Journal of Veterinary Diagnostic Investigation最新文献_第5页

Characterization of amyloid deposits in exocrine pancreatic tumors in cats. 猫外分泌胰腺肿瘤中淀粉样蛋白沉积的特征。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251343842

Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Noboru Machida, Tomoaki Murakami

{"title":"Characterization of amyloid deposits in exocrine pancreatic tumors in cats.","authors":"Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Noboru Machida, Tomoaki Murakami","doi":"10.1177/10406387251343842","DOIUrl":"10.1177/10406387251343842","url":null,"abstract":"Some types of amyloidosis are observed as localized conditions associated with tumors, such as plasmacytoma and C-cell carcinoma. Although pancreatic endocrine tumors have been linked to amyloid deposition, the potential for amyloid formation in exocrine pancreatic tumors has remained unexplored in both animals and humans. We examined amyloid deposits in 24 feline cases of exocrine pancreatic tumors. Histologic analysis identified amyloid deposits in 8 cases, appearing as Congo red-positive amorphous material in the luminal corpora amylacea. Microdissection and mass spectrometry analysis of amyloid deposits from 5 cases identified lithostathine as the major component in 3 of the cases. Immunohistochemistry confirmed the presence of lithostathine in these deposits, identifying lithostathine-derived amyloid. Conversely, other cases had no consistent lithostathine positivity, indicating that multiple amyloidogenic proteins, not just lithostathine, may be involved in exocrine pancreatic tumor-associated amyloidosis.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251343842"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemorrhagic septicemia in the United States: molecular characterization of isolates and comparison to a global collection. 美国出血性败血症：分离株的分子特征和与全球收集的比较。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251342528

Kelli J Maddock, Brianna L S Stenger, Heidi L Pecoraro, Jill C Roberts, John Dustin Loy, Brett T Webb

{"title":"Hemorrhagic septicemia in the United States: molecular characterization of isolates and comparison to a global collection.","authors":"Kelli J Maddock, Brianna L S Stenger, Heidi L Pecoraro, Jill C Roberts, John Dustin Loy, Brett T Webb","doi":"10.1177/10406387251342528","DOIUrl":"10.1177/10406387251342528","url":null,"abstract":"Hemorrhagic septicemia-causing strains of Pasteurella multocida are endemic in Asia and Africa, but naturally occurring hemorrhagic septicemia has not been described in livestock in the United States since 1993. There are 5 capsular types of P. multocida: A, B, D, E, and F. Two capsular types (B, E) cause hemorrhagic septicemia, whereas capsular types A and, to a lesser extent, D are associated with enzootic bovine pneumonia. Here we describe 2 naturally occurring cases of hemorrhagic septicemia caused by P. multocida capsular type B:3,4 in the United States, including molecular characterization of these strains, with a comparison to available reference strains and publicly available genomes of P. multocida capsular type B. Genomic analyses demonstrated that our case strains are similar to a strain isolated from New Jersey cattle in 1968 and to contemporaneous strains from New Zealand and Canada. These strains are different from those circulating globally, as demonstrated by the need to assign new sequence types for our isolates. Hemorrhagic septicemia appears to be re-emerging globally in countries that have not seen outbreaks in decades and may be poised for re-emergence in the United States given the identification of these novel strains.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251342528"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anogenital papillomatosis associated with a novel papillomavirus in a grey-headed flying fox. 灰头狐的肛门生殖器乳头状瘤病与一种新型乳头状瘤病毒有关。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251341935

John S Munday, Susan E Brown, Emily E Kay, Ludovica D Valenza

{"title":"Anogenital papillomatosis associated with a novel papillomavirus in a grey-headed flying fox.","authors":"John S Munday, Susan E Brown, Emily E Kay, Ludovica D Valenza","doi":"10.1177/10406387251341935","DOIUrl":"10.1177/10406387251341935","url":null,"abstract":"A 0.5-cm nodular thickening of the vagina was observed in a flying fox (Pteropus poliocephalus) that had been rescued after becoming entangled in fruit netting. Over the following 6 mo, the thickening progressed to diffuse multinodular mucosal thickening of both the vagina and anus. The proliferative lesions were removed surgically. Histologically, the thickened mucosa was arranged in numerous small exophytic papillomas. Cells within the basilar layers were crowded and basophilic. Rarely, enlarged cells that contained increased quantities of pale, smudged eosinophilic cytoplasm [consistent with papillomavirus (PV)-induced cellular changes] were visible. PCR amplified a PV DNA sequence from a sample of affected vaginal mucosa; the sequence was ~90% similar to a PV DNA sequence previously detected as a subclinical infection in an African species of fruit bat. The lesion had not recurred within 6 mo of surgical excision. This is the second report of PV-associated disease in bats; to our knowledge, PV infection has not been reported previously in association with anogenital lesions in bats. Additionally, to our knowledge, a PV has not been identified previously in an Australian bat species.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251341935"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of serologic evidence of orthoflavivirus infection in dogs with meningoencephalitis of unknown origin and steroid-responsive meningitis-arteritis in the Netherlands. 荷兰不明原因脑膜脑炎和类固醇反应性脑膜炎动脉炎犬中正黄病毒感染的血清学证据缺乏。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-21 DOI: 10.1177/10406387251340619

Koen M Santifort, Kiki Streng, Niklas Bergknut, Iris Van Soens, Marta Plonek, Wim H M van der Poel

{"title":"Lack of serologic evidence of orthoflavivirus infection in dogs with meningoencephalitis of unknown origin and steroid-responsive meningitis-arteritis in the Netherlands.","authors":"Koen M Santifort, Kiki Streng, Niklas Bergknut, Iris Van Soens, Marta Plonek, Wim H M van der Poel","doi":"10.1177/10406387251340619","DOIUrl":"10.1177/10406387251340619","url":null,"abstract":"The pathogenesis of meningoencephalomyelitis of unknown origin (MUO) and steroid-responsive meningitis-arteritis (SRMA) in dogs remains enigmatic. Numerous studies have attempted and failed to identify (viral) pathogens in samples from MUO- or SRMA-diagnosed dogs. Orthoflavivirus-associated meningoencephalitis or meningoencephalomyelitis has been diagnosed in dogs in several European countries. We investigated serologic evidence for orthoflavivirus infection in dogs with clinical diagnoses of MUO or SRMA in the Netherlands. Twelve dogs with a clinical diagnosis of MUO based on signalment, neurologic examination, MRI studies, CSF analysis, and response to treatment were included in the study (age range: 1-11 y; 4 females, 8 males; weight range: 8-44 kg). Serum samples from all 12 dogs tested negative in a commercial competitive ELISA and virus neutralization tests for West Nile virus, Usutu virus, and tick-borne encephalitis virus. We did not find serologic evidence of orthoflavivirus infection in dogs with MUO or SRMA in the Netherlands.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251340619"},"PeriodicalIF":1.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina. 草酸盐肾病在牛与阿根廷大鳄消费有关。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-19 DOI: 10.1177/10406387251336265

Agustín Avellaneda-Cáceres, Stephen T Lee, Álvaro Ruiz, Gabriela V Sandoval, Luis A Colque-Caro, Daniel Cook, Laura S Aguirre, Francisco A Uzal, Juan F Micheloud

{"title":"Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina.","authors":"Agustín Avellaneda-Cáceres, Stephen T Lee, Álvaro Ruiz, Gabriela V Sandoval, Luis A Colque-Caro, Daniel Cook, Laura S Aguirre, Francisco A Uzal, Juan F Micheloud","doi":"10.1177/10406387251336265","DOIUrl":"10.1177/10406387251336265","url":null,"abstract":"Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251336265"},"PeriodicalIF":1.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory assessment of recovery of porcine circovirus 2 and porcine reproductive and respiratory syndrome virus using 2 commercial hollow-fiber ultrafilters. 使用两种商用中空纤维超滤器回收猪圆环病毒 2 和猪繁殖与呼吸综合征病毒的实验室评估。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1177/10406387251322506

Aaron D Firnstahl, Gabrielle E Doughan, Sarah A Opelt, Rachel M Cook, Joseph A Heffron, Karen M Krueger, Mark A Borchardt, Locke A Karriker, Joel P Stokdyk, Tucker R Burch

{"title":"Laboratory assessment of recovery of porcine circovirus 2 and porcine reproductive and respiratory syndrome virus using 2 commercial hollow-fiber ultrafilters.","authors":"Aaron D Firnstahl, Gabrielle E Doughan, Sarah A Opelt, Rachel M Cook, Joseph A Heffron, Karen M Krueger, Mark A Borchardt, Locke A Karriker, Joel P Stokdyk, Tucker R Burch","doi":"10.1177/10406387251322506","DOIUrl":"10.1177/10406387251322506","url":null,"abstract":"Groundwater near swine farms is an uninvestigated reservoir for porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circoviruses (PCVs). Enteric microorganisms are often collected from groundwater via dead-end ultrafiltration, but recovery of PRRSV and PCV with this method has not been assessed. We recovered PRRSV2 and PCV2 by dead-end ultrafiltration followed by polyethylene glycol (PEG) precipitation, nucleic acid extraction, and reverse-transcription quantitative real-time PCR. We also compared 2 commercial hemodialysis ultrafilters (Asahi Kasei Rexeed-25A, Nipro Elisio-25H) and compared PRRSV2 recovery in these filters to other waterborne microorganisms. On average, 8 ± 1% of PRRSV2 was recovered by dead-end ultrafiltration and PEG precipitation, compared to 25 ± 6% for adenovirus 41. Full-process recovery of bacteria in the same filters was 5-15%; Cryptosporidium parvum recovery was 42 ± 12%. PCV2 was detected in 4 of 12 replicate filters, but low stock concentrations precluded quantitative recovery estimates. Elisio-25H ultrafilters performed similarly to Rexeed-25A filters for all organisms tested and is an effective replacement for the Rexeed-25A, which is no longer available in the United States. Our recovery of PRRSV2 and PCV2 by dead-end ultrafiltration in the laboratory suggests that PRRSV2 detection limits are as low as 3-50 genomic copies/L in sample volumes of 100-1,500 L. Based on quantitative microbial risk assessment, these concentrations are relevant to PRRSV2 infection rates in the U.S. swine herd.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"439-447"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High prevalence and broad geographic distribution of urine shedding of bovine polyomavirus 1 (Epsilonpolyomavirus bovis) by cattle in Uruguay. 乌拉圭牛尿中牛多瘤病毒 1（Epsilonpolyomavirus bovis）的高流行率和广泛地理分布。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI: 10.1177/10406387251321421

Matías Castells, Leticia Zarantonelli, Caroline da Silva Silveira, Rodney Colina, Federico Giannitti

{"title":"High prevalence and broad geographic distribution of urine shedding of bovine polyomavirus 1 (Epsilonpolyomavirus bovis) by cattle in Uruguay.","authors":"Matías Castells, Leticia Zarantonelli, Caroline da Silva Silveira, Rodney Colina, Federico Giannitti","doi":"10.1177/10406387251321421","DOIUrl":"10.1177/10406387251321421","url":null,"abstract":"In 2021, bovine polyomavirus 1 (BoPyV1; Polyomaviridae, Epsilonpolyomavirus bovis) was associated with nephritis in an aborted bovine fetus in Uruguay, with renal lesions resembling those typical of polyomavirus-associated nephropathy of humans. Given that little is known about the epidemiology of BoPyV1 infection in cattle, we screened for BoPyV1 in urine samples collected in 2015-2017 from beef and dairy herds from 12 of the 19 departments in Uruguay. We tested for BoPyV1 by PCR in 156 urine pools and 249 individual urine samples from 42 herds. We detected BoPyV1 in 33 of 42 (79%) farms across 100% of the departments studied, in similar proportions in beef (22 of 30; 73%) and dairy (11 of 12; 92%) herds. At the animal level, BoPyV1 was detected in 80 of 249 (32%) animals; this frequency was significantly higher in dairy (51 of 119; 43%) than beef (29 of 130; 22%) cattle, and in cows (36 of 81; 44%) than heifers (32 of 121; 26%). BoPyV1 strains circulating in Uruguay have a high degree (98.7-100%) of sequence identity at the major capsid protein VP1, which is slightly lower (96.2-99.7%) than for strains from other countries. We conclude that shedding of BoPyV1 in the urine of dairy and beef cattle is prevalent and geographically widespread in Uruguay.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"489-494"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bovine abortions due to the rare Salmonella serovars Kingston and Kedougou. 因罕见的金斯顿沙门氏菌和克杜古沙门氏菌引起的牛流产。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1177/10406387251324261

Laurie Boucher, Pierre Hélie, Julie-Hélène Fairbrother, Sonia Chénier, Samuel Morin, Guillaume St-Jean

引用次数: 0

Enterotoxemia in a 2-day-old lamb produced by a Clostridium perfringens type D lambda toxin-positive strain. 产气荚膜梭菌D型毒素阳性菌株引起的2日龄羔羊肠毒血症。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1177/10406387251320943

Kaylin Moctezuma, Hernando D Acevedo, Eileen E Henderson, Javier Asin, John M Adaska, Francisco A Uzal

{"title":"Enterotoxemia in a 2-day-old lamb produced by a Clostridium perfringens type D lambda toxin-positive strain.","authors":"Kaylin Moctezuma, Hernando D Acevedo, Eileen E Henderson, Javier Asin, John M Adaska, Francisco A Uzal","doi":"10.1177/10406387251320943","DOIUrl":"10.1177/10406387251320943","url":null,"abstract":"Clostridium perfringens type D is a gram-positive bacterium that causes enterotoxemia in sheep, goats, and, less frequently, other animals. This microorganism encodes 2 major toxins, alpha (CPA) and epsilon (ETX). Enterotoxemia occurs when epsilon prototoxin (pETX) is produced in the intestine and is activated by one or more proteases before being absorbed into the general circulation. Traditionally, it was believed that neonatal animals were not susceptible to type D enterotoxemia due to the trypsin-inhibitory action of colostrum in the intestinal tract and the lack of protease activation of pETX, although cases of enterotoxemia have been reported in 2 neonatal goat kids. A 2-d-old lamb, with a history of frailty, hunched posture, shallow breathing, and diarrhea followed by death, was submitted for postmortem examination and diagnostic workup. Autopsy revealed hydropericardium, pulmonary edema, and congested intestines. Histologically, there was pulmonary congestion and edema, and intestinal congestion. C. perfringens type D carrying the gene for lambda toxin was isolated from the small intestine and colon. Both CPA and ETX were detected in the small intestine and colon contents. We speculate that lambda toxin (a protease) activated pETX, and that ETX, in turn, produced enterotoxemia in this lamb.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"504-506"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bovine herpesviral meningoencephalitis: large case study and literature review. 牛疱疹病毒性脑膜脑炎：大型病例研究和文献回顾。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-01 Epub Date: 2025-02-18 DOI: 10.1177/10406387251319804

Bethânia S Santos, Ricardo A A Lemos, Raquel R Rech, Claudio S L Barros, Daniel R Rissi

{"title":"Bovine herpesviral meningoencephalitis: large case study and literature review.","authors":"Bethânia S Santos, Ricardo A A Lemos, Raquel R Rech, Claudio S L Barros, Daniel R Rissi","doi":"10.1177/10406387251319804","DOIUrl":"10.1177/10406387251319804","url":null,"abstract":"Bovine herpesviral meningoencephalitis (BHM) is an infectious disease of cattle caused by bovine alphaherpesvirus 1 (BoAHV1; Orthoherpesviridae, Varicellovirus bovinealpha1) or 5 (BoAHV5; Orthoherpesviridae, Varicellovirus bovinealpha5). Cases are frequent in South America, but the disease is sporadic in other countries. Infection typically leads to fatal necrotizing meningoencephalitis that most often affects calves <1-y-old and yearlings under stressful situations, including weaning, large concentrations of animals, transport, and introduction of cattle from other locations into a herd. Clinical disease lasts from 1-10 d and often leads to typical gross and histologic lesions that are more prominent in the frontal lobes of the brain. This particular neuroanatomic distribution of lesions results from retrograde viral infection from the nasal mucosa along the olfactory nerves and bulbs with subsequent spread to the rostral cerebrum. Because of its particular geographic distribution, many aspects of BHM are still poorly documented in the English language veterinary literature, and thus a comprehensive review of the disease is warranted. Here we review the main aspects of BHM, including its historical timeline, etiology, pathogenesis, epidemiology, clinical and pathologic findings, diagnosis, and control and prophylaxis.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"417-428"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0