Journal of Ultrasound in Medicine最新文献

{"title":"Ultrasound-Based Machine Learning and SHapley Additive exPlanations Method Evaluating Risk of Gallbladder Cancer: A Bicentric and Validation Study.","authors":"Binqiong Chen, Huohu Zhong, Jiaojiao Lin, Guorong Lyu, Shanshan Su","doi":"10.1002/jum.70027","DOIUrl":"https://doi.org/10.1002/jum.70027","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to construct and evaluate 8 machine learning models by integrating ultrasound imaging features, clinical characteristics, and serological features to assess the risk of gallbladder cancer (GBC) occurrence in patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on ultrasound and clinical data of 300 suspected GBC patients who visited the Second Affiliated Hospital of Fujian Medical University from January 2020 to January 2024 and 69 patients who visited the Zhongshan Hospital Affiliated to Xiamen University from January 2024 to January 2025. Key relevant features were selected using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Predictive models were constructed using XGBoost, logistic regression, support vector machine, k-nearest neighbors, random forest, decision tree, naive Bayes, and neural network, with the SHapley Additive exPlanations (SHAP) method employed to explain model interpretability.</p><p><strong>Results: </strong>The LASSO regression demonstrated that gender, age, alkaline phosphatase (ALP), clarity of interface with liver, stratification of the gallbladder wall, intracapsular anechoic lesions, and intracapsular punctiform strong lesions were key features for GBC. The XGBoost model demonstrated an area under receiver operating characteristic curve (AUC) of 0.934, 0.916, and 0.813 in the training, validating, and test sets. SHAP analysis revealed the importance ranking of factors as clarity of interface with liver, stratification of the gallbladder wall, intracapsular anechoic lesions, and intracapsular punctiform strong lesions, ALP, gender, and age. Personalized prediction explanations through SHAP values demonstrated the contribution of each feature to the final prediction, enhancing result interpretability. Furthermore, decision plots were generated to display the influence trajectory of each feature on model predictions, aiding in analyzing which features had the greatest impact on these mispredictions; thereby facilitating further model optimization or feature adjustment.</p><p><strong>Conclusion: </strong>This study proposed a GBC ML model based on ultrasound, clinical, and serological characteristics, indicating the superior performance of the XGBoost model and enhancing the interpretability of the model through the SHAP method.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical Vein Doppler Evaluation in Small for Gestational Age Fetuses With Normal Umbilical Artery Doppler Findings: A Prospective Cohort Study.","authors":"Mohammadamin Parsaei, Zeynab Zamanpour, Zahra Ghasemipour Afshar, Mohammadamin Noorafrooz, Mohadese Dashtkoohi, Mobina Taghva Nakhjiri, Zahra Hamidi Madani, Maryam Aliasgharpoor, Zahra Panahi, Fahimeh Ghotbizadeh, Sedigheh Borna, Sedigheh Hantoushzadeh, Bahram Salmanian","doi":"10.1002/jum.70007","DOIUrl":"https://doi.org/10.1002/jum.70007","url":null,"abstract":"<p><strong>Objectives: </strong>The umbilical vein (UV) plays a crucial role in fetal oxygenation, and its dysfunction may contribute to adverse outcomes in small-for-gestational-age (SGA) fetuses. We hypothesized that UV Doppler assessment could enhance risk stratification and guide delivery timing. This study compared UV hemodynamics between SGA and appropriately-for-gestational-age (AGA) fetuses to evaluate their predictive value for low birth weight.</p><p><strong>Methods: </strong>In this prospective cohort study (Tehran, Iran; July-December 2024), we included singleton pregnancies >32 weeks. SGA was defined as estimated fetal weight (EFW) or abdominal circumference (AC) <10th percentile, excluding fetal growth restriction (EFW/AC <3rd percentile or additional Doppler abnormalities). UV flow (UVF), EFW-normalized UVF (nUVF), and UV diameters (intra-abdominal and free-loop) were compared between SGA and AGA cohorts. Predictive performance for low birth weight (<2500 g) was assessed via receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Among 322 pregnancies (78 SGA, 24.2%), SGA fetuses exhibited significantly lower UVF (172.1 versus 216.3 mL/min; P < .001), nUVF (76.4 versus 81.4 mL/minute/kg; P = .048), and narrower UV diameters (both P < .001). After adjustment, differences persisted except for nUVF. UVF and UV diameters moderately predicted low birth weight (areas under the ROC curve [AUCs] > .70), with free-loop diameter showing the highest discrimination (AUC = .798, 95% confidence interval: 0.687-0.909).</p><p><strong>Conclusions: </strong>SGA fetuses with normal umbilical artery Doppler demonstrate significant UV hemodynamic changes. UV Doppler, particularly free-loop diameter, may help identify high-risk pregnancies, aiding delivery planning. These findings support further exploration of UV assessment in SGA management protocols.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Sonographic and Intraoperative Findings of Deep-Infiltrating Endometriosis.","authors":"Shivani Parikh, Rebecca Barbaresso, Vanessa Brown, Jeremy T Gaskins, Resad Pasic","doi":"10.1002/jum.70023","DOIUrl":"https://doi.org/10.1002/jum.70023","url":null,"abstract":"<p><strong>Objective: </strong>Endometriosis is a chronic inflammatory condition affecting approximately 5%-10% of reproductive-aged women. Transvaginal ultrasound (TVUS) is increasingly used to diagnose deep-infiltrating endometriosis (DIE). This study assesses the sonographic accuracy of detecting intraoperative DIE lesions after implementing a structured protocol and its ability to predict the need for advanced laparoscopic procedures in patients undergoing excisional endometriosis surgery.</p><p><strong>Methods: </strong>An IRB-exempt retrospective study was conducted over a 12-month period at a tertiary-level academic hospital. Inclusion criteria included women >18 years old who underwent a laparoscopic excision of endometriosis with or without hysterectomy and had a preoperative office TVUS performed based on the International Deep Endometriosis Analysis consensus within 6 months of surgery. Demographic data, endometriosis history, sonographic, operative, and pathology reports were collected. Appropriate statistical tests were applied.</p><p><strong>Results: </strong>Of 117 patients, 89 women met inclusion criteria. Endometriosis pathology was confirmed in 90% of patients. TVUS had a sensitivity of 61% (95% confidence interval [CI]: 49-72), specificity of 94% (95% CI: 71-100), negative predictive value of 36% (95% CI: 22-52), positive predictive value of 98% (95% CI: 88-100), and odds ratio (OR) of 24.4 (95% CI: 3.4-1071; P < .001). Negative sliding sign (OR 7.12, P = .006) and rectovaginal space abnormality (OR 19.9, P = .002) were associated with intraoperative DIE and advanced laparoscopic procedures, including enterolysis or adhesiolysis >30 minutes (OR 11.3, P < .001) and ureterolysis (OR 3.29, P = .013).</p><p><strong>Conclusions: </strong>Sonographic markers, particularly sliding sign and posterior compartment abnormalities, can predict intraoperative DIE and the need for complex laparoscopic procedures. TVUS may aid in surgical planning and improve patient counseling and outcomes.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Reintervention Rates for Type 1 and Type 2 Uterine Fibroids Treated With HIFU Ablation With Varying Non-Perfused Volume Ratios to That With TCRM.","authors":"Tao Tan, Shuang Li, Zhiyun Yang, Jinfeng Lin, Meijie Yang, Liang Hu, Jinyun Chen","doi":"10.1002/jum.70011","DOIUrl":"https://doi.org/10.1002/jum.70011","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to investigate the correlation between long-term reintervention rates following high-intensity focused ultrasound (HIFU) ablation with varying non-perfused volume ratios (NPVR) and hysteroscopic transcervical resection of myoma (TCRM) for type 1 and 2 fibroids. Additionally, the study aims to define the technical success criteria in this context.</p><p><strong>Methods: </strong>This retrospective study included patients with type 1 and 2 fibroids who underwent treatment with HIFU or TCRM between January 2012 and December 2019. Follow-up assessments were conducted to monitor reintervention rates. NPVR, assessed via magnetic resonance imaging (MRI) post-HIFU treatment, served as a technical indicator for comparing reintervention outcomes between HIFU and TCRM. Logistic regression analysis was employed to identify factors influencing reintervention in patients.</p><p><strong>Results: </strong>A total of 445 patients were enrolled, with successful follow-up on 325 cases, including 181 cases in the HIFU group and 144 cases in the TCRM group, resulting in a follow-up rate of 73%. When NPVR was ≥70% (n = 151), the long-term reintervention rate following HIFU was comparable to that of TCRM. Binary logistic regression analysis revealed age and long-term symptom relief as independent influencing factors influencing reintervention. The cut-off value of age in patients from the HIFU group was determined as 41.5 using receiver operating characteristic curve (ROC) analysis. The reintervention rate was found to be 10.1% (n = 79) for patients aged over 41.5 years, compared to 34.7% (n = 72) for those aged below it.</p><p><strong>Conclusion: </strong>HIFU emerges as an effective and reliable treatment modality for large type 1 and type 2 uterine fibroids, providing a viable non-invasive alternative for their management. NPVR ≥70% can serve as a technical criterion for successful operation.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic Evaluation of the Myotendinous Junction of the Long Head of the Biceps Tendon: The Horseshoe Sign.","authors":"Stefan Diermayr, Sebastian Halm, Raphael Trefzer, Marco Etter","doi":"10.1002/jum.70019","DOIUrl":"https://doi.org/10.1002/jum.70019","url":null,"abstract":"<p><p>In this pictorial essay, we describe the sonographic characteristics of the myotendinous junction of the long head of the biceps tendon in healthy individuals and demonstrate its relevance in the sonographic assessment of biceps tendon pathology and postoperative controls, such as biceps tenodesis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Tricuspid Annular Plane Systolic Excursion in the Surveillance of Intra-Abdominal Umbilical Vein Varix.","authors":"Yossi Geron, Lior Drukker, Sharon Perlman, Ran Matot, Victoria Hermann, Natav Hendin, Ron Bardin, Yinon Gilboa, Ron Charach","doi":"10.1002/jum.70026","DOIUrl":"https://doi.org/10.1002/jum.70026","url":null,"abstract":"<p><strong>Objective: </strong>To describe the application of tricuspid annular plane systolic excursion (TAPSE) in monitoring cardiac function in cases of fetal intra-abdominal umbilical vein varix (FIUVV).</p><p><strong>Methods: </strong>The sample consisted of all cases of FIUVV diagnosed in a tertiary medical center between 2018 and 2023 that were assessed by sonographic fetal TAPSE. Cases were identified by retrospective database review. Data on maximal umbilical vein varix diameter, associated anatomic or genetic anomalies, and pregnancy outcomes were collected from the electronic files.</p><p><strong>Results: </strong>Seventeen cases met the inclusion criteria; 13/17 (76.5%) had isolated FIUVV. The mean maximal varix diameter was 12.6 ± 2.1 mm. In 14/17 cases (82.4%), TAPSE was above the 75th percentile, including 10/17 (58.8%) in which TAPSE measured above the 90th percentile. There were no instances of thrombosis formation or intrauterine fetal demise.</p><p><strong>Conclusions: </strong>Our findings suggest a hyperdynamic cardiac state in fetuses with FIUVV. Fetal TAPSE may serve as a complementary tool in the surveillance of these cases, potentially aiding in the early identification of cardiac decompensation and guiding the optimal timing of delivery.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-Care Ultrasound in Undergraduate Medical Education: A National Survey.","authors":"Frances M Russell, Reena Park, Molly Campbell, Laura Lemen","doi":"10.1002/jum.70021","DOIUrl":"https://doi.org/10.1002/jum.70021","url":null,"abstract":"<p><strong>Objective: </strong>The primary aim of this study was to assess the state of point-of-care ultrasound (POCUS) integration in undergraduate medical education (UME) at medical schools in the United States.</p><p><strong>Methods: </strong>This was a cross-sectional survey study on POCUS implementation at 155 allopathic medical schools. The survey, which was distributed to Clinical Ultrasound Directors and medical school curricular deans, consisted of 18 questions and collected data on school characteristics and POCUS curricula details.</p><p><strong>Results: </strong>The survey response rate was 84% (130/155). Data showed that 66% (84/130) of schools had an approved POCUS curriculum, and 13 had a 4-year longitudinal curriculum. Most schools required POCUS education in the preclinical years. Curricula taught a broad range of modalities for diagnostic POCUS, with focused assessment with sonography in trauma and cardiac being the most taught exams. Forty-nine schools evaluated students' progress and understanding of POCUS.</p><p><strong>Conclusions: </strong>When compared to 5 years ago, more schools are implementing POCUS in UME, with 84 having an approved curriculum. Few schools offer a longitudinal curriculum, and only 49 are assessing students' POCUS knowledge.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic Function in Late-Onset FGR Insights From Ultrasound-Based Quantification","authors":"Recep Taha Ağaoğlu MD,&nbsp;Ayşe Çiğdem Bayrak MD,&nbsp;Özgür Volkan Akbulut MD,&nbsp;Aziz Kindan MD,&nbsp;Eda Tüfekçioğlu MD,&nbsp;Mehmet Kaya MD,&nbsp;İzzet Özgürlük MD,&nbsp;Zehra Vural Yilmaz MD,&nbsp;Kadriye Yakut Yücel MD","doi":"10.1002/jum.70025","DOIUrl":"10.1002/jum.70025","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We aimed to investigate diaphragm functions via ultrasonography in fetuses with late-onset fetal growth restriction (LO-FGR) and to examine the relationship of these parameters with composite adverse perinatal outcomes (CAPO).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective cohort study included 40 fetuses with LO-FGR and 40 healthy controls matched for gestational age. Diaphragmatic functions were evaluated using ultrasonography by measuring diaphragm thickness (DT) during inspiration and expiration, diaphragm thickness fraction (DTF), diaphragm excursion (DE), and costophrenic angle (CPA). CAPO was defined as a 5-minute Apgar score of less than 7 and/or infant respiratory complications or admission to the neonatal intensive care unit (NICU). The LO-FGR group was categorized into 2 subgroups: those with CAPO and those without. Statistical analyses evaluated the association between sonographic measurements of the diaphragm and CAPO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the LO-FGR group, DT (both inspiratory and expiratory), DTF, DE, and expiratory CPA were markedly reduced (<i>P</i> &lt; .001). In LO-FGR cases that developed CAPO, DT (both inspiratory and expiratory), DTF, and DE were significantly lower (<i>P</i> &lt; .001). Inspiratory DT exhibited the best predictive value for CAPO (area under the curve [AUC]: 0.923), followed by expiratory DT (AUC: 0.865) and DE (AUC: 0.786). Additionally, DUS parameters exhibited better predictive capability relative to Doppler measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Diaphragmatic ultrasonography-derived functional parameters serve as clinically relevant biomarkers for predicting unfavorable perinatal outcomes in LO-FGR. The incorporation of DUS into standard prenatal assessment procedures may enhance the monitoring and management of LO-FGR cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 10","pages":"1893-1901"},"PeriodicalIF":2.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Proximal and Distal Transverse Aortic Arch and Aortic Isthmus Measurements Between 19 and 34 Weeks of Gestation.","authors":"Hakan Erenel, Kubra Kurt Bilirer, Firat Ersan, Verda Alpay, Isa Ozyilmaz","doi":"10.1002/jum.70024","DOIUrl":"https://doi.org/10.1002/jum.70024","url":null,"abstract":"<p><strong>Objectives: </strong>To assess fetal proximal and distal transverse aortic arch and aortic isthmus (AI) diameters between 19 and 34 weeks of gestation.</p><p><strong>Methods: </strong>A prospective cross-sectional descriptive study was performed in 466 low-risk pregnancies between 19 and 34 weeks of gestation. Proximal transverse aortic arch (PTAA), distal transverse aortic arch (DTAA), and the AI diameters (sagittal and three-vessel trachea view) were measured.</p><p><strong>Results: </strong>The mean ± SD, and 5th, 50th, 95th centile charts according to gestational age for PTAA, DTAA, and AI diameter were constructed. Pearson's correlation coefficients for PTAA, DTAA, and AI diameter (sagittal and three-vessel trachea view) by gestational week were 0.884, 0.877, 0.890, and 0.898, respectively (P < .0001). The mean AI diameter, in both sagittal and three-vessel trachea planes, was significantly lower than that of the proximal and distal transverse aortic arch (P = .001).</p><p><strong>Conclusions: </strong>We demonstrated the growth curve and nomogram of the PTAA. With the aid of nomograms, the prenatal identification of proximal transverse aortic arch hypoplasia may facilitate a better understanding of the severity of transverse aortic arch hypoplasia and assist in planning the appropriate postnatal surgical intervention.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimode Ultrasound Features in Skeletal Muscle Lymphoma: A Retrospective Observational Study.","authors":"Yang Sun, Li Zhang, Jing Su, Iryna Vyacheslavovna Nazarenko, Dzmitry Ivanovich Haurylenka, Ligang Cui, Wen Chen","doi":"10.1002/jum.70018","DOIUrl":"https://doi.org/10.1002/jum.70018","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the ultrasound findings in skeletal muscle lymphoma and investigate the correlations between ultrasound findings and histopathological characteristics.</p><p><strong>Methods: </strong>Ultrasonographic images with skeletal muscle lymphoma obtained between June 2014 and June 2024 were retrospectively reviewed. The ultrasonographic examinations comprised gray-scale (n = 35), color-Doppler (n = 35), contrast-enhanced (n = 5), and elastography imaging (n = 5). Biopsy samples underwent histopathological analysis to identify the histopathologic basis of the typical ultrasound features. Kappa statistics were used to assess the consistency between ultrasound findings and histopathological features.</p><p><strong>Results: </strong>The study comprised 35 patients (mean age, 63 years ±15 [standard deviation], 17 men). In gray-scale sonography, 35 lesions (100%) appeared as hypoechoic areas in the muscle with poorly defined margins. Residual myofiber-like echoes were observed in 25 (71.4%) lesions, and a \"cobblestone\" appearance was noted in 18 (51.4%). In color-Doppler sonography, 10 (28.6%) patients had intact transverse vessels perpendicular to the long axis of the muscle. In contrast-enhanced sonography, 4 out of 5 (80%) lesions showed synchronous high enhancement. Four out of 5 (80%) lesions exhibited high stiffness on elastography imaging. Myofiber-like echoes (κ: 0.800, P < 0.001) and the \"cobblestone\" appearance (κ: 0.521, P < .017) are consistent with myofibers in pathology.</p><p><strong>Conclusion: </strong>Skeletal muscle lymphoma demonstrates specific features on multimodal ultrasound.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}