomenon of opioid tolerance has not been examined in the context of wounds. The purpose of this exploratory study was to compare patient/wound factors, wound microbiome and inflammatory mediators between individuals who were opioid-tolerant versus those who were not opioid-tolerant.</p><p><strong>Method: </strong>Patients with acute open wounds were enrolled in this cross-sectional study. All study data were collected before and during a one-time study dressing change.</p><p><strong>Results: </strong>The study included a total of 385 participants. Opioid-tolerant participants were significantly younger (p<0.0001); had higher levels of depression (p=0.0055) and anxiety (p=0.0118); had higher pain catastrophising scores (p=0.0035); reported higher resting wound pain (p<0.0001); had a higher number of wounds of <30 days' duration (p=0.0486); and had wounds with lower bacterial richness (p=0.0152) than participants who were not opioid-tolerant. A backward elimination logistic regression model showed that four predictors-resting wound pain, age, bacterial richness and depression-were the most important variables in predicting opioid-tolerance status.</p><p><strong>Conclusion: </strong>These findings provide the first insights into the phenomenon of opioid tolerance in the context of open wounds. This study provides findings from which to guide hypothesis-driven research in the future.</p>","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 Sup2","pages":"S6-S16"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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